FI63060C - Foerfarande foer foeroekning av rotavirus in vitro i sellkulturer - Google Patents

Foerfarande foer foeroekning av rotavirus in vitro i sellkulturer Download PDF

Info

Publication number: FI63060C
Authority: FI; Finland
Prior art keywords: culture; rotavirus; cells; virus; cultures
Prior art date: 1977-12-01

Application number

FI783663A

Other languages

English (en)

Finnish (fi)

Other versions

FI783663A (fi

FI63060B (fi

Inventor

June Dalziel Almeida

Original Assignee

Wellcome Found

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1977-12-01

Filing date

1978-11-30

Publication date

1983-04-11

1978-11-30 Application filed by Wellcome Found filed Critical Wellcome Found

1979-06-02 Publication of FI783663A publication Critical patent/FI783663A/fi

1982-12-31 Application granted granted Critical

1982-12-31 Publication of FI63060B publication Critical patent/FI63060B/fi

1983-04-11 Publication of FI63060C publication Critical patent/FI63060C/fi

Links

241000702670 Rotavirus Species 0.000 title description 28
238000000338 in vitro Methods 0.000 title description 6
238000007689 inspection Methods 0.000 title 1
241000700605 Viruses Species 0.000 description 32
210000004027 cell Anatomy 0.000 description 32
108090000631 Trypsin Proteins 0.000 description 18
102000004142 Trypsin Human genes 0.000 description 18
239000012588 trypsin Substances 0.000 description 18
229960001322 trypsin Drugs 0.000 description 18
238000004113 cell culture Methods 0.000 description 16
UCSJYZPVAKXKNQ-HZYVHMACSA-N streptomycin Chemical compound CN[C@H]1[C@H](O)[C@@H](O)[C@H](CO)O[C@H]1O[C@@H]1[C@](C=O)(O)[C@H](C)O[C@H]1O[C@@H]1[C@@H](NC(N)=N)[C@H](O)[C@@H](NC(N)=N)[C@H](O)[C@H]1O UCSJYZPVAKXKNQ-HZYVHMACSA-N 0.000 description 16
238000000034 method Methods 0.000 description 13
244000309466 calf Species 0.000 description 12
239000002609 medium Substances 0.000 description 11
229930182555 Penicillin Natural products 0.000 description 8
JGSARLDLIJGVTE-MBNYWOFBSA-N Penicillin G Chemical compound N([C@H]1[C@H]2SC([C@@H](N2C1=O)C(O)=O)(C)C)C(=O)CC1=CC=CC=C1 JGSARLDLIJGVTE-MBNYWOFBSA-N 0.000 description 8
UIIMBOGNXHQVGW-UHFFFAOYSA-M Sodium bicarbonate Chemical compound [Na+].OC([O-])=O UIIMBOGNXHQVGW-UHFFFAOYSA-M 0.000 description 8
210000003292 kidney cell Anatomy 0.000 description 8
229940049954 penicillin Drugs 0.000 description 8
229960005322 streptomycin Drugs 0.000 description 8
102000035195 Peptidases Human genes 0.000 description 7
108091005804 Peptidases Proteins 0.000 description 7
210000001519 tissue Anatomy 0.000 description 7
230000000120 cytopathologic effect Effects 0.000 description 6
241000282693 Cercopithecidae Species 0.000 description 5
VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 5
239000007640 basal medium Substances 0.000 description 5
238000001493 electron microscopy Methods 0.000 description 5
210000003608 fece Anatomy 0.000 description 5
241000282414 Homo sapiens Species 0.000 description 4
239000001963 growth medium Substances 0.000 description 4
210000002966 serum Anatomy 0.000 description 4
229910000030 sodium bicarbonate Inorganic materials 0.000 description 4
235000017557 sodium bicarbonate Nutrition 0.000 description 4
230000003612 virological effect Effects 0.000 description 4
241000702673 Bovine rotavirus Species 0.000 description 3
241000617996 Human rotavirus Species 0.000 description 3
239000004365 Protease Substances 0.000 description 3
238000005119 centrifugation Methods 0.000 description 3
238000012258 culturing Methods 0.000 description 3
LOKCTEFSRHRXRJ-UHFFFAOYSA-I dipotassium trisodium dihydrogen phosphate hydrogen phosphate dichloride Chemical compound P(=O)(O)(O)[O-].[K+].P(=O)(O)([O-])[O-].[Na+].[Na+].[Cl-].[K+].[Cl-].[Na+] LOKCTEFSRHRXRJ-UHFFFAOYSA-I 0.000 description 3
230000000694 effects Effects 0.000 description 3
239000002953 phosphate buffered saline Substances 0.000 description 3
241000894007 species Species 0.000 description 3
238000010186 staining Methods 0.000 description 3
239000000725 suspension Substances 0.000 description 3
229960005486 vaccine Drugs 0.000 description 3
210000003501 vero cell Anatomy 0.000 description 3
241000283690 Bos taurus Species 0.000 description 2
108010004032 Bromelains Proteins 0.000 description 2
108090000317 Chymotrypsin Proteins 0.000 description 2
102000004190 Enzymes Human genes 0.000 description 2
108090000790 Enzymes Proteins 0.000 description 2
208000005577 Gastroenteritis Diseases 0.000 description 2
206010017913 Gastroenteritis rotavirus Diseases 0.000 description 2
108010019160 Pancreatin Proteins 0.000 description 2
241001494479 Pecora Species 0.000 description 2
CDBYLPFSWZWCQE-UHFFFAOYSA-L Sodium Carbonate Chemical compound [Na+].[Na+].[O-]C([O-])=O CDBYLPFSWZWCQE-UHFFFAOYSA-L 0.000 description 2
108090000787 Subtilisin Proteins 0.000 description 2
241000282887 Suidae Species 0.000 description 2
235000019835 bromelain Nutrition 0.000 description 2
229960002376 chymotrypsin Drugs 0.000 description 2
229940088598 enzyme Drugs 0.000 description 2
239000000706 filtrate Substances 0.000 description 2
208000015181 infectious disease Diseases 0.000 description 2
230000002458 infectious effect Effects 0.000 description 2
239000002054 inoculum Substances 0.000 description 2
210000003734 kidney Anatomy 0.000 description 2
229940055695 pancreatin Drugs 0.000 description 2
239000002245 particle Substances 0.000 description 2
239000011148 porous material Substances 0.000 description 2
229940024999 proteolytic enzymes for treatment of wounds and ulcers Drugs 0.000 description 2
210000005084 renal tissue Anatomy 0.000 description 2
239000012679 serum free medium Substances 0.000 description 2
239000004017 serum-free culture medium Substances 0.000 description 2
239000006228 supernatant Substances 0.000 description 2
108091003079 Bovine Serum Albumin Proteins 0.000 description 1
OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 description 1
206010012735 Diarrhoea Diseases 0.000 description 1
238000002965 ELISA Methods 0.000 description 1
241000287828 Gallus gallus Species 0.000 description 1
241000282412 Homo Species 0.000 description 1
241000124008 Mammalia Species 0.000 description 1
102000018697 Membrane Proteins Human genes 0.000 description 1
108010052285 Membrane Proteins Proteins 0.000 description 1
241001465754 Metazoa Species 0.000 description 1
241000699670 Mus sp. Species 0.000 description 1
108010059712 Pronase Proteins 0.000 description 1
241000702263 Reovirus sp. Species 0.000 description 1
229940124859 Rotavirus vaccine Drugs 0.000 description 1
101710151387 Serine protease 1 Proteins 0.000 description 1
102100032491 Serine protease 1 Human genes 0.000 description 1
101710119665 Trypsin-1 Proteins 0.000 description 1
239000000654 additive Substances 0.000 description 1
239000005557 antagonist Substances 0.000 description 1
239000003242 anti bacterial agent Substances 0.000 description 1
229940088710 antibiotic agent Drugs 0.000 description 1
239000000427 antigen Substances 0.000 description 1
102000036639 antigens Human genes 0.000 description 1
108091007433 antigens Proteins 0.000 description 1
230000002238 attenuated effect Effects 0.000 description 1
239000000872 buffer Substances 0.000 description 1
239000011575 calcium Substances 0.000 description 1
229910052791 calcium Inorganic materials 0.000 description 1
230000032823 cell division Effects 0.000 description 1
238000011072 cell harvest Methods 0.000 description 1
230000022534 cell killing Effects 0.000 description 1
235000013330 chicken meat Nutrition 0.000 description 1
230000000295 complement effect Effects 0.000 description 1
238000011109 contamination Methods 0.000 description 1
238000012136 culture method Methods 0.000 description 1
230000034994 death Effects 0.000 description 1
231100000517 death Toxicity 0.000 description 1
238000011161 development Methods 0.000 description 1
238000002405 diagnostic procedure Methods 0.000 description 1
201000010099 disease Diseases 0.000 description 1
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
235000013601 eggs Nutrition 0.000 description 1
230000002550 fecal effect Effects 0.000 description 1
239000012894 fetal calf serum Substances 0.000 description 1
230000001605 fetal effect Effects 0.000 description 1
238000001914 filtration Methods 0.000 description 1
239000012634 fragment Substances 0.000 description 1
238000007429 general method Methods 0.000 description 1
PCHJSUWPFVWCPO-UHFFFAOYSA-N gold Chemical compound [Au] PCHJSUWPFVWCPO-UHFFFAOYSA-N 0.000 description 1
239000010931 gold Substances 0.000 description 1
229910052737 gold Inorganic materials 0.000 description 1
230000035931 haemagglutination Effects 0.000 description 1
230000003053 immunization Effects 0.000 description 1
238000002649 immunization Methods 0.000 description 1
230000000951 immunodiffusion Effects 0.000 description 1
238000002955 isolation Methods 0.000 description 1
239000007788 liquid Substances 0.000 description 1
239000010871 livestock manure Substances 0.000 description 1
238000012423 maintenance Methods 0.000 description 1
238000004519 manufacturing process Methods 0.000 description 1
239000000463 material Substances 0.000 description 1
238000000386 microscopy Methods 0.000 description 1
239000000203 mixture Substances 0.000 description 1
239000008188 pellet Substances 0.000 description 1
238000002360 preparation method Methods 0.000 description 1
238000003127 radioimmunoassay Methods 0.000 description 1
229910000029 sodium carbonate Inorganic materials 0.000 description 1
239000000243 solution Substances 0.000 description 1
238000001179 sorption measurement Methods 0.000 description 1
241000712461 unidentified influenza virus Species 0.000 description 1
210000000605 viral structure Anatomy 0.000 description 1
238000005406 washing Methods 0.000 description 1

Classifications

- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2720/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsRNA viruses
- C12N2720/00011—Details
- C12N2720/12011—Reoviridae
- C12N2720/12311—Rotavirus, e.g. rotavirus A
- C12N2720/12361—Methods of inactivation or attenuation
- C12N2720/12364—Methods of inactivation or attenuation by serial passage

Landscapes

Life Sciences & Earth Sciences (AREA)
Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Genetics & Genomics (AREA)
Organic Chemistry (AREA)
Zoology (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Wood Science & Technology (AREA)
Virology (AREA)
Biotechnology (AREA)
Microbiology (AREA)
Biomedical Technology (AREA)
Medicinal Chemistry (AREA)
Biochemistry (AREA)
General Engineering & Computer Science (AREA)
General Health & Medical Sciences (AREA)
Immunology (AREA)
Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Micro-Organisms Or Cultivation Processes Thereof (AREA)

FI783663A 1977-12-01 1978-11-30 Foerfarande foer foeroekning av rotavirus in vitro i sellkulturer FI63060C (fi)

Applications Claiming Priority (4)

Application Number	Priority Date	Filing Date	Title
GB5009477		1977-12-01
GB5009477		1977-12-01
GB5390677		1977-12-24
GB5390677		1977-12-24

Publications (3)

Publication Number	Publication Date
FI783663A FI783663A (fi)	1979-06-02
FI63060B FI63060B (fi)	1982-12-31
FI63060C true FI63060C (fi)	1983-04-11

Family

ID=26266615

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
FI783663A FI63060C (fi)	1977-12-01	1978-11-30	Foerfarande foer foeroekning av rotavirus in vitro i sellkulturer

Country Status (10)

Country	Link
US (1)	US4205131A (da)
JP (1)	JPS5495789A (da)
CH (1)	CH646194A5 (da)
DE (1)	DE2851928A1 (da)
DK (1)	DK152516C (da)
FI (1)	FI63060C (da)
FR (1)	FR2410675A1 (da)
GB (1)	GB2009786A (da)
NL (1)	NL191183C (da)
SE (1)	SE445466B (da)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4500513A (en) *	1979-05-15	1985-02-19	Miles Laboratories, Inc.	Influenza vaccine production in liquid cell culture
USRE33164E (en) *	1979-05-15	1990-02-13	Mobay Corporation	Influenza vaccine production in liquid cell culture
EP0152295B1 (en) *	1984-02-09	1991-03-20	Royal Children's Hospital Research Foundation	Live attenuated human rotavirus vaccine and preparation thereof
US4636385A (en) *	1985-02-15	1987-01-13	The Wistar Institute Of Anatomy & Biology	Vaccine, method for its preparation, and use thereof in vaccinating humans against rotavirus infection
US5626851A (en) *	1987-11-30	1997-05-06	The Wistar Institute Of Anatomy And Biology	Rotavirus reassortant vaccine
US5147639A (en) *	1990-06-19	1992-09-15	Ambico, Inc.	Type-c rotavirus cultures and uses therefor
US5610049A (en) *	1991-05-01	1997-03-11	The Wistar Institute Of Anatomy And Biology	Human rotavirus HCR3A and method of growing said rotavirus
ES2378409T3 (es) *	1994-11-10	2012-04-12	Baxter Healthcare S.A.	Método para producir sustancias biológicas en cultivo sin proteínas
US5698433A (en) *	1994-11-10	1997-12-16	Immuno Ag	Method for producing influenza virus and vaccine
US5753489A (en) *	1994-11-10	1998-05-19	Immuno Ag	Method for producing viruses and vaccines in serum-free culture
US5756341A (en) *	1994-11-10	1998-05-26	Immuno Ag	Method for controlling the infectivity of viruses
US6146873A (en) *	1994-11-10	2000-11-14	Baxter Aktiengesellschaft	Production of orthomyxoviruses in monkey kidney cells using protein-free media
CN1209837A (zh) *	1996-10-18	1999-03-03	财团法人阪大微生物病研会	用于轮状病毒感染的轮状病毒属抗原、疫苗和诊断试剂以及用于产生抗原的方法
US6110461A (en) *	1997-08-13	2000-08-29	Oncolytics Biotech Inc.	Reovirus for the treatment of neoplasia
US6656719B1 (en) *	1997-10-27	2003-12-02	Merck & Co., Inc.	Serum-free, low-protein media for rotavirus vaccine production
FR2801900B1 (fr) *	1999-12-03	2004-02-27	Pasteur Merieux Serums Vacc	Methode de production de cellules animales adherentes
US6830917B2 (en)	2001-12-10	2004-12-14	Baxter Healthcare S.A.	Method of isolation and purification of trypsin from pronase protease and use thereof
CA2640286C (en) *	2006-02-13	2018-01-02	Oncolytics Biotech Inc.	Use of local immune suppression to enhance oncolytic viral therapy
AU2007251122B2 (en) *	2006-05-12	2013-01-10	Bharat Biotech International Limited	A composition useful as a vaccine
CN117070475B (zh) *	2023-10-13	2023-12-29	金宇保灵生物药品有限公司	牛轮状病毒无血清悬浮培养方法及其产品和应用

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB1539221A (en) *	1976-09-30	1979-01-31	Wellcome Found	Viral preparations

1978
- 1978-11-29 SE SE7812283A patent/SE445466B/sv not_active IP Right Cessation
- 1978-11-30 NL NL7811763A patent/NL191183C/xx not_active IP Right Cessation
- 1978-11-30 FI FI783663A patent/FI63060C/fi not_active IP Right Cessation
- 1978-11-30 US US05/965,045 patent/US4205131A/en not_active Expired - Lifetime
- 1978-11-30 DK DK542878A patent/DK152516C/da not_active IP Right Cessation
- 1978-11-30 CH CH1226878A patent/CH646194A5/de not_active IP Right Cessation
- 1978-11-30 DE DE19782851928 patent/DE2851928A1/de active Granted
- 1978-11-30 JP JP14855678A patent/JPS5495789A/ja active Granted
- 1978-11-30 GB GB7846602A patent/GB2009786A/en not_active Expired - Lifetime
- 1978-11-30 FR FR7833793A patent/FR2410675A1/fr active Granted

Also Published As

Publication number	Publication date
SE445466B (sv)	1986-06-23
FR2410675A1 (fr)	1979-06-29
DK542878A (da)	1979-06-02
NL7811763A (nl)	1979-06-06
DE2851928A1 (de)	1979-06-21
NL191183C (nl)	1995-03-01
JPS5495789A (en)	1979-07-28
JPS6150599B2 (da)	1986-11-05
NL191183B (nl)	1994-10-03
US4205131A (en)	1980-05-27
FR2410675B1 (da)	1983-12-16
DK152516B (da)	1988-03-07
SE7812283L (sv)	1979-06-02
CH646194A5 (de)	1984-11-15
FI783663A (fi)	1979-06-02
FI63060B (fi)	1982-12-31
GB2009786A (en)	1979-06-20
DE2851928C2 (da)	1987-06-04
DK152516C (da)	1988-08-01

Legal Events

Date	Code	Title	Description
1978-11-30	MA	Patent expired
1994-10-20	PC	Transfer of assignment of patent	Owner name: MALLINCKRODT VETERINARY, INC.
2004-08-31	MA	Patent expired	Owner name: MALLINCKRODT VETERINARY, INC.

Publication	Publication Date	Title
FI63060C (fi)	1983-04-11	Foerfarande foer foeroekning av rotavirus in vitro i sellkulturer
KR100241221B1 (ko)	2000-03-02	돼지 불임 및 호흡기계 중후백신 및 그의 진단법
KR100374295B1 (ko)	2003-12-24	돼지생식및호흡증후군바이러스의생육방법과백신에서그의용도
Uhnoo et al.	1990	Extramucosal spread and development of hepatitis in immunodeficient and normal mice infected with rhesus rotavirus
Hughes	1993	Physical and chemical methods for enhancing rapid detection of viruses and other agents
US3959466A (en)	1976-05-25	Highly attenuated cytomegalovirus vaccine and production thereof
Lee et al.	1986	Pathogenesis of experimental Hantaan virus infection in laboratory rats
Hasegawa et al.	1982	Isolation of human rotaviruses in primary cultures of monkey kidney cells
McNulty et al.	1977	Cell culture studies with a cytopathic bovine rotavirus
KR20010101005A (ko)	2001-11-14	Ａ형 간염-홍역 복합 백신 및 그의 제조 방법
EP1024189B1 (en)	2005-04-06	Novel antigenic class of avian reoviruses
Koptopoulos et al.	1988	The epizootology of caprine herpesvirus (BHV-6) infections in goat populations in Greece
Blaškovič et al.	1970	Experimental infection of weanling pigs with A/Swine influenza virus: 2. The shedding of virus by infected animals
Dunnebacke et al.	1957	Preparation and cultivation of primary human amnion cells
CA2065847C (en)	2002-02-12	Rotavirus reassortant vaccine
Schumacher et al.	1972	Markers for measles virus: II. Tissue culture properties
AU660996B2 (en)	1995-07-13	Human rotavirus HCR3, reassortants thereof and vaccine compositions containing them
Bayyari et al.	1996	Pathogenicity studies of an Arkansas variant infectious bursal disease virus
JPH08188515A (ja)	1996-07-23	組織培養物において効能のあるトキソプラズマゴンデイブラデイゾイトワクチンの生産
Mancini et al.	1967	Cultivation of avian encephalomyelitis virus in vitro. 1. In chick embryo neuroglial cell culture
Murakami et al.	1983	Primary isolation of cytopathic bovine rotaviruses on fetal rhesus monkey kidney cells
Igarashi	1979	A mutant of Chikungunya virus isolated from a line of Singh's Aedes albopictus cells by plaque formation on virus-sensitive cloned cells obtained from another Singh's A. albopictus cell line
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CN115786276B (zh)	2024-04-09	牦牛轮状病毒分离株及其应用
RU2173344C2 (ru)	2001-09-10	Вакцинный штамм вируса краснухи "орлов-д" и способ получения вакцины против краснухи