FR2102170A2 - Monoamides of cyclic diacids - antiinflammatories - Google Patents

Monoamides of cyclic diacids - antiinflammatories

Info

Publication number
FR2102170A2
FR2102170A2 FR7104679A FR7104679A FR2102170A2 FR 2102170 A2 FR2102170 A2 FR 2102170A2 FR 7104679 A FR7104679 A FR 7104679A FR 7104679 A FR7104679 A FR 7104679A FR 2102170 A2 FR2102170 A2 FR 2102170A2
Authority
FR
France
Prior art keywords
monoamides
antiinflammatories
phenyl
treated
cyclic diacids
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR7104679A
Other languages
French (fr)
Other versions
FR2102170B2 (en
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
So Ci Bre
Socibre
Original Assignee
So Ci Bre
Socibre
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from IL35098A external-priority patent/IL35098A/en
Application filed by So Ci Bre, Socibre filed Critical So Ci Bre
Publication of FR2102170A2 publication Critical patent/FR2102170A2/en
Application granted granted Critical
Publication of FR2102170B2 publication Critical patent/FR2102170B2/fr
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/81—Amides; Imides
    • C07D213/82—Amides; Imides in position 3

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

The title cpds. are of formula (I) where the X and Y rings are phenyl or pyridyl and R1 and R2 = X >=1 of lower alkyl, haloalkyl, hal, acyl, OH, alkoxy, acyloxy, thioalkoxy, sulphone, amino, or NO2. They are prepd. by reaction of the dicarboxylic acid anhydride with the appropriate amine. In an example, 11.8g. phthalic anhydride was treated with 10.2g. 3-chloraniline in methylene chloride, and the prodt. treated with KHCO3, then with CHl to give (I), X = Y = phenyl; R1 = 3-Cl; R2 = H, m.pt. 162 degrees C.
FR7104679A 1970-08-11 1971-02-11 Monoamides of cyclic diacids - antiinflammatories Granted FR2102170A2 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IL35098A IL35098A (en) 1969-08-14 1970-08-11 Pharmaceutical compositions containing mono-amides of phthalic and pyridine dicarboxylic acids

Publications (2)

Publication Number Publication Date
FR2102170A2 true FR2102170A2 (en) 1972-04-07
FR2102170B2 FR2102170B2 (en) 1974-08-23

Family

ID=11045530

Family Applications (1)

Application Number Title Priority Date Filing Date
FR7104679A Granted FR2102170A2 (en) 1970-08-11 1971-02-11 Monoamides of cyclic diacids - antiinflammatories

Country Status (1)

Country Link
FR (1) FR2102170A2 (en)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0617020A1 (en) * 1992-04-02 1994-09-28 Shudo, Koichi, Prof. Dr. Carboxylic acid derivatives having retinoic acid-like activity
WO2004022525A1 (en) * 2002-09-05 2004-03-18 Neurosearch A/S Amide derivatives and their use as chloride channel blockers

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0617020A1 (en) * 1992-04-02 1994-09-28 Shudo, Koichi, Prof. Dr. Carboxylic acid derivatives having retinoic acid-like activity
WO2004022525A1 (en) * 2002-09-05 2004-03-18 Neurosearch A/S Amide derivatives and their use as chloride channel blockers

Also Published As

Publication number Publication date
FR2102170B2 (en) 1974-08-23

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