FI20060533L - Enhanced expression of tuberculosis vaccine proteins in plants - Google Patents
Enhanced expression of tuberculosis vaccine proteins in plants Download PDFInfo
- Publication number
- FI20060533L FI20060533L FI20060533A FI20060533A FI20060533L FI 20060533 L FI20060533 L FI 20060533L FI 20060533 A FI20060533 A FI 20060533A FI 20060533 A FI20060533 A FI 20060533A FI 20060533 L FI20060533 L FI 20060533L
- Authority
- FI
- Finland
- Prior art keywords
- proteins
- tuberculosis vaccine
- plants
- enhanced expression
- vaccine proteins
- Prior art date
Links
- 108090000623 proteins and genes Proteins 0.000 title abstract 7
- 102000004169 proteins and genes Human genes 0.000 title abstract 5
- 229960002109 tuberculosis vaccine Drugs 0.000 title abstract 4
- 230000014509 gene expression Effects 0.000 title abstract 2
- 108020004635 Complementary DNA Proteins 0.000 abstract 1
- 241000700605 Viruses Species 0.000 abstract 1
- 238000009825 accumulation Methods 0.000 abstract 1
- 238000001261 affinity purification Methods 0.000 abstract 1
- 230000001413 cellular effect Effects 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 210000000056 organ Anatomy 0.000 abstract 1
- 238000000746 purification Methods 0.000 abstract 1
- 230000001105 regulatory effect Effects 0.000 abstract 1
- 230000003362 replicative effect Effects 0.000 abstract 1
- 230000009466 transformation Effects 0.000 abstract 1
- 230000010474 transient expression Effects 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01H—NEW PLANTS OR NON-TRANSGENIC PROCESSES FOR OBTAINING THEM; PLANT REPRODUCTION BY TISSUE CULTURE TECHNIQUES
- A01H5/00—Angiosperms, i.e. flowering plants, characterised by their plant parts; Angiosperms characterised otherwise than by their botanic taxonomy
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
- C12N15/8241—Phenotypically and genetically modified plants via recombinant DNA technology
- C12N15/8242—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits
- C12N15/8257—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits for the production of primary gene products, e.g. pharmaceutical products, interferon
- C12N15/8258—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits for the production of primary gene products, e.g. pharmaceutical products, interferon for the production of oral vaccines (antigens) or immunoglobulins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/02—Bacterial antigens
- A61K39/04—Mycobacterium, e.g. Mycobacterium tuberculosis
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Genetics & Genomics (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Molecular Biology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Organic Chemistry (AREA)
- Biomedical Technology (AREA)
- Wood Science & Technology (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Microbiology (AREA)
- Physics & Mathematics (AREA)
- Plant Pathology (AREA)
- Biophysics (AREA)
- Cell Biology (AREA)
- Biochemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Immunology (AREA)
- Mycology (AREA)
- Pulmonology (AREA)
- Communicable Diseases (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Physiology (AREA)
- Botany (AREA)
- Developmental Biology & Embryology (AREA)
- Environmental Sciences (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Abstract
The present invention provides constructs and methods for expression and accumulation of tuberculosis vaccine proteins in tissue or organ of a plant. The proteins are obtained by transient expression in and/or stable transformation of plants with non-replicating genes or virus-based vector cDNAs encoding the proteins. The genes include cellular compartment-specific, regulatory and/or affinity purification tag sequences. The plant tissue fractions containing the tuberculosis vaccine proteins themselves or after purification are useful as a tuberculosis vaccine.
Priority Applications (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FI20060533A FI20060533L (en) | 2006-06-01 | 2006-06-01 | Enhanced expression of tuberculosis vaccine proteins in plants |
PCT/FI2007/000147 WO2007138155A1 (en) | 2006-06-01 | 2007-05-30 | Improved expression of tuberculosis vaccine proteins in plants |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FI20060533A FI20060533L (en) | 2006-06-01 | 2006-06-01 | Enhanced expression of tuberculosis vaccine proteins in plants |
Publications (2)
Publication Number | Publication Date |
---|---|
FI20060533A0 FI20060533A0 (en) | 2006-06-01 |
FI20060533L true FI20060533L (en) | 2007-12-02 |
Family
ID=36651361
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
FI20060533A FI20060533L (en) | 2006-06-01 | 2006-06-01 | Enhanced expression of tuberculosis vaccine proteins in plants |
Country Status (2)
Country | Link |
---|---|
FI (1) | FI20060533L (en) |
WO (1) | WO2007138155A1 (en) |
Families Citing this family (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
IT1394596B1 (en) * | 2008-09-30 | 2012-07-05 | Fond Parco Tecnologico Padano | PRODUCTION OF NGF IN PLANT. |
CN101845456B (en) * | 2010-03-31 | 2012-11-21 | 暨南大学 | Corn expression vector of tubercle Ag85B gene and application thereof |
US20150196627A1 (en) * | 2011-10-24 | 2015-07-16 | University Of Central Florida Research Foundation, Inc. | Plastid-expressed mycobacterium tuberculosis vaccine antigens esat-6 and mtb72f fused to cholera toxin b subunit |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE10143205A1 (en) * | 2001-09-04 | 2003-03-20 | Icon Genetics Ag | Process for protein production in plants |
DE10321963A1 (en) * | 2003-05-15 | 2004-12-02 | Icon Genetics Ag | Process for the production of a plastid-directed protein in plant cells |
-
2006
- 2006-06-01 FI FI20060533A patent/FI20060533L/en unknown
-
2007
- 2007-05-30 WO PCT/FI2007/000147 patent/WO2007138155A1/en active Application Filing
Also Published As
Publication number | Publication date |
---|---|
WO2007138155A1 (en) | 2007-12-06 |
FI20060533A0 (en) | 2006-06-01 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
BR112015005674A2 (en) | hppd variants and methods of use | |
TR201803560T4 (en) | Preparation methods of plant derived proteins. | |
MX2013007678A (en) | Nucleic acid molecules that target the rho1 small gtp-binding protein and confer resistance to coleopteran pests. | |
UA109418C2 (en) | Zinc Finger Protein Designed for Plant Genes Involved in Fatty Acid Biosynthesis | |
CO6620067A2 (en) | Delta genes -endotoxins axmi218, axmi219, axmi220, axmi226, axmi227, axmi228, axmi229, axmi230 and axmi231 and methods for use | |
MX357803B (en) | Artificial nucleic acid molecules. | |
MX2013003681A (en) | Engineered nucleic acids and methods of use thereof. | |
MX358706B (en) | Artificial nucleic acid molecules comprising a 5'top utr. | |
CO6630079A2 (en) | Delta genes -endotoxins axmi221z, axmi222z, axmi223z, axmi224z and axmi225z and methods for use | |
AR061467A1 (en) | AXMI-031 AXMI-039 AXMI-040 AND AXMI-049 A FAMILY OF NEW DELTA-ENDOTOXIN GENES AND METHODS FOR USE | |
MX2011000047A (en) | Use of plant-derived recombinant growth factors in skin care. | |
EA201171006A1 (en) | VARIANT GENES AXMI-R1 DELTA-ENDOTOXIN AND METHODS FOR THEIR APPLICATION | |
MX2008011038A (en) | Plants having increased yield and a method for making the same. | |
AR067672A1 (en) | PLANTS THAT HAVE IMPROVED FEATURES RELATED TO PERFORMANCE AND A METHOD FOR OBTAINING THEM | |
AR075799A1 (en) | METHODS AND COMPOSITIONS FOR CONTROLLING PLANT PESTS | |
UY35366A (en) | ? TOXINE GENES AND METHODS FOR USE ?. | |
AR070693A1 (en) | PLANTS THAT HAVE INCREASED FEATURES RELATED TO PERFORMANCE AND A METHOD FOR OBTAINING THEM FROM THE EXPRESSION OF NITRATE 2 POLYPEPTIDE (NRT2) | |
BR112012009381A2 (en) | "insecticide proteins" | |
PE20220960A1 (en) | PROTEINS OF VARIANTS OF AMINO ACID SEQUENCES OF CRY1DA1 ACTIVE FOR LEPIDOPTERA | |
UA115235C2 (en) | Bacillus thuringiensis toxin gene axmi335 and methods for its use | |
EA201270001A1 (en) | DROUGHT RESISTANT PLANTS | |
CR20200121A (en) | Plant regulatory elements and uses thereof | |
MX2018010353A (en) | Antifungal plant proteins, peptides, and methods of use. | |
MX366170B (en) | Nucleic acid sequences and peptides/ proteins of the ft family providing flower-repressing properties in tobacco and transgenic plants transformed therewith. | |
UA113843C2 (en) | BACTERIA TRANSGENIC PLANT CONTAINING T3SS DIFFUNCTIONAL PROTEINS |