FR2081564A1 - N-amino carbonyl-piperazines analgesics - antiinflammatories ,hypotensives and spasmolytics - Google Patents

N-amino carbonyl-piperazines analgesics - antiinflammatories ,hypotensives and spasmolytics

Info

Publication number
FR2081564A1
FR2081564A1 FR7007821A FR7007821A FR2081564A1 FR 2081564 A1 FR2081564 A1 FR 2081564A1 FR 7007821 A FR7007821 A FR 7007821A FR 7007821 A FR7007821 A FR 7007821A FR 2081564 A1 FR2081564 A1 FR 2081564A1
Authority
FR
France
Prior art keywords
hypotensives
spasmolytics
antiinflammatories
piperazines
analgesics
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR7007821A
Other languages
French (fr)
Other versions
FR2081564B1 (en
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Synthelabo SA
Original Assignee
Delalande SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Delalande SA filed Critical Delalande SA
Priority to FR7007821A priority Critical patent/FR2081564A1/en
Publication of FR2081564A1 publication Critical patent/FR2081564A1/en
Application granted granted Critical
Publication of FR2081564B1 publication Critical patent/FR2081564B1/fr
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
    • C07D295/20—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carbonic acid, or sulfur or nitrogen analogues thereof
    • C07D295/215—Radicals derived from nitrogen analogues of carbonic acid

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Compounds of formula (where R = alkyl or alkenyl of 1-4C straight or branched cycloaliphatic, or aromatic; R' = propyloxycarbonyl, dihydroxyethyl, or aminocarbonyl) are prepd. by treating cpds. of formula R-N=C=O with Prefd. compounds have R= CH3, C2H5, m-propyl, isopropyl, butyl, allyl, cyclohexyl or phenyl, and R' = pyrrolidinocarbonyl or isopropylaminocarbonyl. In an example, propyl isocyanate is treated with 1-(isopropylamino-carbonylmethyl) piperazine in tetrahydrofuran in the cold, and the product is converted into its maleate salt.
FR7007821A 1970-03-05 1970-03-05 N-amino carbonyl-piperazines analgesics - antiinflammatories ,hypotensives and spasmolytics Granted FR2081564A1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
FR7007821A FR2081564A1 (en) 1970-03-05 1970-03-05 N-amino carbonyl-piperazines analgesics - antiinflammatories ,hypotensives and spasmolytics

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR7007821A FR2081564A1 (en) 1970-03-05 1970-03-05 N-amino carbonyl-piperazines analgesics - antiinflammatories ,hypotensives and spasmolytics

Publications (2)

Publication Number Publication Date
FR2081564A1 true FR2081564A1 (en) 1971-12-10
FR2081564B1 FR2081564B1 (en) 1973-04-06

Family

ID=9051697

Family Applications (1)

Application Number Title Priority Date Filing Date
FR7007821A Granted FR2081564A1 (en) 1970-03-05 1970-03-05 N-amino carbonyl-piperazines analgesics - antiinflammatories ,hypotensives and spasmolytics

Country Status (1)

Country Link
FR (1) FR2081564A1 (en)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4247549A (en) * 1978-12-27 1981-01-27 Ici Americas Inc. Piperazine-1-carboxylic acid esters possessing antidepressant or analgesic activity
EP0123977A1 (en) * 1983-04-28 1984-11-07 CASSELLA Aktiengesellschaft Substituted piperazin-1-yl-acetic-acid amides, process for their preparation and their use
US4666911A (en) * 1981-07-14 1987-05-19 Taiho Pharmaceutical Company Limited Allophanoylpiperazine compound and analgesic composition containing same as active ingredient

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE647594A (en) * 1963-06-28 1964-11-06

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE647594A (en) * 1963-06-28 1964-11-06

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4247549A (en) * 1978-12-27 1981-01-27 Ici Americas Inc. Piperazine-1-carboxylic acid esters possessing antidepressant or analgesic activity
US4666911A (en) * 1981-07-14 1987-05-19 Taiho Pharmaceutical Company Limited Allophanoylpiperazine compound and analgesic composition containing same as active ingredient
EP0123977A1 (en) * 1983-04-28 1984-11-07 CASSELLA Aktiengesellschaft Substituted piperazin-1-yl-acetic-acid amides, process for their preparation and their use

Also Published As

Publication number Publication date
FR2081564B1 (en) 1973-04-06

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Legal Events

Date Code Title Description
ST Notification of lapse