FI893532A0 - Förfarande för framställning av terapeutiskt användbar GRF-analog, vilken innehåller en ringstruktur - Google Patents

Förfarande för framställning av terapeutiskt användbar GRF-analog, vilken innehåller en ringstruktur

Info

Publication number: FI893532A0
Authority: FI; Finland
Prior art keywords: ala; arg; leu; gln; phe
Prior art date: 1988-07-22

Application number

FI893532A

Other languages

English (en)

Finnish (fi)

Other versions

FI91074B (sv

FI91074C (sv

FI893532A (sv

Inventor

Jean Edouard Frederic Rivier

Catherine Laure Rivier

Jr Wylie Walker Vale

Original Assignee

Salk Inst For Biological Studi

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1988-07-22

Filing date

1989-07-21

Publication date

1989-07-21

1989-07-21 Application filed by Salk Inst For Biological Studi filed Critical Salk Inst For Biological Studi

1989-07-21 Publication of FI893532A0 publication Critical patent/FI893532A0/sv

1990-01-23 Publication of FI893532A publication Critical patent/FI893532A/sv

1994-01-31 Publication of FI91074B publication Critical patent/FI91074B/sv

1994-05-10 Application granted granted Critical

1994-05-10 Publication of FI91074C publication Critical patent/FI91074C/sv

Links

238000004519 manufacturing process Methods 0.000 title 1
-1 Met Chemical compound 0.000 abstract 4
FFEARJCKVFRZRR-SCSAIBSYSA-N D-methionine Chemical compound CSCC[C@@H](N)C(O)=O FFEARJCKVFRZRR-SCSAIBSYSA-N 0.000 abstract 2
OUYCCCASQSFEME-MRVPVSSYSA-N D-tyrosine Chemical compound OC(=O)[C@H](N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-MRVPVSSYSA-N 0.000 abstract 2
COLNVLDHVKWLRT-QMMMGPOBSA-N L-phenylalanine Chemical compound OC(=O)[C@@H](N)CC1=CC=CC=C1 COLNVLDHVKWLRT-QMMMGPOBSA-N 0.000 abstract 2
102000004196 processed proteins & peptides Human genes 0.000 abstract 2
108090000765 processed proteins & peptides Proteins 0.000 abstract 2
XKCWNEVAXQCMGP-RXMQYKEDSA-N (2R)-2-amino-5-[carbamimidoyl(methyl)amino]pentanoic acid Chemical compound CN(CCC[C@@H](N)C(O)=O)C(N)=N XKCWNEVAXQCMGP-RXMQYKEDSA-N 0.000 abstract 1
CKLJMWTZIZZHCS-UHFFFAOYSA-N D-OH-Asp Chemical group OC(=O)C(N)CC(O)=O CKLJMWTZIZZHCS-UHFFFAOYSA-N 0.000 abstract 1
QNAYBMKLOCPYGJ-UWTATZPHSA-N D-alanine Chemical compound C[C@@H](N)C(O)=O QNAYBMKLOCPYGJ-UWTATZPHSA-N 0.000 abstract 1
QNAYBMKLOCPYGJ-UHFFFAOYSA-N D-alpha-Ala Chemical group CC([NH3+])C([O-])=O QNAYBMKLOCPYGJ-UHFFFAOYSA-N 0.000 abstract 1
ODKSFYDXXFIFQN-SCSAIBSYSA-N D-arginine Chemical compound OC(=O)[C@H](N)CCCNC(N)=N ODKSFYDXXFIFQN-SCSAIBSYSA-N 0.000 abstract 1
CKLJMWTZIZZHCS-UWTATZPHSA-N D-aspartic acid Chemical group OC(=O)[C@H](N)CC(O)=O CKLJMWTZIZZHCS-UWTATZPHSA-N 0.000 abstract 1
HNDVDQJCIGZPNO-RXMQYKEDSA-N D-histidine Chemical compound OC(=O)[C@H](N)CC1=CN=CN1 HNDVDQJCIGZPNO-RXMQYKEDSA-N 0.000 abstract 1
KDXKERNSBIXSRK-RXMQYKEDSA-N D-lysine Chemical compound NCCCC[C@@H](N)C(O)=O KDXKERNSBIXSRK-RXMQYKEDSA-N 0.000 abstract 1
COLNVLDHVKWLRT-MRVPVSSYSA-N D-phenylalanine Chemical compound OC(=O)[C@H](N)CC1=CC=CC=C1 COLNVLDHVKWLRT-MRVPVSSYSA-N 0.000 abstract 1
SGCGMORCWLEJNZ-UWVGGRQHSA-N His-His Chemical compound C([C@H]([NH3+])C(=O)N[C@@H](CC=1NC=NC=1)C([O-])=O)C1=CN=CN1 SGCGMORCWLEJNZ-UWVGGRQHSA-N 0.000 abstract 1
DEFJQIDDEAULHB-IMJSIDKUSA-N L-alanyl-L-alanine Chemical group C[C@H](N)C(=O)N[C@@H](C)C(O)=O DEFJQIDDEAULHB-IMJSIDKUSA-N 0.000 abstract 1
ODKSFYDXXFIFQN-BYPYZUCNSA-N L-arginine Chemical compound OC(=O)[C@@H](N)CCCN=C(N)N ODKSFYDXXFIFQN-BYPYZUCNSA-N 0.000 abstract 1
KDXKERNSBIXSRK-YFKPBYRVSA-N L-lysine Chemical compound NCCCC[C@H](N)C(O)=O KDXKERNSBIXSRK-YFKPBYRVSA-N 0.000 abstract 1
241001465754 Metazoa Species 0.000 abstract 1
150000001413 amino acids Chemical class 0.000 abstract 1
UCMIRNVEIXFBKS-UHFFFAOYSA-N beta-alanine Chemical group NCCC(O)=O UCMIRNVEIXFBKS-UHFFFAOYSA-N 0.000 abstract 1
210000004899 c-terminal region Anatomy 0.000 abstract 1
230000007515 enzymatic degradation Effects 0.000 abstract 1
125000000267 glycino group Chemical group [H]N([*])C([H])([H])C(=O)O[H] 0.000 abstract 1
231100000252 nontoxic Toxicity 0.000 abstract 1
230000003000 nontoxic effect Effects 0.000 abstract 1
230000001817 pituitary effect Effects 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/60—Growth hormone-releasing factor [GH-RF], i.e. somatoliberin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Endocrinology (AREA)
Medicinal Chemistry (AREA)
General Health & Medical Sciences (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Molecular Biology (AREA)
Genetics & Genomics (AREA)
Biophysics (AREA)
Biochemistry (AREA)
Gastroenterology & Hepatology (AREA)
Toxicology (AREA)
Zoology (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Public Health (AREA)
General Chemical & Material Sciences (AREA)
Animal Behavior & Ethology (AREA)
Diabetes (AREA)
Pharmacology & Pharmacy (AREA)
Chemical Kinetics & Catalysis (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Veterinary Medicine (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Peptides Or Proteins (AREA)
Amplifiers (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Diaphragms For Electromechanical Transducers (AREA)
Luminescent Compositions (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Control Of El Displays (AREA)

FI893532A 1988-07-22 1989-07-21 Förfarande för framställning av terapeutiskt användbar GRF-analog, vilken innehåller en ringstruktur FI91074C (sv)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US22327788		1988-07-22
US07/223,277 US5043322A (en)	1988-07-22	1988-07-22	Cyclic GRF analogs

Publications (4)

Publication Number	Publication Date
FI893532A0 true FI893532A0 (sv)	1989-07-21
FI893532A FI893532A (sv)	1990-01-23
FI91074B FI91074B (sv)	1994-01-31
FI91074C FI91074C (sv)	1994-05-10

Family

ID=22835815

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
FI893532A FI91074C (sv)	1988-07-22	1989-07-21	Förfarande för framställning av terapeutiskt användbar GRF-analog, vilken innehåller en ringstruktur

Country Status (13)

Country	Link
US (1)	US5043322A (sv)
EP (1)	EP0352014B1 (sv)
JP (1)	JP2739910B2 (sv)
KR (1)	KR0138907B1 (sv)
AT (1)	ATE103609T1 (sv)
DE (1)	DE68914205T2 (sv)
DK (1)	DK355889A (sv)
ES (1)	ES2055792T3 (sv)
FI (1)	FI91074C (sv)
IE (1)	IE892378L (sv)
IL (1)	IL90766A0 (sv)
NO (1)	NO892970L (sv)
ZA (1)	ZA895050B (sv)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CA2084061A1 (en) *	1991-04-09	1992-10-10	Arthur M. Felix	Growth hormone releasing factor analogs
US5262519A (en) *	1991-05-15	1993-11-16	The Salk Institute For Biological Studies	GRF analogs XI
US5371070A (en) *	1992-11-09	1994-12-06	The Salk Institute For Biological Studies	Bicyclic GnRH antagonists and a method for regulating the secretion of gonadotropins
US6008058A (en) *	1993-06-18	1999-12-28	University Of Louisville	Cyclic peptide mixtures via side chain or backbone attachment and solid phase synthesis
US5639598A (en) *	1994-05-19	1997-06-17	The Trustees Of The University Of Pennsylvania	Method and kit for identification of antiviral agents capable of abrogating HIV Vpr-Rip-1 binding interactions
US5780220A (en) *	1994-05-19	1998-07-14	Trustees Of The University Of Pennsylvania	Methods and compositions for inhibiting HIV replication
US5942489A (en) *	1996-05-03	1999-08-24	The Administrators Of The Tulane Educational Fund	HGH-RH(1-29)NH2 analogues having antagonistic activity
EP1194548A4 (en) *	1999-06-23	2003-06-18	Wistar Inst	NOVEL PYRRHOCORICIN-DERIVED PEPTIDES AND METHODS OF IMPLEMENTING THE SAME
US7015309B1 (en)	1999-06-23	2006-03-21	The Wistar Institute Of Anatomy And Biology	Pyrrhocoricin-derived peptides, and methods of use thereof
JP5649825B2 (ja)	2007-01-31	2015-01-07	デイナファーバーキャンサーインスティチュート，インコーポレイテッド	安定化させたｐ５３ペプチドおよびその使用法
KR20160061439A (ko)	2007-03-28	2016-05-31	프레지던트 앤드 펠로우즈 오브 하바드 칼리지	스티칭된 폴리펩티드
KR102104762B1 (ko)	2010-08-13	2020-04-24	에일러론 테라퓨틱스 인코포레이티드	펩티도미메틱 거대고리
AU2011348220B2 (en)	2010-12-22	2017-09-07	The Salk Institute For Biological Studies	Cyclic CRF antagonist peptides
KR20140100937A (ko) *	2011-10-18	2014-08-18	에일러론 테라퓨틱스 인코포레이티드	펩티도미메틱 거대고리
CN107216380A (zh)	2012-02-15	2017-09-29	爱勒让治疗公司	拟肽大环化合物
CN104144695A (zh)	2012-02-15	2014-11-12	爱勒让治疗公司	***交联的和硫醚交联的拟肽大环化合物
KR20150082307A (ko)	2012-11-01	2015-07-15	에일러론 테라퓨틱스 인코포레이티드	이치환 아미노산 및 이의 제조 및 사용 방법
BR112017005598A2 (pt)	2014-09-24	2017-12-12	Aileron Therapeutics Inc	macrociclos peptidomiméticos e usos dos mesmos
EP3294318A4 (en)	2015-03-20	2019-04-03	Aileron Therapeutics, Inc.	PEPTIDOMIMETIC MACROCYCLES AND USES THEREOF

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4595676A (en) *	1983-04-26	1986-06-17	The Salk Institute For Biological Studies	Rat hypothalamic GRF
US4563352A (en) *	1982-10-04	1986-01-07	The Salk Institute For Biological Studies	Human pancreatic GRF
US4518586A (en) *	1983-01-13	1985-05-21	The Salk Institute For Biological Studies	GRF Analogs III
US4626523A (en) *	1983-09-13	1986-12-02	The Salk Institute For Biological Studies	GRF analogs II
US4528190A (en) *	1983-10-25	1985-07-09	The Salk Institute For Biological Studies	GRF Analogs IV
US4661472A (en) *	1985-05-09	1987-04-28	The Salk Institute For Biological Studies	GnRH antagonists IX
US4734399A (en) *	1985-08-06	1988-03-29	Hoffmann-La Roche Inc.	Growth hormone releasing factor analogs
US4689318A (en) *	1985-08-29	1987-08-25	The Salk Institute For Biological Studies	GRF analogs
IL84758A (en) *	1987-01-13	1992-03-29	Salk Inst For Biological Studi	Peptides stimulating the release of pituitary growth hormone in fish and amphibians,and pharmaceutical compositions containing them
US4784987A (en) *	1987-01-13	1988-11-15	The Salk Institute For Biological Studies	GRF analogs VI
ES2054754T3 (es) *	1987-09-18	1994-08-16	Hoffmann La Roche	Analogos ciclicos del grf.

1988
- 1988-07-22 US US07/223,277 patent/US5043322A/en not_active Expired - Lifetime
1989
- 1989-06-27 IL IL90766A patent/IL90766A0/xx not_active IP Right Cessation
- 1989-07-03 ZA ZA895050A patent/ZA895050B/xx unknown
- 1989-07-13 DE DE68914205T patent/DE68914205T2/de not_active Expired - Fee Related
- 1989-07-13 AT AT89307089T patent/ATE103609T1/de not_active IP Right Cessation
- 1989-07-13 EP EP89307089A patent/EP0352014B1/en not_active Expired - Lifetime
- 1989-07-13 ES ES89307089T patent/ES2055792T3/es not_active Expired - Lifetime
- 1989-07-18 DK DK355889A patent/DK355889A/da not_active Application Discontinuation
- 1989-07-20 NO NO89892970A patent/NO892970L/no unknown
- 1989-07-21 KR KR1019890010373A patent/KR0138907B1/ko not_active IP Right Cessation
- 1989-07-21 FI FI893532A patent/FI91074C/sv not_active IP Right Cessation
- 1989-07-21 IE IE892378A patent/IE892378L/xx unknown
- 1989-07-24 JP JP1191231A patent/JP2739910B2/ja not_active Expired - Fee Related

Also Published As

Publication number	Publication date
DK355889D0 (da)	1989-07-18
FI91074B (sv)	1994-01-31
EP0352014B1 (en)	1994-03-30
NO892970D0 (no)	1989-07-20
NO892970L (no)	1990-01-23
KR0138907B1 (ko)	1998-04-30
FI91074C (sv)	1994-05-10
ATE103609T1 (de)	1994-04-15
JP2739910B2 (ja)	1998-04-15
KR910002900A (ko)	1991-02-26
EP0352014A2 (en)	1990-01-24
ES2055792T3 (es)	1994-09-01
EP0352014A3 (en)	1991-07-03
ZA895050B (en)	1990-04-25
IL90766A0 (en)	1990-01-18
US5043322A (en)	1991-08-27
FI893532A (sv)	1990-01-23
DK355889A (da)	1990-01-23
DE68914205D1 (de)	1994-05-05
IE892378L (en)	1990-01-22
JPH0269499A (ja)	1990-03-08
DE68914205T2 (de)	1994-07-07

Legal Events

Date	Code	Title	Description
1994-01-03	BB	Publication of examined application
1996-02-14	MM	Patent lapsed
2004-08-31	MM	Patent lapsed	Owner name: THE SALK INSTITUTE FOR BIOLOGICAL

Publication	Publication Date	Title
EG17394A (en)	1992-12-30	G r f analogs iv
ES8600217A1 (es)	1985-10-01	Un procedimiento para producir peptidos que influyen en la funcion de la glandula pituitaria
FI893532A0 (sv)	1989-07-21	Förfarande för framställning av terapeutiskt användbar GRF-analog, vilken innehåller en ringstruktur
FI906240A0 (sv)	1990-12-18	Förfarande för framställning av en farmaceutiskt användbar, syntetisk peptidanalog av en tillväxthormonfrigörande faktor eller ett icke giftigt salt därav