FI893751A0 - CHEMICAL FOERENINGAR. - Google Patents

CHEMICAL FOERENINGAR.

Info

Publication number
FI893751A0
FI893751A0 FI893751A FI893751A FI893751A0 FI 893751 A0 FI893751 A0 FI 893751A0 FI 893751 A FI893751 A FI 893751A FI 893751 A FI893751 A FI 893751A FI 893751 A0 FI893751 A0 FI 893751A0
Authority
FI
Finland
Prior art keywords
alkyl
compounds
disclosed
foereningar
chemical
Prior art date
Application number
FI893751A
Other languages
Finnish (fi)
Other versions
FI893751A (en
Inventor
Ian Harold Coates
Original Assignee
Glaxo Group Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Glaxo Group Ltd filed Critical Glaxo Group Ltd
Publication of FI893751A0 publication Critical patent/FI893751A0/en
Publication of FI893751A publication Critical patent/FI893751A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Pain & Pain Management (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Transition And Organic Metals Composition Catalysts For Addition Polymerization (AREA)
  • Saccharide Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Indole Compounds (AREA)

Abstract

Compounds are disclosed of formula (I) <CHEM> wherein R1 represents C1-6 alkyl; R2 represents H or C1-6 alkyl; R3 represents H or C1-3 alkyl; and pharmaceutically acceptable salts and solvates (for example hydrates) thereof. The compounds are indicated as useful for the treatment of migraine, cluster headache, chronic paroxysmal hemicrania and headache associated with vascular disorders. Processes and intermediates for their preparation and pharmaceutical compositions containing them are also disclosed.
FI893751A 1988-08-10 1989-08-09 CHEMICAL FOERENINGAR. FI893751A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB888819024A GB8819024D0 (en) 1988-08-10 1988-08-10 Chemical compounds

Publications (2)

Publication Number Publication Date
FI893751A0 true FI893751A0 (en) 1989-08-09
FI893751A FI893751A (en) 1990-02-11

Family

ID=10641919

Family Applications (1)

Application Number Title Priority Date Filing Date
FI893751A FI893751A (en) 1988-08-10 1989-08-09 CHEMICAL FOERENINGAR.

Country Status (13)

Country Link
US (1) US5036078A (en)
EP (1) EP0354777B1 (en)
JP (1) JP2941309B2 (en)
KR (1) KR900003151A (en)
AT (1) ATE92485T1 (en)
AU (1) AU3945589A (en)
DE (1) DE68908040T2 (en)
DK (1) DK391289A (en)
FI (1) FI893751A (en)
GB (1) GB8819024D0 (en)
NO (1) NO893205L (en)
PT (1) PT91417B (en)
ZA (1) ZA896067B (en)

Families Citing this family (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2208646B (en) * 1987-08-13 1991-06-26 Glaxo Group Ltd Indole derivatives
DK733788A (en) * 1988-01-14 1989-07-15 Fujisawa Pharmaceutical Co INDOLYL PIPERIDE INGREDIENTS AND PROCEDURES FOR PREPARING THEREOF
SI21560B (en) * 1990-06-07 2005-04-30 Astrazeneca Ab 3,5-disubstituted indole derivatives as "5-ht1-similar" receptor agonist1
DK152090D0 (en) * 1990-06-22 1990-06-22 Lundbaek A S H PIPERIDYL-SUBSTITUTED INDEX DERIVATIVES
WO1992006973A1 (en) * 1990-10-15 1992-04-30 Pfizer Inc. Indole derivatives
US5643784A (en) * 1990-12-04 1997-07-01 H, Lundbeck A/S Indan derivatives
NZ243065A (en) * 1991-06-13 1995-07-26 Lundbeck & Co As H Piperidine derivatives and pharmaceutical compositions
EP0619805B1 (en) * 1991-11-25 2000-03-15 Pfizer Inc. 5-(hetero- or carbocyclylamino)-indole derivatives, their preparation and their use as 5-ht1 agonists
TW288010B (en) * 1992-03-05 1996-10-11 Pfizer
US5747501A (en) 1992-04-07 1998-05-05 Pfizer, Inc. Indole derivatives
US6380233B1 (en) 1992-04-07 2002-04-30 Pfizer Inc Indole derivatives as 5-HT1 agonists
UA34452C2 (en) * 1992-04-10 2001-03-15 Пфайзер Інк. Acylaminoindole derivatives as serotonin 5-ht1 agonists and aminoindole derivatives as intermediates
GB9207930D0 (en) * 1992-04-10 1992-05-27 Pfizer Ltd Indoles
GB9211277D0 (en) 1992-05-28 1992-07-15 Glaxo Group Inc Pharmaceutical compositions
TW251284B (en) * 1992-11-02 1995-07-11 Pfizer
JPH06162097A (en) * 1992-11-16 1994-06-10 Mitsutoyo Corp System for setting retrieval condition of database
GB9320115D0 (en) * 1993-09-29 1993-11-17 Glaxo Group Ltd Process
US5521196A (en) * 1994-10-05 1996-05-28 Eli Lilly And Company 5-HT1F agonists for the treatment of migraine
US5521197A (en) * 1994-12-01 1996-05-28 Eli Lilly And Company 3-<1-alkylenearyl>-4-<1,2,3,6-tetrahydropyridinyl>-and 3-<1-alkylenearyl>-4-piperidinyl-1h-indoles: new 5-HT1F agonists
JPH11502816A (en) * 1995-03-20 1999-03-09 イーライ・リリー・アンド・カンパニー 5-Substituted-3- (1,2,3,6-tetrahydropyridin-4-yl)-and 3- (piperidin-4-yl) -1H-indoles: new 5-HT (1F) agonists
GB9523583D0 (en) * 1995-11-17 1996-01-17 Merck Sharp & Dohme Therapeutic agents
GB9706089D0 (en) * 1997-03-24 1997-05-14 Scherer Ltd R P Pharmaceutical composition
US7189753B1 (en) 1997-11-06 2007-03-13 Cady Roger K Preemptive prophylaxis of migraine
ATE444965T1 (en) 2002-06-21 2009-10-15 Suven Life Sciences Ltd ARYLALKYLINDOLS SUITABLE AS THERAPEUTIC AGENTS HAVING AFFINITY FOR THE SEROTONINE RECEPTOR, METHOD FOR THE PRODUCTION THEREOF AND PHARMACEUTICAL COMPOSITIONS CONTAINING SAME
RU2340619C2 (en) 2002-06-21 2008-12-10 Сувен Лайф Сайенсиз Лимитед Novel tetracyclic arylsulfonyl-indoles with affinity for serotonin receptors, accetable as medications, method of their obtaining and pharmaceutical compositions containing them
CN102249981A (en) 2002-11-28 2011-11-23 苏文生命科学有限公司 N-arylsulfonyl-3-aminoalkoxyindoles
AU2003237599B2 (en) 2002-11-28 2009-06-18 Suven Life Sciences Limited N-arylsulfonyl-3-substituted indoles having serotonin receptor affinity, process for their preparation and pharmaceutical composition containing them
AU2003292510B2 (en) 2002-12-18 2009-04-23 Suven Life Sciences Limited Tetracyclic 3-substituted indoles having serotonin receptor affinity
US20050282879A1 (en) * 2004-06-17 2005-12-22 Foad Salehani Methods and composition for treatment of migraine and symptoms thereof

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2362628A1 (en) * 1976-08-26 1978-03-24 Roussel Uclaf NEW DERIVATIVES OF PIPERIDYL-INDOLE AND THEIR SALTS, METHOD OF PREPARATION AND APPLICATION AS MEDICINAL PRODUCTS
FR2421899A1 (en) * 1978-01-16 1979-11-02 Roussel Uclaf NEW TETRAHYDROPYRIDINYL-INDOLE DERIVATIVES AND THEIR SALTS, THE PREPARATION PROCESS AND THE MEDICINAL APPLICATION OF THESE NEW PRODUCTS
ZW19381A1 (en) * 1980-08-12 1983-03-09 Glaxo Group Ltd Heterocyclic compounds
FR2533924A1 (en) * 1982-10-05 1984-04-06 Roussel Uclaf NOVEL 4- (1H-INDOL-3-YL) A-METHYL PIPERIDINE-1-ETHANOL DERIVATIVES, THEIR SALTS, THE PREPARATION PROCESS, THE MEDICINAL APPLICATION AND THE COMPOSITIONS COMPRISING THE SAME
DE3419935A1 (en) * 1984-05-28 1985-11-28 Merck Patent Gmbh, 6100 Darmstadt USE OF HYDROXYINDOL DERIVATIVES IN LOWERING BLOOD PRESSURE
DE3430284A1 (en) * 1984-08-17 1986-02-27 Troponwerke GmbH & Co KG, 5000 Köln NEW TRYPTAMINE DERIVATIVES, A METHOD FOR THEIR PRODUCTION AND THEIR USE
US4548939A (en) * 1984-10-01 1985-10-22 Janssen Pharmaceutica N. V. 1H-Indol-3-yl containing 1,3-dimethyl-1H-purine-2,6-diones
IE58370B1 (en) * 1985-04-10 1993-09-08 Lundbeck & Co As H Indole derivatives
GB8600398D0 (en) * 1986-01-08 1986-02-12 Glaxo Group Ltd Chemical compounds
GB8600397D0 (en) * 1986-01-08 1986-02-12 Glaxo Group Ltd Chemical compounds
GB2208646B (en) * 1987-08-13 1991-06-26 Glaxo Group Ltd Indole derivatives

Also Published As

Publication number Publication date
PT91417B (en) 1995-05-04
US5036078A (en) 1991-07-30
ATE92485T1 (en) 1993-08-15
NO893205D0 (en) 1989-08-09
PT91417A (en) 1990-03-08
AU3945589A (en) 1990-02-15
DE68908040D1 (en) 1993-09-09
FI893751A (en) 1990-02-11
EP0354777B1 (en) 1993-08-04
KR900003151A (en) 1990-03-23
NO893205L (en) 1990-02-12
ZA896067B (en) 1990-06-27
DK391289D0 (en) 1989-08-09
GB8819024D0 (en) 1988-09-14
DE68908040T2 (en) 1993-11-18
EP0354777A3 (en) 1991-04-10
DK391289A (en) 1990-02-11
JPH0291068A (en) 1990-03-30
JP2941309B2 (en) 1999-08-25
EP0354777A2 (en) 1990-02-14

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Legal Events

Date Code Title Description
FD Application lapsed

Owner name: GLAXO GROUP LIMITED