FR2148056A1 - Thiazole-2,4-dimethanol dicarbamates - with circulator and cns activity - Google Patents

Thiazole-2,4-dimethanol dicarbamates - with circulator and cns activity

Info

Publication number
FR2148056A1
FR2148056A1 FR7227138A FR7227138A FR2148056A1 FR 2148056 A1 FR2148056 A1 FR 2148056A1 FR 7227138 A FR7227138 A FR 7227138A FR 7227138 A FR7227138 A FR 7227138A FR 2148056 A1 FR2148056 A1 FR 2148056A1
Authority
FR
France
Prior art keywords
dimethanol
thiazole
dicarbamates
circulator
cns activity
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR7227138A
Other languages
French (fr)
Other versions
FR2148056B1 (en
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
MSD KK
Original Assignee
Banyu Phamaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from JP5676871A external-priority patent/JPS5533435B1/ja
Priority claimed from JP5676771A external-priority patent/JPS5533434B1/ja
Priority claimed from JP5676671A external-priority patent/JPS5758344B1/ja
Application filed by Banyu Phamaceutical Co Ltd filed Critical Banyu Phamaceutical Co Ltd
Publication of FR2148056A1 publication Critical patent/FR2148056A1/en
Application granted granted Critical
Publication of FR2148056B1 publication Critical patent/FR2148056B1/fr
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/22—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C07D277/24—Radicals substituted by oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D277/56—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Cephalosporin Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Title cpds. of formula (I): (where R is lower alkyl or phenyl), which esp. have cardiovascular activity, are prepd. by reacting thiazole-2,4-dimethanol with a cpd. R-NCO.
FR7227138A 1971-07-30 1972-07-27 Thiazole-2,4-dimethanol dicarbamates - with circulator and cns activity Granted FR2148056A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP5676871A JPS5533435B1 (en) 1971-07-30 1971-07-30
JP5676771A JPS5533434B1 (en) 1971-07-30 1971-07-30
JP5676671A JPS5758344B1 (en) 1971-07-30 1971-07-30

Publications (2)

Publication Number Publication Date
FR2148056A1 true FR2148056A1 (en) 1973-03-11
FR2148056B1 FR2148056B1 (en) 1976-05-14

Family

ID=27296030

Family Applications (1)

Application Number Title Priority Date Filing Date
FR7227138A Granted FR2148056A1 (en) 1971-07-30 1972-07-27 Thiazole-2,4-dimethanol dicarbamates - with circulator and cns activity

Country Status (3)

Country Link
DE (1) DE2235377A1 (en)
FR (1) FR2148056A1 (en)
SU (1) SU503522A3 (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2300562A1 (en) * 1975-02-14 1976-09-10 Roussel Uclaf 2-Alkyl-thiazolyl-alkanols and their esters - have antilicpolytic activity

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7452862B2 (en) 2003-07-31 2008-11-18 Tranzyme Pharma, Inc. Conformationally-controlled biologically active macrocyclic small molecules as motilin antagonists or ghrelin agonists
US8088733B2 (en) 2006-07-06 2012-01-03 Tranzyme Pharma Inc. Methods of using macrocyclic agonists of the ghrelin receptor for treatment of gastrointestinal motility disorders

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2300562A1 (en) * 1975-02-14 1976-09-10 Roussel Uclaf 2-Alkyl-thiazolyl-alkanols and their esters - have antilicpolytic activity

Also Published As

Publication number Publication date
SU503522A3 (en) 1976-02-15
DE2235377A1 (en) 1973-02-08
FR2148056B1 (en) 1976-05-14

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Legal Events

Date Code Title Description
ST Notification of lapse