FI920271A0 - Polyamintioler som straolningsskyddande aemnen. - Google Patents

Polyamintioler som straolningsskyddande aemnen.

Info

Publication number
FI920271A0
FI920271A0 FI920271A FI920271A FI920271A0 FI 920271 A0 FI920271 A0 FI 920271A0 FI 920271 A FI920271 A FI 920271A FI 920271 A FI920271 A FI 920271A FI 920271 A0 FI920271 A0 FI 920271A0
Authority
FI
Finland
Prior art keywords
spo3h2
straolningsskyddande
polyamintioler
aemnen
som
Prior art date
Application number
FI920271A
Other languages
English (en)
Other versions
FI920271A (fi
FI111251B (fi
Inventor
Michael Louis Edwards
Ronald Duayne Snyder
Original Assignee
Merrell Dow Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merrell Dow Pharma filed Critical Merrell Dow Pharma
Publication of FI920271A0 publication Critical patent/FI920271A0/fi
Publication of FI920271A publication Critical patent/FI920271A/fi
Application granted granted Critical
Publication of FI111251B publication Critical patent/FI111251B/fi

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/23Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton
    • C07C323/24Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C323/25Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00General protective or antinoxious agents
    • A61P39/02Antidotes
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/23Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton
    • C07C323/31Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton having the sulfur atom of at least one of the thio groups bound to a carbon atom of a six-membered aromatic ring of the carbon skeleton
    • C07C323/32Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton having the sulfur atom of at least one of the thio groups bound to a carbon atom of a six-membered aromatic ring of the carbon skeleton having at least one of the nitrogen atoms bound to an acyclic carbon atom of the carbon skeleton
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/23Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton
    • C07C323/31Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton having the sulfur atom of at least one of the thio groups bound to a carbon atom of a six-membered aromatic ring of the carbon skeleton
    • C07C323/33Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton having the sulfur atom of at least one of the thio groups bound to a carbon atom of a six-membered aromatic ring of the carbon skeleton having at least one of the nitrogen atoms bound to a carbon atom of the same non-condensed six-membered aromatic ring
    • C07C323/34Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton having the sulfur atom of at least one of the thio groups bound to a carbon atom of a six-membered aromatic ring of the carbon skeleton having at least one of the nitrogen atoms bound to a carbon atom of the same non-condensed six-membered aromatic ring the thio group being a mercapto group
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07FACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02Phosphorus compounds
    • C07F9/06Phosphorus compounds without P—C bonds
    • C07F9/16Esters of thiophosphoric acids or thiophosphorous acids
    • C07F9/165Esters of thiophosphoric acids
    • C07F9/1651Esters of thiophosphoric acids with hydroxyalkyl compounds with further substituents on alkyl

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biochemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Toxicology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Polymers With Sulfur, Phosphorus Or Metals In The Main Chain (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Polyurethanes Or Polyureas (AREA)
  • Materials For Medical Uses (AREA)
  • Macromolecular Compounds Obtained By Forming Nitrogen-Containing Linkages In General (AREA)
  • Polyethers (AREA)
  • Display Devices Of Pinball Game Machines (AREA)
  • Heterocyclic Compounds That Contain Two Or More Ring Oxygen Atoms (AREA)
  • Coating Of Shaped Articles Made Of Macromolecular Substances (AREA)
FI920271A 1991-01-23 1992-01-22 Menetelmä säteilyltä suojaavien polyamiinitiolien valmistamiseksi FI111251B (fi)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US07/644,810 US5217964A (en) 1991-01-23 1991-01-23 Polyamine thiols as radioprotective agents
US64481091 1991-01-23

Publications (3)

Publication Number Publication Date
FI920271A0 true FI920271A0 (fi) 1992-01-22
FI920271A FI920271A (fi) 1992-07-24
FI111251B FI111251B (fi) 2003-06-30

Family

ID=24586432

Family Applications (1)

Application Number Title Priority Date Filing Date
FI920271A FI111251B (fi) 1991-01-23 1992-01-22 Menetelmä säteilyltä suojaavien polyamiinitiolien valmistamiseksi

Country Status (16)

Country Link
US (1) US5217964A (fi)
EP (1) EP0497202B1 (fi)
JP (1) JP3203582B2 (fi)
KR (1) KR100195420B1 (fi)
AT (1) ATE127785T1 (fi)
AU (1) AU647570B2 (fi)
CA (1) CA2059817C (fi)
DE (1) DE69204698T2 (fi)
ES (1) ES2079695T3 (fi)
FI (1) FI111251B (fi)
IE (1) IE67961B1 (fi)
IL (1) IL100698A (fi)
NO (1) NO179003C (fi)
NZ (1) NZ241347A (fi)
PT (1) PT100045B (fi)
ZA (1) ZA92360B (fi)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5677351A (en) * 1986-12-02 1997-10-14 University Of Florida Research Foundation, Inc. Sterically hindered tetraamines and method for their production
US5393757A (en) * 1986-12-02 1995-02-28 University Of Florida Polyamines and anti-diarrheal and gastrointestinal anti-spasmodic pharmaceutical compositions and methods of treatment
US5342945A (en) * 1986-12-02 1994-08-30 University Of Florida Research Foundation, Inc. Anti-neoplastic, anti-viral or anti-retroviral spermine derivatives
US5354782A (en) * 1991-01-17 1994-10-11 Merrell Dow Pharmaceuticals Inc. Polyamine phenols as radioprotective agents
US5488042A (en) * 1992-03-13 1996-01-30 Arch Development Corporation Method for protection against genotoxic mutagenesis
KR100311851B1 (ko) * 1993-02-23 2002-04-24 슈테펜엘.네스비트 방사선보호제로서의폴리아민유도체
WO1994027961A1 (en) * 1993-05-26 1994-12-08 Merrell Dow Pharmaceutials Inc. N-alkylthio polyamine derivatives as radioprotective agents
US5994409A (en) * 1997-12-09 1999-11-30 U.S. Bioscience, Inc. Methods for treatment of neuro--and nephro--disorders and therapeutic toxicities using aminothiol compounds
US6482943B1 (en) * 1999-04-30 2002-11-19 Slil Biomedical Corporation Quinones as disease therapies
IL146126A0 (en) * 1999-04-30 2002-07-25 Slil Biomedical Corp Novel polyamine analog conjugates and quinone conjugates as therapies for cancers and prostate diseases
BR0010701A (pt) * 1999-04-30 2002-02-13 Slil Biomedical Corp Análogos de poliamina restritos de forma conformacional como terapias de doenças
US6649587B1 (en) 1999-04-30 2003-11-18 Slil Biomedical Corporation Polyamine analog conjugates and quinone conjugates as therapies for cancers and prostate diseases
US6489312B1 (en) * 1999-06-15 2002-12-03 Medimmune Oncology, Inc. Pharmaceutical formulations comprising aminoalkyl phosphorothioates
WO2001085142A1 (en) * 2000-05-05 2001-11-15 Wisconsin Alumni Research Foundation Compositions and methods for protecting cells during cancer chemotherapy and radiotherapy
EP1337504A4 (en) * 2000-11-08 2005-10-05 Cellgate Inc NOVEL AMINO ACID CONJUGATES AND POLYAMINE ANALOGUES USEFUL AS ANTICANCING AGENTS
US7053072B2 (en) 2001-05-11 2006-05-30 Medimmune Oncology, Inc. Methods for the administration of amifostine and related compounds
WO2003013245A1 (en) * 2001-08-07 2003-02-20 Wisconsin Alumni Research Foundation Polyamines and analogs for protecting cells during cancer chemotherapy and radiotherapy
MXPA04005509A (es) 2001-12-07 2004-12-06 Slil Biomedical Corp Poliaminas sustituidas con cicloalquilo para terapia de cancer y metodos de sintesis de las mismas.
CN1642902A (zh) * 2002-02-07 2005-07-20 威斯康星校友研究基金会 与癌治疗联合使用的聚胺化合物及组合物
WO2005014524A2 (en) * 2003-08-07 2005-02-17 Wisconsin Alumni Research Foundation Amino thiol compounds and compositions for use in conjunction with cancer therapy
WO2007149484A2 (en) * 2006-06-20 2007-12-27 Dana-Farber Cancer Institute Inhibitors of usp1 deubiquitinating enzyme complex
CA2797719C (en) 2010-04-30 2019-11-26 Dana-Farber Cancer Institute, Inc. Small molecule inhibitors of usp1 deubiquitinating enzyme activity
US9725425B1 (en) 2014-02-25 2017-08-08 Dana-Farber Cancer Institute, Inc. Compounds and methods for treating cancer
TWM528362U (zh) * 2016-04-15 2016-09-11 Calendar Entpr Co Ltd 無繩式電動節能捲簾結構改良

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2901503A (en) * 1956-08-28 1959-08-25 Campbell Pharmaceuticals Inc Dialkylaminophenyl esters of thiophosphoric acids
US3368972A (en) * 1965-01-06 1968-02-13 Mobil Oil Corp High molecular weight mannich bases as engine oil additives
ZA88600B (en) * 1987-02-03 1988-07-28 Merrell Dow Pharmaceuticals Inc. Novel polyamine derivatives
ZA887410B (en) * 1987-10-08 1989-06-28 Merrell Dow Pharma Polyamine derivatives as antineoplastic agents

Also Published As

Publication number Publication date
EP0497202B1 (en) 1995-09-13
KR100195420B1 (ko) 1999-06-15
DE69204698T2 (de) 1996-02-15
NO920283D0 (no) 1992-01-22
EP0497202A1 (en) 1992-08-05
AU1030492A (en) 1992-07-30
NO179003B (no) 1996-04-09
AU647570B2 (en) 1994-03-24
NZ241347A (en) 1994-04-27
JP3203582B2 (ja) 2001-08-27
ZA92360B (en) 1992-11-25
US5217964A (en) 1993-06-08
IE67961B1 (en) 1996-05-15
PT100045A (pt) 1993-03-31
FI920271A (fi) 1992-07-24
IE920189A1 (en) 1992-07-29
NO920283L (no) 1992-07-24
CA2059817A1 (en) 1992-07-24
ES2079695T3 (es) 1996-01-16
CA2059817C (en) 2003-07-15
FI111251B (fi) 2003-06-30
KR920014772A (ko) 1992-08-25
DE69204698D1 (de) 1995-10-19
IL100698A (en) 1998-08-16
ATE127785T1 (de) 1995-09-15
NO179003C (no) 1996-07-17
IL100698A0 (en) 1992-09-06
JPH04334362A (ja) 1992-11-20
PT100045B (pt) 1999-10-29

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