FI834421A - Foerfarande foer framstaellning av 4- aminoalkyl-2(3h)-indoloner. - Google Patents

Foerfarande foer framstaellning av 4- aminoalkyl-2(3h)-indoloner. Download PDF

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Publication number
FI834421A
FI834421A FI834421A FI834421A FI834421A FI 834421 A FI834421 A FI 834421A FI 834421 A FI834421 A FI 834421A FI 834421 A FI834421 A FI 834421A FI 834421 A FI834421 A FI 834421A
Authority
FI
Finland
Prior art keywords
indoloner
framstration
aminoalkyl
frequency
frequency framstration
Prior art date
Application number
FI834421A
Other languages
English (en)
Other versions
FI834421A0 (fi
FI77849C (fi
FI77849B (fi
Inventor
Jr Gregory Gallagher
Original Assignee
Smithkline Beckman Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=23776840&utm_source=***_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=FI834421(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Smithkline Beckman Corp filed Critical Smithkline Beckman Corp
Publication of FI834421A0 publication Critical patent/FI834421A0/fi
Publication of FI834421A publication Critical patent/FI834421A/fi
Application granted granted Critical
Publication of FI77849B publication Critical patent/FI77849B/fi
Publication of FI77849C publication Critical patent/FI77849C/fi

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/32—Oxygen atoms
    • C07D209/34—Oxygen atoms in position 2
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/582—Recycling of unreacted starting or intermediate materials

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Indole Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
FI834421A 1982-12-07 1983-12-02 Foerfarande foer framstaellning av farmakologiskt aktiva 4-aminoalkyl-2(3h)-indoloner. FI77849C (fi)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US06/447,564 US4452808A (en) 1982-12-07 1982-12-07 4-Aminoalkyl-2(3H)-indolones
US44756482 1982-12-07

Publications (4)

Publication Number Publication Date
FI834421A0 FI834421A0 (fi) 1983-12-02
FI834421A true FI834421A (fi) 1984-06-08
FI77849B FI77849B (fi) 1989-01-31
FI77849C FI77849C (fi) 1989-05-10

Family

ID=23776840

Family Applications (1)

Application Number Title Priority Date Filing Date
FI834421A FI77849C (fi) 1982-12-07 1983-12-02 Foerfarande foer framstaellning av farmakologiskt aktiva 4-aminoalkyl-2(3h)-indoloner.

Country Status (27)

Country Link
US (1) US4452808A (fi)
EP (1) EP0113964B1 (fi)
JP (1) JPS59112964A (fi)
KR (1) KR910001042B1 (fi)
AU (1) AU560170B2 (fi)
BR (1) BR1100036A (fi)
CA (1) CA1208650A (fi)
CY (1) CY1497A (fi)
CZ (1) CZ398191A3 (fi)
DE (1) DE3367090D1 (fi)
DK (1) DK156514C (fi)
DZ (1) DZ587A1 (fi)
EG (1) EG16556A (fi)
ES (2) ES8600239A1 (fi)
FI (1) FI77849C (fi)
GR (1) GR79121B (fi)
HK (1) HK82089A (fi)
IE (1) IE56347B1 (fi)
IL (1) IL70311A (fi)
LU (1) LU90097I2 (fi)
NL (1) NL970005I2 (fi)
NO (2) NO160135C (fi)
NZ (1) NZ206344A (fi)
PH (1) PH22067A (fi)
PT (1) PT77739B (fi)
ZA (1) ZA839094B (fi)
ZW (1) ZW25883A1 (fi)

Families Citing this family (62)

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US4588740A (en) * 1982-12-07 1986-05-13 Smithkline Beckman Corporation Pharmaceutical methods using 4-aminoalkyl-2(3H)-indolones
US4657929A (en) * 1983-10-25 1987-04-14 Fisons Plc Compounds
US4554284A (en) * 1984-09-12 1985-11-19 Smithkline Beckman Corporation 7-(2-Aminoethyl)-1,3-benzthia- or oxa-zol-2(3H)-ones
GB8621040D0 (en) * 1986-08-30 1986-10-08 Smith Kline French Lab Process
GB8712073D0 (en) * 1987-05-21 1987-06-24 Smith Kline French Lab Medicament
GB8714371D0 (en) * 1987-06-19 1987-07-22 Smith Kline French Lab Process
GB9008605D0 (en) * 1990-04-17 1990-06-13 Smith Kline French Lab Process
GB9015095D0 (en) * 1990-07-09 1990-08-29 Smith Kline French Lab Therapeutic method
IE914003A1 (en) * 1990-11-20 1992-05-20 Astra Pharma Prod Biologically Active Amines
AU4312593A (en) * 1992-05-18 1993-12-13 Smithkline Beecham Plc Use of indolone derivatives for the treatment of memory disorders, sexual dysfunction and Parkinson's disease
GB9300309D0 (en) * 1993-01-08 1993-03-03 Smithkline Beecham Plc Process
TW356468B (en) * 1995-09-15 1999-04-21 Astra Pharma Prod Benzothiazolone compounds useful as beta2-adrenoreceptor and dopamine DA2 receptor agonists process for preparing same and pharmaceutical compositions containing same
US5807570A (en) * 1995-09-29 1998-09-15 Cygnus, Inc. Transdermal administration of ropinirole and analogs thereof
GB9526511D0 (en) * 1995-12-23 1996-02-28 Astra Pharma Prod Pharmaceutically active compounds
JP2000516959A (ja) * 1996-08-27 2000-12-19 アメリカン・ホーム・プロダクツ・コーポレイション ４―アミノエトキシインドロン誘導体
CA2327477A1 (en) * 1998-04-13 1999-10-21 James Albert Nelson 4-amino-(ethylamino)-oxindole dopamine autoreceptor agonists
US6218421B1 (en) * 1999-07-01 2001-04-17 Smithkline Beecham P.L.C. Method of promoting smoking cessation
AR030557A1 (es) 2000-04-14 2003-08-27 Jagotec Ag Una tableta en multicapa de liberacion controlada y metodo de tratamiento
US6277875B1 (en) * 2000-07-17 2001-08-21 Andrew J. Holman Use of dopamine D2/D3 receptor agonists to treat fibromyalgia
DE10041478A1 (de) * 2000-08-24 2002-03-14 Sanol Arznei Schwarz Gmbh Neue pharmazeutische Zusammensetzung
US20020165246A1 (en) * 2001-03-05 2002-11-07 Andrew Holman Administration of sleep restorative agents
FR2821843B1 (fr) * 2001-03-12 2003-05-09 Servier Lab Nouveaux derives d'isoindoloindolones, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
US20030068356A1 (en) * 2001-07-10 2003-04-10 Pather S. Indiran Sequential drug delivery systems
ES2285245T3 (es) * 2002-09-13 2007-11-16 Motac Neuroscience Limited Tratamiento de la disquinesia con 2,3-benzodiazapinas.
ATE360415T1 (de) * 2002-09-17 2007-05-15 Motac Neuroscience Ltd Behandlung von dyskinesie
ES2237307B1 (es) * 2003-10-14 2006-11-01 Urquima, S.A. Procedimiento para la preparacion de ropinirol.
WO2005074387A2 (en) * 2003-12-30 2005-08-18 Sun Pharmaceutical Industries Limited Novel crystal forms of 4-[2-di-n-propylamino)ethyl]-2 (3h)- indolone hydrochloride
US7378439B2 (en) * 2004-01-20 2008-05-27 Usv, Ltd. Process for the preparation of 4-(2-dipropylaminoethyl)-1,3-dihydro-2H-indol-2-one hydrochloride
WO2005105741A1 (en) * 2004-02-11 2005-11-10 Sun Pharmaceutical Industries Limited Substantially pure 4-[2-(di-n-propylamino)ethyl]-2(3h)-indolone hydrochloride
WO2005080333A1 (en) * 2004-02-19 2005-09-01 Torrent Pharmaceuticals Ltd Process for purification of ropinirole
HUP0400953A3 (en) * 2004-05-11 2008-02-28 Egis Gyogyszergyar Nyilvanosan Piperazine derivatives of alkyl-oxindoles, pharmaceutical compositions containing them, process for producing them and their use
EP1751106B1 (en) * 2004-05-11 2008-10-29 EGIS Gyógyszergyár Nyrt Piperazine derivatives of alkyl oxindoles
US20050267096A1 (en) * 2004-05-26 2005-12-01 Pfizer Inc New indazole and indolone derivatives and their use pharmaceuticals
US20050288270A1 (en) * 2004-05-27 2005-12-29 Pfizer Inc New aminopyridine derivatives and their use as pharmaceuticals
EP1863484A1 (en) * 2005-03-21 2007-12-12 Pfizer Limited Substituted triazole derivatives as oxytocin antagonists
CN100457711C (zh) * 2005-06-27 2009-02-04 上海奥博生物医药技术有限公司 2-甲基-3-硝基苯基烷基胺衍生物或其盐的制备方法
WO2007010557A2 (en) * 2005-07-22 2007-01-25 Ind-Swift Laboratorie Limted Process for the preparation of highly pure ropinirole
ATE517865T1 (de) 2006-03-29 2011-08-15 Alembic Ltd Verfahren zur aufreinigung von ropinirolhydrochlorid
PT2010184E (pt) * 2006-04-06 2013-04-03 Nupathe Inc Implantes para o tratamento dos estados associados à dopamina
US20070254941A1 (en) * 2006-04-21 2007-11-01 Glenmark Pharmaceuticals Limited Subtantially pure ropinirole hydrochloride, polymorphic form of ropinirole and process for their preparation
CN100457732C (zh) * 2006-05-25 2009-02-04 药源药物化学（上海）有限公司 罗匹尼罗的制备方法
WO2008001204A2 (en) * 2006-06-29 2008-01-03 Antares Pharma Ipl Ag Transdermal compositions of pramipexole having enhanced permeation properties
TW200815045A (en) * 2006-06-29 2008-04-01 Jazz Pharmaceuticals Inc Pharmaceutical compositions of ropinirole and methods of use thereof
ES2374336T3 (es) * 2007-05-11 2012-02-15 Santen Pharmaceutical Co., Ltd Agente profiláctico o terapéutico para una enfermedad ocular posterior que comprende un agonista selectivo no ergótico del receptor d2 como principio activo.
US20090076124A1 (en) * 2007-09-14 2009-03-19 Protia, Llc Deuterium-enriched ropinirole
US20090247537A1 (en) * 2008-03-25 2009-10-01 William Dale Overfield Methods for preventing or treating bruxism using dopaminergic agents
CN101574341B (zh) * 2008-05-05 2012-12-19 北京德众万全医药科技有限公司 一种罗匹尼罗的口服固体药物组合物
US20110195117A1 (en) * 2008-09-01 2011-08-11 Lupin Limited Controlled release compositions of ropinirole
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US20120253051A1 (en) * 2009-12-16 2012-10-04 Pharmathen S.A. Process for the preparation of ropinirole and salts thereof
AP3030A (en) 2010-04-30 2014-11-30 Teikoku Pharma Usa Inc Propynylaminoindan transdermal compositions
CN101891641B (zh) * 2010-07-27 2015-06-10 北京华禧联合科技发展有限公司 盐酸罗匹尼罗关键中间体的稳定形态及其制备
TWI537274B (zh) 2011-03-14 2016-06-11 橘生藥品工業股份有限公司 新穎之八氫噻吩并喹啉衍生物、含有其之醫藥組成物及該等之用途
KR101853082B1 (ko) 2011-03-24 2018-04-27 테이코쿠 팔마 유에스에이, 인코포레이티드 활성제층 및 활성제 변환층을 포함하는 경피 조성물
WO2013070526A1 (en) 2011-11-09 2013-05-16 Teikoku Pharma Usa, Inc. Methods for the treatment of skin neoplasms
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EP2930175A4 (en) 2012-12-10 2016-12-21 Kissei Pharmaceutical NOVEL OCTAHYDROPYRIDOQUINAZOLINE DERIVATIVE, PHARMACEUTICAL COMPOSITION CONTAINING THE SAME, AND USES THEREFOR, AND THE DERIVATIVE THEREOF
US9155695B2 (en) 2013-03-14 2015-10-13 Medtronic, Inc. Injectable ropinirole compositions and methods for making and using same
CN110621660B (zh) 2017-06-16 2022-06-28 浙江华海立诚药业有限公司 盐酸罗匹尼罗的纯化方法
CN115466209A (zh) * 2022-09-29 2022-12-13 南通大学 一种罗匹尼罗环戊烷并吲哚酮杂质的合成方法

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US3573310A (en) * 1967-09-28 1971-03-30 Miles Lab 1-substituted derivatives of 2-indolinone
JPS5825673B2 (ja) * 1976-03-31 1983-05-28 大塚製薬株式会社 オキシインド−ル誘導体
JPS5840539B2 (ja) * 1976-03-31 1983-09-06 大塚製薬株式会社 α−置換アミノアルカノイルオキシインド−ル誘導体
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US4317944A (en) * 1980-08-15 1982-03-02 General Electric Company Preparation of 2,2-bis(4-hydroxyphenyl) propane
US4314944A (en) * 1980-08-22 1982-02-09 Smithkline Corporation 4-Aminoalkyl-7-hydroxy-2(3H)-indolones

Also Published As

Publication number Publication date
EG16556A (en) 1989-01-30
KR840006963A (ko) 1984-12-04
DK562183D0 (da) 1983-12-06
PT77739B (en) 1986-03-27
NO160135C (no) 1989-03-15
HK82089A (en) 1989-10-20
JPH0150703B2 (fi) 1989-10-31
ES543593A0 (es) 1986-01-16
NO160135B (no) 1988-12-05
LU90097I2 (fr) 1997-07-16
NZ206344A (en) 1987-03-31
ES527827A0 (es) 1985-10-01
ZA839094B (en) 1985-02-27
DK156514B (da) 1989-09-04
NL970005I1 (nl) 1997-04-01
BR1100036A (pt) 2000-01-11
CY1497A (en) 1990-02-16
FI834421A0 (fi) 1983-12-02
AU560170B2 (en) 1987-04-02
IL70311A0 (en) 1984-02-29
ES8604143A1 (es) 1986-01-16
CA1208650A (en) 1986-07-29
AU2158583A (en) 1984-06-14
NL970005I2 (nl) 1997-10-01
JPS59112964A (ja) 1984-06-29
FI77849C (fi) 1989-05-10
PH22067A (en) 1988-05-20
NO834485L (no) 1984-06-08
PT77739A (en) 1983-12-01
DE3367090D1 (de) 1986-11-27
IL70311A (en) 1986-11-30
DK156514C (da) 1990-03-12
DZ587A1 (fr) 2004-09-13
IE832866L (en) 1984-06-07
KR910001042B1 (ko) 1991-02-21
US4452808A (en) 1984-06-05
FI77849B (fi) 1989-01-31
ZW25883A1 (en) 1984-04-18
ES8600239A1 (es) 1985-10-01
CZ398191A3 (en) 1993-02-17
EP0113964A1 (en) 1984-07-25
NO1999011I1 (no) 1999-06-18
EP0113964B1 (en) 1986-10-22
IE56347B1 (en) 1991-07-03
GR79121B (fi) 1984-10-02
DK562183A (da) 1984-06-08

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Legal Events

Date Code Title Description
SPCG Supplementary protection certificate granted

Spc suppl protection certif: L182

Extension date: 20081201

MA Patent expired

Owner name: SMITHKLINE BEECHAM CORPORATION