ES8800221A1 - Un procedimiento para preparar derivados de 1,6-naftiridin-2 (1h)-ona - Google Patents
Un procedimiento para preparar derivados de 1,6-naftiridin-2 (1h)-onaInfo
- Publication number
- ES8800221A1 ES8800221A1 ES551258A ES551258A ES8800221A1 ES 8800221 A1 ES8800221 A1 ES 8800221A1 ES 551258 A ES551258 A ES 551258A ES 551258 A ES551258 A ES 551258A ES 8800221 A1 ES8800221 A1 ES 8800221A1
- Authority
- ES
- Spain
- Prior art keywords
- preparation
- naphthyridin
- ones
- formula
- pyridinecarbonitrile
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/84—Nitriles
- C07D213/85—Nitriles in position 3
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Pyridine Compounds (AREA)
Abstract
PROCEDIMIENTO PARA PREPARAR DERIVADOS DE 1,6-NAFTIRIDIN-2-(1H)-ONA. CONSISTE EN HACER REACCIONAR AL 5-BROMO (O CLORO)-7-R''-1,6-NAFTIRIDIN-2(1H)-ONA DE FORMULA (II) CON EL COMPUESTO 1H-(N AROMATICO DE 5 MIEMBROS)-HETERILO DE FORMULA (III), EN DIMETILFORMAMIDA, EN PRESENCIA DE UN ACEPTOR DE ACIDO COMO CARBONATO DE POTASIO ANHIDRO Y ENTRE 125 Y 225GC, PARA OBTENER UN COMPUESTO DE FORMULA (I). SIENDO: R, H, HALO O ALQUILO INFERIOR; R'', H O METILO; R1, H, ALQUILO INFERIOR, HIDROXIMETILO Y OTROS; X, CL O BR; Y Z, C-HALO, N,C-HIDROXIMETILO Y OTROS. SE UTILIZAN COMO CARDIOTONICOS. *FORMULA* E
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US69560385A | 1985-01-28 | 1985-01-28 | |
US76590085A | 1985-08-14 | 1985-08-14 | |
US81104085A | 1985-12-19 | 1985-12-19 |
Publications (2)
Publication Number | Publication Date |
---|---|
ES8800221A1 true ES8800221A1 (es) | 1987-11-01 |
ES551258A0 ES551258A0 (es) | 1987-11-01 |
Family
ID=27418622
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES551258A Expired ES8800221A1 (es) | 1985-01-28 | 1986-01-27 | Un procedimiento para preparar derivados de 1,6-naftiridin-2 (1h)-ona |
Country Status (12)
Country | Link |
---|---|
EP (1) | EP0189853A3 (es) |
KR (1) | KR870006046A (es) |
AU (1) | AU590870B2 (es) |
DK (1) | DK32086A (es) |
ES (1) | ES8800221A1 (es) |
FI (1) | FI860305A (es) |
GR (1) | GR860180B (es) |
IL (1) | IL77670A (es) |
NO (1) | NO860230L (es) |
NZ (1) | NZ214837A (es) |
PH (1) | PH22347A (es) |
PT (1) | PT81894B (es) |
Families Citing this family (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4567186A (en) * | 1985-01-14 | 1986-01-28 | Sterling Drug Inc. | 5-Heteryl-1,6-naphthyridin-2(1H)-ones, cardiotonic use thereof and intermediates therefor |
MXPA05008612A (es) * | 2003-02-14 | 2005-12-05 | Smithkline Beecham Corp | Compuestos novedosos. |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4415580A (en) * | 1982-08-02 | 1983-11-15 | Sterling Drug Inc. | Certain 2-(1H)-pyridinones cardiotonic compositions containing same and method of using same |
PT79699B (en) * | 1983-12-22 | 1986-12-10 | Pfizer | Process for preparing quinolone inotropic agents |
US4560691A (en) * | 1984-07-13 | 1985-12-24 | Sterling Drug Inc. | 5-(Phenyl)-1,6-naphthyridin-2(1H)-ones, their cardiotonic use and preparation |
-
1986
- 1986-01-15 NZ NZ214837A patent/NZ214837A/xx unknown
- 1986-01-17 AU AU52447/86A patent/AU590870B2/en not_active Expired - Fee Related
- 1986-01-21 IL IL77670A patent/IL77670A/xx unknown
- 1986-01-22 FI FI860305A patent/FI860305A/fi not_active Application Discontinuation
- 1986-01-22 DK DK32086A patent/DK32086A/da not_active Application Discontinuation
- 1986-01-22 NO NO860230A patent/NO860230L/no unknown
- 1986-01-22 KR KR1019860000391A patent/KR870006046A/ko not_active Application Discontinuation
- 1986-01-22 GR GR860180A patent/GR860180B/el unknown
- 1986-01-23 PT PT81894A patent/PT81894B/pt unknown
- 1986-01-23 EP EP86100903A patent/EP0189853A3/en not_active Withdrawn
- 1986-01-23 PH PH33318A patent/PH22347A/en unknown
- 1986-01-27 ES ES551258A patent/ES8800221A1/es not_active Expired
Also Published As
Publication number | Publication date |
---|---|
AU5244786A (en) | 1986-07-31 |
GR860180B (en) | 1986-05-29 |
FI860305A0 (fi) | 1986-01-22 |
AU590870B2 (en) | 1989-11-23 |
EP0189853A3 (en) | 1987-12-16 |
PT81894B (en) | 1987-05-05 |
EP0189853A2 (en) | 1986-08-06 |
PH22347A (en) | 1988-08-12 |
KR870006046A (ko) | 1987-07-08 |
FI860305A (fi) | 1986-07-29 |
IL77670A (en) | 1989-05-15 |
NO860230L (no) | 1986-07-29 |
NZ214837A (en) | 1988-10-28 |
DK32086A (da) | 1986-07-29 |
ES551258A0 (es) | 1987-11-01 |
DK32086D0 (da) | 1986-01-22 |
PT81894A (en) | 1986-02-01 |
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