FI922204A0 - Proteinkomplex med faktor viii:c- aktivitet och framstaellning av desamma. - Google Patents

Proteinkomplex med faktor viii:c- aktivitet och framstaellning av desamma.

Info

Publication number
FI922204A0
FI922204A0 FI922204A FI922204A FI922204A0 FI 922204 A0 FI922204 A0 FI 922204A0 FI 922204 A FI922204 A FI 922204A FI 922204 A FI922204 A FI 922204A FI 922204 A0 FI922204 A0 FI 922204A0
Authority
FI
Finland
Prior art keywords
factor viii
human factor
domain
activity
polypeptide
Prior art date
Application number
FI922204A
Other languages
English (en)
Finnish (fi)
Other versions
FI922204A (fi
Inventor
Barbara Chapman
Rae Lyn Burke
Mirella Ezban Rasmussen
Jan Moeller Mikkelsen
Original Assignee
Novo Nordisk As
Chiron Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novo Nordisk As, Chiron Corp filed Critical Novo Nordisk As
Publication of FI922204A0 publication Critical patent/FI922204A0/fi
Publication of FI922204A publication Critical patent/FI922204A/fi
Priority to FI944903A priority Critical patent/FI944903A0/fi

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/745—Blood coagulation or fibrinolysis factors
    • C07K14/755—Factors VIII, e.g. factor VIII C (AHF), factor VIII Ag (VWF)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/81—Protease inhibitors
    • C07K14/8107—Endopeptidase (E.C. 3.4.21-99) inhibitors
    • C07K14/811—Serine protease (E.C. 3.4.21) inhibitors
    • C07K14/8121—Serpins
    • C07K14/8125—Alpha-1-antitrypsin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2800/00—Nucleic acids vectors
    • C12N2800/10—Plasmid DNA
    • C12N2800/108—Plasmid DNA episomal vectors

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Biophysics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biochemistry (AREA)
  • Zoology (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Wood Science & Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Hematology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Physics & Mathematics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Diabetes (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Plant Pathology (AREA)
  • Microbiology (AREA)
  • Toxicology (AREA)
  • Immunology (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Saccharide Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
FI922204A 1989-11-17 1992-05-14 Proteinkomplex med faktor viii:c- aktivitet och framstaellning av desamma. FI922204A (fi)

Priority Applications (1)

Application Number Priority Date Filing Date Title
FI944903A FI944903A0 (fi) 1989-11-17 1994-10-19 Proteiinikompleksit, joilla on faktori VIII:C-aktiivisuutta ja niiden valmistus

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US43863989A 1989-11-17 1989-11-17
PCT/DK1990/000291 WO1991007490A1 (en) 1989-11-17 1990-11-15 Protein complexes having factor viii:c activity and production thereof

Publications (2)

Publication Number Publication Date
FI922204A0 true FI922204A0 (fi) 1992-05-14
FI922204A FI922204A (fi) 1992-05-14

Family

ID=23741420

Family Applications (2)

Application Number Title Priority Date Filing Date
FI922204A FI922204A (fi) 1989-11-17 1992-05-14 Proteinkomplex med faktor viii:c- aktivitet och framstaellning av desamma.
FI944903A FI944903A0 (fi) 1989-11-17 1994-10-19 Proteiinikompleksit, joilla on faktori VIII:C-aktiivisuutta ja niiden valmistus

Family Applications After (1)

Application Number Title Priority Date Filing Date
FI944903A FI944903A0 (fi) 1989-11-17 1994-10-19 Proteiinikompleksit, joilla on faktori VIII:C-aktiivisuutta ja niiden valmistus

Country Status (22)

Country Link
EP (2) EP0670332A3 (ko)
JP (3) JP2865861B2 (ko)
KR (2) KR927003812A (ko)
AT (1) ATE163194T1 (ko)
AU (1) AU656311B2 (ko)
CA (2) CA2068728A1 (ko)
DE (1) DE69032043T2 (ko)
DK (1) DK0500734T3 (ko)
ES (1) ES2112255T3 (ko)
FI (2) FI922204A (ko)
GR (1) GR3026176T3 (ko)
HU (2) HUT64591A (ko)
IE (1) IE904140A1 (ko)
IL (2) IL96368A0 (ko)
NO (2) NO921946L (ko)
NZ (1) NZ236094A (ko)
PL (1) PL167083B1 (ko)
PT (1) PT95923B (ko)
SK (1) SK130194A3 (ko)
WO (1) WO1991007490A1 (ko)
YU (2) YU218690A (ko)
ZA (1) ZA909167B (ko)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE465222C5 (sv) * 1989-12-15 1998-02-10 Pharmacia & Upjohn Ab Ett rekombinant, humant faktor VIII-derivat och förfarande för dess framställning
US5326700A (en) * 1990-11-06 1994-07-05 Eli Lilly And Company DNA sequences encoding t-PA derivatives with cleavable sites
SE468050C (sv) * 1991-03-15 1998-04-27 Pharmacia & Upjohn Ab Rekombinant derivat av human faktor VIII
CA2078721A1 (en) * 1991-09-24 1993-03-25 Hiroshi Yonemura Process for preparing human coagulation factor viii protein complex
DK53792D0 (da) * 1992-04-24 1992-04-24 Novo Nordisk As Fremgangsmaade til fremstilling af proteiner
KR100234828B1 (ko) * 1995-10-16 1999-12-15 카나가와 치히로 액정조성물 및 이를 함유하는 액정표시소자
EP2202242A1 (en) 1996-04-24 2010-06-30 The Regents of The University of Michigan Inactivation resistant factor VIII related applications
US8183344B2 (en) 1996-04-24 2012-05-22 University Of Michigan Inactivation resistant factor VIII
GB2318732A (en) 1996-11-01 1998-05-06 Johnson & Johnson Medical Wound healing compositions containing alpha-1-antitrypsin
US6200560B1 (en) 1998-10-20 2001-03-13 Avigen, Inc. Adeno-associated virus vectors for expression of factor VIII by target cells
US6221349B1 (en) 1998-10-20 2001-04-24 Avigen, Inc. Adeno-associated vectors for expression of factor VIII by target cells
MXPA02009221A (es) * 2000-03-22 2005-07-25 Octagene Gmbh Produccion de factores de coagulacion sanguineo recombinantes en lineas celular humanas.
WO2005033321A2 (en) 2003-09-30 2005-04-14 The Trustees Of The University Of Pennsylvania Adeno-associated virus (aav) clades, sequences, vectors containing same, and uses therefor
EP1707634A1 (en) 2005-03-29 2006-10-04 Octapharma AG Method for isolation of recombinantly produced proteins
CN102994549B (zh) 2005-04-07 2015-02-11 宾夕法尼亚大学托管会 增强腺相关病毒载体功能的方法
EP1739179A1 (en) 2005-06-30 2007-01-03 Octapharma AG Serum-free stable transfection and production of recombinant human proteins in human cell lines
WO2011095604A1 (en) 2010-02-04 2011-08-11 Octapharma Biopharmaceuticals Gmbh Half-life prolongation of proteins
SG10201502270TA (en) 2010-03-29 2015-05-28 Univ Pennsylvania Pharmacologically induced transgene ablation system
US9315825B2 (en) 2010-03-29 2016-04-19 The Trustees Of The University Of Pennsylvania Pharmacologically induced transgene ablation system
CA2826316C (en) 2011-02-17 2021-04-27 The Trustees Of The University Of Pennsylvania Compositions and methods for altering tissue specificity and improving aav9-mediated gene transfer
US9719106B2 (en) 2013-04-29 2017-08-01 The Trustees Of The University Of Pennsylvania Tissue preferential codon modified expression cassettes, vectors containing same, and uses thereof
EP3283126B1 (en) 2015-04-16 2019-11-06 Emory University Recombinant promoters and vectors for protein expression in liver and use thereof
CA3188420A1 (en) 2020-08-07 2022-02-10 Joseph Bauman Vesicle targeting proteins and uses of same

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3652530A (en) 1967-08-28 1972-03-28 American Nat Red Cross Antihemophilic factor prepared from blood plasma using polyethylene glycol
US3631018A (en) 1970-05-01 1971-12-28 Baxter Laboratories Inc Production of stable high-potency human ahf using polyethylene glycol and glycine to fractionate a cryoprecipitate of ahf concentrate
US4069216A (en) 1975-06-16 1978-01-17 Edward Shanbrom, Inc. Simplified methods for preparation of very high purity Factor VIII concentrate
AU577259B2 (en) * 1982-08-13 1988-09-22 Zymogenetics Inc. Glycolytic promters for regulated protein expression protease inhibitor
JPH07106156B2 (ja) * 1983-10-28 1995-11-15 ジェネティックス、インスティチュ−ト ファクタ−▲ｖｉｉｉ▼および関連生産物の製造
ES8801674A1 (es) * 1985-04-12 1988-02-16 Genetics Inst Un procedimiento para la preparacion de una proteina que presenta actividad procoagulante.
FI98829C (fi) * 1986-01-27 1997-08-25 Chiron Corp Menetelmä rekombinoidun proteiinikompleksin valmistamiseksi, jolla on humaanitekijä VIII:C-aktiivisuutta
AU588965B2 (en) * 1986-02-06 1989-09-28 Alcatel Australia Limited Telephone hook-switch

Also Published As

Publication number Publication date
DE69032043D1 (de) 1998-03-19
HU9201629D0 (en) 1992-08-28
HUT70457A (en) 1995-10-30
JPH05502025A (ja) 1993-04-15
SK130194A3 (en) 1997-06-04
ATE163194T1 (de) 1998-02-15
NZ236094A (en) 1993-04-28
PT95923A (pt) 1991-09-13
PT95923B (pt) 1998-04-30
NO943949D0 (no) 1994-10-18
PL167083B1 (pl) 1995-07-31
ES2112255T3 (es) 1998-04-01
EP0500734B1 (en) 1998-02-11
IE904140A1 (en) 1991-05-22
JPH0856656A (ja) 1996-03-05
NO943949L (no) 1992-07-13
PL287807A1 (en) 1991-09-23
NO921946L (no) 1992-07-13
WO1991007490A1 (en) 1991-05-30
HU9500546D0 (en) 1995-04-28
KR960701899A (ko) 1996-03-28
EP0500734A1 (en) 1992-09-02
YU218690A (sh) 1993-05-28
DK0500734T3 (da) 1998-03-30
AU6752590A (en) 1991-06-13
HUT64591A (en) 1994-01-28
IL111304A0 (en) 1994-12-29
DE69032043T2 (de) 1998-06-04
AU656311B2 (en) 1995-02-02
KR927003812A (ko) 1992-12-18
JPH11130800A (ja) 1999-05-18
ZA909167B (en) 1993-10-15
EP0670332A2 (en) 1995-09-06
NO921946D0 (no) 1992-05-15
JP2865861B2 (ja) 1999-03-08
FI944903A (fi) 1994-10-19
FI944903A0 (fi) 1994-10-19
CA2068728A1 (en) 1991-05-18
YU78194A (sh) 1997-05-28
GR3026176T3 (en) 1998-05-29
CA2135744A1 (en) 1991-05-18
IL96368A0 (en) 1991-08-16
EP0670332A3 (en) 1995-10-25
FI922204A (fi) 1992-05-14
JP2771129B2 (ja) 1998-07-02

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