ES8801920A1 - Procedimiento para la obtencio de enaminas - Google Patents

Procedimiento para la obtencio de enaminas

Info

Publication number
ES8801920A1
ES8801920A1 ES557698A ES557698A ES8801920A1 ES 8801920 A1 ES8801920 A1 ES 8801920A1 ES 557698 A ES557698 A ES 557698A ES 557698 A ES557698 A ES 557698A ES 8801920 A1 ES8801920 A1 ES 8801920A1
Authority
ES
Spain
Prior art keywords
quinolone
bridged
preparation
carboxylic acids
new
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES557698A
Other languages
English (en)
Other versions
ES557698A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bayer AG
Original Assignee
Bayer AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer AG filed Critical Bayer AG
Publication of ES8801920A1 publication Critical patent/ES8801920A1/es
Publication of ES557698A0 publication Critical patent/ES557698A0/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/06—Peri-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C07D215/54—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3
    • C07D215/56—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3 with oxygen atoms in position 4
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/06—Peri-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oncology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Communicable Diseases (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Quinoline Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

PROCEDIMIENTO PARA LA OBTENCION DE ENAMINAS. LAS ENAMINAS (I), DONDE NO EXHAUSTIVAMENTE, Y ES CARBOXILO, NITRILO O ESTER, X1 ES HIDROGENO, NITRO, ALQUILO C1-3 O HALOGENO, X2, X3, X4 Y X5 SON HALOGENO, Z ES OXIGENO O UN RESTO DE AMINO, R1, R2, R3, R4, R5, R6, SON HIDROGENO, ALQUILO C1-6 SUSTITUIDO UNA O VARIAS VECES CON HALOGENO O FORMAN ENTRE SI UN ANILLO DE 3 A 7 MIEMBROS, N ES 0 O 1; SE PREPARAN POR REACCION DE LOS CORRESPONDIENTES ENOLETERES (II) CON AMINAS PRIMARIAS (III). SON PRECURSORES DE PRODUCTOS (IV) TIPO 4-PIRIDIN-3-CARBOXILICO (O 4-QUINOLON-3-CARBOXILICOS) QUE TIENEN UNA REDUCIDA TOXICIDAD Y UN AMPLIO ESPECTRO ANTIBACTERIANO CONTRA GRAM-POSITIVOS Y GRAM-NEGATIVOS, ESPECIALMENTE ENTEROBACTERIAS, Y CONTRA OTROS RESISTENTES A LOS ANTIBIOTICOS.
ES557698A 1985-06-22 1987-08-28 Procedimiento para la obtencio de enaminas Expired ES8801920A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19853522406 DE3522406A1 (de) 1985-06-22 1985-06-22 Verfahren zur herstellung von 1,8-verbrueckten 4-chinolon-3-carbonsaeuren

Publications (2)

Publication Number Publication Date
ES8801920A1 true ES8801920A1 (es) 1988-03-01
ES557698A0 ES557698A0 (es) 1988-03-01

Family

ID=6273930

Family Applications (2)

Application Number Title Priority Date Filing Date
ES556370A Expired ES8801210A1 (es) 1985-06-22 1986-06-20 Procedimiento para la obtencion de acidos 4-quinolon-3-carboxilicos 1,8-puenteados
ES557698A Expired ES8801920A1 (es) 1985-06-22 1987-08-28 Procedimiento para la obtencio de enaminas

Family Applications Before (1)

Application Number Title Priority Date Filing Date
ES556370A Expired ES8801210A1 (es) 1985-06-22 1986-06-20 Procedimiento para la obtencion de acidos 4-quinolon-3-carboxilicos 1,8-puenteados

Country Status (6)

Country Link
US (3) US4762831A (es)
EP (1) EP0206101A1 (es)
JP (1) JPS62452A (es)
KR (1) KR880000439A (es)
DE (1) DE3522406A1 (es)
ES (2) ES8801210A1 (es)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2055656A1 (es) * 1992-10-07 1994-08-16 Etilo Derivados Procedimiento para la obtencion de benzoxazinas utiles para sintesis de ofloxacina, levofloxacina y derivados.

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3522405A1 (de) * 1985-06-22 1987-01-02 Bayer Ag 1,8-verbrueckte 4-chinolon-3-carbonsaeuren, verfahren zu ihrer herstellung sowie diese enthaltende arzneimittel und ihre verwendung zur herstellung von arzneimitteln
US5237060A (en) * 1985-12-10 1993-08-17 Bayer Aktiengesellschaft Process of preparing enantiomerically pure 1,8-bridged 4-quinolone-3-carboxylic acids
US5147871A (en) * 1986-07-03 1992-09-15 Hoffmann La-Roche, Inc. Anti-bacterial cephalosporin compounds
EP0286802B1 (en) * 1987-02-26 1993-06-23 Rohto Pharmaceutical Co., Ltd. Use of ofloxacin in treating or preventing locally periodontal disease
US5290934A (en) * 1987-04-16 1994-03-01 Otsuka Pharmaceutical Company, Limited Benzoheterocyclic compounds
US5563138A (en) * 1987-04-16 1996-10-08 Otsuka Pharmaceutical Company, Limited Benzoheterocyclic compounds
JPH0826029B2 (ja) * 1987-12-22 1996-03-13 第一製薬株式会社 魚類感染症の予防・治療剤
US4920120A (en) 1988-01-25 1990-04-24 Warner-Lambert Company Antibacterial agents
US5585491A (en) * 1988-01-25 1996-12-17 Otsuka Pharmaceutical Co., Ltd. Antibacterial agents
JPH0228178A (ja) * 1988-04-23 1990-01-30 Toyama Chem Co Ltd 新規なピリドンカルボン酸誘導体およびその塩並びにそれらの製造法
CS273349B2 (en) * 1988-03-31 1991-03-12 Hoffmann La Roche Method of cephalosporin's new derivatives production
US5336768A (en) * 1988-05-24 1994-08-09 Hoffmann-La Roche Inc. Antibacterial cephalosporin compounds
DE3902079A1 (de) * 1988-04-15 1989-10-26 Bayer Ag I.m. injektionsformen von gyrase-inhibitoren
US4996355A (en) * 1989-04-14 1991-02-26 Mallinckrodt, Inc. Novel intermediates for the production of 2,4,5-trifluorobenzoyl fluoride
US5162523A (en) * 1989-07-21 1992-11-10 Hoffmann-La Roche Inc. Cephalosporin antibacterial compounds
US5159077A (en) * 1989-07-21 1992-10-27 Hoffmann-La Roche Inc. Penam antibacterial compounds
US5359066A (en) * 1991-02-28 1994-10-25 Wakunaga Pharmaceutical Co., Ltd. Certain tricyclic pyrido[3,2,1-ij]cinnoline-8-carboxylates, useful as antimicrobial agents
EP0619311A1 (en) * 1992-10-07 1994-10-12 Derivados Del Etilo, S.A. Process for obtaining benzoxazines useful for the synthesis of ofloxacin, levofloxacin and derivatives thereof
US5644056A (en) * 1995-06-07 1997-07-01 Hoechst Celanese Corporation Method of preparing 7,8-difluoro-2,3-dihydro-3-methyl-4H-1, 4-benzoxazine
KR100309871B1 (ko) * 1999-02-24 2001-10-29 윤종용 (-)피리도벤즈옥사진 카르복실산 유도체의 제조방법
WO2006009143A1 (ja) * 2004-07-21 2006-01-26 Kyorin Pharmaceutical Co., Ltd. （３ｓ）－３－ヒドロキシメチル－７－オキソピリドベンゾオキサジン－６－カルボン酸エステルの製造方法
ES2343141T3 (es) * 2005-11-16 2010-07-23 F. Hoffmann-La Roche Ag Nuevo procedimiento para la preparacion de thoc.
KR101419554B1 (ko) 2006-03-13 2014-07-17 교린 세이야꾸 가부시키 가이샤 Ｇｓｋ­３ 억제제로서 아미노퀴놀론
US8476261B2 (en) 2007-09-12 2013-07-02 Kyorin Pharmaceutical Co., Ltd. Spirocyclic aminoquinolones as GSK-3 inhibitors
EP2406266B1 (en) 2009-03-11 2013-12-25 Kyorin Pharmaceutical Co., Ltd. 7-cycloalkylaminoquinolones as gsk-3 inhibitors
CN103183684B (zh) * 2011-12-29 2015-11-18 杭州师范大学 一种喹喏酮内酯化合物及其制备方法和应用
CN105037388A (zh) * 2015-08-28 2015-11-11 安徽环球药业股份有限公司 一种安妥沙星的制备方法

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE62321C (de) * O. MEURER in Köln a. Rh., Mühlenbach 54—58 Neuerung an einem Bodenbelag für Malztennen u. dergl
DD62321A (es) *
NL7101049A (es) * 1970-01-28 1971-07-30
US3883522A (en) * 1974-02-11 1975-05-13 Riker Laboratories Inc Substituted pyrido(1,2,3-de)-1,4-benzoxazines
DE2808070A1 (de) * 1978-02-24 1979-08-30 Bayer Ag Verfahren zur herstellung von 4-pyridon-3-carbonsaeuren und/oder deren derivaten
JPS5746986A (en) * 1980-09-02 1982-03-17 Dai Ichi Seiyaku Co Ltd Pyrido(1,2,3-de)(1,4)benzoxazine derivative
SE440354B (sv) * 1981-02-19 1985-07-29 Kyorin Seiyaku Kk Kinolinkarboxylsyraderivat
US4499270A (en) * 1981-04-16 1985-02-12 Riker Laboratories, Inc. Substituted pyridoquinoxaline-6-carboxylic acids and derivatives thereof
US4571396A (en) * 1984-04-16 1986-02-18 Warner-Lambert Company Antibacterial agents
DE3416120A1 (de) * 1984-04-30 1985-10-31 Henkel KGaA, 4000 Düsseldorf Benzoylalanine und ihre verwendung als korrosionsinhibitoren fuer waessrige systeme
US4571346A (en) * 1984-08-01 1986-02-18 General Foods Corporation Method for producing cold-water soluble gelatin dessert mixes and products therefrom
US4777253A (en) * 1986-04-25 1988-10-11 Abbott Laboratories Process for preparation of racemate and optically active ofloxacin and related derivatives

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2055656A1 (es) * 1992-10-07 1994-08-16 Etilo Derivados Procedimiento para la obtencion de benzoxazinas utiles para sintesis de ofloxacina, levofloxacina y derivados.

Also Published As

Publication number Publication date
ES557698A0 (es) 1988-03-01
ES556370A0 (es) 1987-12-16
US4958045A (en) 1990-09-18
DE3522406A1 (de) 1987-01-02
JPS62452A (ja) 1987-01-06
EP0206101A1 (de) 1986-12-30
KR880000439A (ko) 1988-03-25
US4762831A (en) 1988-08-09
US4859773A (en) 1989-08-22
ES8801210A1 (es) 1987-12-16

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Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 19970303