FI943421A - 1,5-bentsodiatsepiinijohdannaiset ja niiden käyttö lääkkeenä - Google Patents

1,5-bentsodiatsepiinijohdannaiset ja niiden käyttö lääkkeenä Download PDF

Info

Publication number: FI943421A
Authority: FI; Finland
Prior art keywords: medicine; benzodiazepine derivatives; benzodiazepine; derivatives
Prior art date: 1992-01-21

Application number

FI943421A

Other languages

English (en)

Swedish (sv)

Other versions

FI111632B (fi

FI943421A0 (fi

Inventor

Harry Finch

David Gordon Trist

Giorgio Tarzia

Aldo Feriani

Original Assignee

Glaxo Spa

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1992-01-21

Filing date

1994-07-19

Publication date

1994-07-19

1994-07-19 Application filed by Glaxo Spa filed Critical Glaxo Spa

1994-07-19 Publication of FI943421A publication Critical patent/FI943421A/fi

1994-07-19 Publication of FI943421A0 publication Critical patent/FI943421A0/fi

2003-08-29 Application granted granted Critical

2003-08-29 Publication of FI111632B publication Critical patent/FI111632B/fi

Links

ZVAPWJGRRUHKGP-UHFFFAOYSA-N 1h-1,5-benzodiazepine Chemical class N1C=CC=NC2=CC=CC=C12 ZVAPWJGRRUHKGP-UHFFFAOYSA-N 0.000 title 1
239000003814 drug Substances 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D243/00—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
- C07D243/06—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4
- C07D243/10—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
- C07D243/12—1,5-Benzodiazepines; Hydrogenated 1,5-benzodiazepines
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Life Sciences & Earth Sciences (AREA)
Veterinary Medicine (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Chemical Kinetics & Catalysis (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Medicinal Chemistry (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Psychiatry (AREA)
Psychology (AREA)
Pain & Pain Management (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)

FI943421A 1992-01-21 1994-07-19 Menetelmä CCK-B-antagonistisesti vaikuttavien 1,5-bentsodiatsepiinijohdannaisten valmistamiseksi FI111632B (fi)

Applications Claiming Priority (4)

Application Number	Priority Date	Filing Date	Title
GB929201180A GB9201180D0 (en)	1992-01-21	1992-01-21	Chemical compounds
GB9201180		1992-01-21
EP9300098		1993-01-19
PCT/EP1993/000098 WO1993014074A1 (en)	1992-01-21	1993-01-19	1,5-benzodiazepine derivatives and their use in medicine

Publications (3)

Publication Number	Publication Date
FI943421A true FI943421A (fi)	1994-07-19
FI943421A0 FI943421A0 (fi)	1994-07-19
FI111632B FI111632B (fi)	2003-08-29

Family

ID=10708914

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
FI943421A FI111632B (fi)	1992-01-21	1994-07-19	Menetelmä CCK-B-antagonistisesti vaikuttavien 1,5-bentsodiatsepiinijohdannaisten valmistamiseksi

Country Status (29)

Country	Link
US (2)	US5580895A (fi)
JP (1)	JP3253723B2 (fi)
KR (1)	KR100263625B1 (fi)
CN (1)	CN1049217C (fi)
AP (1)	AP369A (fi)
AU (2)	AU3450193A (fi)
BG (1)	BG61876B1 (fi)
CA (1)	CA2087672C (fi)
CZ (1)	CZ283950B6 (fi)
FI (1)	FI111632B (fi)
GB (1)	GB9201180D0 (fi)
GE (1)	GEP20001968B (fi)
HU (2)	HU221297B1 (fi)
IL (1)	IL104447A (fi)
IS (1)	IS3970A (fi)
MX (1)	MX9300261A (fi)
MY (1)	MY131307A (fi)
NO (1)	NO305952B1 (fi)
NZ (1)	NZ245715A (fi)
OA (1)	OA09964A (fi)
PH (1)	PH30894A (fi)
PL (1)	PL175340B1 (fi)
RO (1)	RO114128B1 (fi)
RU (1)	RU2124009C1 (fi)
SK (1)	SK280173B6 (fi)
TW (1)	TW226013B (fi)
UA (1)	UA29416C2 (fi)
WO (1)	WO1993014074A1 (fi)
ZA (1)	ZA93375B (fi)

Families Citing this family (45)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB9225492D0 (en) *	1992-12-05	1993-01-27	Glaxo Group Ltd	Amine derivatives
PL311083A1 (en) *	1993-04-15	1996-02-05	Glaxo Wellcome Inc	Derivatives of 1,5-bezodiazepine exhibiting antagonistic activity of cck and/or gastrin
GB9307833D0 (en) *	1993-04-15	1993-06-02	Glaxo Inc	Modulators of cholecystokinin and gastrin
GB9308431D0 (en) *	1993-04-23	1993-06-09	Glaxo Spa	Chemical compounds
GB9308421D0 (en) *	1993-04-23	1993-06-09	Glaxo Spa	Chemical compounds
GB2280182A (en) *	1993-07-20	1995-01-25	Glaxo Spa	Benzodiazepine derivatives
GB9314981D0 (en) *	1993-07-20	1993-09-01	Glaxo Spa	Chemical compounds
GB9314977D0 (en) *	1993-07-20	1993-09-01	Glaxo Spa	Chemical compounds
GB9315018D0 (en) *	1993-07-20	1993-09-01	Glaxo Spa	Chemical compounds
WO1995028419A1 (en) *	1994-04-14	1995-10-26	Glaxo Wellcome Inc.	Cck or gastrin modulating 5-heterocyclic-1,5-benzodiazepines
US5739129A (en) *	1994-04-14	1998-04-14	Glaxo Wellcome Inc.	CCK or gastrin modulating 5-heterocyclic-1, 5 benzodiazepines
PE27497A1 (es) *	1994-04-15	1997-08-07	Glaxo Inc	Derivados de 1,5 benzodiazepina
GB9420748D0 (en) *	1994-10-14	1994-11-30	Glaxo Inc	1,5 benzodiazepine derivatives
US5780464A (en) *	1994-10-14	1998-07-14	Glaxo Wellcome Inc.	Enteric coated compositions of 1,5-benzodiazepine derivatives having CCK antagonistic or agonistic activity
CA2239293A1 (en)	1995-12-11	1997-06-19	New England Medical Center Hosptials, Inc.	Assay for and uses of peptide hormone receptor ligands
US5750353A (en) *	1995-12-11	1998-05-12	New England Medical Center Hospitals, Inc.	Assay for non-peptide agonists to peptide hormone receptors
ATE248823T1 (de) *	1996-12-10	2003-09-15	Zeria Pharm Co Ltd	1,5-benzodiazepinderivate
MXPA05007513A (es)	2003-01-14	2005-09-21	Cytokinetics Inc	Compuestos, composiciones y metodos.
GB0307918D0 (en) *	2003-04-05	2003-05-14	Astrazeneca Ab	Therapeutic use
MXPA06005545A (es) *	2003-11-18	2006-08-17	Boehringer Ingelheim Int	Preparacion farmaceutica solida.
ES2686357T3 (es)	2004-06-17	2018-10-17	Cytokinetics, Inc.	Compuestos, composiciones y procedimientos
US7538223B2 (en)	2005-08-04	2009-05-26	Cytokinetics, Inc.	Compounds, compositions and methods
US20070161617A1 (en)	2005-12-15	2007-07-12	Morgan Bradley P	Certain chemical entities, compositions and methods
US7825120B2 (en)	2005-12-15	2010-11-02	Cytokinetics, Inc.	Certain substituted ((piperazin-1-ylmethyl)benzyl)ureas
US7718657B2 (en)	2005-12-16	2010-05-18	Cytokinetics, Inc.	Certain indanyl urea modulators of the cardiac sarcomere
JP5178526B2 (ja)	2005-12-19	2013-04-10	サイトキネティクス・インコーポレーテッド	化合物、組成物および方法
CU20090172A7 (es)	2009-10-09	2011-10-05	Ct De Investigación Y Desarrollo De Medicamentos	Sistemas tricíclicos y tetracíclicos con actividad sobre el sistema nervioso central y vascular
WO2013018690A1 (ja)	2011-07-29	2013-02-07	国立大学法人徳島大学	Erap1由来ペプチド及びその使用
CN103435562B (zh) *	2013-08-26	2016-02-24	华东理工大学	6-取代苯并二氮卓-2,4-二酮类化合物及其用途
LT3324977T (lt)	2015-07-22	2022-10-25	Enanta Pharmaceuticals, Inc.	Benzodiazepino dariniai kaip rsv inhibitoriai
CN108699077B (zh)	2016-01-15	2021-03-02	英安塔制药有限公司	作为rsv抑制剂的杂环化合物
US10358441B2 (en)	2017-02-16	2019-07-23	Enanta Pharmaceuticals, Inc.	Processes for the preparation of benzodiazepine derivatives
US10752598B2 (en) *	2017-06-07	2020-08-25	Enanta Pharmaceuticals, Inc.	Aryldiazepine derivatives as RSV inhibitors
US10851115B2 (en)	2017-06-30	2020-12-01	Enanta Pharmaceuticals, Inc.	Heterocyclic compounds as RSV inhibitors
WO2019006295A1 (en)	2017-06-30	2019-01-03	Enanta Pharmaceuticals, Inc.	HETEROCYCLIC COMPOUNDS AS RSV INHIBITORS
EP3687543B1 (en)	2017-09-29	2024-03-20	Enanta Pharmaceuticals, Inc.	Combinations of pharmaceutical agents as rsv inhibitors
US10647711B2 (en)	2017-11-13	2020-05-12	Enanta Pharmaceuticals, Inc.	Azepin-2-one derivatives as RSV inhibitors
US10975094B2 (en)	2018-04-11	2021-04-13	Enanta Pharmaceuticals, Inc.	Heterocyclic compounds as RSV inhibitors
US20220098256A1 (en)	2018-11-30	2022-03-31	Tokushima University	Therapeutic agent for breast cancer comprising big3-phb2 interaction-inhibiting peptide derived from phb2
JP2022525893A (ja)	2019-03-18	2022-05-20	エナンタファーマシューティカルズインコーポレイテッド	Ｒｓｖ阻害剤としてのベンゾジアゼピン誘導体
US11179400B2 (en)	2019-04-09	2021-11-23	Enanta Pharmaceuticals, Inc.	Heterocyclic compounds as RSV inhibitors
US11505558B1 (en)	2019-10-04	2022-11-22	Enanta Pharmaceuticals, Inc.	Antiviral heterocyclic compounds
UY39032A (es)	2020-01-24	2021-07-30	Enanta Pharm Inc	Compuestos heterocíclicos como agentes antivirales
US11534439B2 (en)	2020-07-07	2022-12-27	Enanta Pharmaceuticals, Inc.	Dihydroquinoxaline and dihydropyridopyrazine derivatives as RSV inhibitors
US11945824B2 (en)	2020-10-19	2024-04-02	Enanta Pharmaceuticals, Inc.	Heterocyclic compounds as anti-viral agents

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
FR2641280B1 (fr) *	1988-12-29	1994-01-21	Roussel Uclaf	Nouveaux derives de la 2,4-dioxo 2,3,4,5-tetrahydro 1h-1,5-benzodiazepine, leur procede de preparation et leur application comme medicaments

1992
- 1992-01-21 GB GB929201180A patent/GB9201180D0/en active Pending
- 1992-01-21 GE GEAP19922651A patent/GEP20001968B/en unknown
1993
- 1993-01-15 US US08/256,359 patent/US5580895A/en not_active Expired - Fee Related
- 1993-01-19 RO RO94-01216A patent/RO114128B1/ro unknown
- 1993-01-19 CZ CZ941736A patent/CZ283950B6/cs not_active IP Right Cessation
- 1993-01-19 SK SK864-94A patent/SK280173B6/sk unknown
- 1993-01-19 UA UA94005364A patent/UA29416C2/uk unknown
- 1993-01-19 PL PL93304684A patent/PL175340B1/pl unknown
- 1993-01-19 WO PCT/EP1993/000098 patent/WO1993014074A1/en active IP Right Grant
- 1993-01-19 AU AU34501/93A patent/AU3450193A/en not_active Abandoned
- 1993-01-19 HU HU9402150A patent/HU221297B1/hu not_active IP Right Cessation
- 1993-01-19 KR KR1019940702491A patent/KR100263625B1/ko not_active IP Right Cessation
- 1993-01-19 RU RU94037768A patent/RU2124009C1/ru active
- 1993-01-20 NZ NZ245715A patent/NZ245715A/en unknown
- 1993-01-20 CA CA002087672A patent/CA2087672C/en not_active Expired - Fee Related
- 1993-01-20 MX MX9300261A patent/MX9300261A/es not_active IP Right Cessation
- 1993-01-20 IL IL104447A patent/IL104447A/en not_active IP Right Cessation
- 1993-01-20 PH PH45583A patent/PH30894A/en unknown
- 1993-01-20 AU AU31935/93A patent/AU661749B2/en not_active Ceased
- 1993-01-20 MY MYPI93000093A patent/MY131307A/en unknown
- 1993-01-20 IS IS3970A patent/IS3970A/is unknown
- 1993-01-20 JP JP02483193A patent/JP3253723B2/ja not_active Expired - Fee Related
- 1993-01-20 AP APAP/P/1993/000478A patent/AP369A/en active
- 1993-01-20 ZA ZA93375A patent/ZA93375B/xx unknown
- 1993-01-21 CN CN93101143A patent/CN1049217C/zh not_active Expired - Fee Related
- 1993-02-02 TW TW082100666A patent/TW226013B/zh active
1994
- 1994-06-27 BG BG98881A patent/BG61876B1/bg unknown
- 1994-07-18 OA OA60539A patent/OA09964A/en unknown
- 1994-07-19 FI FI943421A patent/FI111632B/fi active
- 1994-07-20 NO NO942720A patent/NO305952B1/no unknown
1995
- 1995-06-16 HU HU95P/P00242P patent/HU211295A9/hu unknown
1996
- 1996-07-01 US US08/674,259 patent/US5637697A/en not_active Expired - Fee Related

Also Published As

Publication number	Publication date
PL175340B1 (pl)	1998-12-31
NO305952B1 (no)	1999-08-23
SK86494A3 (en)	1995-03-08
CZ173694A3 (en)	1995-09-13
US5580895A (en)	1996-12-03
HU9402150D0 (en)	1994-09-28
KR100263625B1 (ko)	2000-11-01
OA09964A (en)	1995-12-11
IL104447A (en)	1998-02-22
AP369A (en)	1994-11-06
FI111632B (fi)	2003-08-29
TW226013B (fi)	1994-07-01
RO114128B1 (ro)	1999-01-29
CN1074678A (zh)	1993-07-28
GEP20001968B (en)	2000-03-05
HU221297B1 (en)	2002-09-28
AU3193593A (en)	1993-07-22
GB9201180D0 (en)	1992-03-11
JPH07118244A (ja)	1995-05-09
HUT67375A (en)	1995-03-28
NO942720L (no)	1994-07-20
BG61876B1 (bg)	1998-08-31
FI943421A0 (fi)	1994-07-19
RU94037768A (ru)	1996-08-10
ZA93375B (en)	1994-07-18
UA29416C2 (uk)	2000-11-15
CA2087672C (en)	2003-08-05
JP3253723B2 (ja)	2002-02-04
WO1993014074A1 (en)	1993-07-22
SK280173B6 (sk)	1999-09-10
NZ245715A (en)	1995-07-26
HU211295A9 (en)	1995-11-28
AU3450193A (en)	1993-08-03
AU661749B2 (en)	1995-08-03
CN1049217C (zh)	2000-02-09
IL104447A0 (en)	1993-05-13
MY131307A (en)	2007-08-30
CZ283950B6 (cs)	1998-07-15
US5637697A (en)	1997-06-10
IS3970A (is)	1993-07-22
MX9300261A (es)	1994-03-31
BG98881A (bg)	1995-03-31
PH30894A (en)	1997-12-23
CA2087672A1 (en)	1993-07-22
AP9300478A0 (en)	1993-01-31
NO942720D0 (no)	1994-07-20
RU2124009C1 (ru)	1998-12-27

Publication	Publication Date	Title
FI943421A (fi)	1994-07-19	1,5-bentsodiatsepiinijohdannaiset ja niiden käyttö lääkkeenä
FI953479A (fi)	1996-01-20	1-aryylipyrimidiinijohdannaiset ja niiden farmaseuttinen käyttö
FI943570A (fi)	1995-01-31	1-bentseenisulfonyyli-1,3-dihydroindol-2-onijohdannaisia, niiden valmistus ja niitä sisältäviä lääkeaineita
DE69224656D1 (de)	1998-04-09	Arzneimittel
FI932655A (fi)	1993-12-12	Imidatderivat av farmaceutiskt anvaendbara antikonvulsiva sulfamat
FI942993A (fi)	1994-12-23	Organoaluminoksituote ja sen käyttö
AU8650291A (en)	1992-04-28	Iridoid derivatives and their use as medicines
FI954491A (fi)	1995-09-22	Heterosykliä sisältäviä amidiinijohdokset, niiden valmistus ja käyttö
FI930574A0 (fi)	1993-02-10	Med keramiskt pigment oeverdragna oxidbaserade haorda partiklar, foerfarande foer framstaellning och anvaendning av dessa
FI941287A (fi)	1994-03-18	Triatsolokinoksalin-1,4-dioneja ja niiden valmistus ja käyttö
FI101382B1 (fi)	1998-06-15	Dihydroksipropyylisulfoetyyliselluloosia, niiden valmistus ja käyttö
DE4294862T1 (de)	1994-06-09	Pharmazeutische Komposition
FI955679A (fi)	1995-11-24	Piperidiinijohdannaisia, niiden valmistus ja käyttö
FI961977A0 (fi)	1996-05-09	N-substituoidut atsabisykloalkaanijohdannaiset, niiden valmistus ja käyttö
FI933376A0 (fi)	1993-07-28	4-amino-3-acylkinolinderivater och deras anvaendning som inhibitorer avmagsyrasekretion
NO308251B1 (no)	2000-08-21	Karbohydratderivater, farmasøytisk blanding inneholdende karbohydratderivater samt anvendelse av samme
FI933605A0 (fi)	1993-08-16	Sammansaettningar av 1-klor-2,2,2-trifluoretyldifluormetyleter och partiellt fluorerade alkanoler
FI955335A0 (fi)	1995-11-06	Bicyklopolyazamakrocyklofosfonsyror, komplex och konjugat daerav foer anvaendning som kontrastmedel och foerfarande foer framstaellning av dessa
FI942468A0 (fi)	1994-05-26	Kemialliset yhdisteet, niiden valmistus ja käyttö
BR9106372A (pt)	1993-04-27	Derivados 1,5-benzotiazepinona,suas preparacoes e uso farmaceutico
NO942228D0 (no)	1994-06-14	Ipsapiron-legemiddeltilberedning
MX9205375A (es)	1993-03-01	Nuevos derivados de bencilamina y el medicamento que los contienen.
GB9206062D0 (en)	1992-05-06	Heterocyclic compounds,their preparation and pharmaceutical use
FI934317A0 (fi)	1993-10-01	Farmaceutiska sammansaettningar, vilka innehaoller ej-joniska ytaktiva aemnen
FI935915A (fi)	1994-07-01	2-tienyyli-imidatso(2,1-b)bentsotiatsol-3-etikkahappojohdannaiset, niiden valmistus ja terapeuttinen käyttö