FI890867A - Tetrahydroisokinolinderivat. - Google Patents

Tetrahydroisokinolinderivat. Download PDF

Info

Publication number
FI890867A
FI890867A FI890867A FI890867A FI890867A FI 890867 A FI890867 A FI 890867A FI 890867 A FI890867 A FI 890867A FI 890867 A FI890867 A FI 890867A FI 890867 A FI890867 A FI 890867A
Authority
FI
Finland
Prior art keywords
tetrahydroisokinolinderivat
Prior art date
Application number
FI890867A
Other languages
English (en)
Other versions
FI890867A0 (fi
Inventor
Alan Naylor
Duncan Bruce Judd
John Bradshaw
David Edward Bays
Ann Gail Hayes
Original Assignee
Glaxo Group Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB888804107A external-priority patent/GB8804107D0/en
Priority claimed from GB888816550A external-priority patent/GB8816550D0/en
Application filed by Glaxo Group Ltd filed Critical Glaxo Group Ltd
Publication of FI890867A0 publication Critical patent/FI890867A0/fi
Publication of FI890867A publication Critical patent/FI890867A/fi

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D217/00Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/02Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines
    • C07D217/04Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines with hydrocarbon or substituted hydrocarbon radicals attached to the ring nitrogen atom
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/04Centrally acting analgesics, e.g. opioids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00Drugs for disorders of the blood or the extracellular fluid
    • A61P7/10Antioedematous agents; Diuretics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/10Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D217/00Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/12Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring
    • C07D217/14Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring other than aralkyl radicals
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D409/00Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/06Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pain & Pain Management (AREA)
  • Vascular Medicine (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
FI890867A 1988-02-23 1989-02-23 Tetrahydroisokinolinderivat. FI890867A (fi)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB888804107A GB8804107D0 (en) 1988-02-23 1988-02-23 Chemical compounds
GB888816550A GB8816550D0 (en) 1988-07-12 1988-07-12 Chemical compounds

Publications (2)

Publication Number Publication Date
FI890867A0 FI890867A0 (fi) 1989-02-23
FI890867A true FI890867A (fi) 1989-08-24

Family

ID=26293523

Family Applications (1)

Application Number Title Priority Date Filing Date
FI890867A FI890867A (fi) 1988-02-23 1989-02-23 Tetrahydroisokinolinderivat.

Country Status (7)

Country Link
EP (1) EP0330469A3 (fi)
JP (1) JPH01301662A (fi)
KR (1) KR890012970A (fi)
AU (1) AU3029389A (fi)
DK (1) DK84789A (fi)
FI (1) FI890867A (fi)
PT (1) PT89780A (fi)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE632371A (fi) * 1962-05-15 1963-09-02
ATE97893T1 (de) * 1988-02-19 1993-12-15 Smithkline Beecham Farma 1,2,3,4-tetrahydroisoquinoline, verfharen zu ihrer herstellung und ihre verwendung als kappa- rezeptor agonisten.
GB8827479D0 (en) * 1988-11-24 1988-12-29 Zambeletti Spa L Novel compounds
FI895821A0 (fi) * 1988-12-07 1989-12-05 Wellcome Found Farmaceutiskt aktiva cns foereningar.
DE3935371A1 (de) * 1988-12-23 1990-07-05 Merck Patent Gmbh Stickstoffhaltige ringverbindungen
GB8830219D0 (en) * 1988-12-23 1989-02-22 Zambeletti Spa L Novel compounds
GB8916395D0 (en) * 1989-07-18 1989-09-06 Zambeletti Spa L Pharmaceuticals
GB8926560D0 (en) * 1989-11-24 1990-01-17 Zambeletti Spa L Pharmaceuticals
DE69029861T2 (de) * 1989-11-24 1997-07-10 Smithkline Beecham Spa N-acyl-substituierte azazyklische verbindungen, verfahren zu deren herstellung und deren verwendung als arzneimittel
WO1991017116A1 (en) * 1990-04-28 1991-11-14 Dr. Lo. Zambeletti S.P.A. Novel 1-(2h-1-oxo-3,4-dihydronaphtyl-6)-acetyl-piperidines, process for their preparation and therapeutic use
WO1992017467A1 (en) * 1991-04-06 1992-10-15 Dr Lo. Zambeletti S.P.A. Substituted azacyclic compounds, process for their preparation and their use as analgesics
WO1992020657A1 (en) * 1991-05-21 1992-11-26 Smithkline Beecham Farmaceutici S.P.A. 2-(pyrrolidinyl-1-methyl)-piperidine derivatives and their use as kappa-recept or agonists
IT1273751B (it) * 1994-02-11 1997-07-10 Smithkline Beecham Farma Derivati azaciclici
US5763445A (en) 1996-03-08 1998-06-09 Adolor Corporation Kappa agonist compounds pharmaceutical formulations and method of prevention and treatment of pruritus therewith
US6239154B1 (en) 1996-03-08 2001-05-29 Adolor Corporation Kappa agonist compounds pharmaceutical formulations and method of prevention and treatment of pruritus therewith
US5760023A (en) * 1997-07-14 1998-06-02 Adolor Corporation Kappa agonist anti-pruritic pharmaceutical formulations and method of treating pruritus therewith
WO1999003459A1 (en) * 1997-07-14 1999-01-28 Adolor Corporation Kappa agonist anti-pruritic pharmaceutical formulations and method of treating pruritus therewith
ES2252230T3 (es) 2000-05-11 2006-05-16 Bristol-Myers Squibb Company Analogos de tetrahidroisoquinolina utiles como secretores de la hormona del crecimiento.
US6649606B1 (en) 2001-11-09 2003-11-18 Bristol-Myers Squibb Co. Tetrahydroisoquinoline analogs as modulators of chemokine receptor activity
CN100503571C (zh) * 2006-07-12 2009-06-24 中国药科大学 四氢异喹啉类衍生物、其制备方法及其医药用途
WO2010058429A1 (en) 2008-11-24 2010-05-27 Council Of Scientific & Industrial Research A process for the preparation of optically active n-benzyl-3 hydroxypyrrolidines
CN103435545B (zh) * 2013-08-14 2015-10-07 中国药科大学 四氢异喹啉季铵盐类衍生物、其制备方法及其镇痛用途
CN103554021A (zh) * 2013-11-25 2014-02-05 中国药科大学 一类茚酮四氢异喹啉衍生物、其制备方法及医药用途

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2361390A1 (de) * 1973-12-10 1975-06-19 Merck Patent Gmbh Isochinolinderivate und verfahren zu ihrer herstellung
GB8531615D0 (en) * 1985-12-23 1986-02-05 Zambeletti Spa L Compounds
GB8601796D0 (en) * 1986-01-24 1986-02-26 Zambeletti Spa L Compounds
ATE97893T1 (de) * 1988-02-19 1993-12-15 Smithkline Beecham Farma 1,2,3,4-tetrahydroisoquinoline, verfharen zu ihrer herstellung und ihre verwendung als kappa- rezeptor agonisten.

Also Published As

Publication number Publication date
PT89780A (pt) 1989-10-04
EP0330469A3 (en) 1990-05-09
EP0330469A2 (en) 1989-08-30
AU3029389A (en) 1989-08-24
JPH01301662A (ja) 1989-12-05
KR890012970A (ko) 1989-09-20
DK84789D0 (da) 1989-02-23
FI890867A0 (fi) 1989-02-23
DK84789A (da) 1989-08-24

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Legal Events

Date Code Title Description
FD Application lapsed

Owner name: GLAXO GROUP LIMITED