ES8801207A1 - Procedimiento para la obtencion de 1,4-dihidropiridincarboxiamidas - Google Patents

Procedimiento para la obtencion de 1,4-dihidropiridincarboxiamidas

Info

Publication number
ES8801207A1
ES8801207A1 ES556986A ES556986A ES8801207A1 ES 8801207 A1 ES8801207 A1 ES 8801207A1 ES 556986 A ES556986 A ES 556986A ES 556986 A ES556986 A ES 556986A ES 8801207 A1 ES8801207 A1 ES 8801207A1
Authority
ES
Spain
Prior art keywords
dihydropyridine
medicaments
preparation
carboxylic acid
acid amides
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES556986A
Other languages
English (en)
Other versions
ES556986A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bayer AG
Original Assignee
Bayer AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer AG filed Critical Bayer AG
Publication of ES8801207A1 publication Critical patent/ES8801207A1/es
Publication of ES556986A0 publication Critical patent/ES556986A0/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/80—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D211/84—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen directly attached to ring carbon atoms
    • C07D211/90—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
    • C07D237/02—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings
    • C07D237/04—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having less than three double bonds between ring members or between ring members and non-ring members
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Vascular Medicine (AREA)
  • Obesity (AREA)
  • Endocrinology (AREA)
  • Urology & Nephrology (AREA)
  • Emergency Medicine (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Pyridine Compounds (AREA)

Abstract

METODO DE OBTENER 1,4-DIHIDROPIRIDINCARBOXIAMIDAS. CONSISTE EN HACER REACCIONAR ALDEHIDOS DE FORMULA (II) CON CETO-COMPUESTOS DE FORMULA (III), O SUS PRODUCTOS DE CONDENSACION DE FORMULA (IV) CON ENAMINAS DE FORMULA (V), PARA OBTENER 1,4-DIHIDROPIRIDINCARBOXIAMIDAS DE FORMULA (I), DONDE R1 Y R3, IGUALES O DIFERENTES, SIGNIFICAN CIANO O ALQUILO DE CADENA LINEAL O RAMIFICADA CON HASTA 6 ATOMOS DE CARBONO; R4 ES H, NITRO, CIANO O LOS RESTOS COR8, CO2R8 Y OTROS; R5 ES ARILO; R6 ES H O ALQUILO DE CADENA LINEAL O RAMIFICADA CON HASTA 7 ATOMOS DE CARBONO; Y R7 ES UN GRUPO DE FORMULA (VI) Y OTROS. TIENE UTILIDAD PARA LA OBTENCION DE MEDICAMENTOS PARA ENFERMEDADES DEL APARATO CIRCULATORIO Y LA TROMBOSIS.
ES556986A 1984-12-15 1986-08-01 Procedimiento para la obtencion de 1,4-dihidropiridincarboxiamidas Expired ES8801207A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19843445852 DE3445852A1 (de) 1984-12-15 1984-12-15 Dihydropyridin-carbonsaeureamide, verfahren zu ihrer herstellung und ihre verwendung in arzneimitteln

Publications (2)

Publication Number Publication Date
ES8801207A1 true ES8801207A1 (es) 1987-12-16
ES556986A0 ES556986A0 (es) 1987-12-16

Family

ID=6252899

Family Applications (4)

Application Number Title Priority Date Filing Date
ES549873A Expired ES8700850A1 (es) 1984-12-15 1985-12-12 1,4-dihidropiridin-carboxiamidas.
ES556987A Expired ES8707501A1 (es) 1984-12-15 1986-08-01 Procedimiento para la obtencion de 1,4-dihidropiridincarboxiamidas
ES556986A Expired ES8801207A1 (es) 1984-12-15 1986-08-01 Procedimiento para la obtencion de 1,4-dihidropiridincarboxiamidas
ES556988A Expired ES8801208A1 (es) 1984-12-15 1986-08-01 Procedimiento para la obtencion de 1,4 dihidropiridincarboxiamidas

Family Applications Before (2)

Application Number Title Priority Date Filing Date
ES549873A Expired ES8700850A1 (es) 1984-12-15 1985-12-12 1,4-dihidropiridin-carboxiamidas.
ES556987A Expired ES8707501A1 (es) 1984-12-15 1986-08-01 Procedimiento para la obtencion de 1,4-dihidropiridincarboxiamidas

Family Applications After (1)

Application Number Title Priority Date Filing Date
ES556988A Expired ES8801208A1 (es) 1984-12-15 1986-08-01 Procedimiento para la obtencion de 1,4 dihidropiridincarboxiamidas

Country Status (11)

Country Link
US (1) US4707479A (es)
EP (1) EP0185964B1 (es)
JP (1) JPH0631224B2 (es)
AT (1) ATE50571T1 (es)
AU (1) AU5107085A (es)
CA (1) CA1259996A (es)
DE (2) DE3445852A1 (es)
DK (1) DK578485A (es)
ES (4) ES8700850A1 (es)
HU (1) HUT40081A (es)
ZA (1) ZA859550B (es)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IN164232B (es) * 1986-04-11 1989-02-04 Hoechst India
DE3712371A1 (de) * 1987-04-11 1988-10-27 Bayer Ag Substituierte 1,4-dihydropyridine, verfahren zu ihrer herstellung und ihre verwendung
DE3712369A1 (de) * 1987-04-11 1988-10-27 Bayer Ag Substituierte 5-nitro-1,4-dihydropyridine, verfahren zur herstellung und ihre verwendung
DE3724909A1 (de) * 1987-07-28 1989-02-09 Bayer Ag Neue substituierte nitro-dihydropyridine, verfahren zu ihrer herstellung und ihre verwendung
GB8804439D0 (en) * 1988-02-25 1988-03-23 Pfizer Ltd Dihydropyridines
DE3833892A1 (de) * 1988-10-05 1990-04-12 Bayer Ag Basische 4-aryl-dhp-amide, verfahren zu ihrer herstellung und ihre verwendung in arzneimitteln
WO1990009377A1 (en) * 1989-02-17 1990-08-23 Institut Organicheskogo Sinteza Akademii Nauk Latviiskoi Ssr Alcaline salts of 2-(2,6-dimethyl-3,5-diethoxycarbonyl-1,4-dihydropyridine-4-carboxamido) ethane sulphonic acid and method of obtaining them
WO1992006087A1 (fr) * 1990-10-02 1992-04-16 Kaken Pharmaceutical Co., Ltd. Derive d'ethynylphenyle a substitution pyridazinone et medicament contre les affections des organes circulatoires contenant ce derive en tant qu'ingredient actif
US5100892A (en) * 1990-11-13 1992-03-31 Glaxo Inc. Dihydropyridine vasodilator agents
DE4118707A1 (de) * 1991-06-07 1992-12-10 Bayer Ag Pharmazeutische verwendung von 3-formyl-1,4-dihydropyridinen, neue verbindungen und verfahren zu ihrer herstellung
DE4202526A1 (de) * 1992-01-30 1993-08-05 Bayer Ag Neue 4-cinnolinyl- und 4-naphthyridinyl-dihydropyridine, verfahren zu ihrer herstellung und ihre verwendung in arzneimitteln
ATE278660T1 (de) * 2000-02-04 2004-10-15 Lonza Ag Verfahren zur herstellung von acetoacetylierten aromatischen aminen
RU2005110062A (ru) 2002-10-07 2006-01-10 Артезиан Терапьютикс, Инк. (US) Дигидропиридиновые соединения, обладающие одновременной способностью к блокированию кальциевых каналов l-типа и к ингибированию активности фосфодиэстеразы типа 3
WO2018086703A1 (en) 2016-11-11 2018-05-17 Bayer Pharma Aktiengesellschaft Dihydropyridazinones substituted with phenylureas
JP2021512103A (ja) 2018-01-31 2021-05-13 バイエル アクチェンゲゼルシャフトＢａｙｅｒ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ Ｎａｍｐｔ阻害剤を含む抗体薬物複合体（ａｄｃｓ）
WO2021013693A1 (en) 2019-07-23 2021-01-28 Bayer Pharma Aktiengesellschaft Antibody drug conjugates (adcs) with nampt inhibitors
EP4252843A1 (en) * 2020-11-30 2023-10-04 Kyushu University, National University Corporation Compound having inhibitory action against excessive mitochondrial divisions

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2752820A1 (de) * 1977-11-26 1979-05-31 Bayer Ag Neue nitrosubstituierte 1,4-dihydropyridine, verfahren zu ihrer herstellung sowie ihre verwendung als arzneimittel
EP0107735B1 (en) * 1981-10-20 1988-10-19 Mitsui Toatsu Kagaku Kabushiki Kaisha Novel pyridazinone derivatives
DE3319956A1 (de) * 1983-06-01 1984-12-06 Bayer Ag, 5090 Leverkusen 1,4-dihydropyridine, verfahren zu ihrer herstellung sowie ihre verwendung in arzneimitteln

Also Published As

Publication number Publication date
US4707479A (en) 1987-11-17
DE3576156D1 (de) 1990-04-05
ES8700850A1 (es) 1986-11-16
EP0185964B1 (de) 1990-02-28
HUT40081A (en) 1986-11-28
JPS61145180A (ja) 1986-07-02
ES549873A0 (es) 1986-11-16
EP0185964A2 (de) 1986-07-02
ES8707501A1 (es) 1987-08-01
ES556988A0 (es) 1987-12-16
JPH0631224B2 (ja) 1994-04-27
AU5107085A (en) 1986-06-19
DE3445852A1 (de) 1986-06-19
DK578485A (da) 1986-06-16
CA1259996A (en) 1989-09-26
ES556986A0 (es) 1987-12-16
DK578485D0 (da) 1985-12-13
ES8801208A1 (es) 1987-12-16
ATE50571T1 (de) 1990-03-15
EP0185964A3 (en) 1986-12-03
ZA859550B (en) 1986-08-27
ES556987A0 (es) 1987-08-01

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