FI107020B - Förfarande för framställning av ett transdermalt terapeutiskt plåster - Google Patents
Förfarande för framställning av ett transdermalt terapeutiskt plåster Download PDFInfo
- Publication number
- FI107020B FI107020B FI934189A FI934189A FI107020B FI 107020 B FI107020 B FI 107020B FI 934189 A FI934189 A FI 934189A FI 934189 A FI934189 A FI 934189A FI 107020 B FI107020 B FI 107020B
- Authority
- FI
- Finland
- Prior art keywords
- layer
- sensitive adhesive
- pressure
- drug
- drug reservoir
- Prior art date
Links
- 238000004519 manufacturing process Methods 0.000 title claims abstract description 12
- 230000001225 therapeutic effect Effects 0.000 title claims abstract description 10
- 239000010410 layer Substances 0.000 claims abstract description 86
- 239000003814 drug Substances 0.000 claims abstract description 50
- 229940079593 drug Drugs 0.000 claims abstract description 46
- 239000004820 Pressure-sensitive adhesive Substances 0.000 claims abstract description 34
- 239000011241 protective layer Substances 0.000 claims abstract description 27
- 238000000034 method Methods 0.000 claims abstract description 15
- 239000013543 active substance Substances 0.000 claims abstract description 13
- 238000004080 punching Methods 0.000 claims abstract description 5
- 230000004888 barrier function Effects 0.000 claims description 13
- 238000002360 preparation method Methods 0.000 claims description 5
- 241000220317 Rosa Species 0.000 claims 1
- 235000013351 cheese Nutrition 0.000 claims 1
- 229920000642 polymer Polymers 0.000 description 15
- 238000005520 cutting process Methods 0.000 description 10
- 239000000853 adhesive Substances 0.000 description 9
- XEKOWRVHYACXOJ-UHFFFAOYSA-N Ethyl acetate Chemical compound CCOC(C)=O XEKOWRVHYACXOJ-UHFFFAOYSA-N 0.000 description 6
- 239000000654 additive Substances 0.000 description 6
- 239000012790 adhesive layer Substances 0.000 description 6
- 229920001577 copolymer Polymers 0.000 description 6
- 229920001296 polysiloxane Polymers 0.000 description 6
- 230000001070 adhesive effect Effects 0.000 description 5
- 238000000576 coating method Methods 0.000 description 5
- 239000007788 liquid Substances 0.000 description 5
- 229920006267 polyester film Polymers 0.000 description 5
- PPBRXRYQALVLMV-UHFFFAOYSA-N Styrene Chemical compound C=CC1=CC=CC=C1 PPBRXRYQALVLMV-UHFFFAOYSA-N 0.000 description 4
- YRKCREAYFQTBPV-UHFFFAOYSA-N acetylacetone Chemical compound CC(=O)CC(C)=O YRKCREAYFQTBPV-UHFFFAOYSA-N 0.000 description 4
- 239000011248 coating agent Substances 0.000 description 4
- 239000000463 material Substances 0.000 description 4
- 239000011159 matrix material Substances 0.000 description 4
- 239000004014 plasticizer Substances 0.000 description 4
- -1 spasmolytes Substances 0.000 description 4
- SMZOUWXMTYCWNB-UHFFFAOYSA-N 2-(2-methoxy-5-methylphenyl)ethanamine Chemical compound COC1=CC=C(C)C=C1CCN SMZOUWXMTYCWNB-UHFFFAOYSA-N 0.000 description 3
- GOXQRTZXKQZDDN-UHFFFAOYSA-N 2-Ethylhexyl acrylate Chemical compound CCCCC(CC)COC(=O)C=C GOXQRTZXKQZDDN-UHFFFAOYSA-N 0.000 description 3
- NIXOWILDQLNWCW-UHFFFAOYSA-N 2-Propenoic acid Natural products OC(=O)C=C NIXOWILDQLNWCW-UHFFFAOYSA-N 0.000 description 3
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 3
- YXFVVABEGXRONW-UHFFFAOYSA-N Toluene Chemical compound CC1=CC=CC=C1 YXFVVABEGXRONW-UHFFFAOYSA-N 0.000 description 3
- XTXRWKRVRITETP-UHFFFAOYSA-N Vinyl acetate Chemical compound CC(=O)OC=C XTXRWKRVRITETP-UHFFFAOYSA-N 0.000 description 3
- 239000004480 active ingredient Substances 0.000 description 3
- 229920005601 base polymer Polymers 0.000 description 3
- 150000002148 esters Chemical class 0.000 description 3
- 229920000058 polyacrylate Polymers 0.000 description 3
- 239000000126 substance Substances 0.000 description 3
- LLVWLCAZSOLOTF-UHFFFAOYSA-N 1-methyl-4-[1,4,4-tris(4-methylphenyl)buta-1,3-dienyl]benzene Chemical compound C1=CC(C)=CC=C1C(C=1C=CC(C)=CC=1)=CC=C(C=1C=CC(C)=CC=1)C1=CC=C(C)C=C1 LLVWLCAZSOLOTF-UHFFFAOYSA-N 0.000 description 2
- RSWGJHLUYNHPMX-UHFFFAOYSA-N Abietic-Saeure Natural products C12CCC(C(C)C)=CC2=CCC2C1(C)CCCC2(C)C(O)=O RSWGJHLUYNHPMX-UHFFFAOYSA-N 0.000 description 2
- NIXOWILDQLNWCW-UHFFFAOYSA-M Acrylate Chemical compound [O-]C(=O)C=C NIXOWILDQLNWCW-UHFFFAOYSA-M 0.000 description 2
- KHPCPRHQVVSZAH-HUOMCSJISA-N Rosin Natural products O(C/C=C/c1ccccc1)[C@H]1[C@H](O)[C@@H](O)[C@@H](O)[C@@H](CO)O1 KHPCPRHQVVSZAH-HUOMCSJISA-N 0.000 description 2
- 229940035676 analgesics Drugs 0.000 description 2
- 239000000730 antalgic agent Substances 0.000 description 2
- 239000003795 chemical substances by application Substances 0.000 description 2
- 238000004132 cross linking Methods 0.000 description 2
- 239000006185 dispersion Substances 0.000 description 2
- 239000002552 dosage form Substances 0.000 description 2
- 150000002314 glycerols Chemical class 0.000 description 2
- FUZZWVXGSFPDMH-UHFFFAOYSA-N hexanoic acid Chemical compound CCCCCC(O)=O FUZZWVXGSFPDMH-UHFFFAOYSA-N 0.000 description 2
- 239000000203 mixture Substances 0.000 description 2
- WWZKQHOCKIZLMA-UHFFFAOYSA-N octanoic acid Chemical compound CCCCCCCC(O)=O WWZKQHOCKIZLMA-UHFFFAOYSA-N 0.000 description 2
- 239000002904 solvent Substances 0.000 description 2
- 230000009885 systemic effect Effects 0.000 description 2
- KHPCPRHQVVSZAH-UHFFFAOYSA-N trans-cinnamyl beta-D-glucopyranoside Natural products OC1C(O)C(O)C(CO)OC1OCC=CC1=CC=CC=C1 KHPCPRHQVVSZAH-UHFFFAOYSA-N 0.000 description 2
- VSKJLJHPAFKHBX-UHFFFAOYSA-N 2-methylbuta-1,3-diene;styrene Chemical compound CC(=C)C=C.C=CC1=CC=CC=C1.C=CC1=CC=CC=C1 VSKJLJHPAFKHBX-UHFFFAOYSA-N 0.000 description 1
- JYZLSYFPFQTNNO-UHFFFAOYSA-N 2-octyldecan-1-ol Chemical compound CCCCCCCCC(CO)CCCCCCCC JYZLSYFPFQTNNO-UHFFFAOYSA-N 0.000 description 1
- 229920000298 Cellophane Polymers 0.000 description 1
- CERQOIWHTDAKMF-UHFFFAOYSA-M Methacrylate Chemical compound CC(=C)C([O-])=O CERQOIWHTDAKMF-UHFFFAOYSA-M 0.000 description 1
- 208000019695 Migraine disease Diseases 0.000 description 1
- 229920002367 Polyisobutene Polymers 0.000 description 1
- 239000000219 Sympatholytic Substances 0.000 description 1
- 239000000150 Sympathomimetic Substances 0.000 description 1
- RTAQQCXQSZGOHL-UHFFFAOYSA-N Titanium Chemical compound [Ti] RTAQQCXQSZGOHL-UHFFFAOYSA-N 0.000 description 1
- 230000002159 abnormal effect Effects 0.000 description 1
- 238000010521 absorption reaction Methods 0.000 description 1
- 239000008186 active pharmaceutical agent Substances 0.000 description 1
- 229910052782 aluminium Inorganic materials 0.000 description 1
- XAGFODPZIPBFFR-UHFFFAOYSA-N aluminium Chemical compound [Al] XAGFODPZIPBFFR-UHFFFAOYSA-N 0.000 description 1
- 230000003288 anthiarrhythmic effect Effects 0.000 description 1
- 239000003242 anti bacterial agent Substances 0.000 description 1
- 230000000844 anti-bacterial effect Effects 0.000 description 1
- 230000001166 anti-perspirative effect Effects 0.000 description 1
- 230000001754 anti-pyretic effect Effects 0.000 description 1
- 239000003416 antiarrhythmic agent Substances 0.000 description 1
- 229940088710 antibiotic agent Drugs 0.000 description 1
- 239000003146 anticoagulant agent Substances 0.000 description 1
- 229940127219 anticoagulant drug Drugs 0.000 description 1
- 239000002220 antihypertensive agent Substances 0.000 description 1
- 229940030600 antihypertensive agent Drugs 0.000 description 1
- 239000003213 antiperspirant Substances 0.000 description 1
- 239000002221 antipyretic Substances 0.000 description 1
- 229940125716 antipyretic agent Drugs 0.000 description 1
- 239000003899 bactericide agent Substances 0.000 description 1
- 239000002368 cardiac glycoside Substances 0.000 description 1
- 229940097217 cardiac glycoside Drugs 0.000 description 1
- 239000000969 carrier Substances 0.000 description 1
- 239000001913 cellulose Substances 0.000 description 1
- 229920002678 cellulose Polymers 0.000 description 1
- 239000013522 chelant Substances 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 238000010924 continuous production Methods 0.000 description 1
- 229940124558 contraceptive agent Drugs 0.000 description 1
- 239000003433 contraceptive agent Substances 0.000 description 1
- 239000003218 coronary vasodilator agent Substances 0.000 description 1
- 230000001419 dependent effect Effects 0.000 description 1
- 206010012601 diabetes mellitus Diseases 0.000 description 1
- 238000009792 diffusion process Methods 0.000 description 1
- 238000002224 dissection Methods 0.000 description 1
- 238000012377 drug delivery Methods 0.000 description 1
- 229940088679 drug related substance Drugs 0.000 description 1
- 238000001035 drying Methods 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 229920001971 elastomer Polymers 0.000 description 1
- 239000003623 enhancer Substances 0.000 description 1
- 239000004744 fabric Substances 0.000 description 1
- 239000000945 filler Substances 0.000 description 1
- 239000011888 foil Substances 0.000 description 1
- 239000000417 fungicide Substances 0.000 description 1
- 150000004676 glycans Chemical class 0.000 description 1
- 239000002920 hazardous waste Substances 0.000 description 1
- 229920001519 homopolymer Polymers 0.000 description 1
- 239000005556 hormone Substances 0.000 description 1
- 229940088597 hormone Drugs 0.000 description 1
- 239000012943 hotmelt Substances 0.000 description 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 description 1
- 238000010030 laminating Methods 0.000 description 1
- 239000012528 membrane Substances 0.000 description 1
- 150000002734 metacrylic acid derivatives Chemical class 0.000 description 1
- 229910052751 metal Inorganic materials 0.000 description 1
- 239000002184 metal Substances 0.000 description 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 description 1
- 206010027599 migraine Diseases 0.000 description 1
- IBMRTYCHDPMBFN-UHFFFAOYSA-N monomethyl glutaric acid Chemical compound COC(=O)CCCC(O)=O IBMRTYCHDPMBFN-UHFFFAOYSA-N 0.000 description 1
- 230000007935 neutral effect Effects 0.000 description 1
- 230000035515 penetration Effects 0.000 description 1
- 239000000546 pharmaceutical excipient Substances 0.000 description 1
- 239000000825 pharmaceutical preparation Substances 0.000 description 1
- 230000000704 physical effect Effects 0.000 description 1
- 229920000728 polyester Polymers 0.000 description 1
- 229920006254 polymer film Polymers 0.000 description 1
- 229920000307 polymer substrate Polymers 0.000 description 1
- 229920000193 polymethacrylate Polymers 0.000 description 1
- 229920001282 polysaccharide Polymers 0.000 description 1
- 239000005017 polysaccharide Substances 0.000 description 1
- 229920001343 polytetrafluoroethylene Polymers 0.000 description 1
- 239000004810 polytetrafluoroethylene Substances 0.000 description 1
- 229920000915 polyvinyl chloride Polymers 0.000 description 1
- 239000004800 polyvinyl chloride Substances 0.000 description 1
- 229940124811 psychiatric drug Drugs 0.000 description 1
- 230000001105 regulatory effect Effects 0.000 description 1
- 238000000518 rheometry Methods 0.000 description 1
- 238000007789 sealing Methods 0.000 description 1
- 150000003377 silicon compounds Chemical class 0.000 description 1
- 239000003381 stabilizer Substances 0.000 description 1
- 229930002534 steroid glycoside Natural products 0.000 description 1
- 150000008143 steroidal glycosides Chemical class 0.000 description 1
- 238000003860 storage Methods 0.000 description 1
- 230000001975 sympathomimetic effect Effects 0.000 description 1
- 229940064707 sympathomimetics Drugs 0.000 description 1
- 239000004753 textile Substances 0.000 description 1
- 239000010936 titanium Substances 0.000 description 1
- 229910052719 titanium Inorganic materials 0.000 description 1
- 239000003860 topical agent Substances 0.000 description 1
- 230000037317 transdermal delivery Effects 0.000 description 1
- 239000002699 waste material Substances 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
- A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
- A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
- A61K9/7038—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer
- A61K9/7046—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds
- A61K9/7053—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds obtained by reactions only involving carbon to carbon unsaturated bonds, e.g. polyvinyl, polyisobutylene, polystyrene
- A61K9/7061—Polyacrylates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
- A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
- A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
- A61K9/7084—Transdermal patches having a drug layer or reservoir, and one or more separate drug-free skin-adhesive layers, e.g. between drug reservoir and skin, or surrounding the drug reservoir; Liquid-filled reservoir patches
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F13/00—Bandages or dressings; Absorbent pads
- A61F13/02—Adhesive bandages or dressings
- A61F13/0276—Apparatus or processes for manufacturing adhesive dressings or bandages
- A61F2013/0296—Apparatus or processes for manufacturing adhesive dressings or bandages for making transdermal patches (chemical processes excluded)
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T156/00—Adhesive bonding and miscellaneous chemical manufacture
- Y10T156/10—Methods of surface bonding and/or assembly therefor
- Y10T156/1052—Methods of surface bonding and/or assembly therefor with cutting, punching, tearing or severing
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T156/00—Adhesive bonding and miscellaneous chemical manufacture
- Y10T156/10—Methods of surface bonding and/or assembly therefor
- Y10T156/1052—Methods of surface bonding and/or assembly therefor with cutting, punching, tearing or severing
- Y10T156/108—Flash, trim or excess removal
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T156/00—Adhesive bonding and miscellaneous chemical manufacture
- Y10T156/10—Methods of surface bonding and/or assembly therefor
- Y10T156/1052—Methods of surface bonding and/or assembly therefor with cutting, punching, tearing or severing
- Y10T156/1084—Methods of surface bonding and/or assembly therefor with cutting, punching, tearing or severing of continuous or running length bonded web
- Y10T156/1085—One web only
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T156/00—Adhesive bonding and miscellaneous chemical manufacture
- Y10T156/10—Methods of surface bonding and/or assembly therefor
- Y10T156/1089—Methods of surface bonding and/or assembly therefor of discrete laminae to single face of additional lamina
- Y10T156/1092—All laminae planar and face to face
- Y10T156/1093—All laminae planar and face to face with covering of discrete laminae with additional lamina
- Y10T156/1095—Opposed laminae are running length webs
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Dermatology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Preparation (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Steroid Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Claims (2)
1. Förfarande för kontinuerlig framställning av transdermala, terapeutiska lappar, vilka uppvisar ett 5 ryggskikt (1) , läkemedelsreservoarskikt (6) , som innehäl-ler läkemedel och som bildas av tryckkänsligt lim, och ett borttagbart skyddsskikt (3), och under vilket förlusten av läkemedel under framställningen bringats tili ett minimum, kännetecknat därav, att i ett laminat, vilket 10 är närvarande i en bändiiknande form och bestär av ett ryggskikt (1), som innehäller tryckkänsligt lim, och ett borttagbart skyddsskikt (3) , insätts individuella, fyr-kantiga läkemedelsreservoarsektioner (2) , som innehäller tryckkänsligt lim, i längdriktningen efter varandra mellan 15 skikten (1,3), varvid spelrummet mellan läkemedelsreservo-arsektionerna förblir konstant i längdriktningen och bred-den av desamma dimensionerats sä att nämnda ryggskikt (1) och det borttagbara skyddsskiktet (3) star ut ytterom ban-det pä bägge sidorna, varefter ryggskiktet (1), som inne-20 häller tryckkänsligt lim, sedan skärs genom stansning pä sädant sätt, att stanslinjen (la) omger de yttre dimen-sionerna av de individuella läkemedelsreservoarsektionerna (2) pä ett betydande avständ, och de resulterande nätres- .V. terna av det läkemedelsfria ryggskiktet (1) , som innehäl- • « 25 ler tryckkänsligt lim, sedan avlägsnas, och skyddsskiktet • (3) skärs i de resulterande utrymmena mellan läkemedels-reservoarsektionerna (2). • · · *ί#·*
2. Förfarande enligt patentkrav 1, k ä n n e - • « · ’·* t e c k n a t därav, att före anbringandet av läkemedels- 30 reservoarskiktet (2), som innehäller tryckkänsligt lim, pä ryggskiktet (1) , som innehäller tryckkänsligt lim, täcks • « · * : den sida av läkemedelsreservoarskiktet, som innehäller ,; tryckkänsligt lim, som vänder sig mot ryggskiktet med ett > « « spärrskikt (5) som är ogenomträngligt för aktiva substan-35 ser. « I € · • ·
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE4110027 | 1991-03-27 | ||
DE4110027A DE4110027C2 (de) | 1991-03-27 | 1991-03-27 | Verfahren zur Konfektionierung transdermaler therapeutischer Pflaster |
PCT/EP1992/000513 WO1992017237A1 (de) | 1991-03-27 | 1992-03-09 | Transdermales therapeutisches pflaster |
EP9200513 | 1992-03-09 |
Publications (3)
Publication Number | Publication Date |
---|---|
FI934189A FI934189A (fi) | 1993-09-24 |
FI934189A0 FI934189A0 (fi) | 1993-09-24 |
FI107020B true FI107020B (sv) | 2001-05-31 |
Family
ID=6428306
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
FI934189A FI107020B (sv) | 1991-03-27 | 1993-09-24 | Förfarande för framställning av ett transdermalt terapeutiskt plåster |
Country Status (26)
Country | Link |
---|---|
US (1) | US6315854B1 (sv) |
EP (1) | EP0577622B1 (sv) |
JP (1) | JPH0665349B2 (sv) |
KR (1) | KR970006100B1 (sv) |
AT (1) | ATE146365T1 (sv) |
AU (1) | AU657314B2 (sv) |
CA (1) | CA2106374C (sv) |
CZ (1) | CZ281267B6 (sv) |
DE (2) | DE4110027C2 (sv) |
DK (1) | DK0577622T3 (sv) |
ES (1) | ES2098500T3 (sv) |
FI (1) | FI107020B (sv) |
GR (1) | GR3022863T3 (sv) |
HR (1) | HRP930668B1 (sv) |
HU (1) | HU210845B (sv) |
IE (1) | IE78823B1 (sv) |
IL (1) | IL101189A (sv) |
MY (1) | MY106656A (sv) |
NO (1) | NO306849B1 (sv) |
NZ (1) | NZ242127A (sv) |
PH (1) | PH31285A (sv) |
SI (1) | SI9210277B (sv) |
SK (1) | SK278995B6 (sv) |
WO (1) | WO1992017237A1 (sv) |
YU (1) | YU48183B (sv) |
ZA (1) | ZA922190B (sv) |
Families Citing this family (22)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE4229230C2 (de) * | 1992-09-02 | 1997-01-16 | Lohmann Therapie Syst Lts | Transdermales therapeutisches System mit Pentetrazol als Wirkstoff |
DE19547691C1 (de) * | 1995-12-20 | 1997-04-24 | Lohmann Therapie Syst Lts | Verfahren zur Herstellung transdermaler therapeutischer Pflaster (TTS) |
DE19702314C2 (de) * | 1997-01-23 | 2000-12-21 | Lohmann Therapie Syst Lts | Ablösbare Schutzfolie für wirkstoffhaltige, insbesondere selbstklebende Pflastersysteme |
DE19736315A1 (de) * | 1997-08-21 | 1999-02-25 | Lohmann Therapie Syst Lts | Wirkstoffhaltige Dochtsysteme |
DE19738855C2 (de) * | 1997-09-05 | 2001-01-04 | Lohmann Therapie Syst Lts | Transdermales therapeutisches System mit haftklebender Reservoirschicht und unidirektional elastischer Rückschicht |
DE19749525C1 (de) * | 1997-11-08 | 1999-06-10 | Lohmann Therapie Syst Lts | Laserstrahl-Schneideverfahren zum Schneiden von Laminat zur Applikation auf die Haut und Fixiervorrichtung |
GB2336310B (en) * | 1998-04-14 | 2003-09-10 | Stowic Resources Ltd | Method of manufacturing transdermal patches |
DE19923427A1 (de) | 1999-05-21 | 2000-11-23 | Lohmann Therapie Syst Lts | Vorrichtung und Verfahren zur Steigerung der transdermalen Permeation von Arzneistoffen |
DE19925338A1 (de) * | 1999-06-02 | 2000-12-07 | Lohmann Therapie Syst Lts | Substratabschnitte mit erhöhter Lagerstabilität während ihrer Lagerung in Beutelverpackung, sowie Verfahren zu ihrer Herstellung |
DK1335689T3 (da) * | 2000-10-23 | 2010-06-14 | Euro Celtique Sa | System til transdermal indgivelse af loratadin og anvendelse deraf |
GB2414397B (en) * | 2004-05-26 | 2009-03-11 | Johnson And Johnson Medical Ltd | Self-irrigating wound dressing |
EP1888048B1 (en) * | 2005-06-10 | 2012-01-04 | 3M Innovative Properties Company | Method for handling adhesive laminate sections |
DE102007006244B4 (de) * | 2007-02-08 | 2012-03-15 | Lts Lohmann Therapie-Systeme Ag | Transdermales Therapeutisches System zur Verabreichung wasserlöslicher Wirkstoffe |
JP2010536445A (ja) * | 2007-08-21 | 2010-12-02 | エルテーエス ローマン テラピー−ジステーメ アーゲー | 経皮治療パッチのマルチトラック製作方法 |
DE102010000661A1 (de) * | 2010-01-04 | 2011-07-07 | Acino Ag, 83714 | Verfahren und Vorrichtung zur Herstellung einer überlappenden Schutzfolie für ein transdermales therapeutisches System |
DE102010064358A1 (de) | 2010-12-29 | 2012-07-05 | Acino Ag | Transdermales Applikationssystem mit überstehender Backingfolie |
EP2682113B1 (de) * | 2012-07-02 | 2018-10-31 | Luye Pharma AG | Verschließen wirkstoffhaltiger Laminate |
EP2818159A1 (de) * | 2013-06-25 | 2014-12-31 | LTS LOHMANN Therapie-Systeme AG | Vorrichtung mit transdermalem therapeutischem System, Positionier- und Penetrationshilfe |
EP2921184A1 (de) * | 2014-03-19 | 2015-09-23 | LTS LOHMANN Therapie-Systeme AG | Überpflaster mit verbesserter Verträglichkeit und einer langen Haftungsdauer und Verfahren zu seiner Herstellung |
EP3233492B1 (en) | 2014-12-18 | 2021-11-10 | Kindeva Drug Delivery L.P. | Methods of handling adhesive laminate patches |
CN112402095B (zh) * | 2020-11-17 | 2022-05-31 | 新领医药技术(深圳)有限公司 | 一种硫酸镁冷敷贴及其制备工艺 |
CN117500923A (zh) | 2021-04-07 | 2024-02-02 | ***纪念研究院 | 用于鉴定和使用非病毒载体的快速设计、构建、测试和学习技术 |
Family Cites Families (27)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2862846A (en) * | 1953-11-23 | 1958-12-02 | Johnson & Johnson | Method of making plastic strip adhesive bandages |
US2703083A (en) * | 1955-01-04 | 1955-03-01 | William J Gross | Adhesive bandage |
US3245855A (en) * | 1962-01-18 | 1966-04-12 | Carl B Stenvall | Method for making adhesive bandage |
CA1192825A (en) * | 1980-11-10 | 1985-09-03 | Minnesota Mining And Manufacturing Company | Device and method for applying conformable, thin adhesive-coated films |
US4725272A (en) | 1981-06-29 | 1988-02-16 | Alza Corporation | Novel bandage for administering beneficial drug |
DE3204582A1 (de) * | 1982-02-10 | 1983-08-25 | Hassia Verpackung Gmbh, 6479 Ranstadt | Verfahren zur kontinuierlichen herstellung von pflasterpackungen fuer die transdermale verabreichung von medikamenten |
US4556441A (en) * | 1983-01-24 | 1985-12-03 | Faasse Jr Adrian L | Pharmaceutical packaging method |
US4704119A (en) * | 1983-02-03 | 1987-11-03 | Alza Corporation | Method comprising transdermal and buccal treatment of angina |
DE3315272C2 (de) * | 1983-04-27 | 1986-03-27 | Lohmann Gmbh & Co Kg, 5450 Neuwied | Pharmazeutisches Produkt und Verfahren zu seiner Herstellung |
US4708716A (en) * | 1983-08-18 | 1987-11-24 | Drug Delivery Systems Inc. | Transdermal drug applicator |
EP0177329B1 (en) * | 1984-10-05 | 1992-09-30 | Hercon Laboratories Corporation | Device for transdermal drug administration |
US4638043A (en) * | 1984-11-13 | 1987-01-20 | Thermedics, Inc. | Drug release system |
US4614076A (en) * | 1985-05-23 | 1986-09-30 | Becton, Dickinson And Company | Flexible packaging apparatus and method |
EP0236266B1 (de) * | 1986-02-14 | 1991-06-19 | Ciba-Geigy Ag | Dermale und transdermale therapeutische Systeme mit musterförmig aufgetragener Klebschicht, sowie Verfahren zur dessen Herstellung |
DE3634016A1 (de) * | 1986-04-17 | 1987-10-29 | Lohmann Gmbh & Co Kg | Flaechenfoermiges therapeutisches system, verfahren zu seiner herstellung und seine verwendung |
DE3629304A1 (de) * | 1986-08-28 | 1988-03-24 | Lohmann Gmbh & Co Kg | Transdermales therapeutisches system, seine verwendung und verfahren zu seiner herstellung |
CH672888A5 (sv) * | 1986-11-07 | 1990-01-15 | Mepha Ag | |
DE3714140A1 (de) * | 1987-04-28 | 1988-11-10 | Lohmann Therapie Syst Lts | Wirkstoffhaltiges pflaster zur kontrollierten verabreichung von wirkstoffen an die haut, seine verwendung sowie verfahren zur gesteuerten verabreichung von wirkstoffen an die haut |
DE3743946A1 (de) * | 1987-09-01 | 1989-03-09 | Lohmann Gmbh & Co Kg | Vorrichtung zur abgabe von nitroglycerin an die haut, verfahren zu ihrer herstellung sowie ihre verwendung |
US4994267A (en) * | 1988-03-04 | 1991-02-19 | Noven Pharmaceuticals, Inc. | Transdermal acrylic multipolymer drug delivery system |
DE3810658A1 (de) * | 1988-03-29 | 1989-10-12 | Lohmann Gmbh & Co Kg | Pflaster, insbesondere epikutantestpflaster und verfahren zur herstellung desselben |
US4867821A (en) * | 1988-07-11 | 1989-09-19 | Morgan Burton D | Process for fabricating self-adhesive bandages |
DE3908432A1 (de) * | 1989-03-14 | 1990-09-27 | Lohmann Therapie Syst Lts | Pflaster als therapeutisches system zur verabreichung von wirkstoffen an die haut mit einer abgestuften wirkstoffabgabe, verfahren zu seiner herstellung sowie verwendung |
DE3910543A1 (de) * | 1989-04-01 | 1990-10-11 | Lohmann Therapie Syst Lts | Transdermales therapeutisches system mit erhoehtem wirkstofffluss und verfahren zu seiner herstellung |
DE3924393A1 (de) * | 1989-07-24 | 1991-01-31 | Roehm Gmbh | Wasserloeslicher druckempfindlicher hauthaftkleber, dessen verwendung und damit ausgeruestete mittel |
US5112618A (en) * | 1989-11-01 | 1992-05-12 | Ndm Acquisition Corp. | Hydrogel wound dressing product |
US5268179A (en) * | 1992-02-14 | 1993-12-07 | Ciba-Geigy Corporation | Ultrasonically sealed transdermal drug delivery systems |
-
1991
- 1991-03-27 DE DE4110027A patent/DE4110027C2/de not_active Expired - Fee Related
-
1992
- 1992-03-09 CZ CS931932A patent/CZ281267B6/cs not_active IP Right Cessation
- 1992-03-09 PH PH44023A patent/PH31285A/en unknown
- 1992-03-09 JP JP4505504A patent/JPH0665349B2/ja not_active Expired - Lifetime
- 1992-03-09 CA CA002106374A patent/CA2106374C/en not_active Expired - Lifetime
- 1992-03-09 KR KR1019930702858A patent/KR970006100B1/ko not_active IP Right Cessation
- 1992-03-09 AT AT92905728T patent/ATE146365T1/de active
- 1992-03-09 HU HU9302700A patent/HU210845B/hu unknown
- 1992-03-09 WO PCT/EP1992/000513 patent/WO1992017237A1/de active IP Right Grant
- 1992-03-09 DE DE59207727T patent/DE59207727D1/de not_active Expired - Lifetime
- 1992-03-09 EP EP92905728A patent/EP0577622B1/de not_active Expired - Lifetime
- 1992-03-09 SK SK1011-93A patent/SK278995B6/sk not_active IP Right Cessation
- 1992-03-09 AU AU13535/92A patent/AU657314B2/en not_active Expired
- 1992-03-09 DK DK92905728.9T patent/DK0577622T3/da active
- 1992-03-09 ES ES92905728T patent/ES2098500T3/es not_active Expired - Lifetime
- 1992-03-10 IL IL10118992A patent/IL101189A/en not_active IP Right Cessation
- 1992-03-18 YU YU27792A patent/YU48183B/sh unknown
- 1992-03-18 MY MYPI92000438A patent/MY106656A/en unknown
- 1992-03-18 SI SI9210277A patent/SI9210277B/sl unknown
- 1992-03-25 NZ NZ242127A patent/NZ242127A/en not_active IP Right Cessation
- 1992-03-26 ZA ZA922190A patent/ZA922190B/xx unknown
- 1992-03-26 IE IE920963A patent/IE78823B1/en not_active IP Right Cessation
-
1993
- 1993-04-01 HR HR930668 patent/HRP930668B1/xx not_active IP Right Cessation
- 1993-09-24 FI FI934189A patent/FI107020B/sv not_active IP Right Cessation
- 1993-09-24 NO NO933414A patent/NO306849B1/no not_active IP Right Cessation
-
1995
- 1995-09-22 US US08/531,890 patent/US6315854B1/en not_active Expired - Lifetime
-
1997
- 1997-03-18 GR GR970400538T patent/GR3022863T3/el unknown
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
FI107020B (sv) | Förfarande för framställning av ett transdermalt terapeutiskt plåster | |
US5032403A (en) | Multilayer plaster | |
KR100439921B1 (ko) | 트랜스더 멀패치의 제조방법 | |
FI89243B (fi) | Terapeutiskt system och foerfarande foer dess anstaellning | |
AU2018203157A1 (en) | Transdermal drug delivery device | |
CA2006828A1 (en) | Application system for drug containing microemulsions | |
JPH0226508B2 (sv) | ||
JP3002772B2 (ja) | 貼付剤及びその製造法 | |
JP3400026B2 (ja) | 軟膏貼付剤 | |
JP3460092B2 (ja) | 軟膏剤系貼付剤の製造方法 | |
HU196133B (en) | Method for producing medical plasters containing non-continuous sticking layer suitable for getting therapeutical agents into epidermis or into organism through the epidermis | |
MXPA00001254A (en) | Transdermal therapy system (tts) for releasing an active agent into an organism through the skin and method for applying said transdermal therapy system to the skin |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
MA | Patent expired |