ES8800257A1 - Compsn. contg. 3-azido-3-deoxy-thymidine or its partly new derivs. - Google Patents

Compsn. contg. 3-azido-3-deoxy-thymidine or its partly new derivs.

Info

Publication number
ES8800257A1
ES8800257A1 ES553013A ES553013A ES8800257A1 ES 8800257 A1 ES8800257 A1 ES 8800257A1 ES 553013 A ES553013 A ES 553013A ES 553013 A ES553013 A ES 553013A ES 8800257 A1 ES8800257 A1 ES 8800257A1
Authority
ES
Spain
Prior art keywords
derivs
azido
monophosphate
compsn
contg
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES553013A
Other languages
Spanish (es)
Other versions
ES553013A0 (en
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Wellcome Foundation Ltd
Original Assignee
Wellcome Foundation Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB858506869A external-priority patent/GB8506869D0/en
Priority claimed from GB858511774A external-priority patent/GB8511774D0/en
Priority claimed from GB858523881A external-priority patent/GB8523881D0/en
Priority claimed from GB868603450A external-priority patent/GB8603450D0/en
Application filed by Wellcome Foundation Ltd filed Critical Wellcome Foundation Ltd
Publication of ES8800257A1 publication Critical patent/ES8800257A1/en
Publication of ES553013A0 publication Critical patent/ES553013A0/en
Expired legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
    • A61K31/7068—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid
    • A61K31/7072—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid having two oxo groups directly attached to the pyrimidine ring, e.g. uridine, uridylic acid, thymidine, zidovudine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/19—Cytokines; Lymphokines; Interferons
    • A61K38/21—Interferons [IFN]
    • A61K38/212—IFN-alpha
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • C07H19/10—Pyrimidine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids

Abstract

Pharmaceutical formulation comprises (1) 3'-azido-3'-deoxythymidine (I), or its pharmaceutically acceptable derivs. as active ingredients and (2) an acceptable carrier. The formulations are pref. administered by injection (partic. using sterile water as the carrier) or orally as tablets or capsules. Derivs. of (I), (A), which are converted in vivo to (I), or to its active metabolites or decomposition prods., are new, excluding the following: monophosphate, disodium-monophosphate, 2-cyanoethyl-monophosphate, triphosphate, p-toluenesulphonate, acetate, methanesulphonate and Ph3C-derivs., and cpds. where 5'-C atom is attached to another nucleotide or nucleoside deriv. Specified (A) are the 5'-(diphosphate,3-methylbutyrate, octanoate, palmitate, 3-chlorobenzoate, benzoate, hydrogensuccinate and pivalate) esters of (I).
ES553013A 1985-03-16 1986-03-14 Compsn. contg. 3-azido-3-deoxy-thymidine or its partly new derivs. Expired ES8800257A1 (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
GB858506869A GB8506869D0 (en) 1985-03-16 1985-03-16 Antiviral compound
GB858511774A GB8511774D0 (en) 1985-05-09 1985-05-09 Antiviral compounds
GB858523881A GB8523881D0 (en) 1985-09-27 1985-09-27 Antiviral compounds
GB868603450A GB8603450D0 (en) 1986-02-12 1986-02-12 Antiviral compounds

Publications (2)

Publication Number Publication Date
ES8800257A1 true ES8800257A1 (en) 1987-11-01
ES553013A0 ES553013A0 (en) 1987-11-01

Family

ID=27449646

Family Applications (2)

Application Number Title Priority Date Filing Date
ES553013A Expired ES8800257A1 (en) 1985-03-16 1986-03-14 Compsn. contg. 3-azido-3-deoxy-thymidine or its partly new derivs.
ES557209A Expired ES8802469A1 (en) 1985-03-16 1986-11-18 Compsn. contg. 3-azido-3-deoxy-thymidine or its partly new derivs.

Family Applications After (1)

Application Number Title Priority Date Filing Date
ES557209A Expired ES8802469A1 (en) 1985-03-16 1986-11-18 Compsn. contg. 3-azido-3-deoxy-thymidine or its partly new derivs.

Country Status (5)

Country Link
KR (1) KR860006987A (en)
AU (2) AU587739B2 (en)
ES (2) ES8800257A1 (en)
HU (2) HU199501B (en)
PH (1) PH27190A (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5276019A (en) * 1987-03-25 1994-01-04 The United States Of America As Represented By The Department Of Health And Human Services Inhibitors for replication of retroviruses and for the expression of oncogene products

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0199451B1 (en) * 1985-03-16 1996-03-06 The Wellcome Foundation Limited Therapeutic nucleosides
US4852127A (en) * 1985-03-22 1989-07-25 American Telephone And Telegraph Company, At&T Bell Laboratories Universal protocol data receiver

Also Published As

Publication number Publication date
HU199501B (en) 1990-02-28
ES557209A0 (en) 1988-07-16
AU1215988A (en) 1988-06-23
ES553013A0 (en) 1987-11-01
AU587739B2 (en) 1989-08-24
HUT40570A (en) 1987-01-28
PH27190A (en) 1993-04-16
AU574620B1 (en) 1988-07-07
KR860006987A (en) 1986-10-06
ES8802469A1 (en) 1988-07-16
HU197209B (en) 1989-03-28

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Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 20070806