FI965153A - metalloproteinase - Google Patents

metalloproteinase Download PDF

Info

Publication number
FI965153A
FI965153A FI965153A FI965153A FI965153A FI 965153 A FI965153 A FI 965153A FI 965153 A FI965153 A FI 965153A FI 965153 A FI965153 A FI 965153A FI 965153 A FI965153 A FI 965153A
Authority
FI
Finland
Prior art keywords
compounds
metalloproteinase
inhibitors
medicine
processes
Prior art date
Application number
FI965153A
Other languages
Finnish (fi)
Swedish (sv)
Other versions
FI965153A0 (en
Inventor
Andrew Miller
Mark Whittaker
Raymond Paul Beckett
Original Assignee
British Biotech Pharm
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB9412514A external-priority patent/GB9412514D0/en
Priority claimed from GBGB9506107.3A external-priority patent/GB9506107D0/en
Application filed by British Biotech Pharm filed Critical British Biotech Pharm
Publication of FI965153A0 publication Critical patent/FI965153A0/en
Publication of FI965153A publication Critical patent/FI965153A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/12—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms
    • C07D295/125—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C07D295/13—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/06—Antianaemics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C259/00—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups
    • C07C259/04—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups without replacement of the other oxygen atom of the carboxyl group, e.g. hydroxamic acids
    • C07C259/06—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups without replacement of the other oxygen atom of the carboxyl group, e.g. hydroxamic acids having carbon atoms of hydroxamic groups bound to hydrogen atoms or to acyclic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C311/01—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms
    • C07C311/02—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton
    • C07C311/03—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton having the nitrogen atoms of the sulfonamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C311/06—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton having the nitrogen atoms of the sulfonamide groups bound to hydrogen atoms or to acyclic carbon atoms to acyclic carbon atoms of hydrocarbon radicals substituted by carboxyl groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C311/01—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms
    • C07C311/12—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms of an unsaturated carbon skeleton containing rings
    • C07C311/13—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms of an unsaturated carbon skeleton containing rings the carbon skeleton containing six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D285/00—Heterocyclic compounds containing rings having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by groups C07D275/00 - C07D283/00
    • C07D285/01—Five-membered rings
    • C07D285/02—Thiadiazoles; Hydrogenated thiadiazoles
    • C07D285/04—Thiadiazoles; Hydrogenated thiadiazoles not condensed with other rings
    • C07D285/06—1,2,3-Thiadiazoles; Hydrogenated 1,2,3-thiadiazoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/14—The ring being saturated

Abstract

Therapeutically active hydroxamic acid derivatives, processes for their preparation, pharmaceutical compositions containing them, and the use of such compounds in medicine. The compounds are inhibitors of metalloproteinases involved in tissue degradation.
FI965153A 1994-06-22 1996-12-20 metalloproteinase FI965153A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB9412514A GB9412514D0 (en) 1994-06-22 1994-06-22 Metalloproteinase inhibitors
GBGB9506107.3A GB9506107D0 (en) 1995-03-24 1995-03-24 Metalloproteinase inhibitors

Publications (2)

Publication Number Publication Date
FI965153A0 FI965153A0 (en) 1996-12-20
FI965153A true FI965153A (en) 1996-12-20

Family

ID=26305102

Family Applications (1)

Application Number Title Priority Date Filing Date
FI965153A FI965153A (en) 1994-06-22 1996-12-20 metalloproteinase

Country Status (17)

Country Link
US (4) US6022898A (en)
EP (2) EP0766664B1 (en)
JP (2) JPH10501806A (en)
CN (1) CN1151157A (en)
AT (2) ATE182581T1 (en)
AU (2) AU695507B2 (en)
CA (2) CA2193692A1 (en)
DE (2) DE69516143T2 (en)
DK (2) DK0766665T3 (en)
ES (2) ES2133785T3 (en)
FI (1) FI965153A (en)
GB (2) GB2303850B (en)
GR (2) GR3031143T3 (en)
NO (1) NO965515L (en)
NZ (2) NZ288299A (en)
PT (1) PT766664E (en)
WO (2) WO1995035275A1 (en)

Families Citing this family (103)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5646167A (en) * 1993-01-06 1997-07-08 Ciba-Geigy Corporation Arylsulfonamido-substituted hydroxamix acids
US6380366B1 (en) * 1994-04-28 2002-04-30 Les Laboratoires Aeterna Inc. Shark cartilage extract:process of making, methods of using and compositions thereof
ES2133785T3 (en) * 1994-06-22 1999-09-16 British Biotech Pharm METALOPROTEINASE INHIBITORS.
US5817822A (en) * 1994-06-24 1998-10-06 Novartis Corporation Certain alpha-azacycloalkyl substituted arylsulfonamido acetohydroxamic acids
US5863949A (en) * 1995-03-08 1999-01-26 Pfizer Inc Arylsulfonylamino hydroxamic acid derivatives
KR980009238A (en) 1995-07-28 1998-04-30 우에노 도시오 Sulfonyl amino acid derivative
ES2185750T3 (en) * 1995-08-08 2003-05-01 Ono Pharmaceutical Co USEFUL HYDROXAMIC ACID DERIVATIVES FOR GELATINASA INHIBITION.
US6207672B1 (en) † 1995-11-13 2001-03-27 Aventis Pharma Deutschland Gmbh Cyclic and heterocyclic N-substituted α-iminohydroxamic and carboxyclic acids
AU725831C (en) * 1995-12-08 2002-10-17 Agouron Pharmaceuticals, Inc. Metalloproteinase inhibitors, pharmaceutical compositions containing them and their pharmaceutical uses, and methods and intermediates useful for their preparation
US6500948B1 (en) 1995-12-08 2002-12-31 Agouron Pharmaceuticals, Inc. Metalloproteinase inhibitors-compositions, uses preparation and intermediates thereof
TW453995B (en) * 1995-12-15 2001-09-11 Novartis Ag Certain alpha-substituted arylsulfonamido acetohydroxamic acids
US6919375B1 (en) 1996-01-23 2005-07-19 Shionogi & Co., Ltd. Sulfonated amino acid derivatives and metalloproteinase inhibitors containing the same
JP3628335B2 (en) * 1996-01-23 2005-03-09 塩野義製薬株式会社 Sulfonated amino acid derivatives and metalloproteinase inhibitors containing the same
CA2242416C (en) * 1996-01-23 2006-03-21 Shionogi & Co., Ltd. Sulfonated amino acid derivatives and metalloproteinase inhibitors containing the same
US5994351A (en) * 1998-07-27 1999-11-30 Pfizer Inc. Arylsulfonylamino hydroxamic acid derivatives
FR2748026B1 (en) * 1996-04-26 1998-06-05 Adir NOVEL METALLOPROTEASE INHIBITORS, PROCESS FOR THEIR PREPARATION AND THE PHARMACEUTICAL COMPOSITIONS CONTAINING THEM
WO1997044315A1 (en) * 1996-05-17 1997-11-27 Warner-Lambert Company Biphenylsulfonamide matrix metalloproteinase inhibitors
JP2000516607A (en) * 1996-08-16 2000-12-12 ワーナー―ランバート・コンパニー Butyrate matrix metalloproteinase inhibitor
KR20000068248A (en) * 1996-08-23 2000-11-25 디. 제이. 우드, 스피겔 알렌 제이 Arylsulfonylamino Hydroxamic Acid Derivatives
CN1228773A (en) * 1996-08-28 1999-09-15 普罗克特和甘保尔公司 Heterocyclic metalloprotease inhibitors
AU736238B2 (en) * 1996-08-28 2001-07-26 Procter & Gamble Company, The Spirocyclic metalloprotease inhibitors
CN1228771A (en) * 1996-08-28 1999-09-15 普罗克特和甘保尔公司 1,3-diheterocyclic metalloprotease inhibitors
CN1228780A (en) * 1996-08-28 1999-09-15 普罗克特和甘保尔公司 Phosphinic acid amides as matrix metalloprotease inhibitors
DK0923561T3 (en) 1996-08-28 2003-02-24 Procter & Gamble Heterocyclic metalloprotease inhibitors
BR9712792A (en) * 1996-08-28 1999-12-14 Procter & Gamble Bidentate metalloprotease inhibitors.
US5929097A (en) * 1996-10-16 1999-07-27 American Cyanamid Company Preparation and use of ortho-sulfonamido aryl hydroxamic acids as matrix metalloproteinase and tace inhibitors
US6228869B1 (en) 1996-10-16 2001-05-08 American Cyanamid Company Ortho-sulfonamido bicyclic hydroxamic acids as matrix metalloproteinase and TACE inhibitors
US6548524B2 (en) 1996-10-16 2003-04-15 American Cyanamid Company Preparation and use of ortho-sulfonamido bicyclic heteroaryl hydroxamic acids as matrix metalloproteinase and TACE inhibitors
KR20000049196A (en) * 1996-10-16 2000-07-25 윌리암 에이취 캘넌, 에곤 이 버그 The preparation and use of ortho-sulfonamido aryl hydroxamic acids as matrix metalloproteinase and tace inhibitors
US5977408A (en) * 1996-10-16 1999-11-02 American Cyanamid Company Preparation and use of β-sulfonamido hydroxamic acids as matrix metalloproteinase and TACE inhibitors
US5962481A (en) 1996-10-16 1999-10-05 American Cyanamid Company Preparation and use of ortho-sulfonamido heteroaryl hydroxamic acids as matrix metalloproteinase and tace inhibitors
CA2268418A1 (en) * 1996-10-22 1998-04-30 Pharmacia & Upjohn Company .alpha.-amino sulfonyl hydroxamic acids as matrix metalloproteinase inhibitors
US6174915B1 (en) 1997-03-25 2001-01-16 Agouron Pharmaceuticals, Inc. Metalloproteinase inhibitors, pharmaceutical compositions containing them and their pharmaceutical uses
US6008243A (en) * 1996-10-24 1999-12-28 Agouron Pharmaceuticals, Inc. Metalloproteinase inhibitors, pharmaceutical compositions containing them, and their use
WO1998018754A1 (en) 1996-10-28 1998-05-07 Versicor, Inc. Methods for solid-phase synthesis of hydroxylamine compounds and derivatives, and combinatorial libraries thereof
US6281245B1 (en) 1996-10-28 2001-08-28 Versicor, Inc. Methods for solid-phase synthesis of hydroxylamine compounds and derivatives, and combinatorial libraries thereof
JP2001509810A (en) * 1997-01-17 2001-07-24 ファルマシア・アンド・アップジョン・カンパニー Bis-sulfonamidohydroxamic acids as MMP inhibitors
ZA98376B (en) * 1997-01-23 1998-07-23 Hoffmann La Roche Sulfamide-metalloprotease inhibitors
US6376506B1 (en) 1997-01-23 2002-04-23 Syntex (U.S.A.) Llc Sulfamide-metalloprotease inhibitors
US6197791B1 (en) 1997-02-27 2001-03-06 American Cyanamid Company N-hdroxy-2-(alkyl, aryl, or heteroaryl, sulfanyl, sulfinyl or sulfonyl)-3-substituted alkyl, aryl or heteroarylamides as matrix metalloproteinase inhibitors
US6172057B1 (en) 1997-02-27 2001-01-09 American Cyanamid Company N-Hydroxy-2-(alkyl, aryl, or heteroaryl sulfanyl, sulfinyl or sulfonyl)-3-substituted alkyl, aryl or heteroarylamides as matrix metalloproteinase inhibitors
US6451791B1 (en) 1997-03-04 2002-09-17 Monsanto Company Amidoaromatic ring sulfonamide hydroxamic acid compounds
GB9706255D0 (en) 1997-03-26 1997-05-14 Smithkline Beecham Plc Novel compounds
US5985900A (en) * 1997-04-01 1999-11-16 Agouron Pharmaceuticals, Inc. Metalloproteinase inhibitors, pharmaceutical compositions containing them and their pharmaceutical uses
WO1998043963A1 (en) * 1997-04-01 1998-10-08 Agouron Pharmaceuticals, Inc. Metalloproteinase inhibitors, pharmaceutical compositions containing them and their pharmaceutical uses
US5756545A (en) * 1997-04-21 1998-05-26 Warner-Lambert Company Biphenysulfonamide matrix metal alloproteinase inhibitors
AU7294098A (en) * 1997-05-09 1998-11-27 Agouron Pharmaceuticals, Inc. Metalloproteinase inhibitors, pharmaceutical compositions containing them and their pharmaceutical uses
ES2165640T3 (en) 1997-05-09 2002-03-16 Hoechst Ag SUBSTITUTED DIAMINOCARBOXYL ACIDS.
DE19719621A1 (en) 1997-05-09 1998-11-12 Hoechst Ag Sulfonylaminocarboxylic acids
DE19719817A1 (en) * 1997-05-13 1998-11-19 Hoechst Ag Substituted 6- and 7-aminotetrahydroisoquinoline carboxylic acids
US6300514B1 (en) 1997-06-25 2001-10-09 Ono Pharmaceutical Co., Ltd. Aryl (sulfide, sulfoxide and sulfone) derivatives and drugs containing the same as the active ingredient
HUP0003851A3 (en) 1997-07-22 2002-10-28 Shionogi & Co Pharmaceutical composition for the treatment or prevention of glomerulopathy
IL134273A0 (en) 1997-07-31 2001-04-30 Procter & Gamble Acyclic metalloprotease inhibitors
PT895988E (en) * 1997-08-08 2002-09-30 Pfizer Prod Inc ARYLSULPHONYLAMINO-HYDROXAMIC ACID DERIVATIVES
US6130220A (en) * 1997-10-16 2000-10-10 Syntex (Usa) Inc. Sulfamide-metalloprotease inhibitors
GB9801690D0 (en) * 1998-01-27 1998-03-25 Pfizer Ltd Therapeutic agents
EP1918278A1 (en) 1998-02-04 2008-05-07 Novartis AG Sulfonylamino derivatives which inhibit matrix-degrading metalloproteinases
US6410580B1 (en) 1998-02-04 2002-06-25 Novartis Ag Sulfonylamino derivatives which inhibit matrix-degrading metalloproteinases
KR20010041089A (en) * 1998-02-19 2001-05-15 윌리암 에이취 캘넌, 에곤 이 버그 N-Hydroxy-2-(alkyl, aryl, or heteroaryl sulfanyl, sulfinyl or sulfonyl)-3-substituted-alkyl, aryl or heteroarylamides as matrix metalloproteinase inhibitors
US6329418B1 (en) 1998-04-14 2001-12-11 The Procter & Gamble Company Substituted pyrrolidine hydroxamate metalloprotease inhibitors
GB9810464D0 (en) * 1998-05-16 1998-07-15 British Biotech Pharm Hydroxamic acid derivatives
AU754050B2 (en) 1998-07-16 2002-10-31 Sanofi-Aventis Deutschland Gmbh Phosphinous and phosphonic acid derivatives used as medicaments
US6107337A (en) * 1998-08-06 2000-08-22 Pfizer Inc. Arylsulfonylamino hydroxamic acid derivatives
DE19851184A1 (en) 1998-11-06 2000-05-11 Aventis Pharma Gmbh N-arylsulfonylamino acid omega amides
CN1178915C (en) 1999-01-27 2004-12-08 惠氏控股有限公司 Alkynyl containing hydroxamic acid derivatives, their preparation and their use as matrix metalloproteinase (MMP) inhibitors/TNF-alpha converting enzyme (TACE) inhibitors
US6753337B2 (en) 1999-01-27 2004-06-22 Wyeth Holdings Corporation Alkynyl containing hydroxamic acid compounds as matrix metalloproteinase/tace inhibitors
US6946473B2 (en) 1999-01-27 2005-09-20 Wyeth Holdings Corporation Preparation and use of acetylenic ortho-sulfonamido and phosphinic acid amido bicyclic heteroaryl hydroxamic acids as TACE inhibitors
US6200996B1 (en) 1999-01-27 2001-03-13 American Cyanamid Company Heteroaryl acetylenic sulfonamide and phosphinic acid amide hydroxamic acid tace inhibitors
US6340691B1 (en) 1999-01-27 2002-01-22 American Cyanamid Company Alkynyl containing hydroxamic acid compounds as matrix metalloproteinase and tace inhibitors
US6326516B1 (en) 1999-01-27 2001-12-04 American Cyanamid Company Acetylenic β-sulfonamido and phosphinic acid amide hydroxamic acid TACE inhibitors
US6762178B2 (en) 1999-01-27 2004-07-13 Wyeth Holdings Corporation Acetylenic aryl sulfonamide and phosphinic acid amide hydroxamic acid TACE inhibitors
US6277885B1 (en) 1999-01-27 2001-08-21 American Cyanamid Company Acetylenic aryl sulfonamide and phosphinic acid amide hydroxamic acid TACE inhibitors
US6225311B1 (en) 1999-01-27 2001-05-01 American Cyanamid Company Acetylenic α-amino acid-based sulfonamide hydroxamic acid tace inhibitors
US6313123B1 (en) 1999-01-27 2001-11-06 American Cyanamid Company Acetylenic sulfonamide thiol tace inhibitors
US6506936B1 (en) * 1999-02-25 2003-01-14 Fibrogen, Inc. N-substituted arylsulfonylamino hydroxamic acids useful as inhibitors of c-proteinase and for treating or preventing disorders related to unregulated collagen production
CN1362951A (en) 1999-03-03 2002-08-07 宝洁公司 Dihetero-substituted metalloprotease inhibitors
BR0008716A (en) 1999-03-03 2002-09-24 Procter & Gamble Metalloprotease inhibitors containing alkenyl or alkynyl
DE60003863T2 (en) 1999-03-31 2004-04-22 Pfizer Products Inc., Groton Dioxocyclopentylhydroxamsäure
DE60023926T2 (en) 1999-09-10 2006-07-20 Merck & Co., Inc. TYROSINE KINASE INHIBITORS
US6696456B1 (en) * 1999-10-14 2004-02-24 The Procter & Gamble Company Beta disubstituted metalloprotease inhibitors
DK2014285T3 (en) 1999-11-26 2010-06-28 Shionogi & Co NPYY5 receptor antagonists
US6797820B2 (en) * 1999-12-17 2004-09-28 Vicuron Pharmaceuticals Inc. Succinate compounds, compositions and methods of use and preparation
US6465508B1 (en) 2000-02-25 2002-10-15 Wyeth Preparation and use of ortho-sulfonamido aryl hydroxamic acids as matrix metalloproteinase inhibitors
MXPA02009312A (en) * 2000-03-21 2003-03-12 Procter & Gamble Heterocyclic side chain containing metalloprotease inhibitors.
EP1265865A2 (en) * 2000-03-21 2002-12-18 The Procter & Gamble Company Difluorobutyric acid derivatives and their use as metalloprotease inhibitors
AR030196A1 (en) * 2000-03-21 2003-08-13 Procter & Gamble COMPOUND CONTAINING CARBOCICLIC SIDE CHAIN, PHARMACEUTICAL COMPOSITION CONTAINING IT AND USE OF SUCH COMPOUND FOR THE MANUFACTURE OF A MEDICINAL PRODUCT
IL151125A0 (en) 2000-03-21 2003-04-10 Procter & Gamble Heterocyclic side chain containing, n-substituted metalloprotease inhibitors
US6495358B1 (en) 2000-04-19 2002-12-17 Wichita State University Sulfamide and bis-sulfamide amino acid derivatives as inhibitors of proteolytic enzymes
AU2001265182A1 (en) 2000-05-30 2001-12-11 Rafael Fridman Inhibitors of matrix metalloproteinases
US20040235896A1 (en) * 2001-03-14 2004-11-25 Fujimoto Roger Aki Certain azacycloalkyl substituted acetic acid derivatives
EP1392648A1 (en) 2001-05-11 2004-03-03 Guilford Pharmaceuticals Inc. Hydroxamic acids and acyl hydroxamines as naaladase inhibitors
ATE316088T1 (en) 2001-06-22 2006-02-15 Merck & Co Inc TYROSINE KINASE INHIBITORS
MXPA04004010A (en) 2001-11-01 2004-07-23 Wyeth Corp Allenic aryl sulfonamide hydroxamic acids as matrix metalloproteinase and tace inhibitors.
AU2003233154A1 (en) 2002-06-10 2003-12-22 Pfizer Inc. Metabolites of prinomastat and their sythesis
US6872724B2 (en) 2002-07-24 2005-03-29 Merck & Co., Inc. Polymorphs with tyrosine kinase activity
WO2005021489A2 (en) 2002-12-23 2005-03-10 Wyeth Holdings Corporation Acetylenic aryl sulfonate hydroxamic acid tace and matrix metalloproteinase inhibitors
KR20050086949A (en) * 2002-12-27 2005-08-30 안지오테크 인터내셔날 아게 Compositions and methods of using collajolie
JP2006516548A (en) 2002-12-30 2006-07-06 アンジオテック インターナショナル アクツィエン ゲゼルシャフト Drug delivery from rapidly gelled polymer compositions
US7576222B2 (en) * 2004-12-28 2009-08-18 Wyeth Alkynyl-containing tryptophan derivative inhibitors of TACE/matrix metalloproteinase
WO2006125208A1 (en) 2005-05-19 2006-11-23 Wayne State University Inhibitors of matrix metalloproteinases
US20110112076A1 (en) * 2008-07-14 2011-05-12 Mcquire Leslie Wighton Selective hydroxamic acid based mmp-12 and mmp-13 inhibitors
US8937151B2 (en) 2010-03-04 2015-01-20 University Of Notre Dame Du Lac Gelatinase inhibitors and prodrugs
WO2012038944A1 (en) 2010-09-24 2012-03-29 Ranbaxy Laboratories Limited Matrix metalloproteinase inhibitors

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4077998A (en) * 1975-10-28 1978-03-07 Morton-Norwich Products, Inc. Phthaloyl amino acid hydroxamic acids
US4885027A (en) * 1985-04-05 1989-12-05 Chevron Research Company Herbicidal arylmethylenesulfonamido-acetamide and thioacetamide derivatives
DK77487A (en) * 1986-03-11 1987-09-12 Hoffmann La Roche hydroxylamine
WO1989005787A2 (en) * 1987-12-18 1989-06-29 Schering Corporation Processes and compounds useful for resolving 1-methyl-3-phenylpropylamine
GB8827305D0 (en) * 1988-11-23 1988-12-29 British Bio Technology Compounds
AU652596B2 (en) * 1990-12-03 1994-09-01 Celltech Limited Peptidyl derivatives
US5239113A (en) * 1991-10-15 1993-08-24 Monsanto Company Substituted β-amino acid derivatives useful as platelet aggregation inhibitors and intermediates thereof
US5455258A (en) * 1993-01-06 1995-10-03 Ciba-Geigy Corporation Arylsulfonamido-substituted hydroxamic acids
US5552419A (en) * 1993-01-06 1996-09-03 Ciba-Geigy Corporation Arylsulfonamido-substituted hydroxamic acids
ES2133785T3 (en) * 1994-06-22 1999-09-16 British Biotech Pharm METALOPROTEINASE INHIBITORS.
US5817822A (en) * 1994-06-24 1998-10-06 Novartis Corporation Certain alpha-azacycloalkyl substituted arylsulfonamido acetohydroxamic acids
WO1997044315A1 (en) * 1996-05-17 1997-11-27 Warner-Lambert Company Biphenylsulfonamide matrix metalloproteinase inhibitors

Also Published As

Publication number Publication date
NO965515L (en) 1997-02-20
WO1995035275A1 (en) 1995-12-28
GB2303629B (en) 1998-09-02
CA2193691A1 (en) 1995-12-28
PT766664E (en) 2000-08-31
AU2746595A (en) 1996-01-15
NZ288298A (en) 1998-12-23
GB2303850B (en) 1998-06-10
JPH10501806A (en) 1998-02-17
DK0766665T3 (en) 1999-12-06
US6022898A (en) 2000-02-08
ATE182581T1 (en) 1999-08-15
GR3031143T3 (en) 1999-12-31
WO1995035276A1 (en) 1995-12-28
CN1151157A (en) 1997-06-04
JPH10507158A (en) 1998-07-14
AU695507B2 (en) 1998-08-13
ES2145913T3 (en) 2000-07-16
ATE191468T1 (en) 2000-04-15
EP0766665A2 (en) 1997-04-09
DE69511089D1 (en) 1999-09-02
DK0766664T3 (en) 2000-07-31
GB2303850A (en) 1997-03-05
EP0766665B1 (en) 1999-07-28
US6124332A (en) 2000-09-26
NO965515D0 (en) 1996-12-20
GB2303629A (en) 1997-02-26
AU2746695A (en) 1996-01-15
DE69511089T2 (en) 1999-12-16
EP0766664B1 (en) 2000-04-05
EP0766664A2 (en) 1997-04-09
CA2193692A1 (en) 1995-12-28
GB9623809D0 (en) 1997-01-08
AU690703B2 (en) 1998-04-30
DE69516143T2 (en) 2000-10-19
DE69516143D1 (en) 2000-05-11
GR3033446T3 (en) 2000-09-29
FI965153A0 (en) 1996-12-20
ES2133785T3 (en) 1999-09-16
NZ288299A (en) 1998-06-26
US5962529A (en) 1999-10-05
GB9623675D0 (en) 1997-01-08
US6124329A (en) 2000-09-26

Similar Documents

Publication Publication Date Title
DE69516143T2 (en) METALLOPROTEINASE INHIBITORS
SE9402431D0 (en) New tablet formulation
BR9406363A (en) Pharmaceutical composition process for the preparation of the same use and process for the treatment of diseases related to gastric acid
NO20051966L (en) New pyrimidinamide derivatives and their use
UA50719C2 (en) Precursor for therapy of cancer and inflammation
TR199801184T2 (en) New compounds with analgesic action.
ATE286395T1 (en) ANTITHRBOTIC AGENTS
FI932654A0 (en) Hydroxamsyraderivat, som hindrar lipoxigenas
HUP0203321A2 (en) 6-methoxy-2-naphthylacetic acid prodrugs compositions for treating inflammation
ES2194899T3 (en) PHARMACEUTICAL COMPOSITION FOR SYSTEMIC TRANSDERMAL ADMINISTRATION OF THE MORFINA-6-GLUCURONIDO ACTIVE PRINCIPLE.
TR200003451T2 (en) Pyrimidine-Aminomethyl-Pyridine Derivatives, Their Preparation and Their Use in the Control of Helicobacter Bacteria
DE69910787D1 (en) NEW, ACTIVE PHARMACEUTICAL CONNECTION
TR200100906T2 (en) Benzamide derivatives as thrombin inhibitors
NO20001846L (en) New pharmaceutically active compounds, their preparation and use as ECE inhibitors
ATE268768T1 (en) ANTITHROMBOTIC AGENTS
ATE109981T1 (en) THERAPEUTIC REMEDIES.
JO1881B1 (en) Multiple unit tableted dosage from ii
IT1255678B (en) PHARMACEUTICAL COMPOSITIONS FOR THE ADMINISTRATION OF PARATORMONE, ITS BIOLOGICALLY ACTIVE FRAGMENTS OR RECTAL RELATED PEPTIDES.
MX9503130A (en) Metaloproteinase inhibitors, process for their preparation and pharmaceutical or veterinarian compositions containing them.