FI882176A - Menetelmä terapeuttisesti aktiivisten heterosyklisten peptidien valmistamiseksi ja niiden valmistuksessa käyttökelpoisia välituotteita - Google Patents

Menetelmä terapeuttisesti aktiivisten heterosyklisten peptidien valmistamiseksi ja niiden valmistuksessa käyttökelpoisia välituotteita Download PDF

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Publication number
FI882176A
FI882176A FI882176A FI882176A FI882176A FI 882176 A FI882176 A FI 882176A FI 882176 A FI882176 A FI 882176A FI 882176 A FI882176 A FI 882176A FI 882176 A FI882176 A FI 882176A
Authority
FI
Finland
Prior art keywords
preparation
formula
peptides
therapeutically active
intermediates useful
Prior art date
Application number
FI882176A
Other languages
English (en)
Swedish (sv)
Other versions
FI91072C (fi
FI91072B (fi
FI882176A0 (fi
Inventor
Philip Duke Edwards
Joseph James Lewis
Charles William Perkins
Diane Amy Trainor
Richard Alan Wildonger
Original Assignee
Ici America Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB878711050A external-priority patent/GB8711050D0/en
Priority claimed from GB888803206A external-priority patent/GB8803206D0/en
Application filed by Ici America Inc filed Critical Ici America Inc
Publication of FI882176A0 publication Critical patent/FI882176A0/fi
Publication of FI882176A publication Critical patent/FI882176A/fi
Application granted granted Critical
Publication of FI91072B publication Critical patent/FI91072B/fi
Publication of FI91072C publication Critical patent/FI91072C/fi

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
    • C07K5/06034—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 2 to 4 carbon atoms
    • C07K5/06052—Val-amino acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06191—Dipeptides containing heteroatoms different from O, S, or N

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pulmonology (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Pyridine Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
FI882176A 1987-05-11 1988-05-10 Menetelmä terapeuttisesti aktiivisten heterosyklisten peptidien valmistamiseksi ja niiden valmistuksessa käyttökelpoisia välituotteita FI91072C (fi)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
GB8711050 1987-05-11
GB878711050A GB8711050D0 (en) 1987-05-11 1987-05-11 Selected heterocyclic ketones
GB888803206A GB8803206D0 (en) 1988-02-11 1988-02-11 Selected heterocyclic ketones
GB8803206 1988-02-11

Publications (4)

Publication Number Publication Date
FI882176A0 FI882176A0 (fi) 1988-05-10
FI882176A true FI882176A (fi) 1988-11-12
FI91072B FI91072B (fi) 1994-01-31
FI91072C FI91072C (fi) 1994-05-10

Family

ID=26292230

Family Applications (1)

Application Number Title Priority Date Filing Date
FI882176A FI91072C (fi) 1987-05-11 1988-05-10 Menetelmä terapeuttisesti aktiivisten heterosyklisten peptidien valmistamiseksi ja niiden valmistuksessa käyttökelpoisia välituotteita

Country Status (22)

Country Link
US (1) US5164371A (fi)
EP (1) EP0291234B1 (fi)
JP (1) JPS6445395A (fi)
KR (1) KR880013926A (fi)
CN (1) CN1037519A (fi)
AT (1) ATE103293T1 (fi)
AU (1) AU605284B2 (fi)
CA (1) CA1326107C (fi)
DE (1) DE3888568T2 (fi)
DK (1) DK260588A (fi)
ES (1) ES2063034T3 (fi)
FI (1) FI91072C (fi)
GB (1) GB8809316D0 (fi)
HU (1) HU201963B (fi)
IE (1) IE62524B1 (fi)
IL (1) IL86236A (fi)
NO (1) NO176519C (fi)
NZ (1) NZ224452A (fi)
PT (1) PT87454B (fi)
SU (1) SU1678207A3 (fi)
ZA (1) ZA883006B (fi)
ZW (1) ZW4988A1 (fi)

Families Citing this family (53)

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GB8910550D0 (en) * 1989-05-08 1989-06-21 Ici America Inc Substituted amides
GB8910547D0 (en) * 1989-05-08 1989-06-21 Ici America Inc Substituted ketones
ES2129401T3 (es) * 1990-05-24 1999-06-16 Zeneca Ltd Uso de un compuesto terapeutico para el tratamiento de bronquitis.
US5162348A (en) * 1990-05-24 1992-11-10 Imperial Chemical Industries Plc Treatment of cystic fibrosis
IE911697A1 (en) * 1990-05-24 1991-12-04 Zeneca Ltd Therapeutic agent
CA2049100A1 (en) * 1990-09-10 1992-03-11 Hirohiko Yamada Benzoic acid phenylester compounds and elastase inhibiting compositions containing the same
US5618792A (en) * 1994-11-21 1997-04-08 Cortech, Inc. Substituted heterocyclic compounds useful as inhibitors of (serine proteases) human neutrophil elastase
US20020119985A1 (en) * 1994-11-21 2002-08-29 Albert Gyorkos Serine protease inhibitors
US6015791A (en) * 1994-11-21 2000-01-18 Cortech Inc. Serine protease inhibitors-cycloheptane derivatives
US6001811A (en) * 1994-11-21 1999-12-14 Cortech Inc. Serine protease inhibitors--N-substituted derivatives
US5998379A (en) * 1994-11-21 1999-12-07 Cortech Inc. Serine protease inhibitors-proline analogs
US6001814A (en) * 1994-11-21 1999-12-14 Cortech Inc. Serine protease inhibitors
US6159938A (en) * 1994-11-21 2000-12-12 Cortech, Inc. Serine protease inhibitors comprising α-keto heterocycles
US6150334A (en) * 1994-11-21 2000-11-21 Cortech, Inc. Serine protease inhibitors-tripeptoid analogs
US6001813A (en) * 1994-11-21 1999-12-14 Cortech Inc. Val-pro containing α-keto oxadiazoles as serine protease inhibitors
US6100238A (en) * 1994-11-21 2000-08-08 Cortech Inc. Indole and tetrahydroisoquinoline containing Alpha-keto oxadiazoles as serine protease inhibitors
US5556990A (en) * 1994-12-16 1996-09-17 Rhone-Poulenc Rorer Pharmaceuticals Inc. Polyarylcarbamoylaza- and -carbamoylalkanedioic acids
US5804560A (en) * 1995-01-06 1998-09-08 Sibia Neurosciences, Inc. Peptide and peptide analog protease inhibitors
US5872101A (en) * 1995-01-06 1999-02-16 Sibia Neurosciences, Inc. Methods of treating neurodegenerative disorders using protease inhibitors
US6194435B1 (en) 1996-10-11 2001-02-27 Cor Therapeutics, Inc. Lactams as selective factor Xa inhibitors
US6262047B1 (en) 1996-10-11 2001-07-17 Cor Therapeutics, Inc. Selective factor Xa inhibitors
US6369080B2 (en) 1996-10-11 2002-04-09 Cor Therapeutics, Inc. Selective factor Xa inhibitors
US6063794A (en) 1996-10-11 2000-05-16 Cor Therapeutics Inc. Selective factor Xa inhibitors
JP2001523226A (ja) 1997-04-14 2001-11-20 シーオーアール セラピューティクス インコーポレイテッド 選択的Ｘａ因子阻害剤
AU6896398A (en) 1997-04-14 1998-11-11 Cor Therapeutics, Inc. Selective factor xa inhibitors
WO1998046628A1 (en) * 1997-04-14 1998-10-22 Cor Therapeutics, Inc. SELECTIVE FACTOR Xa INHIBITORS
US6274602B1 (en) * 1998-06-03 2001-08-14 Gpi Nil Holdings, Inc. Heterocyclic thioester and ketone hair growth compositions and uses
US6228854B1 (en) 1997-08-11 2001-05-08 Cor Therapeutics, Inc. Selective factor Xa inhibitors
US6333321B1 (en) 1997-08-11 2001-12-25 Cor Therapeutics, Inc. Selective factor Xa inhibitors
US6218382B1 (en) 1997-08-11 2001-04-17 Cor Therapeutics, Inc Selective factor Xa inhibitors
US6177572B1 (en) 1997-08-20 2001-01-23 Sepracor, Inc. Solid and liquid-phase synthesis of benzoxazoles and benzothiazoles and their use
US6656910B2 (en) 1997-12-04 2003-12-02 Cortech, Inc. Serine protease inhibitors
US6184377B1 (en) 1997-12-15 2001-02-06 Sepracor Inc. Compositions containing N-amino- and N-hydroxy-quinazolinones and methods for preparing libraries thereof
EP1135151A4 (en) 1998-06-03 2002-01-02 Cortech Inc ALPHA-KETO OXADIAZOLE CONTAINING PEPTOIDS AND NON-PEPTOIDS AS SERINE PROTEASE INHIBITORS
JP2000256396A (ja) 1999-03-03 2000-09-19 Dainippon Pharmaceut Co Ltd 複素環式化合物およびその中間体ならびにエラスターゼ阻害剤
TW200404789A (en) 1999-03-15 2004-04-01 Axys Pharm Inc Novel compounds and compositions as protease inhibitors
WO2000056724A1 (en) * 1999-03-22 2000-09-28 The Board Of Governors For Higher Education, State Of Rhode Island And Providence Plantations Oxazole and thiazole combinatorial libraries
CA2375229A1 (en) * 1999-06-17 2000-12-28 Source Precision Medicine, Inc. Method and compounds for inhibiting activity of serine elastases
CA2433520A1 (en) 2000-12-22 2002-07-04 Axys Pharmaceuticals, Inc. Novel compounds and compositions as cathepsin inhibitors
US7030116B2 (en) 2000-12-22 2006-04-18 Aventis Pharmaceuticals Inc. Compounds and compositions as cathepsin inhibitors
IL160819A0 (en) 2001-09-14 2004-08-31 Aventis Pharma Inc Novel compounds and compositions as cathepsin inhibitors
BR0214104A (pt) 2001-11-14 2004-09-28 Aventis Pharma Inc Oligopeptìdeos e composições contendo os mesmos como inibidores de catepsina
AU2003231016A1 (en) * 2002-04-16 2003-10-27 Aventis Pharmaceuticals, Inc., Process for preparing heteroaryl and unsaturated heterocycloalkylmagnesium reagents and uses
JP3744890B2 (ja) 2002-11-01 2006-02-15 ハッピー工業株式会社 ミシン
DE102004045648A1 (de) * 2004-09-21 2006-03-23 Boehringer Ingelheim Pharma Gmbh & Co. Kg Neue Betamimetika zur Behandlung von Atemwegserkrankungen
MX2008014839A (es) * 2006-05-23 2008-12-05 Irm Llc Compuestos y composiciones en la forma de inhibidores de proteasa de activacion mediante canal.
JP2010510224A (ja) * 2006-11-17 2010-04-02 アボット・ラボラトリーズ ケモカイン受容体拮抗薬としてのアミノピロリジン類
KR20090108131A (ko) 2007-02-09 2009-10-14 아이알엠 엘엘씨 채널 활성화 프로테아제 억제제로서의 화합물 및 조성물
FR2914920B1 (fr) 2007-04-11 2011-09-09 Clariant Specialty Fine Chem F Procede de deacetalisation d'alpha-aminoacetals.
FR2916441B1 (fr) 2007-05-22 2009-08-28 Clariant Specialty Fine Chem Procede de racemisation d'alpha-aminoacetals optiquement actifs.
WO2009007415A2 (en) * 2007-07-10 2009-01-15 Probiodrug Ag Novel compounds
US20090156509A1 (en) * 2007-12-12 2009-06-18 Accuthera, Inc. Tri-peptide Inhibitors of Serine Elastases
FR2927900B1 (fr) 2008-02-27 2010-09-17 Clariant Specialty Fine Chem Procede de preparation d'alpha-aminoacetals optiquement actifs.

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3481913D1 (de) * 1983-04-27 1990-05-17 Ici America Inc Prolin-derivate.
US4643991A (en) * 1984-12-18 1987-02-17 The University Of Kentucky Research Foundation Peptide elastase inhibitors and methods
GB8600263D0 (en) * 1985-01-22 1986-02-12 Ici America Inc Peptide derivatives
EP0204571B1 (en) * 1985-06-07 1992-01-22 Ici Americas Inc. Selected difluoro derivatives
EP0403605A4 (en) * 1988-09-09 1991-08-21 Univ Kentucky Res Found Elastase inhibiting polymers and methods
GB8910547D0 (en) * 1989-05-08 1989-06-21 Ici America Inc Substituted ketones

Also Published As

Publication number Publication date
DK260588A (da) 1988-11-12
NO882036L (no) 1988-11-14
HU201963B (en) 1991-01-28
HUT46708A (en) 1988-11-28
NO176519B (no) 1995-01-09
PT87454B (pt) 1992-08-31
US5164371A (en) 1992-11-17
KR880013926A (ko) 1988-12-22
PT87454A (pt) 1989-05-31
NO176519C (no) 1995-04-19
CN1037519A (zh) 1989-11-29
DE3888568D1 (de) 1994-04-28
FI91072C (fi) 1994-05-10
NO882036D0 (no) 1988-05-10
ZA883006B (fi) 1988-11-11
AU1539088A (en) 1988-11-17
EP0291234A2 (en) 1988-11-17
ATE103293T1 (de) 1994-04-15
IE62524B1 (en) 1995-02-08
IL86236A (en) 1994-12-29
FI91072B (fi) 1994-01-31
CA1326107C (en) 1994-01-11
IL86236A0 (en) 1988-11-15
IE881416L (en) 1988-11-11
DK260588D0 (da) 1988-05-11
EP0291234B1 (en) 1994-03-23
EP0291234A3 (en) 1990-08-22
GB8809316D0 (en) 1988-05-25
JPS6445395A (en) 1989-02-17
NZ224452A (en) 1991-06-25
ES2063034T3 (es) 1995-01-01
ZW4988A1 (en) 1989-12-06
FI882176A0 (fi) 1988-05-10
SU1678207A3 (ru) 1991-09-15
DE3888568T2 (de) 1994-07-21
AU605284B2 (en) 1991-01-10

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Legal Events

Date Code Title Description
FG Patent granted

Owner name: ICI AMERICAS INC.

BB Publication of examined application
MM Patent lapsed
MM Patent lapsed

Owner name: ICI AMERICAS INC