FR2085635A1 - 4'-disubstd-amino methyl spiro (dibenzo(ad)c - dioxolan (1,3) - Google Patents
4'-disubstd-amino methyl spiro (dibenzo(ad)c - dioxolan (1,3)Info
- Publication number
- FR2085635A1 FR2085635A1 FR7013522A FR7013522A FR2085635A1 FR 2085635 A1 FR2085635 A1 FR 2085635A1 FR 7013522 A FR7013522 A FR 7013522A FR 7013522 A FR7013522 A FR 7013522A FR 2085635 A1 FR2085635 A1 FR 2085635A1
- Authority
- FR
- France
- Prior art keywords
- dioxolan
- dibenzo
- spiro
- disubstd
- amino methyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
- C07D317/72—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 spiro-condensed with carbocyclic rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
spiro- Di-benzo (a,d)cyclopheptadi (or tri)-ene-5:1' dioxolan (1,3) (where Z = -CH2-CH- or -CH=CH-; R, R1 = 1-3C alkyl or together with the N atom form a pyrrolidino, piperidino, hexamethyleneimino or morpholino ring) are prepared by condensing epibromohydrin with dibenzo(a,d)cycloheptade (or tri)enone in the presence of SnCl4 in CCl4 or CHCl3 to give the 4'-bromomethyl spiro deriv. and then condensing this with a secondary amine to form title cpds. The cpds. have analgesic, sedative, antihistaminic, anti-serotonin, anti-inflammatory, anti-convulsant, anti-depressive, spasmolytic, bronchodilator and hypotensive activity.
Priority Applications (16)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR7013522A FR2085635A1 (en) | 1970-04-15 | 1970-04-15 | 4'-disubstd-amino methyl spiro (dibenzo(ad)c - dioxolan (1,3) |
SE7104560A SE377936B (en) | 1970-04-15 | 1971-04-07 | |
CH507271A CH522632A (en) | 1970-04-15 | 1971-04-07 | Process for the preparation of novel derivatives of amino-methyl-4'-spiro (dibenzo (a-d) cycloheptadi- (or tri-) ene-5: 2'-dioxolane (1 ', 3')) |
ZA712214A ZA712214B (en) | 1970-04-15 | 1971-04-07 | New spiro dibenzo cycloalkane dioxalane derivatives and their preparation |
LU62949D LU62949A1 (en) | 1970-04-15 | 1971-04-08 | |
BE765516A BE765516A (en) | 1970-04-15 | 1971-04-08 | NEW DERIVATIVES OF AMINOMETHYL-4'SPIRO (DIBENZO (A-D) CYCLOHEPTADI- (OR TRI-) ENE-5: 2 '-DIOXOLANE (1', 3 ')), THEIR PREPARATION PROCESS AND THEIR THERAPEUTIC APPLICATION |
IL36571A IL36571A (en) | 1970-04-15 | 1971-04-08 | Derivatives of 4'-aminomethyl spiro (dibenzo (a-d)cyclohepta di(tri)ene-5,2'-dioxolane),their preparation and pharmaceutical compositions containing them |
DE2117358A DE2117358C3 (en) | 1970-04-15 | 1971-04-08 | 4'-aminomethyl-spiro square bracket on dibenzo square bracket on a, square bracket on cycloheptadi- (or tri-) en-5,2 '- (1 \ 3'-dioxolane) square bracket on derivatives, method for their Manufacture and medicinal products containing these compounds |
JP2145171A JPS5323304B1 (en) | 1970-04-15 | 1971-04-08 | |
CS7100002531A CS180572B2 (en) | 1970-04-15 | 1971-04-08 | Method of preparing derivatives of 4'-aminomethylspiro/dibenzo/a-d/cycloheptadi-/or tri-/ene-5,2-/1,3'-dioxolane// |
ES390064A ES390064A1 (en) | 1970-04-15 | 1971-04-08 | Dibenzo(a-d)cycloheptadi(or tri)ene-5:2'-dioxalanes(i,3') |
US00133441A US3726900A (en) | 1970-04-15 | 1971-04-12 | Dibenzo(a-d)cycloheptadi(or tri)ene-5:2'-dioxalanes(i,3') |
CA110,359*7A CA945157A (en) | 1970-04-15 | 1971-04-14 | Derives de l'aminomethyl-4'spiro (dibenzo (a-d) cycloheptatriene-5:2'-dioxolane (1',3')) leur procede de preparation et leur application en therapeutique |
NL7105014.A NL161449C (en) | 1970-04-15 | 1971-04-15 | PROCESS FOR THE PREPARATION OF 4-ALKYLAMINOMETHYL-1,3-DIOXOLAN COMPOUNDS WITH ANALGETIC ACTION, PROCESS FOR THE PREPARATION OF PHARMACEUTICAL PREPARATIONS USING COMPOUNDS, PREPARATORED PREVENTED ARMS |
SU1647378A SU465788A3 (en) | 1970-04-15 | 1971-04-15 | "Method for preparing spiro (dibenzo (a-) -cycloheptadiene or three) derivatives of en-5: 2" (4 "-aminomethyldioxalan 1" 3 ") |
GB1295815D GB1295815A (en) | 1970-04-15 | 1971-04-19 |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR7013522A FR2085635A1 (en) | 1970-04-15 | 1970-04-15 | 4'-disubstd-amino methyl spiro (dibenzo(ad)c - dioxolan (1,3) |
Publications (2)
Publication Number | Publication Date |
---|---|
FR2085635A1 true FR2085635A1 (en) | 1971-12-31 |
FR2085635B1 FR2085635B1 (en) | 1973-06-08 |
Family
ID=9053974
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
FR7013522A Granted FR2085635A1 (en) | 1970-04-15 | 1970-04-15 | 4'-disubstd-amino methyl spiro (dibenzo(ad)c - dioxolan (1,3) |
Country Status (2)
Country | Link |
---|---|
FR (1) | FR2085635A1 (en) |
ZA (1) | ZA712214B (en) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2208652A2 (en) * | 1972-12-05 | 1974-06-28 | Delalande Sa | 4'-aminomethyl-spiro(dibenzo(a,d)cycloheptadi(or tri) - ene-5,2' -(1,3)dioxolan)- antidepressants,analgesics,antiinflammatory |
-
1970
- 1970-04-15 FR FR7013522A patent/FR2085635A1/en active Granted
-
1971
- 1971-04-07 ZA ZA712214A patent/ZA712214B/en unknown
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2208652A2 (en) * | 1972-12-05 | 1974-06-28 | Delalande Sa | 4'-aminomethyl-spiro(dibenzo(a,d)cycloheptadi(or tri) - ene-5,2' -(1,3)dioxolan)- antidepressants,analgesics,antiinflammatory |
Also Published As
Publication number | Publication date |
---|---|
FR2085635B1 (en) | 1973-06-08 |
ZA712214B (en) | 1972-01-26 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
ST | Notification of lapse |