FR2012022A1 - Benzodiazepine compounds psychosedatives, antidepressives - Google Patents

Benzodiazepine compounds psychosedatives, antidepressives

Info

Publication number
FR2012022A1
FR2012022A1 FR6918042A FR6918042A FR2012022A1 FR 2012022 A1 FR2012022 A1 FR 2012022A1 FR 6918042 A FR6918042 A FR 6918042A FR 6918042 A FR6918042 A FR 6918042A FR 2012022 A1 FR2012022 A1 FR 2012022A1
Authority
FR
France
Prior art keywords
lower alkyl
carbamoyl
amino
alkyl
substd
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR6918042A
Other languages
French (fr)
Other versions
FR2012022B1 (en
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sankyo Co Ltd
Original Assignee
Sankyo Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from JP43076013A external-priority patent/JPS4830076B1/ja
Application filed by Sankyo Co Ltd filed Critical Sankyo Co Ltd
Publication of FR2012022A1 publication Critical patent/FR2012022A1/en
Application granted granted Critical
Publication of FR2012022B1 publication Critical patent/FR2012022B1/fr
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C233/02—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having nitrogen atoms of carboxamide groups bound to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

(A) Benzodiazepines of general formula (I): R1, R2 and R3 are same or different H, lower alkyl, lower alkoxy, halogen, hydroxy, nitro, cyano, acyl, trifluoremethyl, amino, acylamino, N-mono (lower-alkyl) amino, N-di(lower alkyl) amino, acyloxy, carboxyl, alkoxycarbonyl, carbamoyl, N-mono(lower alkyl) carbamoyl, N-di(lower alkyl) carbamoyl, lower alkylthio, lower alkylsulphinyl or lower alkylsulphonyl; R4 = H, lower alkyl, cycloalkyl, aralkyl, aryl or phenacyl; R5 and R6 are same or different H or lower alkyl; A = polymethylene opt. substd. with lower alkyl, hydroxy-substd. lower alkyl or phenyl X = -O or -S (B) Intermediates of general formula (II): (I) have psychosedative and antidepressive activity and may be used as tranquillising agents against various psychoneurotic depressions. They have very low toxicity and few side-effects. Cpds. (II) are intermediates in the synthesis of (I).
FR6918042A 1968-07-01 1969-06-02 Benzodiazepine compounds psychosedatives, antidepressives Granted FR2012022A1 (en)

Applications Claiming Priority (8)

Application Number Priority Date Filing Date Title
JP4572268 1968-07-01
JP6270068 1968-08-31
JP6269968 1968-08-31
JP7601268 1968-10-18
JP43076013A JPS4830076B1 (en) 1968-10-18 1968-10-18
JP7749868 1968-10-24
JP7749968 1968-10-24
JP7876868 1968-10-29

Publications (2)

Publication Number Publication Date
FR2012022A1 true FR2012022A1 (en) 1970-03-13
FR2012022B1 FR2012022B1 (en) 1973-07-13

Family

ID=27572335

Family Applications (1)

Application Number Title Priority Date Filing Date
FR6918042A Granted FR2012022A1 (en) 1968-07-01 1969-06-02 Benzodiazepine compounds psychosedatives, antidepressives

Country Status (3)

Country Link
BG (2) BG19177A3 (en)
FR (1) FR2012022A1 (en)
OA (1) OA04237A (en)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0000299A1 (en) * 1977-06-16 1979-01-10 Pierre Fabre S.A. Novel derivatives of substituted 2-benzoyl-4-chloro-glycinanilides, their preparation and their use as medicines.
EP0022017A1 (en) * 1979-06-25 1981-01-07 Pierre Fabre S.A. Derivatives of 2-benzoyl-4-nitro anilides, their preparation and their use as medicines

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE706803A (en) * 1966-11-23 1968-05-21

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE706803A (en) * 1966-11-23 1968-05-21

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0000299A1 (en) * 1977-06-16 1979-01-10 Pierre Fabre S.A. Novel derivatives of substituted 2-benzoyl-4-chloro-glycinanilides, their preparation and their use as medicines.
EP0022017A1 (en) * 1979-06-25 1981-01-07 Pierre Fabre S.A. Derivatives of 2-benzoyl-4-nitro anilides, their preparation and their use as medicines
FR2459793A1 (en) * 1979-06-25 1981-01-16 Fabre Sa Pierre NOVEL BENZOYL-2 NITRO-4 ANILIDE DERIVATIVES, THEIR PREPARATION AND THEIR APPLICATION AS MEDICAMENTS

Also Published As

Publication number Publication date
BG17604A3 (en) 1973-11-10
OA04237A (en) 1979-12-31
BG19177A3 (en) 1975-04-30
FR2012022B1 (en) 1973-07-13

Similar Documents

Publication Publication Date Title
GB1457129A (en) Herbicidal antidote compositions with substituted oxazolidines and thiazolidines
DZ1634A1 (en) Indolpyrrolcarbazole derivatives the derivatives of indolopyrolocarbazole.
ES451575A1 (en) 1-(4-Phenoxy-phenyl)-1,3,5-triazines
NL7412390A (en) INSERTION FURNACE, PARTICULARLY FOR THE COMBUSTION OF WASTE.
GB1238241A (en)
NL7413613A (en) PROCEDURE FOR THE PREPARATION OF NEW O-BENZYLPHENOLS AND THEIR USE FOR THE CONTROL OF HARMFUL MICROORGANISMS.
IE780792L (en) N-monosubstituted-9-amino-9-deoxyclavulanic acid derivatives
FR2012022A1 (en) Benzodiazepine compounds psychosedatives, antidepressives
ATE137749T1 (en) BENZOMORPHANES AND THEIR USE AS MEDICINAL PRODUCTS
ES472284A1 (en) 6-Deoxyneamines aminoglycoside compounds
NL158531B (en) PROCEDURE FOR PROTECTING SURFACES AGAINST THE AGGREGATION OF WATER ORGANISMS.
ES371746A1 (en) Thiophene-3-isonitriles
AU7426174A (en) Nitro heterocyclic compounds and pharmaceutical use
ES421011A1 (en) Imidazo{8 2,1-b{9 thiazole derivatives
FR2110308A1 (en) 2, 2'-bl-imidazole derivs - antibacterial and antiparasitic agents
FR2071171A6 (en) 1,1-diphenyl-azaborolidines - with insecticidal acaricidal - herbicidal and fungicidal activity
FR2113909A1 (en) Cns-active tricyclic benzodiazepines prepn - from 2-acylaminophenyl heterocyclyl ketones
NL7708967A (en) Psycholeptic benzodiazepines
FR2283133A1 (en) Herbicidal and fungicidal oxadiazines - prepd. by cyclisation of an acyliso(thio)cyanate with an iso(thio)cyanate
FR2113908A1 (en) Tricyclic benzodiazepine derivatives - with cns depressant activity
FR2068454A1 (en) Alpha-amino - penicillins
IL45899A0 (en) S-triazine derivatives and their use as pesticides
FR2100890A1 (en) 3, 4- dihydro-2 (1h)-quin azolinones - anti-inflammatories and analge
IL44690A0 (en) Heterocyclic urea derivatives and their use in plant protection
IE34023L (en) Benzodiazepines