FI61031C - Foerfarande foer framstaellning av bronkolytiskt verkande kvaternaera n-(teofyllinyl-(7)-alkyl)nortropinderivat - Google Patents
Foerfarande foer framstaellning av bronkolytiskt verkande kvaternaera n-(teofyllinyl-(7)-alkyl)nortropinderivat Download PDFInfo
- Publication number
- FI61031C FI61031C FI760428A FI760428A FI61031C FI 61031 C FI61031 C FI 61031C FI 760428 A FI760428 A FI 760428A FI 760428 A FI760428 A FI 760428A FI 61031 C FI61031 C FI 61031C
- Authority
- FI
- Finland
- Prior art keywords
- acid
- formula
- compounds
- group
- compound
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/08—Bronchodilators
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- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pulmonology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Claims (2)
1. Förfarande för framställning av bronkolytiskt verkande kvaternära N-[teofyllinyl-(7)-alkyl]nortropinderivat med formeln I H2C _CH _CH2 ch3_nA^n\-R·--p»3 V-co-ch-^Q a(-» ΛΙ H2C -CH-CH2 CH2OH CH3 väri R' betyder en rak eller förgrenad alkylen med 2-4 kolatomer, och vilken eventuellt kan vara substituerad med en hydroxigrupp, varvid denna hydroxylgrupp är bunden tili en sadan kolatom som vidare är bunden endast tili koi- och väteatomer, och A ^ är en ekvivalent anjon i en fysiologiskt acceptabel, en- eller flervärd syra, omsätter en förening med formeln II: Z' - Y II med en förening med formeln III H2C._CH_CH2 N-Z N\hO-CO-CH il III H2C_ U—c4 ch2oh varvid i formlerna II och III antingen Z' är en teofyllinyl-(7)-R'-grupp och Z är en metylgrupp eller Z' är en metylgrupp och Z är en teofyllinyl-(7)-R'-grupp, varvid R' betecknar det samma som ovan och Y är en halogenatom, en arylsufonsyragrupp ArSC>20- eller en grupp ROSOKO- och eventuellt i de erhällna föreningarna överförs anjonen Av ' genom omsättning med en syra, vilken deriverats frän en annan anjon respektive med ett sait av en dylik syra, i en annan anjon.
2. Förfarande enligt patentkravet 1 för framställning av föreningar enligt formeln I, kännetecknat därav, att i formeln I är R1 en alkylen med 3 kolatomer, och A^ ^ betyder anjonen i klor-, brom- eller jodvätesyra eller i salpetersyra eller i p-toluensulfonsyra.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| AT135575A AT343291B (de) | 1975-02-21 | 1975-02-21 | Verfahren zur herstellung von neuen quartaren xanthinylalkyl-nortropinderivaten |
| AT135575 | 1975-02-21 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| FI760428A FI760428A (sv) | 1976-08-22 |
| FI61031B FI61031B (fi) | 1982-01-29 |
| FI61031C true FI61031C (fi) | 1982-05-10 |
Family
ID=3512094
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| FI760428A FI61031C (fi) | 1975-02-21 | 1976-02-20 | Foerfarande foer framstaellning av bronkolytiskt verkande kvaternaera n-(teofyllinyl-(7)-alkyl)nortropinderivat |
Country Status (25)
| Country | Link |
|---|---|
| US (1) | US4060618A (sv) |
| JP (1) | JPS51131890A (sv) |
| AR (1) | AR214394A1 (sv) |
| AT (1) | AT343291B (sv) |
| AU (1) | AU500145B2 (sv) |
| BE (1) | BE838732A (sv) |
| CA (1) | CA1061339A (sv) |
| CH (1) | CH619959A5 (sv) |
| CS (1) | CS194741B2 (sv) |
| DD (1) | DD123990A5 (sv) |
| DE (1) | DE2605728A1 (sv) |
| DK (1) | DK141730B (sv) |
| EG (1) | EG12608A (sv) |
| ES (1) | ES445343A1 (sv) |
| FI (1) | FI61031C (sv) |
| FR (1) | FR2301256A1 (sv) |
| GB (1) | GB1524623A (sv) |
| HU (1) | HU175894B (sv) |
| IT (1) | IT1061216B (sv) |
| NL (1) | NL7601759A (sv) |
| PL (1) | PL99163B1 (sv) |
| PT (1) | PT64831B (sv) |
| SE (1) | SE411210B (sv) |
| SU (1) | SU858566A3 (sv) |
| ZA (1) | ZA761027B (sv) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4874850A (en) * | 1986-08-07 | 1989-10-17 | Medice Chem.-Pharm. Fabrik Putter Gmbh & Co. | Pharmaceutical preparations |
| WO1999031101A1 (en) * | 1997-12-17 | 1999-06-24 | University Of South Florida | Adenosine receptor antagonists with improved bioactivity |
| US6440618B1 (en) * | 2000-05-26 | 2002-08-27 | Eastman Kodak Company | Imaging element containing a blocked photographically useful compound |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE1670048C3 (de) * | 1966-01-26 | 1980-09-04 | C.H. Boehringer Sohn, 6507 Ingelheim | Neue Norscopolaminderivate |
| US3505337A (en) * | 1967-12-22 | 1970-04-07 | Boehringer Sohn Ingelheim | N - hydrocarbyl-substituted noratropinium,haloalkylates and o-acyl derivatives thereof |
-
1975
- 1975-02-21 AT AT135575A patent/AT343291B/de not_active IP Right Cessation
-
1976
- 1976-02-03 FR FR7602923A patent/FR2301256A1/fr active Granted
- 1976-02-04 AU AU10813/76A patent/AU500145B2/en not_active Expired
- 1976-02-06 US US05/656,085 patent/US4060618A/en not_active Expired - Lifetime
- 1976-02-13 DE DE19762605728 patent/DE2605728A1/de not_active Withdrawn
- 1976-02-16 EG EG87/76A patent/EG12608A/xx active
- 1976-02-17 SU SU762322550A patent/SU858566A3/ru active
- 1976-02-19 BE BE6045372A patent/BE838732A/xx not_active IP Right Cessation
- 1976-02-19 CS CS761089A patent/CS194741B2/cs unknown
- 1976-02-19 GB GB6563/76A patent/GB1524623A/en not_active Expired
- 1976-02-19 DD DD191335A patent/DD123990A5/xx unknown
- 1976-02-20 HU HU76DE907A patent/HU175894B/hu unknown
- 1976-02-20 CA CA246,223A patent/CA1061339A/en not_active Expired
- 1976-02-20 PT PT64831A patent/PT64831B/pt unknown
- 1976-02-20 ZA ZA1027A patent/ZA761027B/xx unknown
- 1976-02-20 PL PL1976187347A patent/PL99163B1/pl unknown
- 1976-02-20 CH CH210976A patent/CH619959A5/de not_active IP Right Cessation
- 1976-02-20 IT IT48209/76A patent/IT1061216B/it active
- 1976-02-20 DK DK72276AA patent/DK141730B/da not_active IP Right Cessation
- 1976-02-20 NL NL7601759A patent/NL7601759A/xx not_active Application Discontinuation
- 1976-02-20 ES ES445343A patent/ES445343A1/es not_active Expired
- 1976-02-20 JP JP51017858A patent/JPS51131890A/ja active Pending
- 1976-02-20 SE SE7602068A patent/SE411210B/sv unknown
- 1976-02-20 FI FI760428A patent/FI61031C/fi not_active IP Right Cessation
- 1976-02-23 AR AR262334A patent/AR214394A1/es active
Also Published As
| Publication number | Publication date |
|---|---|
| FI760428A (sv) | 1976-08-22 |
| AT343291B (de) | 1978-05-26 |
| ZA761027B (en) | 1977-01-26 |
| FR2301256B1 (sv) | 1978-08-18 |
| PL99163B1 (pl) | 1978-06-30 |
| ES445343A1 (es) | 1977-06-01 |
| CA1061339A (en) | 1979-08-28 |
| AU1081376A (en) | 1977-08-11 |
| HU175894B (en) | 1980-11-28 |
| DK141730C (sv) | 1980-10-20 |
| AU500145B2 (en) | 1979-05-10 |
| CH619959A5 (sv) | 1980-10-31 |
| SU858566A3 (ru) | 1981-08-23 |
| BE838732A (fr) | 1976-08-19 |
| DK141730B (da) | 1980-06-02 |
| PT64831A (de) | 1976-03-01 |
| NL7601759A (nl) | 1976-08-24 |
| PT64831B (de) | 1977-06-07 |
| DE2605728A1 (de) | 1976-09-02 |
| AR214394A1 (es) | 1979-06-15 |
| EG12608A (en) | 1979-06-30 |
| SE411210B (sv) | 1979-12-10 |
| CS194741B2 (en) | 1979-12-31 |
| US4060618A (en) | 1977-11-29 |
| GB1524623A (en) | 1978-09-13 |
| FR2301256A1 (fr) | 1976-09-17 |
| IT1061216B (it) | 1983-02-28 |
| JPS51131890A (en) | 1976-11-16 |
| DK72276A (sv) | 1976-08-22 |
| DD123990A5 (sv) | 1977-01-26 |
| SE7602068L (sv) | 1976-08-23 |
| ATA135575A (de) | 1977-09-15 |
| FI61031B (fi) | 1982-01-29 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MM | Patent lapsed |
Owner name: DEUTSCHE GOLD- UND SILBER-SCHEIDEANSTALT |