FI59173C - Spaedningsmedel foer utspaedning av blodprov - Google Patents

Spaedningsmedel foer utspaedning av blodprov Download PDF

Info

Publication number: FI59173C
Authority: FI; Finland
Prior art keywords: blood; diluent; hemoglobin; blood cells; coulter
Prior art date: 1975-01-13

Application number

FI752687A

Other languages

English (en)

Finnish (fi)

Other versions

FI752687A (de

FI59173B (fi

Inventor

Douglas Armstrong

Original Assignee

Coulter Electronics

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1975-01-13

Filing date

1975-09-25

Publication date

1981-06-10

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=24156076&utm_source=***_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=FI59173(C) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

1975-09-25 Application filed by Coulter Electronics filed Critical Coulter Electronics

1976-07-14 Publication of FI752687A publication Critical patent/FI752687A/fi

1981-02-27 Publication of FI59173B publication Critical patent/FI59173B/fi

1981-06-10 Application granted granted Critical

1981-06-10 Publication of FI59173C publication Critical patent/FI59173C/fi

Links

210000004369 blood Anatomy 0.000 description 26
239000008280 blood Substances 0.000 description 26
239000003085 diluting agent Substances 0.000 description 24
108010054147 Hemoglobins Proteins 0.000 description 19
102000001554 Hemoglobins Human genes 0.000 description 19
PXIPVTKHYLBLMZ-UHFFFAOYSA-N Sodium azide Chemical compound [Na+].[N-]=[N+]=[N-] PXIPVTKHYLBLMZ-UHFFFAOYSA-N 0.000 description 14
210000003743 erythrocyte Anatomy 0.000 description 14
239000000523 sample Substances 0.000 description 14
210000004027 cell Anatomy 0.000 description 11
239000000243 solution Substances 0.000 description 10
210000000601 blood cell Anatomy 0.000 description 9
239000002245 particle Substances 0.000 description 9
KCXVZYZYPLLWCC-UHFFFAOYSA-N EDTA Chemical group OC(=O)CN(CC(O)=O)CCN(CC(O)=O)CC(O)=O KCXVZYZYPLLWCC-UHFFFAOYSA-N 0.000 description 6
WCUXLLCKKVVCTQ-UHFFFAOYSA-M Potassium chloride Chemical compound [Cl-].[K+] WCUXLLCKKVVCTQ-UHFFFAOYSA-M 0.000 description 6
HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 6
210000000265 leukocyte Anatomy 0.000 description 6
PUZPDOWCWNUUKD-UHFFFAOYSA-M sodium fluoride Chemical compound [F-].[Na+] PUZPDOWCWNUUKD-UHFFFAOYSA-M 0.000 description 6
FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 5
238000003556 assay Methods 0.000 description 5
238000005534 hematocrit Methods 0.000 description 5
238000000034 method Methods 0.000 description 5
230000003204 osmotic effect Effects 0.000 description 5
238000004458 analytical method Methods 0.000 description 4
239000000022 bacteriostatic agent Substances 0.000 description 4
238000004820 blood count Methods 0.000 description 4
238000006243 chemical reaction Methods 0.000 description 4
108700042971 cyanomethemoglobin Proteins 0.000 description 4
239000003792 electrolyte Substances 0.000 description 4
239000008151 electrolyte solution Substances 0.000 description 4
239000012530 fluid Substances 0.000 description 4
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 4
239000003146 anticoagulant agent Substances 0.000 description 3
229940127219 anticoagulant drug Drugs 0.000 description 3
150000001540 azides Chemical class 0.000 description 3
239000000872 buffer Substances 0.000 description 3
239000003795 chemical substances by application Substances 0.000 description 3
239000004615 ingredient Substances 0.000 description 3
239000001103 potassium chloride Substances 0.000 description 3
235000011164 potassium chloride Nutrition 0.000 description 3
239000003755 preservative agent Substances 0.000 description 3
239000011780 sodium chloride Substances 0.000 description 3
239000011775 sodium fluoride Substances 0.000 description 3
235000013024 sodium fluoride Nutrition 0.000 description 3
QCDWFXQBSFUVSP-UHFFFAOYSA-N 2-phenoxyethanol Chemical compound OCCOC1=CC=CC=C1 QCDWFXQBSFUVSP-UHFFFAOYSA-N 0.000 description 2
RYGMFSIKBFXOCR-UHFFFAOYSA-N Copper Chemical compound [Cu] RYGMFSIKBFXOCR-UHFFFAOYSA-N 0.000 description 2
238000004364 calculation method Methods 0.000 description 2
239000002738 chelating agent Substances 0.000 description 2
229910052802 copper Inorganic materials 0.000 description 2
239000010949 copper Substances 0.000 description 2
238000007865 diluting Methods 0.000 description 2
239000012895 dilution Substances 0.000 description 2
238000010790 dilution Methods 0.000 description 2
230000005684 electric field Effects 0.000 description 2
229940021013 electrolyte solution Drugs 0.000 description 2
229910001385 heavy metal Inorganic materials 0.000 description 2
230000002489 hematologic effect Effects 0.000 description 2
238000004519 manufacturing process Methods 0.000 description 2
238000005259 measurement Methods 0.000 description 2
229960005323 phenoxyethanol Drugs 0.000 description 2
150000003013 phosphoric acid derivatives Chemical class 0.000 description 2
230000002335 preservative effect Effects 0.000 description 2
239000000126 substance Substances 0.000 description 2
241000894006 Bacteria Species 0.000 description 1
241000233866 Fungi Species 0.000 description 1
206010018910 Haemolysis Diseases 0.000 description 1
DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 1
101100208721 Mus musculus Usp5 gene Proteins 0.000 description 1
108010046377 Whey Proteins Proteins 0.000 description 1
230000002159 abnormal effect Effects 0.000 description 1
238000009825 accumulation Methods 0.000 description 1
239000002253 acid Substances 0.000 description 1
239000004480 active ingredient Substances 0.000 description 1
230000002411 adverse Effects 0.000 description 1
230000004520 agglutination Effects 0.000 description 1
238000013459 approach Methods 0.000 description 1
239000007864 aqueous solution Substances 0.000 description 1
230000001580 bacterial effect Effects 0.000 description 1
230000003385 bacteriostatic effect Effects 0.000 description 1
238000004159 blood analysis Methods 0.000 description 1
239000006172 buffering agent Substances 0.000 description 1
230000003139 buffering effect Effects 0.000 description 1
150000001875 compounds Chemical class 0.000 description 1
-1 cyanomethemoglobin Chemical class 0.000 description 1
238000002405 diagnostic procedure Methods 0.000 description 1
BNIILDVGGAEEIG-UHFFFAOYSA-L disodium hydrogen phosphate Chemical compound [Na+].[Na+].OP([O-])([O-])=O BNIILDVGGAEEIG-UHFFFAOYSA-L 0.000 description 1
229910000397 disodium phosphate Inorganic materials 0.000 description 1
235000019800 disodium phosphate Nutrition 0.000 description 1
238000004090 dissolution Methods 0.000 description 1
239000012153 distilled water Substances 0.000 description 1
235000012489 doughnuts Nutrition 0.000 description 1
239000000383 hazardous chemical Substances 0.000 description 1
230000008588 hemolysis Effects 0.000 description 1
150000007857 hydrazones Chemical class 0.000 description 1
239000000815 hypotonic solution Substances 0.000 description 1
230000003993 interaction Effects 0.000 description 1
230000002452 interceptive effect Effects 0.000 description 1
210000002977 intracellular fluid Anatomy 0.000 description 1
150000002500 ions Chemical class 0.000 description 1
239000007788 liquid Substances 0.000 description 1
229910001507 metal halide Inorganic materials 0.000 description 1
150000005309 metal halides Chemical class 0.000 description 1
229910001463 metal phosphate Inorganic materials 0.000 description 1
244000005700 microbiome Species 0.000 description 1
238000002156 mixing Methods 0.000 description 1
239000000203 mixture Substances 0.000 description 1
229910000403 monosodium phosphate Inorganic materials 0.000 description 1
235000019799 monosodium phosphate Nutrition 0.000 description 1
231100000252 nontoxic Toxicity 0.000 description 1
230000003000 nontoxic effect Effects 0.000 description 1
238000004806 packaging method and process Methods 0.000 description 1
150000003017 phosphorus Chemical class 0.000 description 1
230000000704 physical effect Effects 0.000 description 1
230000001766 physiological effect Effects 0.000 description 1
238000001556 precipitation Methods 0.000 description 1
238000002360 preparation method Methods 0.000 description 1
238000012545 processing Methods 0.000 description 1
150000003839 salts Chemical class 0.000 description 1
238000004513 sizing Methods 0.000 description 1
AJPJDKMHJJGVTQ-UHFFFAOYSA-M sodium dihydrogen phosphate Chemical compound [Na+].OP(O)([O-])=O AJPJDKMHJJGVTQ-UHFFFAOYSA-M 0.000 description 1
239000001488 sodium phosphate Substances 0.000 description 1
230000000087 stabilizing effect Effects 0.000 description 1
238000003756 stirring Methods 0.000 description 1
239000000725 suspension Substances 0.000 description 1
238000012360 testing method Methods 0.000 description 1
UEUXEKPTXMALOB-UHFFFAOYSA-J tetrasodium;2-[2-[bis(carboxylatomethyl)amino]ethyl-(carboxylatomethyl)amino]acetate Chemical compound [Na+].[Na+].[Na+].[Na+].[O-]C(=O)CN(CC([O-])=O)CCN(CC([O-])=O)CC([O-])=O UEUXEKPTXMALOB-UHFFFAOYSA-J 0.000 description 1
231100000331 toxic Toxicity 0.000 description 1
231100000167 toxic agent Toxicity 0.000 description 1
230000002588 toxic effect Effects 0.000 description 1
239000003440 toxic substance Substances 0.000 description 1
239000013026 undiluted sample Substances 0.000 description 1
235000021119 whey protein Nutrition 0.000 description 1

Classifications

- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/96—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving blood or serum control standard
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
- G01N15/10—Investigating individual particles
- G01N15/1031—Investigating individual particles by measuring electrical or magnetic effects
- G01N15/12—Investigating individual particles by measuring electrical or magnetic effects by observing changes in resistance or impedance across apertures when traversed by individual particles, e.g. by using the Coulter principle
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
- G01N15/10—Investigating individual particles
- G01N15/1031—Investigating individual particles by measuring electrical or magnetic effects
- G01N15/12—Investigating individual particles by measuring electrical or magnetic effects by observing changes in resistance or impedance across apertures when traversed by individual particles, e.g. by using the Coulter principle
- G01N15/131—Details
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
- G01N33/5094—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for blood cell populations
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2496/00—Reference solutions for assays of biological material
- G01N2496/05—Reference solutions for assays of biological material containing blood cells or plasma
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T436/00—Chemistry: analytical and immunological testing
- Y10T436/10—Composition for standardization, calibration, simulation, stabilization, preparation or preservation; processes of use in preparation for chemical testing
- Y10T436/101666—Particle count or volume standard or control [e.g., platelet count standards, etc.]
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T436/00—Chemistry: analytical and immunological testing
- Y10T436/10—Composition for standardization, calibration, simulation, stabilization, preparation or preservation; processes of use in preparation for chemical testing
- Y10T436/105831—Protein or peptide standard or control [e.g., hemoglobin, etc.]
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T436/00—Chemistry: analytical and immunological testing
- Y10T436/10—Composition for standardization, calibration, simulation, stabilization, preparation or preservation; processes of use in preparation for chemical testing
- Y10T436/106664—Blood serum or blood plasma standard or control
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T436/00—Chemistry: analytical and immunological testing
- Y10T436/10—Composition for standardization, calibration, simulation, stabilization, preparation or preservation; processes of use in preparation for chemical testing
- Y10T436/107497—Preparation composition [e.g., lysing or precipitation, etc.]
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T436/00—Chemistry: analytical and immunological testing
- Y10T436/10—Composition for standardization, calibration, simulation, stabilization, preparation or preservation; processes of use in preparation for chemical testing
- Y10T436/108331—Preservative, buffer, anticoagulant or diluent

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Chemical & Material Sciences (AREA)
Immunology (AREA)
Engineering & Computer Science (AREA)
Hematology (AREA)
General Physics & Mathematics (AREA)
General Health & Medical Sciences (AREA)
Biochemistry (AREA)
Analytical Chemistry (AREA)
Pathology (AREA)
Molecular Biology (AREA)
Physics & Mathematics (AREA)
Urology & Nephrology (AREA)
Biomedical Technology (AREA)
Cell Biology (AREA)
Microbiology (AREA)
Biotechnology (AREA)
Dispersion Chemistry (AREA)
Food Science & Technology (AREA)
Medicinal Chemistry (AREA)
Tropical Medicine & Parasitology (AREA)
Ecology (AREA)
Investigating Or Analysing Biological Materials (AREA)
Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

FI752687A 1975-01-13 1975-09-25 Spaedningsmedel foer utspaedning av blodprov FI59173C (fi)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US05/540,584 US3962125A (en)	1975-01-13	1975-01-13	Multi-purpose diluent for use in blood analysis by electronic instrumentation of the coulter type
US54058475		1975-01-13

Publications (3)

Publication Number	Publication Date
FI752687A FI752687A (de)	1976-07-14
FI59173B FI59173B (fi)	1981-02-27
FI59173C true FI59173C (fi)	1981-06-10

Family

ID=24156076

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
FI752687A FI59173C (fi)	1975-01-13	1975-09-25	Spaedningsmedel foer utspaedning av blodprov

Country Status (18)

Country	Link
US (2)	US3962125A (de)
JP (1)	JPS5422319B2 (de)
AU (1)	AU502597B2 (de)
BE (1)	BE834872A (de)
CA (1)	CA1045960A (de)
CH (1)	CH612010A5 (de)
DE (1)	DE2553918C3 (de)
DK (1)	DK145476C (de)
FI (1)	FI59173C (de)
FR (1)	FR2297422A1 (de)
GB (1)	GB1475470A (de)
IE (1)	IE41665B1 (de)
IL (1)	IL48053A (de)
IT (1)	IT1047096B (de)
NL (1)	NL162210C (de)
NO (1)	NO146174C (de)
SE (1)	SE409374B (de)
ZA (1)	ZA755824B (de)

Families Citing this family (78)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3962125A (en) *	1975-01-13	1976-06-08	Coulter Diagnostics, Inc.	Multi-purpose diluent for use in blood analysis by electronic instrumentation of the coulter type
JPS5258993A (en) *	1975-11-10	1977-05-14	Toa Medical Electronics	Preparation method of blood diluting liquids for blood inspection
CA1076008A (en) *	1976-03-26	1980-04-22	Coulter Electronics	Stabilized hematological reagent solutions
US4090977A (en) *	1976-11-22	1978-05-23	Research Corporation	Osmotically balanced anticoaglant
US4179398A (en) *	1977-03-21	1979-12-18	ICN Medical Laboratories, Inc.	Platelet control composition
US4160644A (en) *	1977-06-13	1979-07-10	Streck Laboratories, Inc.	Platelet reference control and method of preparation
CA1101300A (en) *	1978-05-26	1981-05-19	John Foerster	Preservative solutions containing sodium dehydroacetate with or without sodium borate decahydrate and/or disodium edetate
US4219440A (en) *	1979-06-06	1980-08-26	Coulter Electronics, Inc.	Multiple analysis hematology reference control reagent and method of making the same
US4288343A (en) *	1978-07-17	1981-09-08	Beckman Instruments, Inc.	Method for increasing shelf-life of a serum bilirubin reference composition and composition produced thereby
US4213876A (en) *	1978-08-22	1980-07-22	Coulter Electronics, Inc.	Multi-purpose blood diluent for use in electronic blood analysis instrumentation
US4282326A (en) *	1978-10-12	1981-08-04	Jeanne Moldenhauer	Cell culture medium supplement
DE2850603A1 (de) *	1978-11-22	1980-06-19	Merck Patent Gmbh	Haemolysierloesung und verfahren zur haemolyse von blut
US4250051A (en) *	1978-12-26	1981-02-10	Coulter Electronics, Inc.	Preservative for use in calibrator compositions for blood analysis
US4324687A (en) *	1979-02-15	1982-04-13	Louderback Allan Lee	Blood biochemistry control standard
US4403038A (en) *	1979-04-11	1983-09-06	Toshio Asakura	Buffered serum substitute for blood oxygen analyzer
US4358394A (en) *	1979-05-07	1982-11-09	Coulter Electronics, Inc.	Process for preparing whole blood reference controls having long term stability
US4299726A (en) *	1979-05-07	1981-11-10	Coulter Electronics, Inc.	Process for preparing whole blood reference controls having long term stability, preconditioning diluent and media therefor
US4259207A (en) *	1979-09-19	1981-03-31	American Hospital Supply Corporation	Suspending medium for immunologic reactions
US4311482A (en) *	1979-10-09	1982-01-19	Abbott Laboratories	Method and apparatus for collecting blood samples
US4286963A (en) *	1979-11-23	1981-09-01	Coulter Electronics, Inc.	Differential lymphoid-myeloid determination of leukocytes in whole blood
US4244837A (en) *	1979-12-03	1981-01-13	Coulter Electronics, Inc.	Multi-purpose blood diluent for use in electronic blood analysis instrumentation
US4962038A (en) *	1980-06-16	1990-10-09	Coulter Electronics, Inc.	Multi-purpose blood diluent and lysing agent for differential determination of lymphoid-myeloid population of leukocytes
US4346018A (en) *	1980-06-16	1982-08-24	Coulter Electronics, Inc.	Multi-purpose blood diluent and lysing agent for differential determination of lymphoid-myeloid population of leukocytes
US4521518A (en) *	1980-06-16	1985-06-04	Coulter Electronics, Inc.	Multi-purpose blood diluent and lysing agent for differential determination of lymphoid-myeloid population of leukocytes
US4322313A (en) *	1980-10-02	1982-03-30	J. T. Baker Chemicals B.V.	Stabilized multi-purpose blood diluent
US4405719A (en) *	1981-05-29	1983-09-20	Coulter Electronics, Inc.	Method of stabilizing platelets for determining multiple platelet parameters in reference control and calibrator compositions; diluents therefor; and combination stabilization procedures
US4389490A (en) *	1981-05-29	1983-06-21	Coulter Electronics, Inc.	Method of stabilizing platelets for determining multiple platelet parameters in reference control and calibrator compositions; and diluents thereof
US5045472A (en) *	1981-06-26	1991-09-03	Technicon Instruments Corporation	Reagent mixture and composition for treating red blood cells to effect sphering
US4465774A (en) *	1981-07-16	1984-08-14	Sherwood Medical Company	Standard or control material for glysocylated or total hemoglobin determination
US4668618A (en) *	1981-09-14	1987-05-26	Thornthwaite Jerry T	Nuclear isolation medium and procedure for separating cell nuclei
US4906561A (en) *	1981-09-14	1990-03-06	Thornthwaite Jerry T	Nuclear isolation medium and procedure for separating cell nuclei
US4489162A (en) *	1981-12-21	1984-12-18	American Hospital Supply Corporation	Fresh blood (unfixed) hematology control
US4528274A (en) *	1982-07-06	1985-07-09	Coulter Electronics, Inc.	Multi-purpose blood diluent and lysing agent for differential determination of lymphoid-myeloid population of leukocytes
US4485174A (en) *	1982-09-29	1984-11-27	Instrumentation Laboratory Inc.	Hemoglobin-based blood gas control
US4506018A (en) *	1982-12-30	1985-03-19	Becton, Dickinson And Company	Blood diluent
US4579824A (en) *	1983-05-18	1986-04-01	Louderback Allan Lee	Hematology control
US4529705A (en) *	1983-06-06	1985-07-16	Coulter Electronics, Inc.	Reagent for combined diluting and lysing whole blood
US4637986A (en) *	1983-08-22	1987-01-20	Ortho Diagnostic Systems, Inc.	Flow cytometry lysing reagent with leukoprotective agent for producing a 3-part WBC count
JPS61502280A (ja) *	1984-05-31	1986-10-09	ク−ルタ−・エレクトロニクス・インコ−ポレ−テッド	白血球のクラスおよびサブクラスの同定、計数並びに試験方法およびそれに用いる試薬系
US4717654A (en) *	1984-06-19	1988-01-05	Akzo N.V.	Process for solid phase platelet antibody assay
US4818703A (en) *	1985-10-23	1989-04-04	Pizzolante John M	Stabilized alkaline picrate reagent for jaffe creatinine determination
US4968629A (en) *	1986-08-20	1990-11-06	Hematology Marketing Associates, Inc.	Blood diluent for automatic and semi-automatic determination of white cells and method of utilizing same
IL85532A (en) *	1987-03-13	1992-03-29	Coulter Electronics	Method and lytic reagent system for isolation,identification and/or analysis of leukocytes from whole blood samples
GB8722252D0 (en) *	1987-09-22	1987-10-28	Brewing Res Found	Atp extraction
US5008202A (en) *	1988-11-29	1991-04-16	Sequoia Turner Corporation	Blood diluent for red blood cell analysis
WO1990006055A1 (en) *	1988-11-29	1990-06-14	Unilever Plc	Antimicrobial agents and uses thereof
CA2016699C (en) *	1989-05-15	2003-11-18	Paul N. Marshall	Lytic agents and uses thereof
DE3938907C2 (de) *	1989-11-24	1999-11-04	Dade Behring Marburg Gmbh	Mittel zum Lagern und Suspendieren von Zellen, insbesondere Erythrozyten
US5098603A (en) *	1990-01-16	1992-03-24	Eastman Kodak Company	Stabilized phenol solution
US5620852A (en) *	1990-11-14	1997-04-15	Hri Research, Inc.	Nucleic acid preparation methods
US5654179A (en) *	1990-11-14	1997-08-05	Hri Research, Inc.	Nucleic acid preparation methods
IL113805A0 (en) *	1994-05-23	1995-08-31	Coulter Corp	Detection of reticulocytes
AU3094695A (en) *	1994-07-14	1996-02-16	Abbott Laboratories	Methods and reagents for cyanide-free determination of hemoglobin and leukocytes in whole blood
US5834315A (en) *	1994-12-23	1998-11-10	Coulter Corporation	Cyanide-free reagent and method for hemoglobin determination and leukocyte differentitation
US5888752A (en) *	1995-05-16	1999-03-30	Bayer Corporation	Universal rinse reagent and method for use in hematological analyses of whole blood samples
US5888822A (en) *	1995-10-04	1999-03-30	Hycor Biomedical Inc.	Erythrocyte sedimentation rate control
GB9526676D0 (en)	1995-12-29	1996-02-28	Shine Thomas A	Method for testing a cell suspension
IT1288767B1 (it) *	1996-10-18	1998-09-24	Hospal Dasco Spa	Metodo di determinazione del valore del ricircolo di una sospensione sottoposta a trattamento.
US5895760A (en) *	1997-02-04	1999-04-20	Hycor Biomedical, Inc.	Erythrocyte sedimentation rate control
US5935857A (en) *	1997-08-01	1999-08-10	Coulter International Corp.	Blood diluent
US6060322A (en) *	1998-10-20	2000-05-09	Coulter International Corp.	Method for identification of reticulated cells
US6271035B1 (en)	1998-10-20	2001-08-07	Coulter International Corp.	Methods and compositions for rapid staining of nucleic acids in whole cells
US6159682A (en) *	1999-04-30	2000-12-12	Streck Laboratories, Inc.	Blood control and system for erythrocyte sedimentation measurement
US6124089A (en) *	1999-04-30	2000-09-26	Streck Laboratories, Inc.	Blood control and system for erythrocyte sedimentation measurement
US6368864B1 (en)	2000-05-05	2002-04-09	Coulter International Corp.	Dyes and methods of reticulocyte enumeration
US6531321B1 (en)	2000-09-15	2003-03-11	Streck Laboratories, Inc.	Blood control and system for erythrocyte sedimentation measurement
US7217570B2 (en) *	2001-08-23	2007-05-15	The Wistar Institute Of Anatomy And Biology	Organotypic intestinal culture and methods of use thereof
US20040031067A1 (en) *	2001-10-11	2004-02-12	Meenhard Herlyn	Regulation of human skin healing
EP1522593A4 (de) *	2002-07-17	2008-07-23	Arkray Inc	Verfahren zum abbau von protein mit einer sulfonsäureverbindung
US6941005B2 (en) *	2002-11-01	2005-09-06	Coulter International Corp.	Monitoring and control of droplet sorting
US6955872B2 (en) *	2003-03-20	2005-10-18	Coulter International Corp.	Dye compositions which provide enhanced differential fluorescence and light scatter characteristics
US7674598B2 (en) *	2004-05-21	2010-03-09	Beckman Coulter, Inc.	Method for a fully automated monoclonal antibody-based extended differential
US7625712B2 (en) *	2004-05-21	2009-12-01	Beckman Coulter, Inc.	Method for a fully automated monoclonal antibody-based extended differential
US7560283B2 (en) *	2006-01-27	2009-07-14	Bio-Rad Laboratories, Inc.	Storage-stable cellular whole blood composition containing elevated amounts of D-dimer
WO2009058876A1 (en)	2007-10-29	2009-05-07	Beckman Coulter, Inc.	Method for a rapid antibody-based analysis of platelet populations
US20120326671A1 (en)	2010-03-15	2012-12-27	Brusa Elektronik Ag	Balancing the states of charge of charge accumulators
US9091677B2 (en)	2010-08-09	2015-07-28	Beckman Coulter, Inc.	Isotonic buffered composition and method that enables counting of cells
CN109540645B (zh) *	2019-01-23	2021-10-15	北京仁基源医学研究院有限公司	核型分析专用制备高分辨染色体带纹解析液

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3412037A (en) *	1966-01-26	1968-11-19	Technicon Corp	Method and means for the calibration of particle counting apparatus
US3519572A (en) *	1966-10-03	1970-07-07	Pfizer & Co C	Blood control
US3546131A (en) *	1968-07-05	1970-12-08	Uni Tech Chem Mfg Co	Stabilized cyanmethemoglobin reagent containing ferricyanide,cyanide and polyvinylpyrrolidone
US3574137A (en) *	1969-02-25	1971-04-06	Pfizer	Multiple-analysis hematology control comprising human red blood cells and fowl red blood cells in an anticoagulant containing human serologically compatible plasma medium
US3558522A (en) *	1969-03-05	1971-01-26	Baxter Laboratories Inc	Hematology control standard comprising washed red blood cells and synthetic latex particles
US3632735A (en) *	1970-03-11	1972-01-04	Pfizer & Co C	Method of stabilizing fowl red blood cells for use in hematology control compositions
US3859049A (en) *	1973-09-14	1975-01-07	Arnold G Ware	Blood reference standard and process for blood gas test
US3873467A (en) *	1974-02-01	1975-03-25	United Medical Lab Inc	Hematologic reference control
US3874852A (en) *	1974-07-05	1975-04-01	Coulter Diagnostics Inc	Reagent and method for determining leukocytes and hemoglobin in the blood
US3962125A (en) *	1975-01-13	1976-06-08	Coulter Diagnostics, Inc.	Multi-purpose diluent for use in blood analysis by electronic instrumentation of the coulter type
US3964865A (en) *	1975-01-30	1976-06-22	Sigma Chemical Company	Lyophilized human hemoglobin standard for colorimetric determination of total hemoglobin

1975
- 1975-01-13 US US05/540,584 patent/US3962125A/en not_active Expired - Lifetime
- 1975-09-03 IE IE1919/75A patent/IE41665B1/en unknown
- 1975-09-04 IL IL48053A patent/IL48053A/xx unknown
- 1975-09-04 CA CA234,776A patent/CA1045960A/en not_active Expired
- 1975-09-12 GB GB3765175A patent/GB1475470A/en not_active Expired
- 1975-09-12 ZA ZA755824A patent/ZA755824B/xx unknown
- 1975-09-15 AU AU84846/75A patent/AU502597B2/en not_active Expired
- 1975-09-18 FR FR7528583A patent/FR2297422A1/fr active Granted
- 1975-09-23 SE SE7510626A patent/SE409374B/xx unknown
- 1975-09-23 CH CH1232275A patent/CH612010A5/xx not_active IP Right Cessation
- 1975-09-24 IT IT51486/75A patent/IT1047096B/it active
- 1975-09-25 DK DK432075A patent/DK145476C/da active
- 1975-09-25 FI FI752687A patent/FI59173C/fi not_active IP Right Cessation
- 1975-09-26 NO NO753282A patent/NO146174C/no unknown
- 1975-10-09 NL NL7511844.A patent/NL162210C/xx not_active IP Right Cessation
- 1975-10-24 BE BE6045229A patent/BE834872A/xx not_active IP Right Cessation
- 1975-11-20 JP JP13882475A patent/JPS5422319B2/ja not_active Expired
- 1975-12-01 DE DE2553918A patent/DE2553918C3/de not_active Expired
1976
- 1976-03-26 US US05/670,924 patent/US4102810A/en not_active Expired - Lifetime

Also Published As

Publication number	Publication date
JPS5181696A (de)	1976-07-17
IL48053A0 (en)	1975-11-25
US3962125A (en)	1976-06-08
NL7511844A (nl)	1976-07-15
NO146174B (no)	1982-05-03
ZA755824B (en)	1977-04-27
SE7510626L (sv)	1976-07-14
DK145476C (da)	1983-04-18
BE834872A (fr)	1976-04-26
FI752687A (de)	1976-07-14
AU8484675A (en)	1977-03-24
FI59173B (fi)	1981-02-27
AU502597B2 (en)	1979-08-02
DE2553918C3 (de)	1979-11-22
NO146174C (no)	1982-08-11
JPS5422319B2 (de)	1979-08-06
FR2297422B1 (de)	1978-08-25
IL48053A (en)	1978-12-17
IT1047096B (it)	1980-09-10
GB1475470A (en)	1977-06-01
NL162210B (nl)	1979-11-15
DK432075A (da)	1976-07-14
DK145476B (da)	1982-11-22
NO753282L (de)	1976-07-14
NL162210C (nl)	1980-04-15
FR2297422A1 (fr)	1976-08-06
CA1045960A (en)	1979-01-09
DE2553918A1 (de)	1976-09-16
US4102810A (en)	1978-07-25
DE2553918B2 (de)	1979-03-29
CH612010A5 (de)	1979-06-29
IE41665L (en)	1976-07-13
SE409374B (sv)	1979-08-13
IE41665B1 (en)	1980-02-27

Legal Events

Date	Code	Title	Description
2004-08-31	MM	Patent lapsed	Owner name: COULTER ELECTRONICS INC.

Publication	Publication Date	Title
FI59173C (fi)	1981-06-10	Spaedningsmedel foer utspaedning av blodprov
US4213876A (en)	1980-07-22	Multi-purpose blood diluent for use in electronic blood analysis instrumentation
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Fogh-Andersen et al.	1978	Measurement of free calcium ion in capillary blood and serum.
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US4506018A (en)	1985-03-19	Blood diluent
US4322313A (en)	1982-03-30	Stabilized multi-purpose blood diluent
Li et al.	1971	Determination of serum ionic calcium with an ion-selective electrode: Evaluation of methodology and normal values
Brittin et al.	1969	Evaluation of the Coulter counter model S
US4090977A (en)	1978-05-23	Osmotically balanced anticoaglant
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Ben Rayana et al.	2008	IFCC guideline for sampling, measuring and reporting ionized magnesium in plasma
WO1997015829A1 (en)	1997-05-01	Measurement of carbon dioxide in blood
STEEL et al.	1977	The application of an electronic particle counter with a mean cell volume computer and an hematocrit accessory to avian hematology
Lucas et al.	1983	Comparison of initial-flow-rate and positive-pressure filtration methods for the study of erythrocyte deformability
Ryan et al.	1990	A new platelet function test
Rushton et al.	1973	Measurement of total, ultrafilterable and ionised serum calcium
CN1072020A (zh)	1993-05-12	多用途血液稀释剂
Bremmelgaard et al.	1991	Interference by cryoglobulins with white blood cell measurements on Coulter Counter
JP4231721B2 (ja)	2009-03-04	補体価測定用試薬及びそれを用いた補体価測定値の安定化方法
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Dow et al.	1967	Determination of the chloride content of small muscle samples
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