FR2098755A5 - Mevalolactone and its homologues - prepd from 4-hydroxy-2-butanone and an acid - Google Patents

Mevalolactone and its homologues - prepd from 4-hydroxy-2-butanone and an acid

Info

Publication number
FR2098755A5
FR2098755A5 FR7027582A FR7027582A FR2098755A5 FR 2098755 A5 FR2098755 A5 FR 2098755A5 FR 7027582 A FR7027582 A FR 7027582A FR 7027582 A FR7027582 A FR 7027582A FR 2098755 A5 FR2098755 A5 FR 2098755A5
Authority
FR
France
Prior art keywords
acid
mevalolactone
prepd
butanone
hydroxy
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
FR7027582A
Other languages
French (fr)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
LAIRE PRODUITS CHIMIE
Original Assignee
LAIRE PRODUITS CHIMIE
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by LAIRE PRODUITS CHIMIE filed Critical LAIRE PRODUITS CHIMIE
Priority to FR7027582A priority Critical patent/FR2098755A5/en
Application granted granted Critical
Publication of FR2098755A5 publication Critical patent/FR2098755A5/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
    • C07D309/16—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D309/28—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D309/30—Oxygen atoms, e.g. delta-lactones
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
    • C07D309/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C07D309/08—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D309/10—Oxygen atoms
    • C07D309/12—Oxygen atoms only hydrogen atoms and one oxygen atom directly attached to ring carbon atoms, e.g. tetrahydropyranyl ethers

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

Mevalolactone (I) and other lactones with the same nuclear skeleton are prepd. by reaction of 4-hydroxy-2-butanone (II) or a higher homologue, with an aliphatic acid of >=2C atoms, an aryl aliphatic acid or a cycloaliphatic acid, in the presence of Li, Na or K and an aromatic solvent having >=2 rings. The mevalonic acid produced is converted into (I) by dilute acid. (I) is a precursor in the biosynthesis of steroids.
FR7027582A 1970-07-27 1970-07-27 Mevalolactone and its homologues - prepd from 4-hydroxy-2-butanone and an acid Expired FR2098755A5 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
FR7027582A FR2098755A5 (en) 1970-07-27 1970-07-27 Mevalolactone and its homologues - prepd from 4-hydroxy-2-butanone and an acid

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR7027582A FR2098755A5 (en) 1970-07-27 1970-07-27 Mevalolactone and its homologues - prepd from 4-hydroxy-2-butanone and an acid

Publications (1)

Publication Number Publication Date
FR2098755A5 true FR2098755A5 (en) 1972-03-10

Family

ID=9059284

Family Applications (1)

Application Number Title Priority Date Filing Date
FR7027582A Expired FR2098755A5 (en) 1970-07-27 1970-07-27 Mevalolactone and its homologues - prepd from 4-hydroxy-2-butanone and an acid

Country Status (1)

Country Link
FR (1) FR2098755A5 (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2392016A1 (en) * 1977-05-24 1978-12-22 Sankyo Co MEVALONOLACTONE DERIVATIVES, THEIR PREPARATION PROCESS AND THEIR THERAPEUTIC APPLICATION

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2392016A1 (en) * 1977-05-24 1978-12-22 Sankyo Co MEVALONOLACTONE DERIVATIVES, THEIR PREPARATION PROCESS AND THEIR THERAPEUTIC APPLICATION

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Legal Events

Date Code Title Description
TP Transmission of property
ST Notification of lapse