FR2186470A1 - Purine nucleoside nitrates - for treating cardiac insufficiency - Google Patents

Purine nucleoside nitrates - for treating cardiac insufficiency

Info

Publication number
FR2186470A1
FR2186470A1 FR7318902A FR7318902A FR2186470A1 FR 2186470 A1 FR2186470 A1 FR 2186470A1 FR 7318902 A FR7318902 A FR 7318902A FR 7318902 A FR7318902 A FR 7318902A FR 2186470 A1 FR2186470 A1 FR 2186470A1
Authority
FR
France
Prior art keywords
purine nucleoside
cardiac insufficiency
nitrates
treating cardiac
prepd
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR7318902A
Other languages
French (fr)
Other versions
FR2186470B1 (en
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Henning Berlin GmbH Chemie- und Pharmawerk
Original Assignee
Henning Berlin GmbH Chemie- und Pharmawerk
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Henning Berlin GmbH Chemie- und Pharmawerk filed Critical Henning Berlin GmbH Chemie- und Pharmawerk
Publication of FR2186470A1 publication Critical patent/FR2186470A1/en
Application granted granted Critical
Publication of FR2186470B1 publication Critical patent/FR2186470B1/fr
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals

Abstract

Novel title cpds are of formula (I): (R=NH2 or OH; R1 and R2=H or NO2; R3=NO2) and are prepd by reacting corresp. purine nucleoside with fuming HNO3 opt. mixed with acetic anhydride, pref. at between -70 degrees C and room temp. (I) are useful in treatment of cardiac insufficiency and also in purine nucleoside chemistry since the NO2 gps are relatively stable acids and bases but easily removed by hydrogenolysis.
FR7318902A 1972-05-30 1973-05-24 Purine nucleoside nitrates - for treating cardiac insufficiency Granted FR2186470A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19722226295 DE2226295A1 (en) 1972-05-30 1972-05-30 NITRIC ACID ESTERS OF PURIN NUCLEOSIDES AND METHOD FOR MANUFACTURING THE SAME

Publications (2)

Publication Number Publication Date
FR2186470A1 true FR2186470A1 (en) 1974-01-11
FR2186470B1 FR2186470B1 (en) 1976-06-11

Family

ID=5846334

Family Applications (1)

Application Number Title Priority Date Filing Date
FR7318902A Granted FR2186470A1 (en) 1972-05-30 1973-05-24 Purine nucleoside nitrates - for treating cardiac insufficiency

Country Status (3)

Country Link
AT (1) AT323336B (en)
DE (1) DE2226295A1 (en)
FR (1) FR2186470A1 (en)

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1758596A2 (en) * 2004-05-26 2007-03-07 Inotek Pharmaceuticals Corporation Purine derivatives as adenosine a1 receptor agonists and methods of use thereof
US7732424B2 (en) 2005-11-30 2010-06-08 Inotek Pharmaceuticals Corporation Purine derivatives and methods of use thereof
US9278991B2 (en) 2012-01-26 2016-03-08 Inotek Pharmaceuticals Corporation Anhydrous polymorphs of [(2R,3S,4R,5R)-5-(6-(cyclopentylamino)-9H-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl)} methyl nitrate and processes of preparation thereof
US9289383B2 (en) 2010-03-26 2016-03-22 Inotek Pharmaceuticals Corporation Method of reducing intraocular pressure in humans
US9370530B2 (en) 2010-01-11 2016-06-21 Inotek Pharmaceuticals Corporation Combination, kit and method of reducing intraocular pressure
US9522160B2 (en) 2013-03-15 2016-12-20 Inotek Pharmaceuticals Corporation Ophthalmic formulations

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3595853A (en) * 1968-03-19 1971-07-27 Kohjin Co Ribofuranosyl cytosine and arabinofuranosyl cytosine derivatives
DE2105560A1 (en) * 1971-02-06 1972-09-07 Boehringer Mannheim Gmbh, 6800 Mannheim Purine ribonucleoside derivatives and processes for making the same
FR2152507A1 (en) * 1971-09-10 1973-04-27 Hoffmann La Roche

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3595853A (en) * 1968-03-19 1971-07-27 Kohjin Co Ribofuranosyl cytosine and arabinofuranosyl cytosine derivatives
DE2105560A1 (en) * 1971-02-06 1972-09-07 Boehringer Mannheim Gmbh, 6800 Mannheim Purine ribonucleoside derivatives and processes for making the same
FR2152507A1 (en) * 1971-09-10 1973-04-27 Hoffmann La Roche

Cited By (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NO339450B1 (en) * 2004-05-26 2016-12-12 Inotek Pharmaceuticals Corp Purine derivatives such as adenosine A1 receptor agonists, preparations containing them and applications thereof
EP1758596A4 (en) * 2004-05-26 2007-08-01 Inotek Pharmaceuticals Corp Purine derivatives as adenosine a1 receptor agonists and methods of use thereof
US7423144B2 (en) 2004-05-26 2008-09-09 Inotek Pharmaceuticals Corporation Purine Derivatives as adenosine A1 receptor agonists and methods of use thereof
EP1758596A2 (en) * 2004-05-26 2007-03-07 Inotek Pharmaceuticals Corporation Purine derivatives as adenosine a1 receptor agonists and methods of use thereof
EP2221307A1 (en) * 2004-05-26 2010-08-25 Inotek Pharmaceuticals Corporation Purine derivatives as adenosine A1 receptor agonists and methods of use thereof
AU2005249430B2 (en) * 2004-05-26 2011-06-23 Inotek Pharmaceuticals Corporation Purine derivatives as adenosine A1 receptor agonists and methods of use thereof
US8183224B2 (en) 2004-05-26 2012-05-22 Inotek Pharmaceuticals Corporation Purine derivatives as adenosine A1 receptor agonists and methods of use thereof
US8609833B2 (en) 2004-05-26 2013-12-17 Inotek Pharmaceuticals Corporation Purine derivatives as adenosine A1 receptor agonists and methods of use thereof
US7732424B2 (en) 2005-11-30 2010-06-08 Inotek Pharmaceuticals Corporation Purine derivatives and methods of use thereof
US9370530B2 (en) 2010-01-11 2016-06-21 Inotek Pharmaceuticals Corporation Combination, kit and method of reducing intraocular pressure
US9289383B2 (en) 2010-03-26 2016-03-22 Inotek Pharmaceuticals Corporation Method of reducing intraocular pressure in humans
US9278991B2 (en) 2012-01-26 2016-03-08 Inotek Pharmaceuticals Corporation Anhydrous polymorphs of [(2R,3S,4R,5R)-5-(6-(cyclopentylamino)-9H-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl)} methyl nitrate and processes of preparation thereof
US9718853B2 (en) 2012-01-26 2017-08-01 Inotek Pharmaceuticals Corporation Anhydrous polymorphs of [(2R,3S,4R,5R)-5-(6-(cyclopentylamino)-9H-purin-9-YL)-3,4-dihydroxytetrahydrofuran-2-YL)] methyl nitrate and processes of preparation thereof
US9522160B2 (en) 2013-03-15 2016-12-20 Inotek Pharmaceuticals Corporation Ophthalmic formulations

Also Published As

Publication number Publication date
FR2186470B1 (en) 1976-06-11
DE2226295A1 (en) 1973-12-20
AT323336B (en) 1975-07-10

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