FI66874B - Foerfarande foer framstaellning av kristallina salter av 7beta-(2-(2-amino-4-tiazolyl)-2-metoxi-iminoacetamido)-3-cefem-4-karboxylsyra-pivaloyloximetylester - Google Patents

Foerfarande foer framstaellning av kristallina salter av 7beta-(2-(2-amino-4-tiazolyl)-2-metoxi-iminoacetamido)-3-cefem-4-karboxylsyra-pivaloyloximetylester Download PDF

Info

Publication number
FI66874B
FI66874B FI810270A FI810270A FI66874B FI 66874 B FI66874 B FI 66874B FI 810270 A FI810270 A FI 810270A FI 810270 A FI810270 A FI 810270A FI 66874 B FI66874 B FI 66874B
Authority
FI
Finland
Prior art keywords
amino
thiazolyl
crystalline
ester
pivaloyloximethyl
Prior art date
Application number
FI810270A
Other languages
English (en)
Finnish (fi)
Other versions
FI810270L (fi
Inventor
Riccardo Scartazzini
Original Assignee
Ciba Geigy Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ciba Geigy Ag filed Critical Ciba Geigy Ag
Publication of FI810270L publication Critical patent/FI810270L/fi
Application granted granted Critical
Publication of FI66874B publication Critical patent/FI66874B/fi

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/14—Compounds having a nitrogen atom directly attached in position 7
    • C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
    • C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
    • C07D501/24—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with hydrocarbon radicals, substituted by hetero atoms or hetero rings, attached in position 3
    • C07D501/26—Methylene radicals, substituted by oxygen atoms; Lactones thereof with the 2-carboxyl group
    • C07D501/34—Methylene radicals, substituted by oxygen atoms; Lactones thereof with the 2-carboxyl group with the 7-amino radical acylated by carboxylic acids containing hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Cephalosporin Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Liquid Crystal Substances (AREA)
  • Seasonings (AREA)
  • Saccharide Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Sorption Type Refrigeration Machines (AREA)
  • Magnetic Heads (AREA)
  • Fats And Perfumes (AREA)
FI810270A 1980-02-01 1981-01-30 Foerfarande foer framstaellning av kristallina salter av 7beta-(2-(2-amino-4-tiazolyl)-2-metoxi-iminoacetamido)-3-cefem-4-karboxylsyra-pivaloyloximetylester FI66874B (fi)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CH83680 1980-02-01
CH83680 1980-02-01

Publications (2)

Publication Number Publication Date
FI810270L FI810270L (fi) 1981-08-02
FI66874B true FI66874B (fi) 1984-08-31

Family

ID=4196332

Family Applications (1)

Application Number Title Priority Date Filing Date
FI810270A FI66874B (fi) 1980-02-01 1981-01-30 Foerfarande foer framstaellning av kristallina salter av 7beta-(2-(2-amino-4-tiazolyl)-2-metoxi-iminoacetamido)-3-cefem-4-karboxylsyra-pivaloyloximetylester

Country Status (26)

Country Link
US (1) US4411897A (it)
EP (1) EP0033518B1 (it)
JP (1) JPS56122382A (it)
KR (1) KR840000502B1 (it)
AT (1) ATE3550T1 (it)
AU (1) AU6677981A (it)
CA (1) CA1146540A (it)
CS (1) CS219851B2 (it)
DD (1) DD157462A5 (it)
DE (1) DE3160328D1 (it)
DK (1) DK32081A (it)
ES (1) ES498989A0 (it)
FI (1) FI66874B (it)
GR (1) GR78221B (it)
IE (1) IE50888B1 (it)
IL (1) IL62017A (it)
MC (1) MC1367A1 (it)
MT (1) MTP882B (it)
NO (1) NO810338L (it)
NZ (1) NZ196159A (it)
OA (1) OA06732A (it)
PL (1) PL125899B1 (it)
PT (1) PT72421A (it)
SU (1) SU1036250A1 (it)
ZA (1) ZA81631B (it)
ZW (1) ZW2281A1 (it)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2111043B (en) * 1980-12-12 1985-02-06 Ciba Geigy Ag Novel cephalosporin esters
US4400503A (en) * 1981-10-30 1983-08-23 Eli Lilly And Company Purification of syn-7-[[(2-amino-4-thiazolyl)(methoxyimino) acetyl]amino]-3-methyl-3-cephem-4-carboxylic acid
US4594417A (en) * 1981-10-30 1986-06-10 Eli Lilly Company Crystalline antibiotic salt
JPS60190783A (ja) * 1983-12-21 1985-09-28 Sumitomo Seiyaku Kk セフエム系化合物
US4683227A (en) * 1985-07-09 1987-07-28 Eli Lilly And Company Antibiotic derivatives of 7β-[2-(thiazol-4-yl)acetamide]-3-chloro-3-cephem-4-carboxylic acids and compositions and method of use thereof
JPH02101081A (ja) * 1988-10-08 1990-04-12 Meiji Seika Kaisha Ltd セファロスポリン誘導体結晶性二塩酸塩及びその製造法
EP0638573A1 (en) * 1993-08-10 1995-02-15 Lucky Ltd. Crystalline hydrates of cephalosporin and process for preparation thereof
US20040067192A1 (en) * 2002-10-07 2004-04-08 The Procter & Gamble Company Conversion of sodium bromide to anhydrous hydrobromic acid and sodium bisulfate
MXPA05010083A (es) * 2003-03-27 2005-11-23 Basilea Pharmaceutica Ag Cefalosporina en forma cristalina.

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PH17188A (en) 1977-03-14 1984-06-14 Fujisawa Pharmaceutical Co New cephem and cepham compounds and their pharmaceutical compositions and method of use
US4370326A (en) * 1977-09-13 1983-01-25 Fujisawa Pharmaceutical Co., Ltd. Cephem compounds and composition
GB2025933B (en) 1978-06-13 1982-10-27 Fujisawa Pharmaceutical Co Cephem and cepham compounds
MA18686A1 (fr) * 1978-07-07 1980-10-01 Ciba Geigy Ag Composes aminothiazoliques
JPS5543011A (en) * 1978-09-20 1980-03-26 Shionogi & Co Ltd 7-halothiazolylalkoxyiminoacetamido-3-cephem compound
JPS5579393A (en) * 1978-12-11 1980-06-14 Takeda Chem Ind Ltd Cephalosporin derivative and its preparation
JPS55151588A (en) * 1979-05-14 1980-11-26 Takeda Chem Ind Ltd Preparation of cephalosporin salt crystal

Also Published As

Publication number Publication date
MC1367A1 (fr) 1981-10-23
PL125899B1 (en) 1983-06-30
GR78221B (it) 1984-09-26
IE810176L (en) 1981-08-01
ES8204439A1 (es) 1982-05-01
KR830005235A (ko) 1983-08-03
DD157462A5 (de) 1982-11-10
IL62017A0 (en) 1981-02-27
ES498989A0 (es) 1982-05-01
SU1036250A1 (ru) 1983-08-15
IE50888B1 (en) 1986-08-06
PT72421A (de) 1981-02-01
EP0033518A1 (de) 1981-08-12
OA06732A (fr) 1982-06-30
CA1146540A (en) 1983-05-17
CS219851B2 (en) 1983-03-25
AU6677981A (en) 1981-08-06
IL62017A (en) 1984-06-29
NO810338L (no) 1981-08-03
DK32081A (da) 1981-08-02
ATE3550T1 (de) 1983-06-15
EP0033518B1 (de) 1983-05-25
ZW2281A1 (en) 1981-09-02
NZ196159A (en) 1983-09-30
DE3160328D1 (en) 1983-07-07
PL229457A1 (it) 1981-10-02
MTP882B (en) 1984-06-05
KR840000502B1 (ko) 1984-04-16
US4411897A (en) 1983-10-25
ZA81631B (en) 1982-02-24
FI810270L (fi) 1981-08-02
JPS56122382A (en) 1981-09-25

Similar Documents

Publication Publication Date Title
US5407929A (en) Triazolylthiomethylthio cephalosporin hydrochhloride, its crystalline hydrate and the production of the same
FI76093B (fi) Foerfarande foer framstaellning av en amorf form av 1-acetoxietylester av (6r,7r)-3-karbamoyloximetyl-7- /(z)-2-(fur-2-yl)-2-metoxiiminoacetamido/cef-3-em-4-karboxylsyra eller cefuroximaxetil.
FI65623C (fi) Foerfarande foer framstaellning av antibiotiskt aktiv (6r 7r)-3-karbamoyloximetyl-7-(2-(fur-2-yl)-2-metoxiiminoacetamido)-cef-3-em-4-karboxylsyra samt dennas icke-giftiga salter
JP5852562B2 (ja) 新規なセフェム誘導体
JPS5858354B2 (ja) セフェム誘導体
HU184835B (en) Process for preparing crystallic pentahydrate of cefem-carboxylic acid derivatives
FI66874B (fi) Foerfarande foer framstaellning av kristallina salter av 7beta-(2-(2-amino-4-tiazolyl)-2-metoxi-iminoacetamido)-3-cefem-4-karboxylsyra-pivaloyloximetylester
FI67385B (fi) Foerfarande foer framstaellning av (6r,7r)-7-(2-(2-amino-4-tiazolyl)-2-(z-metoxiimino)acetamido)-3-cefem-4-karboxylsyraderivat
FI65069C (fi) Foerfarande foer framstaellning av kristallvattenfri ny-kristallin form av natrium-7-(d-alfa-formyloxi-alfa-fenylacetamido)-3-(1-metyl-1h-tetrazol-5-yltiometyl)-3-cefem-4-karboxylat
EP0264091B1 (en) 3-propenylcephem derivative, preparation thereof, chemical intermediates therein, pharmaceutical composition and use
DE3500090A1 (de) Cephalosporin-antibiotika
US8916526B2 (en) Flavanone derivative
US4189479A (en) Cephalosporin esters
KR910008350B1 (ko) 세팔로스포린 에스테르 유도체의 제조방법
KR830001130B1 (ko) 세팔로스포린 항생제의 제조방법
US4959469A (en) Crystalline cephalosporin compounds
US4734408A (en) Crystalline cephalosporin antibiotic salts and solvates
FI83877C (fi) Foerfarande foer framstaellning av en ny terapeutiskt anvaendbar 7-(3-klorisoxazol-5-yl)-acetamido-3- (1-metyl-1h-1,2,3,4-tetrazol-5-yl)-tiometyl-cef-3-em-4-karboxylsyra
JP2575590B2 (ja) トリアゾリルチオメチルチオセファロスポリン塩酸塩およびその水和物結晶ならびにそれらの製法
US5068322A (en) Crystalline cephalosporin compounds
HU182498B (en) Process for producing 7-bracket-iminoacetamido-bracket closed-3-thiomethyl-ceph-3-eme-4-caraoxylic acid
EP0883621A1 (en) Cephalosporin derivatives and processes for the preparation thereof
CN111187285B (zh) 氟氧头孢钠的晶型、制备方法、药物组合物及应用
KR950010084B1 (ko) 결정성 세팔로스포린 화합물, 그의 제조법 및 그의 제조 중간체
PT93352A (pt) Processo para a preparacao de compostos beta-lactamicos

Legal Events

Date Code Title Description
FA Application withdrawn

Owner name: CIBA-GEIGY AG