ES8704443A1 - Un procedimiento para la preparacion de derivados sustituidos ester benzoato de 3-hidroximorfinanos. - Google Patents
Un procedimiento para la preparacion de derivados sustituidos ester benzoato de 3-hidroximorfinanos.Info
- Publication number
- ES8704443A1 ES8704443A1 ES544852A ES544852A ES8704443A1 ES 8704443 A1 ES8704443 A1 ES 8704443A1 ES 544852 A ES544852 A ES 544852A ES 544852 A ES544852 A ES 544852A ES 8704443 A1 ES8704443 A1 ES 8704443A1
- Authority
- ES
- Spain
- Prior art keywords
- hydroxymorphinans
- intermediates
- processes
- prodrug derivatives
- ester prodrug
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D489/00—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula:
- C07D489/06—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: with a hetero atom directly attached in position 14
- C07D489/08—Oxygen atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
- C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
- C07D221/22—Bridged ring systems
- C07D221/28—Morphinans
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D489/00—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula:
- C07D489/02—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: with oxygen atoms attached in positions 3 and 6, e.g. morphine, morphinone
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
PROCEDIMIENTO PARA PREPARAR DERIVADOS SUSTITUIDOS ESTERBENZOATO DE 3-HIDROXIMORFINANOS. CONSISTE EN HACER REACCIONAR A UN 3-HIDROXIMORFINANO DE FORMULA (II) CON UN AGENTE DE ACILACION DE FORMULA (III), EN CLORURO DE METILENO O TETRAHIDROFURANO, EN PRESENCIA DE TIETILAMINA O PIRIDINA, ENTRE 0JC Y EL PUNTO DE EBULLICION DEL DISOLVENTE, Y DURANTE 0,5 A 24 HORAS, PARA OBTENER UN COMPUESTO DE FORMULA (I). SIENDO: A, UN ENLACE SENCILLO O DOBLE; R, METILO, ALILO O CICLOPROPILMETILO; R1 Y R2, H U OH; R3 Y R4, H; R6, H, ALQUILO DE C 1 A 4 Y OTROS; Y X E Y, H, OR6 Y NHR6. SE UTILIZA PARA EL TRATAMIENTO DEL DOLOR EN MAMIFEROS.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US62792384A | 1984-07-05 | 1984-07-05 | |
US06/733,464 US4668685A (en) | 1984-07-05 | 1985-05-14 | Substituted benzoate ester prodrug derivatives of 3-hydroxymorphinans, which are analgesics or narcotic antagonists |
Publications (2)
Publication Number | Publication Date |
---|---|
ES544852A0 ES544852A0 (es) | 1987-04-01 |
ES8704443A1 true ES8704443A1 (es) | 1987-04-01 |
Family
ID=27090564
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES544852A Expired ES8704443A1 (es) | 1984-07-05 | 1985-07-04 | Un procedimiento para la preparacion de derivados sustituidos ester benzoato de 3-hidroximorfinanos. |
Country Status (18)
Country | Link |
---|---|
US (1) | US4668685A (es) |
EP (1) | EP0170090B1 (es) |
AU (1) | AU578391B2 (es) |
CA (1) | CA1301150C (es) |
DE (1) | DE3573251D1 (es) |
DK (1) | DK160501C (es) |
ES (1) | ES8704443A1 (es) |
FI (1) | FI83215C (es) |
GR (1) | GR851653B (es) |
HK (1) | HK39790A (es) |
HU (1) | HU193995B (es) |
IE (1) | IE58136B1 (es) |
IL (1) | IL75721A (es) |
MX (1) | MX160445A (es) |
NO (1) | NO171209C (es) |
NZ (1) | NZ212641A (es) |
PT (1) | PT80773B (es) |
SU (2) | SU1450742A3 (es) |
Families Citing this family (49)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4673679A (en) * | 1986-05-14 | 1987-06-16 | E. I. Du Pont De Nemours And Company | Use of prodrugs of 3-hydroxymorphinans to prevent bitter taste upon buccal, nasal or sublingual administration |
DK107688D0 (da) * | 1988-03-01 | 1988-03-01 | Novo Industri As | Carbaminsyreestere af substituerede 7-hydroxy-2,3,4,5-tetrahydro-1h-3-benzazepiner |
US6702705B1 (en) | 1988-05-04 | 2004-03-09 | Igen International, Inc. | Prodrugs activated by targeted catalytic proteins |
DK24089D0 (da) * | 1989-01-20 | 1989-01-20 | Hans Bundgaard | Novel prodrug derivatives of biologically active agents containing hydroxyl groups or nh-acidic groups |
US6258360B1 (en) * | 1989-05-04 | 2001-07-10 | Igen International, Inc. | Prodrugs activated by targeted catalytic proteins |
KR100334697B1 (ko) * | 1991-08-05 | 2002-04-27 | 리차아드제이마세이 | 표적화된 촉매 단백질에 의해 활성화되는 선구 약제 |
US5968551A (en) * | 1991-12-24 | 1999-10-19 | Purdue Pharma L.P. | Orally administrable opioid formulations having extended duration of effect |
US6323212B1 (en) * | 1992-01-23 | 2001-11-27 | Toray Industries, Inc. | Morphinan derivative and its pharmaceutical applications |
TW372972B (en) * | 1992-10-23 | 1999-11-01 | Novartis Ag | Antiretroviral acyl compounds |
DE69427551T2 (de) * | 1993-03-15 | 2002-05-16 | National Science Council, Taipeh/T'ai-Pei | Nalbuphinester und diese enthaltende Arzneimittel mit verzögerter Wirkstoffabgabe |
EP0663401B1 (en) * | 1993-07-23 | 2000-06-07 | Toray Industries, Inc. | Morphinan derivative and medicinal use |
US5376662A (en) * | 1993-12-08 | 1994-12-27 | Ockert; David M. | Method of attenuating nerve injury induced pain |
US5869669A (en) * | 1996-07-26 | 1999-02-09 | Penick Corporation | Preparation of 14-hydroxynormorphinones from normorphinone dienol acylates |
US6225321B1 (en) * | 1997-06-05 | 2001-05-01 | Oliver Yoa-Pu Hu | Long analgesic acting nalbuphine polyester derivative and method of use |
ES2412409T3 (es) | 1997-12-22 | 2013-07-11 | Euro-Celtique S.A. | Forma farmacéutica para dosificación oral que comprende una combinación de un agonista opiáceo y un antagonista opiáceo |
US6375957B1 (en) | 1997-12-22 | 2002-04-23 | Euro-Celtique, S.A. | Opioid agonist/opioid antagonist/acetaminophen combinations |
DE60001487T2 (de) * | 2000-04-27 | 2003-12-24 | Oliver Yoa-Pu Hu | Polynalbuphinderivat |
US6569449B1 (en) | 2000-11-13 | 2003-05-27 | University Of Kentucky Research Foundation | Transdermal delivery of opioid antagonist prodrugs |
CA2446550C (en) | 2001-05-11 | 2012-03-06 | Endo Pharmaceuticals, Inc. | Abuse-resistant controlled-release opioid dosage form |
US20040033253A1 (en) * | 2002-02-19 | 2004-02-19 | Ihor Shevchuk | Acyl opioid antagonists |
CA2708900C (en) * | 2002-04-05 | 2019-06-04 | Purdue Pharma | Pharmaceutical preparation containing oxycodone and naloxone |
US20040202717A1 (en) | 2003-04-08 | 2004-10-14 | Mehta Atul M. | Abuse-resistant oral dosage forms and method of use thereof |
US20080020028A1 (en) * | 2003-08-20 | 2008-01-24 | Euro-Celtique S.A. | Transdermal dosage form comprising an active agent and a salt and a free-base form of an adverse agent |
EP1604667A1 (en) * | 2004-06-08 | 2005-12-14 | Euro-Celtique S.A. | Opioids for the treatment of the restless leg syndrome |
EP1604666A1 (en) * | 2004-06-08 | 2005-12-14 | Euro-Celtique S.A. | Opioids for the treatment of the Chronic Obstructive Pulmonary Disease (COPD) |
US20060069086A1 (en) * | 2004-09-23 | 2006-03-30 | Alexander Michalow | Methods for regulating neurotransmitter systems by inducing counteradaptations |
US20080045610A1 (en) * | 2004-09-23 | 2008-02-21 | Alexander Michalow | Methods for regulating neurotransmitter systems by inducing counteradaptations |
KR20090029856A (ko) * | 2005-01-28 | 2009-03-23 | 유로-셀띠끄 소시에떼 아노님 | 알코올 저항성 제형 |
EP1702558A1 (en) * | 2005-02-28 | 2006-09-20 | Euro-Celtique S.A. | Method and device for the assessment of bowel function |
EP1695700A1 (en) * | 2005-02-28 | 2006-08-30 | Euro-Celtique S.A. | Dosage form containing oxycodone and naloxone |
US8163701B2 (en) | 2005-08-19 | 2012-04-24 | Signature Therapeutics, Inc. | Prodrugs of active agents |
GB0606124D0 (en) * | 2006-03-28 | 2006-05-03 | Reckitt Benckiser Healthcare | Buprenorphine derivatives and uses thereof |
BRPI0808651A2 (pt) * | 2007-03-09 | 2014-08-19 | Green Cross Corp | Pró-medicamentos oralmente biodisponíveis de (+)-3-hidroximorfinano para a prevenção ou o tratamento da doença de parkinson. |
PE20110422A1 (es) * | 2008-07-07 | 2011-07-01 | Euro Celtique Sa | Composicion farmaceutica que comprende antagonistas opioides |
PT2405915T (pt) | 2009-03-10 | 2019-01-29 | Euro Celtique Sa | Composições farmacêuticas de libertação imediata compreendendo oxicodona e naloxona |
US10849981B2 (en) | 2009-07-02 | 2020-12-01 | KemPham, Inc. | Benzoic acid, benzoic acid derivatives and heteroaryl carboxylic acid conjugates of hydrocodone, prodrugs, methods of making and use thereof |
UA102916C2 (uk) | 2009-07-02 | 2013-08-27 | Кемфарм, Інк. | Композиція на основі кон'югату гідрокодону з бензойною кислотою, похідними бензойної кислоти або гетероарилкарбоновою кислотою, проліки, спосіб лікування від зловживань |
US8623888B2 (en) * | 2009-07-15 | 2014-01-07 | Mallinckrodt Llc | 3-oxy-hydromorphone derivatives |
RS59256B1 (sr) * | 2010-11-12 | 2019-10-31 | Shionogi & Co | Kristalni derivat 6,7-nezasićenog-7-karbamoil morfinana, i postupak njegove proizvodnje |
RU2573388C2 (ru) | 2011-10-26 | 2016-01-20 | Кемфарм Инк. | Бензойная кислота, производные бензойной кислоты и конъюгаты гетероарилкарбоновой кислоты с гидроморфоном, пролекарства, способы получения и их применение |
EP3024461B1 (en) | 2013-07-23 | 2020-05-13 | Euro-Celtique S.A. | A combination of oxycodone and naloxone for use in treating pain in patients suffering from pain and a disease resulting in intestinal dysbiosis and/or increasing the risk for intestinal bacterial translocation |
SG11201704178UA (en) | 2014-11-25 | 2017-06-29 | Kempharm Inc | Benzoic acid, benzoic acid derivatives and heteroaryl carboxylic acid conjugates of oxycodone |
CA2969221C (en) | 2014-12-02 | 2021-01-12 | Travis Mickle | Benzoic acid, benzoic acid derivatives and heteroaryl carboxylic acid conjugates of oxymorphone, prodrugs, methods of making and use thereof |
US10155771B2 (en) * | 2015-11-04 | 2018-12-18 | Noramco, Inc. | Selective reduction of morphinan alkaloids |
US10807995B2 (en) | 2018-07-13 | 2020-10-20 | Alkermes Pharma Ireland Limited | Thienothiophene compounds for long-acting injectable compositions and related methods |
US10799496B2 (en) | 2018-07-13 | 2020-10-13 | Alkermes Pharma Ireland Limited | Naphthylenyl compounds for long-acting injectable compositions and related methods |
US11186585B2 (en) | 2018-08-17 | 2021-11-30 | Kappa-Pharma LLC | Compositions and methods of enhancing opioid receptor engagement by opioid hexadienoates and optionally substituted hexadienoates |
WO2020094634A1 (en) | 2018-11-05 | 2020-05-14 | Alkermes Pharma Ireland Limited | Thiophene prodrugs of naltroxene for long-acting injectable compositions and related methods |
CA3149152A1 (en) | 2019-08-11 | 2021-02-18 | Kappa-Pharma LLC | Compositions and methods of enhancing opioid receptor engagement by opioid hexadienoates and optionally substituted hexadienoates |
Family Cites Families (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE224197C (es) * | ||||
US3254088A (en) * | 1961-03-14 | 1966-05-31 | Lewenstein | Morphine derivative |
FR1602610A (en) * | 1962-10-10 | 1971-01-04 | 10.10.62.-17.4.63. 38445-15209 thebaine derivs | |
US3332950A (en) * | 1963-03-23 | 1967-07-25 | Endo Lab | 14-hydroxydihydronormorphinone derivatives |
IL26896A (en) * | 1966-01-19 | 1970-11-30 | Endo Lab | 14 - Hydroxynormorphinins and 14 - Hydroxynormorphinones |
GB1097167A (en) * | 1966-05-31 | 1967-12-29 | Shionogi & Co | 3-hydroxy-6-oxo-n-phenethylmorphinan compounds and their production |
CH560194A5 (es) * | 1967-08-25 | 1975-03-27 | Hoffmann La Roche | |
US3654280A (en) * | 1968-03-21 | 1972-04-04 | Shionogi & Co | L-n allylic-3-hydroxy-6-oxomorphinans |
DE2323192A1 (de) * | 1972-05-10 | 1973-12-13 | Endo Lab | Injizierbare, langwirkende antagonistpraeparate gegen narkotika und rauschgifte |
US4161597A (en) * | 1976-12-20 | 1979-07-17 | Research Corporation | N-alkyl-14-hydroxymorphinans and derivatives |
JPS59184163A (ja) * | 1983-04-02 | 1984-10-19 | Res Inst For Prod Dev | 3−ベンゾイルチオ−17−メチルモルヒナン |
JPS59184183A (ja) * | 1983-04-02 | 1984-10-19 | Res Inst For Prod Dev | 3−ベンゾイルチオ−4、5α−エポキシ−7α−〔1(R)−ヒドロキシ−1−メチルブチル〕−6−メトキシ−17−メチル−6、14−エンド−エテノモルヒナン |
JPS59184182A (ja) * | 1983-04-02 | 1984-10-19 | Res Inst For Prod Dev | 3−ベンゾイルチオ−4、5α−エポキシ−7α−〔1(R)−ヒドロキシ−1−メチルベンチル〕−6−メトキシ−17−メチル−6、14−エンド−エタノモルヒナン |
JPS59186987A (ja) * | 1983-04-06 | 1984-10-23 | Res Inst For Prod Dev | 3−ベンゾイルチオ−4、5α−エポキシ−7α−〔1(R)−ヒドロキシ−1−メチルブチル〕−6−メトキシ−17−メチル−6、14−エンド−エテノモルヒナン |
-
1985
- 1985-05-14 US US06/733,464 patent/US4668685A/en not_active Expired - Lifetime
- 1985-06-27 CA CA000485661A patent/CA1301150C/en not_active Expired - Lifetime
- 1985-07-03 DE DE8585108258T patent/DE3573251D1/de not_active Expired
- 1985-07-03 EP EP85108258A patent/EP0170090B1/en not_active Expired
- 1985-07-03 AU AU44516/85A patent/AU578391B2/en not_active Ceased
- 1985-07-04 DK DK306885A patent/DK160501C/da not_active IP Right Cessation
- 1985-07-04 PT PT80773A patent/PT80773B/pt not_active IP Right Cessation
- 1985-07-04 HU HU852607A patent/HU193995B/hu not_active IP Right Cessation
- 1985-07-04 GR GR851653A patent/GR851653B/el unknown
- 1985-07-04 NO NO852699A patent/NO171209C/no unknown
- 1985-07-04 NZ NZ212641A patent/NZ212641A/xx unknown
- 1985-07-04 IE IE168385A patent/IE58136B1/en not_active IP Right Cessation
- 1985-07-04 FI FI852659A patent/FI83215C/fi not_active IP Right Cessation
- 1985-07-04 ES ES544852A patent/ES8704443A1/es not_active Expired
- 1985-07-04 IL IL75721A patent/IL75721A/xx not_active IP Right Cessation
- 1985-07-04 SU SU853920678A patent/SU1450742A3/ru active
- 1985-07-05 MX MX6144A patent/MX160445A/es unknown
-
1987
- 1987-07-03 SU SU874202841A patent/SU1508960A3/ru active
-
1990
- 1990-05-24 HK HK397/90A patent/HK39790A/xx unknown
Also Published As
Publication number | Publication date |
---|---|
GR851653B (es) | 1985-11-26 |
DK160501B (da) | 1991-03-18 |
IE851683L (en) | 1986-01-05 |
DE3573251D1 (en) | 1989-11-02 |
DK160501C (da) | 1991-08-26 |
HU193995B (en) | 1987-12-28 |
EP0170090A1 (en) | 1986-02-05 |
MX160445A (es) | 1990-03-02 |
PT80773A (en) | 1985-08-01 |
HK39790A (en) | 1990-06-01 |
SU1508960A3 (ru) | 1989-09-15 |
EP0170090B1 (en) | 1989-09-27 |
SU1450742A3 (ru) | 1989-01-07 |
FI852659L (fi) | 1986-01-06 |
NZ212641A (en) | 1988-10-28 |
CA1301150C (en) | 1992-05-19 |
NO852699L (no) | 1986-01-06 |
PT80773B (pt) | 1987-10-20 |
NO171209C (no) | 1993-02-10 |
AU578391B2 (en) | 1988-10-20 |
FI83215B (fi) | 1991-02-28 |
AU4451685A (en) | 1986-01-09 |
ES544852A0 (es) | 1987-04-01 |
HUT40132A (en) | 1986-11-28 |
DK306885D0 (da) | 1985-07-04 |
FI852659A0 (fi) | 1985-07-04 |
US4668685A (en) | 1987-05-26 |
FI83215C (fi) | 1991-06-10 |
IL75721A (en) | 1990-04-29 |
IL75721A0 (en) | 1985-11-29 |
DK306885A (da) | 1986-01-06 |
IE58136B1 (en) | 1993-07-14 |
NO171209B (no) | 1992-11-02 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
ES8704443A1 (es) | Un procedimiento para la preparacion de derivados sustituidos ester benzoato de 3-hidroximorfinanos. | |
IT1210666B (it) | Preparato farmaceutico ad assorbimento percutaneo per il trattamento di angina pectoris | |
AU7960287A (en) | Prodrug derivatives of carboxylic acid drugs | |
NO954489D0 (no) | Analogifremgangsmåte for fremstilling av farmakologisk aktive pyrimidinforbindelser | |
ES8601965A1 (es) | Un procedimiento para la preparacion de una nueva serie de derivados de (1-piperidinilalquil)pirimidinona | |
ES8800679A1 (es) | Un procedimiento para preparar derivados de piperiliden-dihidrodibenzo-(a,d)-cicloheptenos y derivados aza | |
JO1704B1 (en) | New potent compounds | |
AU1311588A (en) | Pharmacologically active substituted benzamides | |
PT80191A (en) | Process for preparing substituted benzopyrans useful as medicaments | |
DK0736029T3 (da) | Antikonvulsive pseudofructopyranosesulfamater | |
TW364905B (en) | Lactone compound and process of production thereof | |
MY133169A (en) | Substituted heterocyclic benzocycloalkenes and the use thereof as substances having an analgesic effect | |
ES8704875A1 (es) | Procedimiento de producir compuestos para tratar la hiper- tension | |
ES2000714A6 (es) | Un procedimiento para preparar derivados de tetrahidroisoquinoleina | |
FI890678A (fi) | Analogiamenetelmä terapeuttisesti käyttökelpoisten 1,3-dioksaanialkeenihappojohdannaisten valmistamiseksi | |
NO880922D0 (no) | Fremgangsmaate for fremstilling av farmakologisk aktive benzodioksolderivater. | |
AU4478489A (en) | Intermediates for the preparation of penem derivatives | |
NO864818D0 (no) | Fremgangsmaate for fremstilling av nye terapeutisk virksomme tetrahydroisokinolinderivater. | |
NO882256L (no) | Fremgangsmaate for fremstilling av farmakologisk aktive kinolinforbindelser. | |
ZW6789A1 (en) | &-adrenergic receptor antagonists | |
AP9200405A0 (en) | Pharmaceutical formulations comprised of micronised halofantrine. | |
ZA855058B (en) | Substituted benzoate ester prodrug derivatives of 3-hydroxymorphinans,intermediates thereto,and processes | |
ES8606259A1 (es) | Un metodo de producir una composicion farmaceutica que contiene isoxicamato de l-arginina como ingrediente activo. | |
GR77230B (es) | ||
ZW6889A1 (en) | &-adrenergic receptor antagonists |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
FD1A | Patent lapsed |
Effective date: 19970203 |