FI921847A - Farmaceutisk komposition som har endoproteolytisk aktivitet, foerfarande foer endoproteolytisk behandling av (prekursor)proteiner samt foerfarande foer (mikro)bio- logisk framstaellning av proteiner. - Google Patents

Farmaceutisk komposition som har endoproteolytisk aktivitet, foerfarande foer endoproteolytisk behandling av (prekursor)proteiner samt foerfarande foer (mikro)bio- logisk framstaellning av proteiner. Download PDF

Info

Publication number: FI921847A
Authority: FI; Finland
Prior art keywords: endoproteolytisk; proteiner; foerfarande foer; furin; micro
Prior art date: 1989-10-25

Application number

FI921847A

Other languages

English (en)

Other versions

FI921847A0 (fi

FI105348B (fi

Inventor

De Ven Willem Jan Marie Van

Den Ouweland Anna Maria Wi Van

Duijnhoven Johannes Lamber Van

Antonius Johannes Mar Roebroek

Piet Nico Maria Koning

Original Assignee

Holland Biotechnology

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1989-10-25

Filing date

1992-04-24

Publication date

1992-04-24

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=26646599&utm_source=***_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=FI921847(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

1989-10-25 Priority claimed from NL8902651A external-priority patent/NL8902651A/nl

1992-04-24 Application filed by Holland Biotechnology filed Critical Holland Biotechnology

1992-04-24 Publication of FI921847A0 publication Critical patent/FI921847A0/fi

1992-04-24 Publication of FI921847A publication Critical patent/FI921847A/fi

2000-07-31 Application granted granted Critical

2000-07-31 Publication of FI105348B publication Critical patent/FI105348B/fi

Links

Classifications

- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
- C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
- C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
- C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
- C12N9/6424—Serine endopeptidases (3.4.21)
- C12N9/6454—Dibasic site splicing serine proteases, e.g. kexin (3.4.21.61); furin (3.4.21.75) and other proprotein convertases
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/43—Enzymes; Proenzymes; Derivatives thereof
- A61K38/46—Hydrolases (3)
- A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
- A61K38/482—Serine endopeptidases (3.4.21)
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/745—Blood coagulation or fibrinolysis factors
- C07K14/755—Factors VIII, e.g. factor VIII C (AHF), factor VIII Ag (VWF)
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/82—Translation products from oncogenes
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/32—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against translation products of oncogenes
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/40—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against enzymes
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/62—DNA sequences coding for fusion proteins
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
- C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
- C12N9/58—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from fungi
- C12N9/62—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from fungi from Aspergillus
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P21/00—Preparation of peptides or proteins
- C12P21/06—Preparation of peptides or proteins produced by the hydrolysis of a peptide bond, e.g. hydrolysate products
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
- C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/20—Fusion polypeptide containing a tag with affinity for a non-protein ligand
- C07K2319/23—Fusion polypeptide containing a tag with affinity for a non-protein ligand containing a GST-tag
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/32—Fusion polypeptide fusions with soluble part of a cell surface receptor, "decoy receptors"
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/50—Fusion polypeptide containing protease site
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/60—Fusion polypeptide containing spectroscopic/fluorescent detection, e.g. green fluorescent protein [GFP]

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Organic Chemistry (AREA)
Genetics & Genomics (AREA)
Engineering & Computer Science (AREA)
General Health & Medical Sciences (AREA)
Zoology (AREA)
Bioinformatics & Cheminformatics (AREA)
Wood Science & Technology (AREA)
Molecular Biology (AREA)
Medicinal Chemistry (AREA)
Biochemistry (AREA)
Biomedical Technology (AREA)
General Engineering & Computer Science (AREA)
Biotechnology (AREA)
Biophysics (AREA)
Microbiology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Gastroenterology & Hepatology (AREA)
Immunology (AREA)
Animal Behavior & Ethology (AREA)
General Chemical & Material Sciences (AREA)
Public Health (AREA)
Oncology (AREA)
Veterinary Medicine (AREA)
Pharmacology & Pharmacy (AREA)
Chemical Kinetics & Catalysis (AREA)
Hematology (AREA)
Toxicology (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Physics & Mathematics (AREA)
Plant Pathology (AREA)
Epidemiology (AREA)
Mycology (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Peptides Or Proteins (AREA)
Enzymes And Modification Thereof (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Micro-Organisms Or Cultivation Processes Thereof (AREA)

FI921847A 1989-10-25 1992-04-24 Menetelmä proteiinien käsittelemiseksi endoproteolyyttisesti sekä menetelmä proteiinien valmistamiseksi (mikro)biologisesti FI105348B (fi)

Applications Claiming Priority (6)

Application Number	Priority Date	Filing Date	Title
NL8902651		1989-10-25
NL8902651A NL8902651A (nl)	1989-10-25	1989-10-25	Farmaceutisch preparaat met endoproteolytische activiteit; werkwijze voor endoproteolytische processing van eiwitten.
NL9000917		1990-04-18
NL9000917A NL9000917A (nl)	1989-10-25	1990-04-18	Farmaceutisch preparaat met endoproteolytische activiteit; werkwijze voor endoproteolytische processing van (precursor) eiwitten en voor de (micro) biologische bereiding van eiwitten.
PCT/NL1990/000151 WO1991006314A2 (en)	1989-10-25	1990-10-12	Pharmaceutical composition having an endoproteolytic activity; a process for endoproteolytically processing (precursor) proteins and for the (micro)biological production of proteins
NL9000151		1990-10-12

Publications (3)

Publication Number	Publication Date
FI921847A0 FI921847A0 (fi)	1992-04-24
FI921847A true FI921847A (fi)	1992-04-24
FI105348B FI105348B (fi)	2000-07-31

Family

ID=26646599

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
FI921847A FI105348B (fi)	1989-10-25	1992-04-24	Menetelmä proteiinien käsittelemiseksi endoproteolyyttisesti sekä menetelmä proteiinien valmistamiseksi (mikro)biologisesti

Country Status (13)

Country	Link
US (1)	US5989856A (fi)
EP (3)	EP0885956A1 (fi)
JP (2)	JP3191111B2 (fi)
AT (1)	ATE147437T1 (fi)
AU (1)	AU6613290A (fi)
CA (1)	CA2069929C (fi)
DE (1)	DE69029663T3 (fi)
DK (1)	DK0497828T4 (fi)
ES (1)	ES2099714T5 (fi)
FI (1)	FI105348B (fi)
GR (1)	GR3023013T3 (fi)
NL (1)	NL9000917A (fi)
WO (1)	WO1991006314A2 (fi)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5935815A (en) *	1989-10-25	1999-08-10	Katholieke Universiteit Leuven	Process for micro biological production of proteins
EP0785273A1 (en) *	1990-11-26	1997-07-23	Genetics Institute, Inc.	Paired basic amino acid converting enzyme and DNA sequence encoding it
US6348327B1 (en) *	1991-12-06	2002-02-19	Genentech, Inc.	Non-endocrine animal host cells capable of expressing variant proinsulin and processing the same to form active, mature insulin and methods of culturing such cells
DK52293D0 (fi) *	1993-05-05	1993-05-05	Novo Nordisk As
US6005077A (en) *	1995-11-10	1999-12-21	Immuno Aktiengesellschaft	Use of von willebrand factor and pharmaceutical formulation
AT404838B (de)	1995-11-24	1999-03-25	Immuno Ag	Herstellung von proteinen aus pro-proteinen durch fusionsproteine abgeleitet von furin oder furinanalogen
US6596526B1 (en)	2000-06-09	2003-07-22	Baxter Aktiengesellschaft	Furin polypeptides with improved characteristics
WO2005103245A1 (en) *	2004-04-23	2005-11-03	Novozymes A/S	Method for obtaining mature protease by enzymatic digestion
PT2157177E (pt) *	2007-05-22	2013-04-18	Baxter Int	Processo de purificação preparativo para a furina humana
SI2235197T1 (sl)	2007-12-27	2017-10-30	Baxalta GmbH	Procesi celične kulture
BRPI0821467B8 (pt)	2007-12-31	2021-05-25	Baxalta GmbH	composição de furina recombinante, método para produzir a composição de furina recombinante, e, método para produzir uma proteína madura utilizando a composição de furina recombinante
US20130149295A1 (en)	2010-05-12	2013-06-13	Martine Cohen-Solal	Furin and biologically active derivatives thereof for use in the prevention or treatment of an inflammatory disease
SG195261A1 (en)	2011-06-02	2013-12-30	Baxter Int	Formulations of recombinant furin

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
EP0246709A1 (en) *	1986-05-20	1987-11-25	Stichting Katholieke Universiteit	Recombinant DNA and cDNA, mRNA, protein, antibodies, and a method of detecting tumor cells
CA1340740C (en) *	1987-12-08	1999-09-14	Eileen R. Mulvihill	Co-expression in eukaryotic cells

1990
- 1990-04-18 NL NL9000917A patent/NL9000917A/nl not_active Application Discontinuation
- 1990-10-12 EP EP98200913A patent/EP0885956A1/en not_active Withdrawn
- 1990-10-12 AT AT90915837T patent/ATE147437T1/de not_active IP Right Cessation
- 1990-10-12 WO PCT/NL1990/000151 patent/WO1991006314A2/en active IP Right Grant
- 1990-10-12 EP EP90915837A patent/EP0497828B2/en not_active Expired - Lifetime
- 1990-10-12 JP JP51489590A patent/JP3191111B2/ja not_active Expired - Lifetime
- 1990-10-12 DK DK90915837T patent/DK0497828T4/da active
- 1990-10-12 AU AU66132/90A patent/AU6613290A/en not_active Abandoned
- 1990-10-12 US US07/849,420 patent/US5989856A/en not_active Expired - Lifetime
- 1990-10-12 ES ES90915837T patent/ES2099714T5/es not_active Expired - Lifetime
- 1990-10-12 EP EP95202272A patent/EP0693286A1/en not_active Withdrawn
- 1990-10-12 DE DE69029663T patent/DE69029663T3/de not_active Expired - Lifetime
- 1990-10-12 CA CA002069929A patent/CA2069929C/en not_active Expired - Lifetime
1992
- 1992-04-24 FI FI921847A patent/FI105348B/fi active
1997
- 1997-04-02 GR GR970400685T patent/GR3023013T3/el unknown
2000
- 2000-12-15 JP JP2000381776A patent/JP3270760B2/ja not_active Expired - Lifetime

Also Published As

Publication number	Publication date
FI921847A0 (fi)	1992-04-24
US5989856A (en)	1999-11-23
JPH05504051A (ja)	1993-07-01
EP0693286A1 (en)	1996-01-24
EP0497828A1 (en)	1992-08-12
AU6613290A (en)	1991-05-31
JP3191111B2 (ja)	2001-07-23
EP0885956A1 (en)	1998-12-23
ES2099714T3 (es)	1997-06-01
FI105348B (fi)	2000-07-31
WO1991006314A3 (en)	1991-09-05
JP2001238683A (ja)	2001-09-04
DE69029663D1 (de)	1997-02-20
CA2069929C (en)	2002-08-27
DE69029663T2 (de)	1997-09-04
ES2099714T5 (es)	2008-04-01
DK0497828T3 (da)	1997-07-07
JP3270760B2 (ja)	2002-04-02
DK0497828T4 (da)	2008-02-04
ATE147437T1 (de)	1997-01-15
EP0497828B2 (en)	2007-10-03
NL9000917A (nl)	1991-05-16
EP0497828B1 (en)	1997-01-08
GR3023013T3 (en)	1997-07-30
CA2069929A1 (en)	1991-04-26
WO1991006314A2 (en)	1991-05-16
DE69029663T3 (de)	2008-05-21

Legal Events

Date	Code	Title	Description
1995-06-20	GB	Transfer or assigment of application	Owner name: KATHOLIEKE UNIVERSITEIT LEUVEN
1997-02-14	GB	Transfer or assigment of application	Owner name: KATHOLIEKE UNIVERSITEIT LEUVEN

Publication	Publication Date	Title
FI921847A0 (fi)	1992-04-24	Farmaceutisk komposition som har endoproteolytisk aktivitet, foerfarande foer endoproteolytisk behandling av (prekursor)proteiner samt foerfarande foer (mikro)bio- logisk framstaellning av proteiner.
DE68925002T2 (de)	1996-08-29	Verfahren zur Herstellung von optisch-aktiven alpha-substituierten organischen Säuren und Mikroorganismen und Enzyme, die dafür verwendet werden.
SE8800238D0 (sv)	1988-01-26	Flytande enzymkompositioner
DE69331550D1 (de)	2002-03-21	Klonierung und expression von biologisch aktiver alpha-galaktosidase a
IS5905A (is)	2001-03-22	Alzheimer sekretasi
BR8301918A (pt)	1983-12-20	Proteina,sequencia de dna,veiculo de expressao replicavel,microorganismo ou cultura celular,plasmideo,composicao,cultura de celulas,utilizacao de tal proteina,processo de expressao,processo para producao de um veiculo de expressao e processo para preparacao de uma proteina uroquinase
KR970009949B1 (en)	1997-06-19	Novel serine proteolytic enzyme and its process
ES2125530T3 (es)	1999-03-01	Secuencia de acidos nucleicos que codifica una enzima semejante a tripsina y procedimiento para producir la enzima.
ES2043610T3 (es)	1994-01-01	Procedimiento para la produccion de un polipeptido hibrido del tipo activador de plasminogeno.
DE69031042T2 (de)	1998-02-26	Fermentationsprozess zur herstellung von pyrimidin
AU670571B2 (en)	1996-07-25	A method of proteolytically cleaving proteins and the use of said method
BR9404991A (pt)	1995-08-08	Processos para aumentar a produção de proteína C e para aumentar o nível de gama-carboxiliação de uma molécula de proteína C
ES2059472T3 (es)	1994-11-16	Plantas con color de las flores modificado y procedimiento biotecnologico para su obtencion.
Azaryan et al.	1989	The presence of ATP+ ubiquitin-dependent proteinase and multicatalytic proteinase complex in bovine brain
DE58905691D1 (de)	1993-10-28	Verfahren zur Herstellung von L-alpha-Aminosäuren.
Torres et al.	2012	Bmoo FIBMP‐I: A New Fibrinogenolytic Metalloproteinase from Bothrops moojeni Snake Venom
EP0188312A3 (en)	1988-01-13	Process for the production of a protein
ES2052568T3 (es)	1994-07-16	Enzimas que tienen actividad alfa-glicerol-3-fosfato oxidasa, produccion y uso de las mismas.
Kinsella et al.	2002	A preliminary analysis of proteolytic activity of excretory–secretory products from Cyathostominea
DE69232122D1 (de)	2001-11-15	Rekombinante Viren, enthaltend eine künstliche proteolytische Schnittstelle.
DK0635061T3 (da)	1998-02-09	Fremgangsmåde til begrænsning af genetisk manipulerede organismers overlevelse i deres miljø
PT592574E (pt)	2004-02-27	Processo de producao de proteinas recombinantes e celulas hospedeiras utilizadas
PT1121146E (pt)	2004-10-29	Processo para influenciar celulas t hiperactivas por meio de enzimas proteoliticas
KR960017848A (ko)	1996-06-17	인간 적혈구 형성 자극 인자의 신규 제조 방법