FR2001768A1 - N-Alkyl-2-pyrrolidone to improve cutaneous absorption - methyl, ethyl and n-butyl pyrrolidone(s), opt. with water and/or ethanol give improved skin penetration - Google Patents

N-Alkyl-2-pyrrolidone to improve cutaneous absorption - methyl, ethyl and n-butyl pyrrolidone(s), opt. with water and/or ethanol give improved skin penetration

Info

Publication number
FR2001768A1
FR2001768A1 FR6903351A FR6903351A FR2001768A1 FR 2001768 A1 FR2001768 A1 FR 2001768A1 FR 6903351 A FR6903351 A FR 6903351A FR 6903351 A FR6903351 A FR 6903351A FR 2001768 A1 FR2001768 A1 FR 2001768A1
Authority
FR
France
Prior art keywords
pyrrolidone
ethyl
methyl
water
alkyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
FR6903351A
Other languages
French (fr)
Inventor
Laden Karl
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Gillette Co LLC
Original Assignee
Gillette Co LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Gillette Co LLC filed Critical Gillette Co LLC
Publication of FR2001768A1 publication Critical patent/FR2001768A1/en
Withdrawn legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q15/00—Anti-perspirants or body deodorants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/22—Heterocyclic compounds, e.g. ascorbic acid, tocopherol or pyrrolidones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
    • A61K8/4906—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with one nitrogen as the only hetero atom
    • A61K8/4913—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with one nitrogen as the only hetero atom having five membered rings, e.g. pyrrolidone carboxylic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0014—Skin, i.e. galenical aspects of topical compositions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
    • A61Q17/005—Antimicrobial preparations
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
    • A61Q17/04—Topical preparations for affording protection against sunlight or other radiation; Topical sun tanning preparations
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A61Q19/004—Aftersun preparations

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Dermatology (AREA)
  • Epidemiology (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Birds (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Cosmetics (AREA)
  • Medicinal Preparation (AREA)

Abstract

Medicament compsn. for topical application to the skin contains a solution of an active cpd. in a solvent contg. 1-100 wt.% of an N-lower alkyl -2-pyrrolidone. The lower alkyl gp. is pref. methyl, ethyl or n-butyl. The preferred solvent is a mixture of 5-35 wt.% of the pyrrolidone with ethanol and/or water. Typical active cpds. include germicides or fungicides, anti-perspirants (esp. those contg. anticholinergic agents), antiinflammatories and sun creams. The active cpds. usually comprise 0.01-10 wt.%, esp. 0.1-5 wt.%, of the compsn. Solvent system which facilitates the cutaneous absorption of active cpds. These solutions may be formulated for application as lotions, creams, pommades, pastes etc. using classical ingredients (thickeners, preservatives, perfumes, colourants).
FR6903351A 1968-02-12 1969-02-12 N-Alkyl-2-pyrrolidone to improve cutaneous absorption - methyl, ethyl and n-butyl pyrrolidone(s), opt. with water and/or ethanol give improved skin penetration Withdrawn FR2001768A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US70452268A 1968-02-12 1968-02-12

Publications (1)

Publication Number Publication Date
FR2001768A1 true FR2001768A1 (en) 1969-10-03

Family

ID=24829875

Family Applications (1)

Application Number Title Priority Date Filing Date
FR6903351A Withdrawn FR2001768A1 (en) 1968-02-12 1969-02-12 N-Alkyl-2-pyrrolidone to improve cutaneous absorption - methyl, ethyl and n-butyl pyrrolidone(s), opt. with water and/or ethanol give improved skin penetration

Country Status (1)

Country Link
FR (1) FR2001768A1 (en)

Cited By (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2294692A1 (en) * 1974-12-19 1976-07-16 Nelson Res & Dev TOPICAL ANTIMICROBIAL COMPOSITIONS
DE2627772A1 (en) * 1975-06-19 1976-12-30 Nelson Res & Dev 1-SUBSTITUTED AZACYCLOALKAN-2-ONE CONTAINING CARRIER MASS
FR2313080A1 (en) * 1975-04-11 1976-12-31 Nelson Res & Dev TOPICAL COMPOSITION FOR THERAPEUTIC AND COSMETIC TREATMENT AND PROCESS FOR PREPARATION
US4038417A (en) * 1975-06-19 1977-07-26 Nelson Research & Development Company Method for treatment of psoriasis
US4039664A (en) * 1975-04-11 1977-08-02 Nelson Research & Development Company Topical griseofulvin composition and method
EP0038416A2 (en) * 1980-03-11 1981-10-28 CI-CO-ME / Carlo Mebes Formulation of disinfecting agents with a specific mode of action
DE3418565A1 (en) * 1983-05-20 1984-11-22 Nitto Electric Industrial Co., Ltd., Ibaraki, Osaka CARRIER FOR PERCUTANEAN, PHARMACEUTICAL AGENTS CONTAINING AN ACTIVE SUBSTANCE
DE3424058A1 (en) * 1983-07-01 1985-01-10 Nitto Electric Industrial Co., Ltd., Ibaraki, Osaka PHARMACEUTICAL PRODUCT FOR PERCUTANEOUS ADMINISTRATION
DE3424057A1 (en) * 1983-07-01 1985-01-10 Nitto Electric Industrial Co., Ltd., Ibaraki, Osaka PHARMACEUTICAL PRODUCT FOR PERCUTANEOUS ADMINISTRATION
FR2558729A1 (en) * 1984-02-01 1985-08-02 Nitto Electric Ind Co COMPOSITION FOR PERCUTANEOUS ADMINISTRATION OF METOCLOPRAMIDE
JPS62187415A (en) * 1986-02-12 1987-08-15 Lion Corp Composition for promoting transcutaneous absorption
WO1995030441A1 (en) * 1994-05-09 1995-11-16 Colgate-Palmolive Company Composition containing a solubilized antibacterial agent
US5922660A (en) * 1995-12-07 1999-07-13 Colgate-Palmolive Co. Composition
FR2831789A1 (en) * 2001-11-07 2003-05-09 Oreal Process for determining skin type for cosmetic purposes by applying a drop of liquid to the skin and measuring the area wetted by the drop
EP1371355A1 (en) * 2002-06-03 2003-12-17 Ciba SC Holding AG UV-protection formulations
EP2804940A1 (en) 2012-01-17 2014-11-26 Taminco Use of improved n-alkyl pyrrolidone solvents

Cited By (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2294692A1 (en) * 1974-12-19 1976-07-16 Nelson Res & Dev TOPICAL ANTIMICROBIAL COMPOSITIONS
FR2313080A1 (en) * 1975-04-11 1976-12-31 Nelson Res & Dev TOPICAL COMPOSITION FOR THERAPEUTIC AND COSMETIC TREATMENT AND PROCESS FOR PREPARATION
US4039664A (en) * 1975-04-11 1977-08-02 Nelson Research & Development Company Topical griseofulvin composition and method
DE2627772A1 (en) * 1975-06-19 1976-12-30 Nelson Res & Dev 1-SUBSTITUTED AZACYCLOALKAN-2-ONE CONTAINING CARRIER MASS
FR2314731A1 (en) * 1975-06-19 1977-01-14 Nelson Res & Dev AZACYCLOALCAN-2-ONES 1-SUBSTITUTES AND PHARMACEUTICAL COMPOSITIONS CONTAINING THESE COMPOUNDS AS EXCIPIENTS
US4038417A (en) * 1975-06-19 1977-07-26 Nelson Research & Development Company Method for treatment of psoriasis
EP0038416A2 (en) * 1980-03-11 1981-10-28 CI-CO-ME / Carlo Mebes Formulation of disinfecting agents with a specific mode of action
EP0038416A3 (en) * 1980-03-11 1981-11-04 CI-CO-ME / Carlo Mebes Formulation of disinfecting agents with a specific mode of action
DE3418565A1 (en) * 1983-05-20 1984-11-22 Nitto Electric Industrial Co., Ltd., Ibaraki, Osaka CARRIER FOR PERCUTANEAN, PHARMACEUTICAL AGENTS CONTAINING AN ACTIVE SUBSTANCE
DE3424058A1 (en) * 1983-07-01 1985-01-10 Nitto Electric Industrial Co., Ltd., Ibaraki, Osaka PHARMACEUTICAL PRODUCT FOR PERCUTANEOUS ADMINISTRATION
DE3424057A1 (en) * 1983-07-01 1985-01-10 Nitto Electric Industrial Co., Ltd., Ibaraki, Osaka PHARMACEUTICAL PRODUCT FOR PERCUTANEOUS ADMINISTRATION
DE3424058C3 (en) * 1983-07-01 1992-05-07 Nitto Electric Ind Co PHARMACEUTICAL AGENT FOR PERCUTANEOUS ADMINISTRATION
DE3424057C3 (en) * 1983-07-01 1992-05-07 Nitto Electric Ind Co PHARMACEUTICAL AGENT FOR PERCUTANEOUS ADMINISTRATION
US4605670A (en) * 1984-02-01 1986-08-12 Nitto Electric Industrial Co., Ltd. Method for percutaneously administering metoclopramide
FR2558729A1 (en) * 1984-02-01 1985-08-02 Nitto Electric Ind Co COMPOSITION FOR PERCUTANEOUS ADMINISTRATION OF METOCLOPRAMIDE
JPS62187415A (en) * 1986-02-12 1987-08-15 Lion Corp Composition for promoting transcutaneous absorption
WO1995030441A1 (en) * 1994-05-09 1995-11-16 Colgate-Palmolive Company Composition containing a solubilized antibacterial agent
US5629276A (en) * 1994-05-09 1997-05-13 Colgate-Palmolive Company Composition of alkyl pyrrolidone for solubilizing antibacterials
US5922660A (en) * 1995-12-07 1999-07-13 Colgate-Palmolive Co. Composition
EP1310212A1 (en) * 2001-11-07 2003-05-14 L'oreal Method and device for in particular determining the dryness of the skin
FR2831789A1 (en) * 2001-11-07 2003-05-09 Oreal Process for determining skin type for cosmetic purposes by applying a drop of liquid to the skin and measuring the area wetted by the drop
US7211043B2 (en) 2001-11-07 2007-05-01 L' Oreal Method, system and device for evaluating skin type
EP1371355A1 (en) * 2002-06-03 2003-12-17 Ciba SC Holding AG UV-protection formulations
US7101536B2 (en) 2002-06-03 2006-09-05 Ciba Specialty Chemicals Corporation UV-protection formulations
EP2804940A1 (en) 2012-01-17 2014-11-26 Taminco Use of improved n-alkyl pyrrolidone solvents
JP2017095520A (en) * 2012-01-17 2017-06-01 タミンコ Use of improved n-alkyl pyrrolidone solvents
EP2804940B1 (en) 2012-01-17 2018-09-19 Taminco Use of improved n-alkyl pyrrolidone solvents

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