FI954775A - Nya polycykliska föreningar och derivat därav som ämnen vilka främjar frigörelsen av neurotransmitters och vilka är användbara vid behandling av kognitiva rubbningar - Google Patents

Nya polycykliska föreningar och derivat därav som ämnen vilka främjar frigörelsen av neurotransmitters och vilka är användbara vid behandling av kognitiva rubbningar Download PDF

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Publication number
FI954775A
FI954775A FI954775A FI954775A FI954775A FI 954775 A FI954775 A FI 954775A FI 954775 A FI954775 A FI 954775A FI 954775 A FI954775 A FI 954775A FI 954775 A FI954775 A FI 954775A
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FI
Finland
Prior art keywords
derivatives
treatment
cognitive disorders
neurotransmitter release
polycyclic compounds
Prior art date
Application number
FI954775A
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English (en)
Finnish (fi)
Other versions
FI954775A0 (sv
Inventor
Christopher Allan Teleha
Wendell Wilkie Wilkerson
Richard Alan Earl
Original Assignee
Du Pont Merck Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US08/216,881 external-priority patent/US5594001A/en
Application filed by Du Pont Merck Pharma filed Critical Du Pont Merck Pharma
Publication of FI954775A0 publication Critical patent/FI954775A0/sv
Publication of FI954775A publication Critical patent/FI954775A/sv

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/61—Halogen atoms or nitro radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
    • C07D487/14—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)
  • Pyridine Compounds (AREA)
FI954775A 1993-04-08 1995-10-06 Nya polycykliska föreningar och derivat därav som ämnen vilka främjar frigörelsen av neurotransmitters och vilka är användbara vid behandling av kognitiva rubbningar FI954775A (sv)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US4401293A 1993-04-08 1993-04-08
US08/216,881 US5594001A (en) 1993-04-08 1994-03-28 Polycyclic systems, and derivatives thereof, as neurotransmitter release enhancers useful in the treatment of cognitive disorders
PCT/US1994/003673 WO1994024131A1 (en) 1993-04-08 1994-04-04 Novel polycyclic systems, and derivatives thereof, as neurotransmitter release enhancer useful in the treatment of cognitive disorders

Publications (2)

Publication Number Publication Date
FI954775A0 FI954775A0 (sv) 1995-10-06
FI954775A true FI954775A (sv) 1995-10-06

Family

ID=26721086

Family Applications (1)

Application Number Title Priority Date Filing Date
FI954775A FI954775A (sv) 1993-04-08 1995-10-06 Nya polycykliska föreningar och derivat därav som ämnen vilka främjar frigörelsen av neurotransmitters och vilka är användbara vid behandling av kognitiva rubbningar

Country Status (21)

Country Link
US (1) US5990132A (sv)
EP (1) EP0693069A1 (sv)
JP (1) JPH08509713A (sv)
CN (2) CN1058495C (sv)
AU (1) AU690906B2 (sv)
BR (1) BR9405954A (sv)
CA (1) CA2160112A1 (sv)
CZ (1) CZ251995A3 (sv)
FI (1) FI954775A (sv)
HU (1) HUT74104A (sv)
IL (1) IL109237A (sv)
LV (1) LV11179B (sv)
NO (1) NO308745B1 (sv)
NZ (1) NZ265183A (sv)
OA (1) OA10235A (sv)
PL (1) PL178570B1 (sv)
RO (1) RO115162B1 (sv)
RU (1) RU2152944C1 (sv)
SI (1) SI9420022A (sv)
SK (1) SK124695A3 (sv)
WO (1) WO1994024131A1 (sv)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5750528A (en) * 1995-02-01 1998-05-12 The Dupont Merck Pharmaceutical Company Blockade of neuronal m-channels as a therapeutic approach to the treatment of neurological disease
US6262081B1 (en) 1998-07-10 2001-07-17 Dupont Pharmaceuticals Company Composition for and method of treating neurological disorders
JP5581607B2 (ja) 2008-06-05 2014-09-03 住友化学株式会社 高分子化合物及びそれを用いた有機トランジスタ
RS58700B1 (sr) 2012-10-12 2019-06-28 Broad Inst Inc Gsk3 inhibitori i postupci njihove primene
WO2014084612A1 (ko) * 2012-11-30 2014-06-05 주식회사 엘지화학 신규한 화합물 및 이를 이용한 유기 전자 소자
WO2015027021A1 (en) 2013-08-22 2015-02-26 Bristol-Myers Squibb Company Imide and acylurea derivatives as modulators of the glucocorticoid receptor
WO2015027015A1 (en) 2013-08-22 2015-02-26 Bristol-Myers Squibb Company Imidazole-derived modulators of the glucocorticoid receptor
CN106029614B (zh) 2014-02-05 2019-05-31 Vm肿瘤药物有限责任公司 化合物的组合物及其用途
GB201417369D0 (en) * 2014-10-01 2014-11-12 Redx Pharma Ltd Compounds
JP7097623B2 (ja) * 2016-11-07 2022-07-08 ヴァンダービルト ユニヴァーシティ ムスカリン性アセチルコリンレセプターｍ４のポジティブアロステリック調節因子
WO2018187630A1 (en) 2017-04-05 2018-10-11 The Broad Institute, Inc. Tricyclic compounds as glycogen synthase kinase 3 (gsk3) inhibitors and uses thereof

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1052346A (sv) * 1964-09-09
US5173489A (en) * 1986-04-10 1992-12-22 The Dupont Merck Pharmaceutical Co. α,α-disubstituted aromatics and heteroaromatics as cognition enhancers
US4760083A (en) * 1986-04-10 1988-07-26 E. I. Dupont De Nemours & Company 3,3-disubstituted indolines
WO1992021660A1 (en) * 1991-05-29 1992-12-10 Pfizer, Inc. Tricyclic polyhydroxylic tyrosine kinase inhibitors
DE69218795T2 (de) * 1992-01-16 1997-07-10 Du Pont Merck Pharma Verbindungen,die neurotransmitter freisetzen,um die lernfähigkeit zu erhöhen
US5272269A (en) * 1992-01-16 1993-12-21 The Du Pont Merck Pharmaceutical Company Disubstituted polycyclic systems and preparative methods therefor
RU2051151C1 (ru) * 1992-01-16 1995-12-27 Дзе Дюпон Мерк Фармасьютикал Компани Азотсодержащие гетероциклические производные флуорена
US5185447A (en) * 1992-01-29 1993-02-09 Du Pont Merck Pharmaceutical Company Polycyclic ketones and preparative methods therefor
US5359070A (en) * 1993-02-11 1994-10-25 The Du Pont Merck Pharmaceutical Company Unsymmetrical bis-imides as anticancer agents

Also Published As

Publication number Publication date
NO308745B1 (no) 2000-10-23
LV11179B (en) 1997-06-20
CN1295072A (zh) 2001-05-16
IL109237A (en) 1998-02-08
RO115162B1 (ro) 1999-11-30
US5990132A (en) 1999-11-23
NZ265183A (en) 1997-11-24
BR9405954A (pt) 1995-12-26
NO953989L (no) 1995-12-07
HUT74104A (en) 1996-11-28
IL109237A0 (en) 1994-07-31
CN1058495C (zh) 2000-11-15
HU9502929D0 (en) 1995-11-28
EP0693069A1 (en) 1996-01-24
PL310997A1 (en) 1996-01-22
CA2160112A1 (en) 1994-10-27
LV11179A (lv) 1996-04-20
AU6554994A (en) 1994-11-08
CZ251995A3 (en) 1996-01-17
OA10235A (en) 1997-10-07
JPH08509713A (ja) 1996-10-15
PL178570B1 (pl) 2000-05-31
FI954775A0 (sv) 1995-10-06
CN1122135A (zh) 1996-05-08
NO953989D0 (no) 1995-10-06
SK124695A3 (en) 1996-06-05
WO1994024131A1 (en) 1994-10-27
RU2152944C1 (ru) 2000-07-20
SI9420022A (en) 1996-10-31
AU690906B2 (en) 1998-05-07

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Owner name: DUPONT PHARMACEUTICALS COMPANY