FR2073282A1 - 2-phenoxy alkylaminothiazoles - with coronary vasodilator, analgesic, local anaesthetic activity - Google Patents

2-phenoxy alkylaminothiazoles - with coronary vasodilator, analgesic, local anaesthetic activity

Info

Publication number
FR2073282A1
FR2073282A1 FR6944097A FR6944097A FR2073282A1 FR 2073282 A1 FR2073282 A1 FR 2073282A1 FR 6944097 A FR6944097 A FR 6944097A FR 6944097 A FR6944097 A FR 6944097A FR 2073282 A1 FR2073282 A1 FR 2073282A1
Authority
FR
France
Prior art keywords
alkylaminothiazoles
analgesic
phenoxy
local anaesthetic
coronary vasodilator
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR6944097A
Other languages
French (fr)
Other versions
FR2073282B1 (en
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bpifrance Financement SA
Original Assignee
Agence National de Valorisation de la Recherche ANVAR
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Agence National de Valorisation de la Recherche ANVAR filed Critical Agence National de Valorisation de la Recherche ANVAR
Priority to FR6944097A priority Critical patent/FR2073282A1/en
Publication of FR2073282A1 publication Critical patent/FR2073282A1/en
Application granted granted Critical
Publication of FR2073282B1 publication Critical patent/FR2073282B1/fr
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D277/38—Nitrogen atoms
    • C07D277/42—Amino or imino radicals substituted by hydrocarbon or substituted hydrocarbon radicals

Abstract

Cpds. of formula : and their acid-addn. salts (where R is H, opt. substd. alkyl or aryl; X, Y = H, Cl, alkyl; n is 2, 3 or 4) are coronary vasodilators, analgesics, spasmolytics and local anaesthetics, useful at a daily dose of 10-200 mg. 2-(4-Chlorophenoxyethylamino)-4-methylthiazole has an oral LD50 in mice of 57.5 mg/kg. Coronary blood-flow in the isolated rabbit heart is increased by a dose of 100 mu g to 250 mu g. A dose of 100 mu g in rats relieves indcued spasm in the duodenum. It is at least twice as potent as ***e and procaine as a local anaesthetic.
FR6944097A 1969-12-19 1969-12-19 2-phenoxy alkylaminothiazoles - with coronary vasodilator, analgesic, local anaesthetic activity Granted FR2073282A1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
FR6944097A FR2073282A1 (en) 1969-12-19 1969-12-19 2-phenoxy alkylaminothiazoles - with coronary vasodilator, analgesic, local anaesthetic activity

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR6944097A FR2073282A1 (en) 1969-12-19 1969-12-19 2-phenoxy alkylaminothiazoles - with coronary vasodilator, analgesic, local anaesthetic activity

Publications (2)

Publication Number Publication Date
FR2073282A1 true FR2073282A1 (en) 1971-10-01
FR2073282B1 FR2073282B1 (en) 1973-01-12

Family

ID=9044857

Family Applications (1)

Application Number Title Priority Date Filing Date
FR6944097A Granted FR2073282A1 (en) 1969-12-19 1969-12-19 2-phenoxy alkylaminothiazoles - with coronary vasodilator, analgesic, local anaesthetic activity

Country Status (1)

Country Link
FR (1) FR2073282A1 (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2151766A1 (en) * 1971-10-14 1973-04-19 Schering Ag N-thiazol(in)y-2-phenoxyalkanoamides - with herbicidal activity

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2151766A1 (en) * 1971-10-14 1973-04-19 Schering Ag N-thiazol(in)y-2-phenoxyalkanoamides - with herbicidal activity

Also Published As

Publication number Publication date
FR2073282B1 (en) 1973-01-12

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