FI915379A0 - Tnf-muteiner. - Google Patents

Tnf-muteiner.

Info

Publication number
FI915379A0
FI915379A0 FI915379A FI915379A FI915379A0 FI 915379 A0 FI915379 A0 FI 915379A0 FI 915379 A FI915379 A FI 915379A FI 915379 A FI915379 A FI 915379A FI 915379 A0 FI915379 A0 FI 915379A0
Authority
FI
Finland
Prior art keywords
muteiner
tnf
Prior art date
Application number
FI915379A
Other languages
English (en)
Other versions
FI915379A (fi
Inventor
Walter Fiers
Jan Tavernier
Ostade Xaveer Van
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of FI915379A0 publication Critical patent/FI915379A0/fi
Publication of FI915379A publication Critical patent/FI915379A/fi

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/525—Tumour necrosis factor [TNF]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Molecular Biology (AREA)
  • Zoology (AREA)
  • Toxicology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
FI915379A 1990-11-21 1991-11-14 Tnf-muteiner. FI915379A (fi)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP90810901 1990-11-21

Publications (2)

Publication Number Publication Date
FI915379A0 true FI915379A0 (fi) 1991-11-14
FI915379A FI915379A (fi) 1992-05-22

Family

ID=8205969

Family Applications (1)

Application Number Title Priority Date Filing Date
FI915379A FI915379A (fi) 1990-11-21 1991-11-14 Tnf-muteiner.

Country Status (17)

Country Link
US (2) US5422104A (fi)
EP (1) EP0486908A3 (fi)
JP (1) JPH06256395A (fi)
AR (1) AR245783A1 (fi)
AU (1) AU655948B2 (fi)
CA (1) CA2055168A1 (fi)
FI (1) FI915379A (fi)
HU (1) HUT62034A (fi)
IE (1) IE914035A1 (fi)
IL (1) IL100062A0 (fi)
MC (1) MC2300A1 (fi)
MX (1) MX9102110A (fi)
NO (1) NO914541L (fi)
NZ (1) NZ240595A (fi)
PT (1) PT99560A (fi)
UY (1) UY23327A1 (fi)
ZA (1) ZA919035B (fi)

Families Citing this family (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CZ283533B6 (cs) * 1992-04-02 1998-04-15 F. Hoffmann-La Roche Ag TNF - muteiny a způsob jejich výroby
CA2119089A1 (en) * 1993-03-29 1994-09-30 David Banner Tumor necrosis factor muteins
US7070771B1 (en) 1996-12-09 2006-07-04 Regents Of The University Of California Methods of expressing chimeric mouse and human CD40 ligand in human CD40+ cells
JP2002506980A (ja) * 1998-03-20 2002-03-05 ジェンザイム・コーポレーション 新規の相補的レセプター−リガンド対およびそれを使用する養子免疫療法
DE60028830T2 (de) * 2000-02-16 2007-01-18 Genentech, Inc., South San Francisco Anti-april antikörper und hybridomazellen
US7662367B2 (en) 2000-03-02 2010-02-16 Xencor, Inc. Pharmaceutical compositions for the treatment of TNF-α related disorders
US7244823B2 (en) * 2000-03-02 2007-07-17 Xencor TNF-alpha variants proteins for the treatment of TNF-alpha related disorders
US7056695B2 (en) 2000-03-02 2006-06-06 Xencor TNF-α variants
US7101974B2 (en) 2000-03-02 2006-09-05 Xencor TNF-αvariants
US7446174B2 (en) 2001-03-02 2008-11-04 Xencor, Inc. Protein based TNF-α variants for the treatment of TNF-α related disorders
US7687461B2 (en) 2000-03-02 2010-03-30 Xencor, Inc. Treatment of TNF-α related disorders with TNF-α variant proteins
US20070172449A1 (en) * 2000-03-02 2007-07-26 Xencor, Inc. TNF-alpha VARIANT FORMULATIONS FOR THE TREATMENT OF TNF-alpha RELATED DISORDERS
US6579522B1 (en) * 2000-06-27 2003-06-17 Genvec, Inc. Replication deficient adenoviral TNF vector
PL377119A1 (pl) * 2001-08-03 2006-01-23 Genentech, Inc. Peptydy TACIs i BR3 i ich zastosowanie
US20030086903A1 (en) * 2001-11-02 2003-05-08 Genvec, Inc. Therapeutic regimen for treating cancer
US7786282B2 (en) * 2001-12-06 2010-08-31 The Regents Of The University Of California Nucleic acid molecules encoding TNF-α ligand polypeptides having a CD154 domain
AU2003256836A1 (en) * 2002-07-25 2004-02-16 Genentech, Inc. Taci antibodies and uses thereof
WO2004050683A2 (en) * 2002-12-02 2004-06-17 Abgenix, Inc. Antibodies directed to tumor necrosis factor and uses thereof
EP1629001A2 (en) * 2003-06-05 2006-03-01 Genentech, Inc. Blys antagonists and uses thereof
US20050163775A1 (en) * 2003-06-05 2005-07-28 Genentech, Inc. Combination therapy for B cell disorders
DE602004025726D1 (de) * 2003-11-14 2010-04-08 Genvec Inc Pharmazeutische verbindung zur behandlung von lokal fortgeschrittenem primär inoperablen pankreaskarzinom (lapc).
TW201122103A (en) * 2004-01-06 2011-07-01 Hayashibara Biochem Lab Tnf antagonists and tnf inhibitors comprising the same as the active ingredient
EP1598075A1 (en) * 2004-05-21 2005-11-23 LEK Pharmaceuticals d.d. Process for the isolation and / or purification of proteins
GB0425972D0 (en) 2004-11-25 2004-12-29 Celltech R&D Ltd Biological products
JP2008526889A (ja) * 2005-01-10 2008-07-24 リサーチ ディベロップメント ファウンデーション 癌治療のための標的化キメラ分子
US9726673B2 (en) * 2005-11-23 2017-08-08 Genentech, Inc. Methods and compositions related to B cell assays
WO2008127515A1 (en) * 2007-03-01 2008-10-23 Cytologic, Inc. Compositions and method for enhancing immune responses in mammals
WO2008124086A2 (en) * 2007-04-05 2008-10-16 President And Fellows Of Harvard College Chimeric activators: quantitatively designed protein therapeutics and uses thereof
US9605844B2 (en) * 2009-09-01 2017-03-28 Cree, Inc. Lighting device with heat dissipation elements
EP2953634B1 (en) 2013-02-07 2021-05-26 The General Hospital Corporation Methods for expansion or depletion of t-regulatory cells
WO2015168474A1 (en) 2014-04-30 2015-11-05 President And Fellows Of Harvard College Fusion proteins for treating cancer and related methods
JP6925431B2 (ja) 2016-11-09 2021-08-25 フィロジェン エッセ．ピー．アー． Ｉｌ２及びｔｎｆ突然変異体のイムノコンジュゲート
WO2022047243A1 (en) 2020-08-27 2022-03-03 Enosi Life Sciences Corp. Methods and compositions to treat autoimmune diseases and cancer

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4650674A (en) * 1984-07-05 1987-03-17 Genentech, Inc. Synergistic cytotoxic composition
GR851626B (fi) * 1984-07-05 1985-11-26 Genentech Inc
DE3750056T2 (de) * 1986-06-20 1995-04-06 Dainippon Pharmaceutical Co Polypeptid-Mutanten des menschlichen TNF und für diese Mutanten codierende DNS.
JPH07106158B2 (ja) * 1986-12-04 1995-11-15 サントリー株式会社 抗腫瘍活性を有する新規ポリペプチドおよびその製造法
WO1988006625A2 (en) * 1987-02-26 1988-09-07 Cetus Corporation Arginine-depleted human tumor necrosis factor
JPS63291590A (ja) * 1987-05-25 1988-11-29 Teijin Ltd 新規生理活性ポリペプチド
DE3843534A1 (de) * 1988-12-23 1990-07-12 Basf Ag Neue tnf-polypeptide

Also Published As

Publication number Publication date
MX9102110A (es) 1992-07-08
ZA919035B (en) 1992-08-26
HUT62034A (en) 1993-03-29
JPH06256395A (ja) 1994-09-13
NO914541D0 (no) 1991-11-20
IL100062A0 (en) 1992-08-18
IE914035A1 (en) 1992-06-03
EP0486908A3 (en) 1992-11-19
US5422104A (en) 1995-06-06
HU913595D0 (en) 1992-01-28
NZ240595A (en) 1994-09-27
EP0486908A2 (en) 1992-05-27
FI915379A (fi) 1992-05-22
AU8791591A (en) 1992-05-28
AU655948B2 (en) 1995-01-19
AR245783A1 (es) 1994-02-28
PT99560A (pt) 1992-10-30
UY23327A1 (es) 1992-05-19
NO914541L (no) 1992-05-22
CA2055168A1 (en) 1992-05-22
MC2300A1 (fr) 1993-09-06
US5652353A (en) 1997-07-29

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Legal Events

Date Code Title Description
FD Application lapsed