ES8704937A1 - Un procedimiento para la preparacion del isomero optico dextrogiro del diastereomero a del 2,6-dimetil-4(m-nitrofenil)-1,4-dihidropiridin-3,5-ciarboxilato de 3-(1-bencilpirrolidin-3-ilo) y 5-metilo - Google Patents

Un procedimiento para la preparacion del isomero optico dextrogiro del diastereomero a del 2,6-dimetil-4(m-nitrofenil)-1,4-dihidropiridin-3,5-ciarboxilato de 3-(1-bencilpirrolidin-3-ilo) y 5-metilo

Info

Publication number
ES8704937A1
ES8704937A1 ES551767A ES551767A ES8704937A1 ES 8704937 A1 ES8704937 A1 ES 8704937A1 ES 551767 A ES551767 A ES 551767A ES 551767 A ES551767 A ES 551767A ES 8704937 A1 ES8704937 A1 ES 8704937A1
Authority
ES
Spain
Prior art keywords
dihydropyridine
dicarboxylic acid
diastereoisomer
preparation
acid ester
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES551767A
Other languages
English (en)
Other versions
ES551767A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Yamanouchi Pharmaceutical Co Ltd
Original Assignee
Yamanouchi Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from JP7599884A external-priority patent/JPS60231673A/ja
Priority claimed from JP59114098A external-priority patent/JPS60258179A/ja
Priority claimed from JP59165793A external-priority patent/JPS6143187A/ja
Application filed by Yamanouchi Pharmaceutical Co Ltd filed Critical Yamanouchi Pharmaceutical Co Ltd
Publication of ES551767A0 publication Critical patent/ES551767A0/es
Publication of ES8704937A1 publication Critical patent/ES8704937A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/24—Oxygen or sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/80—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D211/84—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen directly attached to ring carbon atoms
    • C07D211/90—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

PROCEIDMIENTO PARA LA PREPARACION DEL ISOMERO OPTICO DEXTROGIRO DEL DIASTEREOMERO A DEL 2,6-DIMETIL-4-(M-NITROFENIL)-1,4-DIHIDROPIRIDIN-3,5-DICARBOXILATO DE 3-(1-BENCILPIRROLIDIN-3-ILO) Y 5-METILO, Y SUS SALES FARMACEUTICAMENTE ACEPTABLES. COMPRENDE LAS SIGUIENTES OPERACIONES: PRIMERA, SE HACE REACCIONAR EL M-NITROBENZALDEHIDO CON UN COMPUESTO DE FORMULA GENERAL (I), EN LA QUE R ES METILO, Y CON UN COMPUESTO DE FORMULA GENERAL (II), EN LA QUE RK TIENE LOS MISMOS SIGNIFICADOS QUE R; SEGUNDA, SE SEPARA EL ISOMERO OPTICO DEXTROGIRO DEL ISOMERO OPTICO LEVORROTATORIO; Y POR ULTIMO, SI SE DESEA, SE FORMA UNA SAL DE ADICION DE ACIDO FARMACEUTICAMENTE ACEPTABLE. DE APLICACION EN LA PREPARACION DE COMPOSICIONES FARMACEUTICAS UTILIZADAS EN MEDICINA POR SU ACTIVIDAD VASODILATADORA E HIPOTENSIVA.
ES551767A 1984-04-16 1986-02-07 Un procedimiento para la preparacion del isomero optico dextrogiro del diastereomero a del 2,6-dimetil-4(m-nitrofenil)-1,4-dihidropiridin-3,5-ciarboxilato de 3-(1-bencilpirrolidin-3-ilo) y 5-metilo Expired ES8704937A1 (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP7599884A JPS60231673A (ja) 1984-04-16 1984-04-16 Ｙｍ−０９７３０のジアステレオマーａまたはその酸付加塩、該化合物の製造方法および該化合物からなる医薬
JP59114098A JPS60258179A (ja) 1984-06-04 1984-06-04 Ｙｍ−０９７３０のジアステレオマ−ａの右旋性光学異性体またはその酸付加塩，該化合物の製造方法および該化合物からなる医薬
JP59165793A JPS6143187A (ja) 1984-08-07 1984-08-07 Ｙｍ−０９７３０のジアステレオマ−ａの右旋性光学異性体の新規製法

Publications (2)

Publication Number Publication Date
ES551767A0 ES551767A0 (es) 1987-04-16
ES8704937A1 true ES8704937A1 (es) 1987-04-16

Family

ID=27302015

Family Applications (4)

Application Number Title Priority Date Filing Date
ES542253A Expired ES8608512A1 (es) 1984-04-16 1985-04-15 Un procedimiento para la preparacion del diastereoisomero de 2,dimetil-4-(m-nitrofenil) 1,4-dihidropiridin-3,5-dicarboxilamato de 3-(1-bencilpirrolidin-3-iio) y 5 metilo
ES551768A Expired ES8707522A1 (es) 1984-04-16 1986-02-07 Un procedimiento para la preparacion del isomero optico dextrogiro del diastereomero a del 2,6-dimetil-4-(m-nitrofenil)-1,4-dihidropiridin-3,5-dicarboxilato de 3-(1-bencilpirrolidin-3-ilo) y 5-metilo
ES551769A Expired ES8704866A1 (es) 1984-04-16 1986-02-07 Un procedimiento para la preparacion del diastereomero a de 2,6-dimetil-4-(m-nitrofenil)-1,4-dihidropiridin-3,5-dicarboxilato de 3-(1-bencilpirrolidin-3-ilo) y 5-metilo
ES551767A Expired ES8704937A1 (es) 1984-04-16 1986-02-07 Un procedimiento para la preparacion del isomero optico dextrogiro del diastereomero a del 2,6-dimetil-4(m-nitrofenil)-1,4-dihidropiridin-3,5-ciarboxilato de 3-(1-bencilpirrolidin-3-ilo) y 5-metilo

Family Applications Before (3)

Application Number Title Priority Date Filing Date
ES542253A Expired ES8608512A1 (es) 1984-04-16 1985-04-15 Un procedimiento para la preparacion del diastereoisomero de 2,dimetil-4-(m-nitrofenil) 1,4-dihidropiridin-3,5-dicarboxilamato de 3-(1-bencilpirrolidin-3-iio) y 5 metilo
ES551768A Expired ES8707522A1 (es) 1984-04-16 1986-02-07 Un procedimiento para la preparacion del isomero optico dextrogiro del diastereomero a del 2,6-dimetil-4-(m-nitrofenil)-1,4-dihidropiridin-3,5-dicarboxilato de 3-(1-bencilpirrolidin-3-ilo) y 5-metilo
ES551769A Expired ES8704866A1 (es) 1984-04-16 1986-02-07 Un procedimiento para la preparacion del diastereomero a de 2,6-dimetil-4-(m-nitrofenil)-1,4-dihidropiridin-3,5-dicarboxilato de 3-(1-bencilpirrolidin-3-ilo) y 5-metilo

Country Status (13)

Country Link
EP (1) EP0160451B1 (es)
KR (1) KR920003626B1 (es)
AT (1) ATE66677T1 (es)
AU (1) AU569618B2 (es)
CA (2) CA1273930A (es)
DE (1) DE3583882D1 (es)
DK (1) DK166386C (es)
ES (4) ES8608512A1 (es)
GR (1) GR850872B (es)
IE (1) IE57811B1 (es)
MX (1) MX7363E (es)
NL (1) NL990023I2 (es)
NO (1) NO159594C (es)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9405833D0 (en) * 1994-03-24 1994-05-11 Pfizer Ltd Separation of the enantiomers of amlodipine
DE4443168A1 (de) * 1994-12-05 1996-06-13 Bayer Ag Neues hochselektives Verfahren zur Herstellung von enantiomerenreinen phenylsubstituierten 1,4-Dihydropyridin-3,5-dicarbonsäurederivaten
KR100939347B1 (ko) 2005-07-20 2010-01-29 (주)카이로드 광학적으로 순수한 (ｓ)-3-히드록시 피롤리딘의 제조방법
ITMI20120513A1 (it) 2012-03-29 2013-09-30 Lusochimica Spa Nuove forme polimorfe della barnidipina cloridrato e processi per la loro preparazione
EP4382529A1 (en) 2022-12-07 2024-06-12 Bayer Consumer Care AG A process for preparing pure (3s)-pyrrolidin-3-ol and pure (3s)-pyrrolidin-3-ol hydrochloride

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS55301A (en) * 1978-02-14 1980-01-05 Yamanouchi Pharmaceut Co Ltd 1,4-dihydropyridine-3,5-dicarboxylic ester derivative and its preparation

Also Published As

Publication number Publication date
GR850872B (es) 1985-11-25
NO159594B (no) 1988-10-10
IE57811B1 (en) 1993-04-21
DK166386B (da) 1993-05-10
NO159594C (no) 1989-01-18
NL990023I2 (nl) 1999-12-01
EP0160451A2 (en) 1985-11-06
ES8608512A1 (es) 1986-07-01
DE3583882D1 (es) 1991-10-02
ES8707522A1 (es) 1987-08-01
DK169185A (da) 1985-10-17
ATE66677T1 (de) 1991-09-15
ES542253A0 (es) 1986-07-01
ES8704866A1 (es) 1987-04-16
CA1273930A (en) 1990-09-11
IE850985L (en) 1985-10-25
ES551769A0 (es) 1987-04-16
EP0160451A3 (en) 1987-07-08
KR920003626B1 (ko) 1992-05-04
AU569618B2 (en) 1988-02-11
KR860008162A (ko) 1986-11-12
ES551767A0 (es) 1987-04-16
AU4131885A (en) 1985-10-24
NO851494L (no) 1985-10-17
ES551768A0 (es) 1987-08-01
CA1289565C (en) 1991-09-24
MX7363E (es) 1988-08-04
DK169185D0 (da) 1985-04-15
EP0160451B1 (en) 1991-08-28
NL990023I1 (nl) 1999-10-01
DK166386C (da) 1993-09-27

Similar Documents

Publication Publication Date Title
JPS55301A (en) 1,4-dihydropyridine-3,5-dicarboxylic ester derivative and its preparation
PH23739A (en) Piperidine derivative and pharmaceutical composition
ATE40126T1 (de) 1,5-benzothiazepinderivate, verfahren zu ihrer herstellung und arzneimittel.
CA2036905A1 (en) Condensed thiazole compounds, their production and use
KR840006644A (ko) 1,4-디히드로피리딘 유도체 및 그제법
ES8704866A1 (es) Un procedimiento para la preparacion del diastereomero a de 2,6-dimetil-4-(m-nitrofenil)-1,4-dihidropiridin-3,5-dicarboxilato de 3-(1-bencilpirrolidin-3-ilo) y 5-metilo
US4166855A (en) 1,4-Dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylic acid ester, and its use as a peripheral vasodilator
IE43984B1 (en) A 1,4-dihydropyridine-3 5-dicarboxylic acid di-ester derivative, several processes for its preparation,and its use as a coronary therapeutic agent
ATE48994T1 (de) Benzimidazol-derivat, verfahren zu seiner herstellung und pharmazeutische zusammensetzung.
DK535384D0 (da) 1,3-dioxan-4-yl-alken- og alkansyrer, fremgangsmaader til fremstilling heraf og midler med indhold heraf
FI853574L (fi) Dihydropyridin -3,5-dikarboxylsyraesterderivat.
FR2623501B1 (fr) Nouveaux derives substitues de 20,21-dinoreburnamenine, leur procede de preparation et les nouveaux intermediaires ainsi obtenus, leur application comme medicaments et les compositions pharmaceutiques les renfermant
JPS57175164A (en) 1,4-dihydropyridine derivative and its preparation
US4675329A (en) Isopropyl 2-(3-trifluoromethylphenoxy)-ethyl 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-pyridine-3,5-dicarboxylate as vaso-dilators
WO1983003097A1 (en) 1,4-dihydropyridine derivatives, preparation thereof and pharmac eutical preparations containing them
DE69021518D1 (de) 1,4-Dihydro-2,6-dimethyl-4-(3-nitrophenyl)-5-nitropyridin-3-carbonsäure-1-azabicyclo[2.2.2]oct-3-ylester-Isomere.
US4769374A (en) Tetrahydroisoquinoline ethyl esters of 1,4-dihydropyridines and antihypertensive compositions
JPS6429359A (en) 1,4-dihydropyridine derivative and production thereof
JPS6438067A (en) 1,4-dihydropyridine derivative labeled with deuterium
HUT63330A (en) Process for producing pharmaceutical compositions comprising 1,4-dihydropyridine derivative
CS200500B2 (cs) Způsob výroby isobutylesteru 2,6-dimethyl-3-methoxykarbonyl-4- -(2'-nitrofenyl)-1,4-dihydropyridin-5-karboxylové kyseliny

Legal Events

Date Code Title Description
SPCF Request for supplementary protection certificate filed

Free format text: CLORHIDRATO DE BARNIDIPINO (VASEXTEN).

Spc suppl protection certif: C200100012

Filing date: 20010329

SPCG Supplementary protection certificate granted

Free format text: CLORHIDRATO DE BARNIDIPINO (VASEXTEN).

Spc suppl protection certif: C200100012

Filing date: 20010329

Expiry date: 20120217

Effective date: 20040914

PC1A Transfer granted
FD2A Announcement of lapse in spain

Effective date: 20151230