ES9100017A1 - Un procedimiento para la preparacion de 2-amino-6-cloropurina. - Google Patents

Un procedimiento para la preparacion de 2-amino-6-cloropurina.

Info

Publication number
ES9100017A1
ES9100017A1 ES553283A ES553283A ES9100017A1 ES 9100017 A1 ES9100017 A1 ES 9100017A1 ES 553283 A ES553283 A ES 553283A ES 553283 A ES553283 A ES 553283A ES 9100017 A1 ES9100017 A1 ES 9100017A1
Authority
ES
Spain
Prior art keywords
preparation
purine
chloro
amino
compound
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
ES553283A
Other languages
English (en)
Other versions
ES553283A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Beecham Group PLC
Original Assignee
Beecham Group PLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Beecham Group PLC filed Critical Beecham Group PLC
Publication of ES553283A0 publication Critical patent/ES553283A0/es
Publication of ES9100017A1 publication Critical patent/ES9100017A1/es
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/40—Heterocyclic compounds containing purine ring systems with halogen atoms or perhalogeno-alkyl radicals directly attached in position 2 or 6

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Catalysts (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

EL PROCEDIMIENTO CONSISTE EN HACER REACCIONAR GUANINA CON UN AGENTE CLORANTE EN PRESENCIA DE UN CATALIZADOR DE TRANSFERENCIA DE FASE QUE CONTIENE IONES CLORURO. LA REACCION SE LLEVA A CABO PREFERENTEMENTE EN UN DISOLVENTE ORGANICO INERTE POLAR, COMO EL ACETONITRILO Y ENTRE LOS CATALIZADORES DE TRANSFERENCIA DE FASE ADECUADOS SE INCLUYEN LOS CLORUROS DE AMUNIO TETRASUSTITUIDOS O LOS CLORUROS DE FOSFONIO TETRASUSTITUIDOS. COMO AGENTE CLORANTE SE UTILIZA EL OXICLORURO DE FOSFORO. CON ESTE PROCEDIMIENTO SE CONSIGUE LA PRODUCCION A GRAN ESCALA DE 2-AMINO-6-CLOROPURINA, COMPUESTO UTIL COMO INTERMEDIO EN LA PREPARACION DE COMPUESTOS FARMACEUTICOS.
ES553283A 1985-03-23 1986-03-21 Un procedimiento para la preparacion de 2-amino-6-cloropurina. Expired - Fee Related ES9100017A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB858507606A GB8507606D0 (en) 1985-03-23 1985-03-23 Process

Publications (2)

Publication Number Publication Date
ES553283A0 ES553283A0 (es) 1991-04-16
ES9100017A1 true ES9100017A1 (es) 1991-04-16

Family

ID=10576527

Family Applications (1)

Application Number Title Priority Date Filing Date
ES553283A Expired - Fee Related ES9100017A1 (es) 1985-03-23 1986-03-21 Un procedimiento para la preparacion de 2-amino-6-cloropurina.

Country Status (15)

Country Link
US (1) US4736029A (es)
EP (1) EP0203685B1 (es)
JP (1) JPH0670058B2 (es)
AU (1) AU589612B2 (es)
CA (1) CA1273337A (es)
DE (1) DE3681500D1 (es)
DK (1) DK165250C (es)
ES (1) ES9100017A1 (es)
GB (1) GB8507606D0 (es)
GR (1) GR860765B (es)
IE (1) IE58371B1 (es)
MX (1) MX167823B (es)
NZ (1) NZ215559A (es)
PT (1) PT82245B (es)
ZA (1) ZA862129B (es)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8817270D0 (en) * 1988-07-20 1988-08-24 Beecham Group Plc Novel process
GB8822236D0 (en) * 1988-09-21 1988-10-26 Beecham Group Plc Chemical process
GB8918827D0 (en) * 1989-08-17 1989-09-27 Beecham Group Plc Novel compounds
DE3941657A1 (de) * 1989-12-16 1991-06-20 Hoechst Ag Verfahren zur herstellung von 2-acylamino-6-halogen-purin aus 2,9-diacylguanin
GB9102127D0 (en) * 1991-01-31 1991-03-13 Smithkline Beecham Plc Pharmaceuticals
CA2076886C (en) * 1991-11-22 2002-06-11 Masami Igi Method for production of 2-amino-6-halogenopurine and synthesis intermediate therefor
GB9201961D0 (en) * 1992-01-30 1992-03-18 Smithkline Beecham Plc Pharmaceuticals
DE4231036A1 (de) * 1992-09-17 1994-03-24 Basf Ag Verfahren zur Herstellung von 2-Amino-6-halogenpurinen
JPH07133276A (ja) * 1993-09-17 1995-05-23 Jiyuuzen Kagaku Kk ２−アセチルアミノ−６−クロロプリンの製造方法
WO1996021664A1 (de) * 1995-01-09 1996-07-18 Lonza Ag Verfahren zur herstellung von 2-amino-6-chlorpurin und zwischenprodukte dafür
US5789590A (en) * 1995-11-09 1998-08-04 Sumika Fine Chemicals Co., Ltd. Double cone-like crystal form of 2-amino-6-chloropurine and preparation
CN107629054A (zh) * 2016-07-18 2018-01-26 苏州赛乐生物科技有限公司 一种6‑溴嘌呤的合成方法

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3485225D1 (de) 1983-08-18 1991-12-05 Beecham Group Plc Antivirale guanin-derivate.

Also Published As

Publication number Publication date
US4736029A (en) 1988-04-05
IE860741L (en) 1986-09-23
GR860765B (en) 1986-07-21
AU5501286A (en) 1986-09-25
DK133586D0 (da) 1986-03-21
MX167823B (es) 1993-04-13
ES553283A0 (es) 1991-04-16
NZ215559A (en) 1989-07-27
DK165250C (da) 1993-03-22
AU589612B2 (en) 1989-10-19
ZA862129B (en) 1987-02-25
IE58371B1 (en) 1993-09-08
EP0203685A3 (en) 1988-06-08
DK165250B (da) 1992-10-26
PT82245B (pt) 1988-02-17
GB8507606D0 (en) 1985-05-01
DE3681500D1 (de) 1991-10-24
DK133586A (da) 1986-09-24
EP0203685B1 (en) 1991-09-18
JPS61227583A (ja) 1986-10-09
CA1273337A (en) 1990-08-28
JPH0670058B2 (ja) 1994-09-07
EP0203685A2 (en) 1986-12-03
PT82245A (en) 1986-04-01

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Legal Events

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FD2A Announcement of lapse in spain

Effective date: 20151230