FR2024548A1 - Ortho-substd phenethylamines and medicaments - Google Patents

Ortho-substd phenethylamines and medicaments

Info

Publication number
FR2024548A1
FR2024548A1 FR6941118A FR6941118A FR2024548A1 FR 2024548 A1 FR2024548 A1 FR 2024548A1 FR 6941118 A FR6941118 A FR 6941118A FR 6941118 A FR6941118 A FR 6941118A FR 2024548 A1 FR2024548 A1 FR 2024548A1
Authority
FR
France
Prior art keywords
alkyl
phenethylamines
substd
medicaments
ortho
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR6941118A
Other languages
French (fr)
Other versions
FR2024548B1 (en
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Novartis AG
Original Assignee
JR Geigy AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by JR Geigy AG filed Critical JR Geigy AG
Publication of FR2024548A1 publication Critical patent/FR2024548A1/en
Application granted granted Critical
Publication of FR2024548B1 publication Critical patent/FR2024548B1/fr
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/06—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 2
    • C07D311/20—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 2 hydrogenated in the hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/56—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds from heterocyclic compounds
    • C07C45/57—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds from heterocyclic compounds with oxygen as the only heteroatom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C59/40—Unsaturated compounds
    • C07C59/42—Unsaturated compounds containing hydroxy or O-metal groups
    • C07C59/52—Unsaturated compounds containing hydroxy or O-metal groups a hydroxy or O-metal group being bound to a carbon atom of a six-membered aromatic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C59/40—Unsaturated compounds
    • C07C59/58—Unsaturated compounds containing ether groups, groups, groups, or groups
    • C07C59/64—Unsaturated compounds containing ether groups, groups, groups, or groups containing six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C59/40—Unsaturated compounds
    • C07C59/76—Unsaturated compounds containing keto groups
    • C07C59/90—Unsaturated compounds containing keto groups containing singly bound oxygen-containing groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
    • C07D307/86—Benzo [b] furans; Hydrogenated benzo [b] furans with an oxygen atom directly attached in position 7

Abstract

new compounds of formula: and their acid addition salts. (where R1 = H, OH, Cl, alkoxy (C1-C4) alkyl (C1-C4); R2 = OH, OCH3, CH3COO-, C2H5COO-; B = alkyl, isoalkyl, or cycloalkyl (C3-C8) or the group CR3R4R5 where R3,R4, R5=alkyl (C1-82)) are prepared by various conventional methods depending on the particular substituents in I. Some unspecified intermediates are new.
FR6941118A 1968-11-29 1969-11-28 Ortho-substd phenethylamines and medicaments Granted FR2024548A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US78680668A 1968-11-29 1968-11-29
US84913569A 1969-08-11 1969-08-11
US86253269A 1969-09-30 1969-09-30

Publications (2)

Publication Number Publication Date
FR2024548A1 true FR2024548A1 (en) 1970-08-28
FR2024548B1 FR2024548B1 (en) 1973-01-12

Family

ID=27419837

Family Applications (1)

Application Number Title Priority Date Filing Date
FR6941118A Granted FR2024548A1 (en) 1968-11-29 1969-11-28 Ortho-substd phenethylamines and medicaments

Country Status (7)

Country Link
AT (2) AT299155B (en)
BE (1) BE742364A (en)
CA (1) CA921048A (en)
DE (1) DE1959898A1 (en)
FR (1) FR2024548A1 (en)
IL (1) IL33453A0 (en)
NL (1) NL6917600A (en)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0006961A1 (en) * 1978-02-21 1980-01-23 Sandoz Ag New phenylethylamines, process for their preparation, and pharmaceutical compositions containing them
US5220064A (en) * 1986-11-26 1993-06-15 Warner-Lambert Company Substituted 4'-hydroxyphenylacetic acid derivatives having antiinflammatory and analgesic activity
EP0474589A1 (en) * 1990-08-02 1992-03-11 Ciba-Geigy Ag Orthophenolacetamides
JP3121061B2 (en) * 1991-10-04 2000-12-25 塩野義製薬株式会社 Method for producing intermediate for producing alkoxyiminoacetamides and intermediate used therein
FR2696453B1 (en) * 1992-10-02 1994-12-23 Adir New arylalkyl (thio) amides, process for their preparation, and pharmaceutical compositions containing them.
WO2004056744A1 (en) 2002-12-23 2004-07-08 Janssen Pharmaceutica N.V. Adamantyl acetamides as hydroxysteroid dehydrogenase inhibitors
US9012494B2 (en) 2004-05-07 2015-04-21 Janssen Pharmaceutica N.V. Pyrrolidin-2-one and piperidin-2-one derivatives as 11-beta hydroxysteroid dehydrogenase inhibitors
ES2334246T3 (en) 2004-08-30 2010-03-08 Janssen Pharmaceutica Nv TRICYCLE DERIVATIVES OF ADAMANTILAMIDE AS INHIBITORS OF 11-BETA-HYDROXIESTEROID-DEHYDROGENASE.
MX2007002449A (en) 2004-08-30 2007-10-10 Janssen Pharmaceutica Nv N-2 adamantanyl-2-phenoxy-acetamide derivatives as 11-beta hydroxysteroid dehydrogenase inhibitors.
DE602005017159D1 (en) 2004-08-30 2009-11-26 Janssen Pharmaceutica Nv OXYSTEROID DEHYDROGENASE INHIBITORS

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB561570A (en) * 1942-02-17 1944-05-24 Burroughs Wellcome Co Esters of secondary phenolic amines

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB561570A (en) * 1942-02-17 1944-05-24 Burroughs Wellcome Co Esters of secondary phenolic amines

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
LA REVUE ALLEMANDE: ANZNEIMIT-TEL FORSCHUNG VOL: 9 1959 PAGES 157-161) *

Also Published As

Publication number Publication date
AT298447B (en) 1972-05-10
FR2024548B1 (en) 1973-01-12
AT299155B (en) 1972-06-12
DE1959898A1 (en) 1970-06-18
BE742364A (en) 1970-05-28
CA921048A (en) 1973-02-13
NL6917600A (en) 1970-06-02
IL33453A0 (en) 1970-01-29

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Legal Events

Date Code Title Description
ST Notification of lapse