FI962639A - Diaryyli-5,6-fuusioituneita heterosyklisiä happoja leukotrieeniantagonisteina - Google Patents

Diaryyli-5,6-fuusioituneita heterosyklisiä happoja leukotrieeniantagonisteina Download PDF

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Publication number
FI962639A
FI962639A FI962639A FI962639A FI962639A FI 962639 A FI962639 A FI 962639A FI 962639 A FI962639 A FI 962639A FI 962639 A FI962639 A FI 962639A FI 962639 A FI962639 A FI 962639A
Authority
FI
Finland
Prior art keywords
diaryl
fused heterocyclic
leukotriene antagonists
heterocyclic acids
acids
Prior art date
Application number
FI962639A
Other languages
English (en)
Swedish (sv)
Other versions
FI962639A0 (fi
Inventor
Robert N Young
Marc Labelle
Yves Leblanc
Cheuk K Lau
Claude Dufresne
Yves Gareau
Yi Bin Xiang
Original Assignee
Merck Frosst Canada Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck Frosst Canada Inc filed Critical Merck Frosst Canada Inc
Publication of FI962639A publication Critical patent/FI962639A/fi
Publication of FI962639A0 publication Critical patent/FI962639A0/fi

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pulmonology (AREA)
  • Immunology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Plural Heterocyclic Compounds (AREA)
FI962639A 1993-12-28 1996-06-26 Diaryyli-5,6-fuusioituneita heterosyklisiä happoja leukotrieeniantagonisteina FI962639A0 (fi)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US17493793A 1993-12-28 1993-12-28
US08/260,592 US5472964A (en) 1992-12-22 1994-06-16 Diaryl 5,6-fused heterocyclic acids as leukotriene antagonists
PCT/CA1994/000716 WO1995018132A1 (en) 1993-12-28 1994-12-22 Diaryl 5,6-fused heterocyclic acids as leukotriene antagonists

Publications (2)

Publication Number Publication Date
FI962639A true FI962639A (fi) 1996-06-26
FI962639A0 FI962639A0 (fi) 1996-06-26

Family

ID=26870689

Family Applications (1)

Application Number Title Priority Date Filing Date
FI962639A FI962639A0 (fi) 1993-12-28 1996-06-26 Diaryyli-5,6-fuusioituneita heterosyklisiä happoja leukotrieeniantagonisteina

Country Status (12)

Country Link
US (1) US5472964A (fi)
EP (1) EP0737196A1 (fi)
JP (1) JP3594603B2 (fi)
CN (1) CN1148389A (fi)
AU (1) AU684884B2 (fi)
CA (1) CA2180014A1 (fi)
CZ (1) CZ187996A3 (fi)
FI (1) FI962639A0 (fi)
HU (1) HUT76544A (fi)
NO (1) NO962717D0 (fi)
SK (1) SK83896A3 (fi)
WO (1) WO1995018132A1 (fi)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5656638A (en) * 1995-04-18 1997-08-12 Geron Corporation Telomerase inhibitors
IL125446A0 (en) * 1996-02-08 1999-03-12 Merck & Co Inc Pharmaceutical composition for the treatment of asthma allergy and inflammation
US6262066B1 (en) * 1998-07-27 2001-07-17 Schering Corporation High affinity ligands for nociceptin receptor ORL-1
EP1321169A1 (en) * 2001-12-18 2003-06-25 Biofrontera Pharmaceuticals AG Combination of a serotonin receptor antagonist with a histidine decarboxylase inhibitor as a medicament
CA2371048C (en) 2002-02-06 2011-01-04 Delmar Chemicals Inc. Process for the preparation of 1-(mercaptomethyl)-cyclopropaneacetic acid
CA2575932A1 (en) * 2004-08-04 2006-02-16 Schering Corporation Pharmaceutical formulations comprising pleconaril for the treatment of airway diseases
EP1817034A1 (en) 2004-10-25 2007-08-15 Schering Corporation M1 and/or m3 receptor antagonists in combination with other actives for treating respiratory disorders
US20090099367A1 (en) * 2006-03-06 2009-04-16 Farmaprojects, S. A. Process for preparing a leukotriene antagonist
CA2657902A1 (en) * 2006-07-11 2008-01-17 Schering Corporation Xinafoate salt of a substituted 5-oxazol-2-yl-quinoline compound
EP2265586A4 (en) * 2008-03-17 2012-10-03 Reddys Lab Ltd Dr PREPARATION OF MONTELUKAST AND ITS SALTS
EP2336125B1 (en) * 2008-04-11 2013-01-09 Janssen Pharmaceutica N.V. Thiazolopyridin-2-yloxy-phenyl and thiazolopyrazin-2-yloxy-phenyl amines as modulators of leukotriene A4 hydrolase
US9532717B2 (en) * 2008-10-28 2017-01-03 The Procter & Gamble Company Method for diagnosing vulvovaginal disorders
JP2012530140A (ja) 2009-06-16 2012-11-29 メルク・シャープ・アンド・ドーム・コーポレーション グルココルチコイド受容体アゴニストとしての新規［３，２−ｃ］ヘテロアリールステロイド、組成物およびこの使用
CN110386888A (zh) * 2019-07-30 2019-10-29 上海红蓝医药科技有限公司 一种低成本、高收率的1-(巯甲基)环丙基乙酸生产工艺
TW202400149A (zh) 2022-05-13 2024-01-01 瑞士商愛杜西亞製藥有限公司 經噻唑并芳基-甲基取代之環狀肼-n-甲醯胺衍生物

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4794188A (en) * 1982-12-01 1988-12-27 Usv Pharmaceutical Corporation Certain unsymmetrical quinolinyl ethers having anti-inflammatory and anti-allergic activity
CA1322005C (en) * 1987-11-25 1993-09-07 Robert N. Young Benzoheterazoles
US5026698A (en) * 1988-11-02 1991-06-25 Nissan Chemical Industries, Ltd. Thienopyridine type mevalonolactones
ATE165088T1 (de) * 1990-10-12 1998-05-15 Merck Frosst Canada Inc Ungesättigte hydroxyalkylchinolinsäuren als leukotrien-antagonisten
HUT61980A (en) * 1990-10-12 1993-03-29 Merck Frosst Canada Inc Process for producing saturated hydroxyalkylquinoline acids and pharmaceutical compositions comprising such compounds as active ingredient
US5308850A (en) * 1991-09-30 1994-05-03 Merck Frosst Canada, Inc. (Bicyclic-hetero-arylmethoxy)indoles as inhibitors of leukotriene biosynthesis
US5506227A (en) * 1992-04-13 1996-04-09 Merck Frosst Canada, Inc. Pyridine-substituted benzyl alcohols as leukotriene antagonists
CA2111372C (en) * 1992-12-22 2007-01-16 Robert N. Young Diaryl 5,6-fusedheterocyclic acids as leukotriene antagonists

Also Published As

Publication number Publication date
SK83896A3 (en) 1997-02-05
AU684884B2 (en) 1998-01-08
US5472964A (en) 1995-12-05
CN1148389A (zh) 1997-04-23
JP3594603B2 (ja) 2004-12-02
NO962717L (no) 1996-06-27
HU9601772D0 (en) 1996-09-30
CA2180014A1 (en) 1995-07-06
NO962717D0 (no) 1996-06-27
HUT76544A (en) 1997-09-29
EP0737196A1 (en) 1996-10-16
AU1378195A (en) 1995-07-17
WO1995018132A1 (en) 1995-07-06
FI962639A0 (fi) 1996-06-26
JPH09507080A (ja) 1997-07-15
CZ187996A3 (en) 1997-01-15

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