FI101227B1 - Menetelmä farmaseuttisesti aktiivisten 4-desoksi-4-epipodofyllotoksiinijohdannaisten valmistamiseksi - Google Patents

Menetelmä farmaseuttisesti aktiivisten 4-desoksi-4-epipodofyllotoksiinijohdannaisten valmistamiseksi

Info

Publication number
FI101227B1
FI101227B1 FI924285A FI924285A FI101227B1 FI 101227 B1 FI101227 B1 FI 101227B1 FI 924285 A FI924285 A FI 924285A FI 924285 A FI924285 A FI 924285A FI 101227 B1 FI101227 B1 FI 101227B1
Authority
FI
Finland
Prior art keywords
deoxy
preparation
pharmaceutically active
epipodophyllotoxin derivatives
epipodophyllotoxin
Prior art date
Application number
FI924285A
Other languages
English (en)
Swedish (sv)
Other versions
FI924285A (fi
FI101227B (fi
FI924285A0 (fi
Inventor
Tadafumi Terada
Katsuhiko Fujimoto
Makoto Nomura
Junichi Yamashita
Setsuo Takeda
Takashi Kobunai
Hideo Yamaguchi
Konstanty Wierzba
Original Assignee
Taiho Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Taiho Pharmaceutical Co Ltd filed Critical Taiho Pharmaceutical Co Ltd
Publication of FI924285A publication Critical patent/FI924285A/fi
Publication of FI924285A0 publication Critical patent/FI924285A0/fi
Application granted granted Critical
Publication of FI101227B publication Critical patent/FI101227B/fi
Publication of FI101227B1 publication Critical patent/FI101227B1/fi

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
    • C07D493/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
FI924285A 1991-01-25 1992-09-24 Menetelmä farmaseuttisesti aktiivisten 4-desoksi-4-epipodofyllotoksiinijohdannaisten valmistamiseksi FI101227B1 (fi)

Applications Claiming Priority (8)

Application Number Priority Date Filing Date Title
JP8714091 1991-01-25
JP8714091 1991-01-25
JP6170691 1991-03-26
JP6170691 1991-03-26
JP9079491 1991-04-22
JP9079491 1991-04-22
PCT/JP1992/000051 WO1992012982A1 (fr) 1991-01-25 1992-01-22 Derive de 4-desoxy-4-epipodophyllotoxine ou sel pharmaceutiquement acceptable de ce derive
JP9200051 1992-01-22

Publications (4)

Publication Number Publication Date
FI924285A FI924285A (fi) 1992-09-24
FI924285A0 FI924285A0 (fi) 1992-09-24
FI101227B FI101227B (fi) 1998-05-15
FI101227B1 true FI101227B1 (fi) 1998-05-15

Family

ID=27297605

Family Applications (1)

Application Number Title Priority Date Filing Date
FI924285A FI101227B1 (fi) 1991-01-25 1992-09-24 Menetelmä farmaseuttisesti aktiivisten 4-desoksi-4-epipodofyllotoksiinijohdannaisten valmistamiseksi

Country Status (17)

Country Link
US (3) US5489698A (fi)
EP (1) EP0522173B1 (fi)
JP (1) JP2631912B2 (fi)
KR (1) KR0145338B1 (fi)
CN (2) CN1035821C (fi)
AT (1) ATE159258T1 (fi)
AU (1) AU636076B2 (fi)
CA (1) CA2078662C (fi)
DE (1) DE69222698T2 (fi)
DK (1) DK0522173T3 (fi)
ES (1) ES2109993T3 (fi)
FI (1) FI101227B1 (fi)
HU (1) HU211961A9 (fi)
NO (1) NO301277B1 (fi)
RU (1) RU2074185C1 (fi)
TW (1) TW221441B (fi)
WO (1) WO1992012982A1 (fi)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5713710A (en) * 1993-03-13 1998-02-03 Strong; Philip Anton Transfer system
GB2290524B (en) * 1993-03-13 1997-03-12 Philip Anton Strong A transfer system
EP2266607A3 (en) 1999-10-01 2011-04-20 Immunogen, Inc. Immunoconjugates for treating cancer
CN1101819C (zh) * 1999-10-21 2003-02-19 国家医药管理局上海医药工业研究院 具有抗肿瘤活性的4－β－碳取代－4－脱氧－4'－去甲表鬼臼毒素衍生物及合成方法和中间体
JP3947103B2 (ja) 2000-07-14 2007-07-18 エフ．ホフマン−ラ ロシュ アーゲー 肝細胞毒性に対する素因を検出する方法
US6624317B1 (en) 2000-09-25 2003-09-23 The University Of North Carolina At Chapel Hill Taxoid conjugates as antimitotic and antitumor agents
US7176236B2 (en) * 2002-06-21 2007-02-13 University Of North Carolina At Chapel Hill Water-soluble etoposide analogs and methods of use thereof
US6566393B1 (en) * 2002-06-21 2003-05-20 The University Of North Carolina At Chapel Hill Etoposide analogs and methods of use thereof
TWI307341B (en) * 2002-10-11 2009-03-11 Plantaceutica Inc Anticancer compounds
FR2859208B1 (fr) * 2003-09-02 2006-01-21 Servier Lab Nouveaux derives de 9-amino-podophyllotoxine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
CN100334090C (zh) * 2005-02-02 2007-08-29 南京医科大学 吡啶类鬼臼毒素化合物及其制备方法和在制备杀虫剂中的应用
GB0514685D0 (en) * 2005-07-19 2005-08-24 Pharma Mar Sa A ntineoplastic compounds
FR2935143B1 (fr) * 2008-08-19 2010-12-03 Pf Medicament Nouveaus derives (poly)aminoalkylaminoalkylamides, alkyl-urees, ou alkyl-sulfonamides d'epipodophyllotoxine, leur procede de preparation et leur application en therapeuthique comme agent cancereux
RU2013103763A (ru) 2010-07-02 2014-08-10 Ангиохем Инк. Короткие и содержащие d-аминокислоты полипептиды для терапевтических конъюгатов и их применения
CA2809003C (en) 2010-08-31 2018-07-17 Axelar Ab Process for preparing cyclolignans
CN103613600B (zh) * 2013-11-15 2017-01-04 湖北工业大学 具抗肿瘤活性的苯胺基鬼臼类衍生物及其制备方法和用途

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS61103883A (ja) * 1984-10-24 1986-05-22 Nippon Kayaku Co Ltd ４′−ハロゲノアセチル−４′−デメチルエピポドフイロトキシンの新規製造法
JPS6310789A (ja) * 1986-07-01 1988-01-18 Nippon Kayaku Co Ltd 新規ポドフイロトキシン誘導体
JPH01117885A (ja) * 1987-10-30 1989-05-10 Dai Ichi Seiyaku Co Ltd 新規ボドフィロトキシン誘導体及びその製造法
JPH01267855A (ja) * 1988-04-19 1989-10-25 Canon Inc 光学情報記録媒体
JPH02191279A (ja) * 1988-10-26 1990-07-27 Warner Lambert Co ４‐ブロモ‐４′‐デメチルエピポドフイロトキシンおよびその新規な誘導体の製法
EP0461141B1 (en) * 1989-02-23 1999-11-03 University Of North Carolina At Chapel Hill Etoposide analogues
JP2587705B2 (ja) * 1989-10-12 1997-03-05 大鵬薬品工業株式会社 ４―デソキシ―４―エピポドフィロトキシン誘導体
JP2001127792A (ja) * 1999-10-22 2001-05-11 Wittei:Kk 逐次処理によるネットワーク通信

Also Published As

Publication number Publication date
KR0145338B1 (ko) 1998-07-15
EP0522173A1 (en) 1993-01-13
RU2074185C1 (ru) 1997-02-27
DE69222698T2 (de) 1998-05-20
CN1035821C (zh) 1997-09-10
CN1064278A (zh) 1992-09-09
US5571914A (en) 1996-11-05
DK0522173T3 (da) 1998-03-09
CA2078662C (en) 2000-04-04
US5489698A (en) 1996-02-06
ES2109993T3 (es) 1998-02-01
TW221441B (fi) 1994-03-01
AU1180592A (en) 1992-08-27
EP0522173A4 (en) 1993-06-16
EP0522173B1 (en) 1997-10-15
NO301277B1 (no) 1997-10-06
FI924285A (fi) 1992-09-24
NO923721D0 (no) 1992-09-24
HU211961A9 (en) 1996-01-29
JP2631912B2 (ja) 1997-07-16
NO923721L (no) 1992-11-23
US5536847A (en) 1996-07-16
DE69222698D1 (de) 1997-11-20
CN1126723A (zh) 1996-07-17
CA2078662A1 (en) 1992-07-26
FI101227B (fi) 1998-05-15
CN1046521C (zh) 1999-11-17
AU636076B2 (en) 1993-04-08
ATE159258T1 (de) 1997-11-15
FI924285A0 (fi) 1992-09-24
WO1992012982A1 (fr) 1992-08-06

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Legal Events

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MA Patent expired