FI781811A - Nya carbostyrilderivat - Google Patents

Nya carbostyrilderivat

Info

Publication number
FI781811A
FI781811A FI781811A FI781811A FI781811A FI 781811 A FI781811 A FI 781811A FI 781811 A FI781811 A FI 781811A FI 781811 A FI781811 A FI 781811A FI 781811 A FI781811 A FI 781811A
Authority
FI
Finland
Prior art keywords
carbostyrilderivat
nya
nya carbostyrilderivat
Prior art date
Application number
FI781811A
Other languages
English (en)
Other versions
FI69300B (fi
FI69300C (fi
Inventor
Takao Nishi
Hiraki Ueda
Kazuyuki Nakagawa
Original Assignee
Otsuka Pharma Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from JP6931977A external-priority patent/JPS545981A/ja
Priority claimed from JP7586377A external-priority patent/JPS5412385A/ja
Priority claimed from JP53023012A external-priority patent/JPS6059912B2/ja
Application filed by Otsuka Pharma Co Ltd filed Critical Otsuka Pharma Co Ltd
Publication of FI781811A publication Critical patent/FI781811A/fi
Publication of FI69300B publication Critical patent/FI69300B/fi
Application granted granted Critical
Publication of FI69300C publication Critical patent/FI69300C/fi

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/20—Oxygen atoms
    • C07D215/22—Oxygen atoms attached in position 2 or 4
    • C07D215/227—Oxygen atoms attached in position 2 or 4 only one oxygen atom which is attached in position 2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/20—Oxygen atoms
    • C07D215/24—Oxygen atoms attached in position 8
    • C07D215/26—Alcohols; Ethers thereof

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Quinoline Compounds (AREA)
FI781811A 1977-06-10 1978-06-07 Foerfarande foer framstaellning av terapeutiskt anvaendbara ny karbostyrilderivat FI69300C (fi)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
JP6931977A JPS545981A (en) 1977-06-10 1977-06-10 Carbostyryl derivatives
JP6931977 1977-06-10
JP7586377A JPS5412385A (en) 1977-06-24 1977-06-24 Carbostyril derivative
JP7586377 1977-06-24
JP2301278 1978-02-28
JP53023012A JPS6059912B2 (ja) 1978-02-28 1978-02-28 カルボスチリル誘導体

Publications (3)

Publication Number Publication Date
FI781811A true FI781811A (fi) 1978-12-11
FI69300B FI69300B (fi) 1985-09-30
FI69300C FI69300C (fi) 1986-01-10

Family

ID=27284068

Family Applications (1)

Application Number Title Priority Date Filing Date
FI781811A FI69300C (fi) 1977-06-10 1978-06-07 Foerfarande foer framstaellning av terapeutiskt anvaendbara ny karbostyrilderivat

Country Status (21)

Country Link
US (1) US4298739A (fi)
AR (2) AR224345A1 (fi)
AT (1) AT367038B (fi)
AU (1) AU510138B2 (fi)
CA (1) CA1098907A (fi)
CH (1) CH636087A5 (fi)
DE (1) DE2825048A1 (fi)
DK (1) DK149449C (fi)
ES (2) ES470690A1 (fi)
FI (1) FI69300C (fi)
FR (1) FR2393795B1 (fi)
GB (1) GB2002745B (fi)
IE (1) IE46852B1 (fi)
IT (1) IT1108326B (fi)
MX (1) MX5527E (fi)
NL (1) NL178074C (fi)
NO (1) NO148813C (fi)
NZ (1) NZ187452A (fi)
PH (1) PH14670A (fi)
PT (1) PT68157A (fi)
SE (1) SE444562B (fi)

Families Citing this family (36)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SU843739A3 (ru) * 1978-02-17 1981-06-30 Карл Томэ Гмбх (Фирма) Способ получени карбостириловыхили ОКСиНдОлОВыХ пРОизВОдНыХ
AT383594B (de) * 1980-02-29 1987-07-27 Otsuka Pharma Co Ltd Verfahren zum herstellen von neuen carbostyrilderivaten und ihren salzen
JPS56122356A (en) 1980-02-29 1981-09-25 Otsuka Pharmaceut Co Ltd Carbostyril derivative
FI77852C (fi) * 1981-02-17 1989-05-10 Otsuka Pharma Co Ltd Foerfarande foer framstaellning av nya, saosom hjaertmediciner anvaendbara substituerade amid- och (maettad heterocykel)karbonylkarbostyrilderivat.
US4442111A (en) * 1981-07-25 1984-04-10 Dr. Karl Thomae Gesellschaft Mit Beschrankter Haftung Antithrombotic sulfimino and sulfoximino indolinones-2
FI80022C (fi) * 1982-07-05 1990-04-10 Otsuka Pharma Co Ltd Foerfarande foer framstaellning av ett nytt, terapeutiskt anvaendbart karbostyrilderivat.
CH655110A5 (de) * 1982-09-03 1986-03-27 Otsuka Pharma Co Ltd Carbostyrilderivate, verfahren zu deren herstellung und arzneimittel, welche diese enthalten.
US4663320A (en) * 1983-02-16 1987-05-05 Syntex (U.S.A.) Inc. (2-oxo-1,2,3,5-tetrahydroimidazo[2,1-b]quinoazolinyl)oxyalkylamides, compositions and the use thereof
US4490371A (en) * 1983-02-16 1984-12-25 Syntex (U.S.A.) Inc. N,N-Disubstituted-(2-oxo-1,2,3,5-tetrahydroimidazo-[2,1-B]quinazolinyl)oxyalkylamides
EP0153152A3 (en) * 1984-02-15 1987-07-15 Syntex (U.S.A.) Inc. (2-oxo-1,2,3,5-tetrahydroimidazo-/2,1-b/quinnazolinyl)-oxyalkylamides, their preparation, compositions containing them and their use in making medicaments
US4670434A (en) * 1985-11-14 1987-06-02 Syntex (U.S.A.) Inc. (2-oxo-3-methylene-1,2,3,5-tetrahydroimidazo[2,1-b]quinazolinyl)oxyalkylamides useful as cyclic AMP phosphodiesterase inhibitors
JP2753622B2 (ja) 1988-05-02 1998-05-20 大塚製薬株式会社 カルボスチリル誘導体
US5227381A (en) * 1988-05-02 1993-07-13 Otsuka Pharmaceutical Co., Ltd. Carbostyril derivative
TW201305B (fi) * 1991-04-03 1993-03-01 Otsuka Pharma Co Ltd
KR930702307A (ko) * 1991-08-23 1993-09-08 오오쓰까 아끼히꼬 카르보스티릴 유도체 및 혈소판 응집 억제제
US5958926A (en) * 1996-11-01 1999-09-28 Nitromed, Inc. Nitrosated and nitrosylated phosphodiesterase inhibitor compounds, compositions and their uses
US7772188B2 (en) 2003-01-28 2010-08-10 Ironwood Pharmaceuticals, Inc. Methods and compositions for the treatment of gastrointestinal disorders
RU2008122978A (ru) 2005-11-09 2009-12-20 Комбинаторкс, Инкорпорейтед (Us) Способы, композиции и наборы для лечения медицинских состояний
EA020466B1 (ru) 2007-06-04 2014-11-28 Синерджи Фармасьютикалз Инк. Агонисты гуанилатциклазы, пригодные для лечения желудочно-кишечных нарушений, воспаления, рака и других заболеваний
US8969514B2 (en) 2007-06-04 2015-03-03 Synergy Pharmaceuticals, Inc. Agonists of guanylate cyclase useful for the treatment of hypercholesterolemia, atherosclerosis, coronary heart disease, gallstone, obesity and other cardiovascular diseases
DE102008022221A1 (de) 2008-05-06 2009-11-12 Universität des Saarlandes Inhibitoren der humanen Aldosteronsynthase CYP11B2
CA2726917C (en) 2008-06-04 2018-06-26 Synergy Pharmaceuticals Inc. Agonists of guanylate cyclase useful for the treatment of gastrointestinal disorders, inflammation, cancer and other disorders
CA2730603C (en) 2008-07-16 2019-09-24 Synergy Pharmaceuticals Inc. Agonists of guanylate cyclase useful for the treatment of gastrointestinal disorders, inflammation, cancer and other disorders
EP2196453A1 (en) * 2008-12-10 2010-06-16 Cellvir Novel substituted aryl derivatives, their process of preparation and their therapeutical uses as anti-HIV agents
TWI481601B (zh) * 2009-08-21 2015-04-21 Otsuka Pharma Co Ltd 含氮化合物及藥學組成物
JP5649577B2 (ja) 2009-08-21 2015-01-07 大塚製薬株式会社 ベンゾ［ｂ］［１，４］ジアゼピン−２，４−ジオン化合物の製造方法
US8541404B2 (en) 2009-11-09 2013-09-24 Elexopharm Gmbh Inhibitors of the human aldosterone synthase CYP11B2
US9616097B2 (en) 2010-09-15 2017-04-11 Synergy Pharmaceuticals, Inc. Formulations of guanylate cyclase C agonists and methods of use
WO2012118972A2 (en) 2011-03-01 2012-09-07 Synegy Pharmaceuticals Inc. Process of preparing guanylate cyclase c agonists
EP2804603A1 (en) 2012-01-10 2014-11-26 President and Fellows of Harvard College Beta-cell replication promoting compounds and methods of their use
WO2014131024A2 (en) 2013-02-25 2014-08-28 Synergy Pharmaceuticals Inc. Agonists of guanylate cyclase and their uses
CA2905435A1 (en) 2013-03-15 2014-09-25 Synergy Pharmaceuticals Inc. Compositions useful for the treatment of gastrointestinal disorders
EP2970384A1 (en) 2013-03-15 2016-01-20 Synergy Pharmaceuticals Inc. Agonists of guanylate cyclase and their uses
CN113388007A (zh) 2013-06-05 2021-09-14 博士医疗爱尔兰有限公司 鸟苷酸环化酶c的超纯激动剂、制备和使用所述激动剂的方法
MX2016001714A (es) 2013-08-09 2016-10-03 Ardelyx Inc Compuestos y metodos para inhibir el transporte de fosfato.
US20200368223A1 (en) 2019-05-21 2020-11-26 Ardelyx, Inc. Methods for inhibiting phosphate transport

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AR207554A1 (es) * 1972-12-02 1976-10-15 Otsuka Pharma Co Ltd Procedimiento para producir derivados de 3-alquil-5-((3,4-dihidro-5-carbostiril)oximetil)-oxazolidinona-(2)
JPS5239035B2 (fi) * 1972-12-14 1977-10-03
JPS5234629B2 (fi) * 1973-02-03 1977-09-05
SE431451B (sv) * 1973-10-24 1984-02-06 Otsuka Pharma Co Ltd Forfarande for framstellning av 2,3-dihydroxipropoxikinoliner eller -isokinoliner
US4022784A (en) * 1974-01-31 1977-05-10 Otsuka Pharmaceutical Company Limited 5-[1-Hydroxy-2-(substituted-amino)]alkyl-8-substituted-carbostyril and -3,4-dihydrocarbostyril derivatives
US4070470A (en) * 1974-06-24 1978-01-24 Otsuka Pharmaceutical Co., Ltd. Platelet aggregation inhibiting carbostyrils, their compositions and method of use
JPS54119478A (en) * 1978-03-06 1979-09-17 Otsuka Pharmaceut Co Ltd Carbostyril derivative

Also Published As

Publication number Publication date
NL7806245A (nl) 1978-12-12
GB2002745A (en) 1979-02-28
CH636087A5 (de) 1983-05-13
CA1098907A (en) 1981-04-07
FI69300B (fi) 1985-09-30
SE7806710L (sv) 1978-12-11
IE46852B1 (en) 1983-10-05
US4298739A (en) 1981-11-03
IE781104L (en) 1978-12-10
AR224345A1 (es) 1981-11-30
SE444562B (sv) 1986-04-21
ES470690A1 (es) 1979-10-16
AU3686678A (en) 1979-12-13
DE2825048A1 (de) 1978-12-14
FR2393795A1 (fr) 1979-01-05
IT7868355A0 (it) 1978-06-09
AU510138B2 (en) 1980-06-12
PT68157A (en) 1978-07-01
PH14670A (en) 1981-10-30
DK254878A (da) 1979-02-09
NZ187452A (en) 1980-05-27
IT1108326B (it) 1985-12-09
AT367038B (de) 1982-05-25
NO148813C (no) 1983-12-21
NO782022L (no) 1978-12-12
DE2825048C2 (fi) 1991-05-08
GB2002745B (en) 1982-02-17
DK149449B (da) 1986-06-16
FR2393795B1 (fr) 1986-07-25
ES479138A1 (es) 1979-07-01
AR225755A1 (es) 1982-04-30
NL178074C (nl) 1986-01-16
DK149449C (da) 1986-11-24
FI69300C (fi) 1986-01-10
MX5527E (es) 1983-09-23
NO148813B (no) 1983-09-12
ATA421378A (de) 1981-10-15

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Legal Events

Date Code Title Description
MM Patent lapsed

Owner name: OTSUKA PHARMACEUTICAL CO. LTD.