FI925167A0 - 2-substituerade sackarinderivat, som aer inhibitorer foer proteolytiska enzymer - Google Patents

2-substituerade sackarinderivat, som aer inhibitorer foer proteolytiska enzymer

Info

Publication number
FI925167A0
FI925167A0 FI925167A FI925167A FI925167A0 FI 925167 A0 FI925167 A0 FI 925167A0 FI 925167 A FI925167 A FI 925167A FI 925167 A FI925167 A FI 925167A FI 925167 A0 FI925167 A0 FI 925167A0
Authority
FI
Finland
Prior art keywords
sackarinderivat
proteolytiska
inhibitorer
enzymer
substituerade
Prior art date
Application number
FI925167A
Other languages
English (en)
Other versions
FI925167A (fi
Inventor
Richard Paul Dunlap
Neil Warren Boaz
Albert Joseph Mura
Dennis John Hlasta
Ranjit Chimanlal Desai
Chakrapani Subramanyam
Lee Hamilton Latimer
Eric Piatt Lodge
Original Assignee
Sterling Winthrop Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sterling Winthrop Inc filed Critical Sterling Winthrop Inc
Publication of FI925167A0 publication Critical patent/FI925167A0/fi
Publication of FI925167A publication Critical patent/FI925167A/fi

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D275/00—Heterocyclic compounds containing 1,2-thiazole or hydrogenated 1,2-thiazole rings
    • C07D275/04—Heterocyclic compounds containing 1,2-thiazole or hydrogenated 1,2-thiazole rings condensed with carbocyclic rings or ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D275/00—Heterocyclic compounds containing 1,2-thiazole or hydrogenated 1,2-thiazole rings
    • C07D275/04—Heterocyclic compounds containing 1,2-thiazole or hydrogenated 1,2-thiazole rings condensed with carbocyclic rings or ring systems
    • C07D275/06—Heterocyclic compounds containing 1,2-thiazole or hydrogenated 1,2-thiazole rings condensed with carbocyclic rings or ring systems with hetero atoms directly attached to the ring sulfur atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6536—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having nitrogen and sulfur atoms with or without oxygen atoms, as the only ring hetero atoms
    • C07F9/6539—Five-membered rings
    • C07F9/6541—Five-membered rings condensed with carbocyclic rings or carbocyclic ring systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biochemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Molecular Biology (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
FI925167A 1991-11-15 1992-11-13 2-substituerade sackarinderivat, som aer inhibitorer foer proteolytiska enzymer FI925167A (fi)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/793,033 US5236917A (en) 1989-05-04 1991-11-15 Saccharin derivatives useful as proteolytic enzyme inhibitors and compositions and method of use thereof

Publications (2)

Publication Number Publication Date
FI925167A0 true FI925167A0 (fi) 1992-11-13
FI925167A FI925167A (fi) 1993-05-16

Family

ID=25158880

Family Applications (1)

Application Number Title Priority Date Filing Date
FI925167A FI925167A (fi) 1991-11-15 1992-11-13 2-substituerade sackarinderivat, som aer inhibitorer foer proteolytiska enzymer

Country Status (17)

Country Link
US (5) US5236917A (fi)
EP (1) EP0542372A1 (fi)
JP (1) JPH05194444A (fi)
KR (1) KR930010015A (fi)
AU (1) AU654581B2 (fi)
CA (1) CA2079822A1 (fi)
CZ (1) CZ339092A3 (fi)
FI (1) FI925167A (fi)
HU (2) HUT66873A (fi)
IL (1) IL103748A (fi)
MX (1) MX9206008A (fi)
MY (1) MY107740A (fi)
NO (1) NO303119B1 (fi)
NZ (1) NZ244446A (fi)
RU (1) RU2101281C1 (fi)
SG (1) SG55181A1 (fi)
TW (1) TW221433B (fi)

Families Citing this family (91)

* Cited by examiner, † Cited by third party
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US5296496A (en) * 1991-12-27 1994-03-22 Sterling Winthrop Inc. 2-saccharinylmethyl phosphates, phosphonates and phosphinates useful as proteolytic enzyme inhibitors and compositions and method of use thereof
US5187173A (en) * 1991-12-27 1993-02-16 Sterling Winthrop Inc. 2-saccharinylmethyl and 4,5,6,7-tetrahydro-2-saccharinylmethyl phosphates, phosphonates and phosphinates useful as proteolytic enzyme inhibitors and compositions and method of use thereof
DE4427996A1 (de) * 1994-08-08 1996-02-15 Basf Ag Verfahren zur Herstellung von Saccharincarbonsäuren und -carbonsäureestern
US5541168A (en) * 1994-12-02 1996-07-30 Sterling Winthrop Inc. Substituted 2-(phosphinyloxymethyl)-1,2,5-thiadiazolidin-3-one 1,1-dioxides and compositions and method of use thereof
US5494925A (en) * 1994-12-02 1996-02-27 Sterling Winthrop Inc. 2-heterocyclyloxymethyl and 2-heterocyclylthiomethyl-1,2,5-thiadiazolidin-3-one 1,1-dioxides and compositions and method of use thereof
US5512576A (en) * 1994-12-02 1996-04-30 Sterling Winthrop Inc. 2-substituted 1,2,5,-thiadiazolidin-3-one 1,1-dioxides and compositions and method of use thereof
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US5596012A (en) 1997-01-21
US5371074A (en) 1994-12-06
IL103748A (en) 1997-02-18
FI925167A (fi) 1993-05-16
US5874432A (en) 1999-02-23
HU9203566D0 (en) 1993-01-28
JPH05194444A (ja) 1993-08-03
TW221433B (fi) 1994-03-01
KR930010015A (ko) 1993-06-21
HU211663A9 (en) 1995-12-28
SG55181A1 (en) 1998-12-21
CA2079822A1 (en) 1993-05-16
US5650422A (en) 1997-07-22
RU2101281C1 (ru) 1998-01-10
NO303119B1 (no) 1998-06-02
MX9206008A (es) 1993-11-01
EP0542372A1 (en) 1993-05-19
MY107740A (en) 1996-05-30
US5236917A (en) 1993-08-17
HUT66873A (en) 1995-01-30
AU654581B2 (en) 1994-11-10
NO924401D0 (no) 1992-11-13
CZ339092A3 (en) 1993-06-16
NO924401L (no) 1993-05-18
IL103748A0 (en) 1993-04-04
NZ244446A (en) 1994-09-27
AU2534092A (en) 1993-05-20

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