FR2189058A1 - S-substd 2-thioadenosines - as coronary vasodilators and blood platelet aggregation inhibitors - Google Patents

S-substd 2-thioadenosines - as coronary vasodilators and blood platelet aggregation inhibitors

Info

Publication number
FR2189058A1
FR2189058A1 FR7322316A FR7322316A FR2189058A1 FR 2189058 A1 FR2189058 A1 FR 2189058A1 FR 7322316 A FR7322316 A FR 7322316A FR 7322316 A FR7322316 A FR 7322316A FR 2189058 A1 FR2189058 A1 FR 2189058A1
Authority
FR
France
Prior art keywords
substd
thioadenosines
platelet aggregation
blood platelet
aggregation inhibitors
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR7322316A
Other languages
French (fr)
Other versions
FR2189058B1 (en
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Kohjin Co
Original Assignee
Kohjin Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from JP47060464A external-priority patent/JPS5216120B2/ja
Priority claimed from JP12961972A external-priority patent/JPS4986392A/ja
Priority claimed from JP12962072A external-priority patent/JPS4986393A/ja
Priority claimed from JP48011159A external-priority patent/JPS5238040B2/ja
Priority claimed from JP2798573A external-priority patent/JPS49110694A/ja
Priority claimed from JP3270373A external-priority patent/JPS544959B2/ja
Application filed by Kohjin Co filed Critical Kohjin Co
Publication of FR2189058A1 publication Critical patent/FR2189058A1/en
Application granted granted Critical
Publication of FR2189058B1 publication Critical patent/FR2189058B1/fr
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
    • C07H19/20—Purine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Cpds. (I) and their 51-monophosphates- (where R is alkyl, cycloalkyl, cycloalkyl-alkyl, each of 5 or more C atoms, opt. substd. allyl, opt. substd. benzyl or dialkylaminoalkyl), are prepd. by reacting 2-thioadenosine with R.Halide and opt. phosphorylating the prodt. Thus (I; R = PhCH2) is prepd. by reacting 2-thioadenosine with PhCH2Br in the presence of NaOH.
FR7322316A 1972-06-19 1973-06-19 S-substd 2-thioadenosines - as coronary vasodilators and blood platelet aggregation inhibitors Granted FR2189058A1 (en)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
JP47060464A JPS5216120B2 (en) 1972-06-19 1972-06-19
JP12961972A JPS4986392A (en) 1972-12-26 1972-12-26
JP12962072A JPS4986393A (en) 1972-12-26 1972-12-26
JP48011159A JPS5238040B2 (en) 1973-01-29 1973-01-29
JP2798573A JPS49110694A (en) 1973-03-12 1973-03-12
JP3270373A JPS544959B2 (en) 1973-03-23 1973-03-23

Publications (2)

Publication Number Publication Date
FR2189058A1 true FR2189058A1 (en) 1974-01-25
FR2189058B1 FR2189058B1 (en) 1976-10-22

Family

ID=27548319

Family Applications (1)

Application Number Title Priority Date Filing Date
FR7322316A Granted FR2189058A1 (en) 1972-06-19 1973-06-19 S-substd 2-thioadenosines - as coronary vasodilators and blood platelet aggregation inhibitors

Country Status (2)

Country Link
FR (1) FR2189058A1 (en)
SE (1) SE401679B (en)

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
CHEMICAL ABSTRACTS 59 (1962) 1742C cite CHEM. PHARM. BULL. (TOKYO) 10, pages 647 - 652 *

Also Published As

Publication number Publication date
SE401679B (en) 1978-05-22
FR2189058B1 (en) 1976-10-22

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Legal Events

Date Code Title Description
ST Notification of lapse