FI923050A0 - NYA BENZOMORFANER OCH DERAS ANVAENDNING SOM LAEKEMEDEL. - Google Patents

NYA BENZOMORFANER OCH DERAS ANVAENDNING SOM LAEKEMEDEL.

Info

Publication number
FI923050A0
FI923050A0 FI923050A FI923050A FI923050A0 FI 923050 A0 FI923050 A0 FI 923050A0 FI 923050 A FI923050 A FI 923050A FI 923050 A FI923050 A FI 923050A FI 923050 A0 FI923050 A0 FI 923050A0
Authority
FI
Finland
Prior art keywords
alkyl
benzomorfaner
nya
och deras
deras anvaendning
Prior art date
Application number
FI923050A
Other languages
Finnish (fi)
Other versions
FI923050A (en
FI105913B (en
Inventor
Adrian Carter
Helmut Ensinger
Matthias Grauert
Franz Josef Kuhn
Herbert Merz
Enzio Muller
Werner Stransky
Ilse Streller
Original Assignee
Boehringer Ingelheim Kg
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Ingelheim Kg filed Critical Boehringer Ingelheim Kg
Publication of FI923050A0 publication Critical patent/FI923050A0/en
Publication of FI923050A publication Critical patent/FI923050A/en
Application granted granted Critical
Publication of FI105913B publication Critical patent/FI105913B/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
    • C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
    • C07D221/22—Bridged ring systems
    • C07D221/26—Benzomorphans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Psychiatry (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Vascular Medicine (AREA)
  • Hospice & Palliative Care (AREA)
  • Urology & Nephrology (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Transition And Organic Metals Composition Catalysts For Addition Polymerization (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)

Abstract

Benzomorphane derivs. of formula (I) are new. In (I), X = O or S; R1 = 1-8C alkyl, 3-6C alkenyl, 3-6C alkynyl or aryl; R2 = H, 1-8C alkyl, 3-6C alkenyl, 3-6C alkynyl, aryl or aralkyl; R3 = H or 1-6C alkyl; R4 and R5 = each 1-8C alkyl; R6 = 1-8C alkyl or aryl; R7 and R8 = each H, 1-8C alkyl, halogen, OH, 1-8C alkoxy, O-Acyl, CN, NO2, NH2, NH(1-8C alkyl), N(1-8C alkyl)2 (n which the alkyl gps. are opt. different), NH-acyl or N-acyl-(1-8C alkyl).
FI923050A 1991-07-02 1992-07-01 Process for the preparation of pharmaceutically valuable benzomorphans FI105913B (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE4121821 1991-07-02
DE4121821A DE4121821A1 (en) 1991-07-02 1991-07-02 NEW BENZOMORPHANE AND ITS USE AS A MEDICAMENT

Publications (3)

Publication Number Publication Date
FI923050A0 true FI923050A0 (en) 1992-07-01
FI923050A FI923050A (en) 1993-01-03
FI105913B FI105913B (en) 2000-10-31

Family

ID=6435223

Family Applications (1)

Application Number Title Priority Date Filing Date
FI923050A FI105913B (en) 1991-07-02 1992-07-01 Process for the preparation of pharmaceutically valuable benzomorphans

Country Status (24)

Country Link
EP (1) EP0521422B1 (en)
JP (1) JP3324785B2 (en)
KR (1) KR100251256B1 (en)
AT (1) ATE137749T1 (en)
AU (1) AU657330B2 (en)
CA (1) CA2072814C (en)
CZ (1) CZ286949B6 (en)
DE (2) DE4121821A1 (en)
DK (1) DK0521422T3 (en)
ES (1) ES2086585T3 (en)
FI (1) FI105913B (en)
GR (1) GR3020124T3 (en)
HK (1) HK1003111A1 (en)
HU (1) HU220873B1 (en)
IE (1) IE74400B1 (en)
IL (1) IL102361A (en)
MX (1) MX9203845A (en)
NO (1) NO178263C (en)
NZ (1) NZ243388A (en)
PH (1) PH31430A (en)
SG (1) SG43001A1 (en)
SK (1) SK280776B6 (en)
TW (1) TW214547B (en)
ZA (1) ZA924883B (en)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19528472A1 (en) * 1995-08-03 1997-02-06 Boehringer Ingelheim Kg New process for the production of norbenzomorphan of an intermediate stage in the production of pharmaceutically valuable benzomorphan derivatives, in particular of (-) - (1R, 5S, S "R) -3'-hydroxy-2- (2-methoxypropyl -) - 5.9.9 -trimethyl-6.7 benzomorphan
DE19740110A1 (en) 1997-09-12 1999-03-18 Boehringer Ingelheim Pharma New hydroxy substituted benzomorphan derivatives
JPH1196519A (en) * 1997-09-17 1999-04-09 Alps Electric Co Ltd Spin valve type thin-film element and its production
US6136980A (en) * 1998-05-01 2000-10-24 Boehringer Ingelheim Kg Method of preparing norbenzomorphane as an intermediate in the preparation of pharmaceutically useful benzomorphane derivatives, in particular (-)-(1R,5S,2"R)-3'-hydroxy-2-(2-methoxypropyl)-5,9,9-trimethyl-6,7-benzo morphane
DE19826365A1 (en) * 1998-06-12 1999-12-16 Gruenenthal Gmbh Use of benzomorphan derivatives as an analgesic
US6355652B1 (en) 1999-11-27 2002-03-12 Boehringer Ingelheim Pharma Kg Substituted 1,2,3,4,5,6-hexahydro-2,6-methano-3-benzazocines and their use as pharmaceutical compositions
DE19957156A1 (en) * 1999-11-27 2001-05-31 Boehringer Ingelheim Pharma New amino and fluoro substituted 1,2,3,4,5,6-hexahydro-2,6-methano-3-benzazocine derivatives useful in treatment of e.g. arrythmias, spasms, ischaemia, pain and neurodegenerative disorders
DE10204276A1 (en) * 2002-02-02 2003-08-07 Boehringer Ingelheim Pharma N-Allyloxyethyl-1,2,3,4,5,6-hexahydro-2,6-methano-3-benzazocines and their use as pharmaceuticals
US7501433B2 (en) 2002-05-17 2009-03-10 Jenken Biosciences, Inc. Opioid and opioid-like compounds and uses thereof
US7923454B2 (en) 2002-05-17 2011-04-12 Jenken Biosciences, Inc. Opioid and opioid-like compounds and uses thereof
EP2987788A1 (en) 2002-05-17 2016-02-24 Taiwanj Pharmaceuticals Co., Ltd. Opioid and opioid-like compounds and uses thereof
US8017622B2 (en) 2003-05-16 2011-09-13 Jenken Biosciences, Inc. Opioid and opioid-like compounds and uses thereof
US8859580B2 (en) * 2007-11-16 2014-10-14 Boehringer Ingelheim International Gmbh Aryl- and heteroarylcarbonyl derivatives of benzomorphanes and related scaffolds, medicaments containing such compounds and their use
WO2015097545A1 (en) 2013-12-26 2015-07-02 Purdue Pharma L.P. Opioid receptor modulating oxabicyclo[2.2.2]octane morphinans

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL7804509A (en) * 1978-04-26 1979-10-30 Acf Chemiefarma Nv Novel 6,7-benzomorphan derivatives and their acid addition salts.
DE2828039A1 (en) * 1978-06-26 1980-01-10 Boehringer Sohn Ingelheim 2- (2-ALKOXYETHYL) -2'-HYDROXY-6,7-BENZOMORPHANES THEIR ACID ADDITION SALTS, THESE MEDICINAL PRODUCTS, AND METHOD FOR THE PRODUCTION THEREOF
NL7907800A (en) * 1979-10-23 1981-04-27 Acf Chemiefarma Nv Novel 6,7-benzomorphan derivatives and their acid addition salts, pharmaceutical compositions containing such a compound, and process for the preparation of these compounds and their pharmaceutical compositions.

Also Published As

Publication number Publication date
SK280776B6 (en) 2000-07-11
DE59206212D1 (en) 1996-06-13
KR930002321A (en) 1993-02-22
HK1003111A1 (en) 1998-10-09
SK207592A3 (en) 1997-01-08
CZ207592A3 (en) 1993-08-11
NO178263C (en) 1996-02-21
ATE137749T1 (en) 1996-05-15
CZ286949B6 (en) 2000-08-16
JPH05201987A (en) 1993-08-10
TW214547B (en) 1993-10-11
HU9202199D0 (en) 1992-10-28
IL102361A (en) 1997-02-18
ZA924883B (en) 1993-02-24
DE4121821A1 (en) 1993-01-14
NO922603L (en) 1993-01-04
HU220873B1 (en) 2002-06-29
NO178263B (en) 1995-11-13
NZ243388A (en) 1994-11-25
EP0521422B1 (en) 1996-05-08
HUT66410A (en) 1994-11-28
AU1868692A (en) 1993-01-07
EP0521422A1 (en) 1993-01-07
CA2072814A1 (en) 1993-01-03
CA2072814C (en) 2003-09-23
JP3324785B2 (en) 2002-09-17
DK0521422T3 (en) 1996-06-10
GR3020124T3 (en) 1996-08-31
IE74400B1 (en) 1997-07-30
KR100251256B1 (en) 2000-05-01
ES2086585T3 (en) 1996-07-01
AU657330B2 (en) 1995-03-09
MX9203845A (en) 1993-01-01
FI923050A (en) 1993-01-03
NO922603D0 (en) 1992-07-01
FI105913B (en) 2000-10-31
SG43001A1 (en) 1997-10-17
PH31430A (en) 1998-11-03
IE922144A1 (en) 1993-01-13
IL102361A0 (en) 1993-01-14

Similar Documents

Publication Publication Date Title
LU92544I2 (en) Ezetimibe in combination with rosuvastatin or pharmaceutically acceptable salts, including rosuvastatin in the form of zinc salt
FI923050A0 (en) NYA BENZOMORFANER OCH DERAS ANVAENDNING SOM LAEKEMEDEL.
CY1107830T1 (en) ANTI-CANCER analogues
NO304740B1 (en) 10 desacetoksytaxolderivater
DK0671156T3 (en) Cosmetic or pharmaceutical preparations containing liposomes
NO912940D0 (en) IMMUNE REPRESENTATIVE AGENT AND PROCEDURE FOR PREPARING THE SAME.
YU12992A (en) 2-AMINO-1,2,3,4, -TETRAHYDRONAPHTHALENE SUBSTITUTED IN THE RING
DK0873993T3 (en) New heterocyclic compounds, processes for their preparation and compositions containing them

Legal Events

Date Code Title Description
MA Patent expired