ES8607964A1 - Un procedimiento para la preparacion del isomero (3s, 4r) de un compuesto - Google Patents
Un procedimiento para la preparacion del isomero (3s, 4r) de un compuestoInfo
- Publication number
- ES8607964A1 ES8607964A1 ES530958A ES530958A ES8607964A1 ES 8607964 A1 ES8607964 A1 ES 8607964A1 ES 530958 A ES530958 A ES 530958A ES 530958 A ES530958 A ES 530958A ES 8607964 A1 ES8607964 A1 ES 8607964A1
- Authority
- ES
- Spain
- Prior art keywords
- alkyl
- carbon atoms
- hydrogen
- isomers
- alkylcarbonyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyrane Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
PROCEDIMIENTO PARA LA OBTENCION DE ISOMEROS (3S, 4R) DE LOS COMPUESTOS DE FORMULA (I). CONSISTE EN LA RESOLUCION DE UNA MEZCLA DE LOS ISOMEROS (3S, 4R) Y (4S, 3R) DE UN COMPUESTO DE FORMULA (I), DONDE R1, R2, R3, R4 Y R5 SON HIDROGENO O DIFERENTES RADICALES Y N ES 1 O 2, MEDIANTE LA REACCION DE DICHA MEZCLA CON UN REACTIVO OPTICAMENTE ACTIVO ADECUADO PARA RESOLVER ALCOHOLES, TAL COMO ISOCIANATO DE (-)-A-METILBENCILO, A LA TEMPERATURA DE REFLUJO EN UN DISOLVENTE INERTE, TAL COMO TOLUENO; SEGUIDA DE LA SEPARACION DE LA MEZCLA DE CARBAMATOS OBTENIDA POR CRISTALIZACION FRACCIONADA EN EL SENO DE UN DISOLVENTE ADECUADO. ESTOS COMPUESTOS TIENEN APLICACIONES FARMACOLOGICAS POR SU ACTIVIDAD ANTIHIPERTENSIVA.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB838308062A GB8308062D0 (en) | 1983-03-24 | 1983-03-24 | Active compounds |
Publications (2)
Publication Number | Publication Date |
---|---|
ES8607964A1 true ES8607964A1 (es) | 1986-06-01 |
ES530958A0 ES530958A0 (es) | 1986-06-01 |
Family
ID=10540102
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES530958A Expired ES8607964A1 (es) | 1983-03-24 | 1984-03-23 | Un procedimiento para la preparacion del isomero (3s, 4r) de un compuesto |
Country Status (12)
Country | Link |
---|---|
EP (1) | EP0120428B1 (es) |
JP (1) | JPH0791188B2 (es) |
AU (1) | AU571498B2 (es) |
CA (1) | CA1284150C (es) |
CS (1) | CS391391A3 (es) |
DE (1) | DE3482323D1 (es) |
ES (1) | ES8607964A1 (es) |
GB (1) | GB8308062D0 (es) |
GR (1) | GR81923B (es) |
IE (1) | IE57119B1 (es) |
NZ (1) | NZ207594A (es) |
ZA (1) | ZA842123B (es) |
Families Citing this family (20)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
PT84806B (pt) * | 1986-05-03 | 1989-12-29 | Beecham Group Plc | Processo para a preparacao de benzopiranos |
GB8625185D0 (en) * | 1986-10-21 | 1986-11-26 | Beecham Group Plc | Active compounds |
DE3881714D1 (de) * | 1987-02-04 | 1993-07-22 | Hoechst Ag | Alkylsubstituierte n-benzopyranyllactame, verfahren zu ihrer herstellung, ihre verwendung sowie pharmazeutische praeparate auf basis dieser verbindungen. |
DE3703227A1 (de) * | 1987-02-04 | 1988-08-18 | Hoechst Ag | Substituierte 3,4-dihydro-2h-benzopyrane, verfahren zu ihrer herstellung, ihre verwendung sowie pharmazeutische praeparate auf basis dieser verbindungen |
FR2615191B1 (fr) * | 1987-05-16 | 1991-01-11 | Sandoz Sa | Nouveaux benzo(b)pyrannes et pyrannopyridines, leur preparation et leur utilisation comme medicaments |
DE3811017A1 (de) * | 1988-03-31 | 1989-10-19 | Hoechst Ag | Ungesaettigte n-benzopyranyllactame |
DE3818245A1 (de) * | 1988-05-28 | 1989-12-07 | Hoechst Ag | Kombination von angiotensin-converting-enzyme-hemmern mit kaliumkanal-modulatoren sowie deren verwendung in arzneimitteln |
US4988723A (en) * | 1988-06-02 | 1991-01-29 | Fujisawa Pharmaceutical Co., Ltd. | Benzopyran derivatives and their use as anti-hypertensives |
DE3823533A1 (de) * | 1988-07-12 | 1990-02-08 | Beiersdorf Ag | Substituierte 4-heterocyclyl-2h-benzo(b)pyrane, verfahren und 4-hydroxy-3-brom-, 3,4-oxiranyl-3,4-dehydro-2h-benzo(b)pyrane als zwischenprodukte zu ihrer herstellung, sowie sie enthaltende pharmazeutsche praeparate |
DE3901720A1 (de) * | 1989-01-21 | 1990-07-26 | Hoechst Ag | Substituierte benzo(b)pyrane, verfahren zu ihrer herstellung, ihre verwendung sowie pharmazeutische praeparate auf basis dieser verbindungen |
US5239090A (en) * | 1989-02-01 | 1993-08-24 | Beecham Group P.L.C. | Certain optically active 3,4-dihydrobenzopyran-4-ols which are intermediates |
GB8902118D0 (en) * | 1989-02-01 | 1989-03-22 | Beecham Group Plc | Chemical process |
US5162553A (en) * | 1989-03-03 | 1992-11-10 | Yoshitomi Pharmaceutical Industries, Ltd. | Processes for preparing optically active 3,4-dihydro-3,4-epoxy-2H-1-benzopyran compounds and intermediates therefor |
US5066816A (en) * | 1989-03-03 | 1991-11-19 | Yoshitomi Pharmaceutical Industries, Ltd. | Processes for preparing optically active 3,4-dihydro-3,4-epoxy-2h-1-benzopyran compounds and intermediates therefor |
IE63935B1 (en) * | 1989-06-27 | 1995-06-28 | Chem Pharm Forsch Gmbh | Novel thienopyran derivatives a process for their preparation and their use |
DE3922392A1 (de) | 1989-07-07 | 1991-01-17 | Merck Patent Gmbh | Chromanderivate |
HU207861B (en) * | 1989-07-21 | 1993-06-28 | Alkaloida Vegyeszeti Gyar | Process for producing benzopirane derivative of blood pressure lowering activity |
HUT72741A (en) * | 1992-12-19 | 1996-05-28 | Alkaloida Vegyeszeti Gyar | Method for producing benzopyrane derivatives and pharmaceutical compositions containing them |
WO2000067754A1 (en) | 1999-05-12 | 2000-11-16 | Nitromed, Inc. | Nitrosated and nitrosylated potassium channel activators, compositions and methods of use |
EP3099304B1 (en) | 2014-01-31 | 2024-07-17 | Mayo Foundation for Medical Education and Research | Chroman derivatives and their use in the treatment of glaucoma |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB1548222A (en) * | 1976-12-17 | 1979-07-04 | Beecham Group Ltd | Trans-4-heterocyclyl-3,4-dihydro-2h-benzo pyarn-3-ol derivatives |
DE2965739D1 (en) * | 1978-10-04 | 1983-07-28 | Beecham Group Plc | Chromanol derivatives, a process for their preparation and pharmaceutical compositions comprising them |
GB2064514B (en) * | 1979-10-29 | 1984-01-18 | Maruko Pharmaceutical Co | Flavan compounds and acid addition salts thereof and pharmaceutical compositions thereof |
DE3163018D1 (en) * | 1980-02-02 | 1984-05-17 | Beecham Group Plc | Pyrano derivatives, a process for their preparation and antihypertensive compositions containing them |
GB2107706A (en) * | 1981-09-25 | 1983-05-05 | Beecham Group Plc | Benzopyrans |
JPH0471072A (ja) * | 1990-07-11 | 1992-03-05 | Fujitsu Ltd | アナログ/ディジタル混載集積回路のシミュレーション方法 |
-
1983
- 1983-03-24 GB GB838308062A patent/GB8308062D0/en active Pending
-
1984
- 1984-03-17 DE DE8484102963T patent/DE3482323D1/de not_active Expired - Lifetime
- 1984-03-17 EP EP84102963A patent/EP0120428B1/en not_active Expired - Lifetime
- 1984-03-22 IE IE707/84A patent/IE57119B1/en not_active IP Right Cessation
- 1984-03-22 NZ NZ207594A patent/NZ207594A/en unknown
- 1984-03-22 CA CA000450251A patent/CA1284150C/en not_active Expired - Lifetime
- 1984-03-22 AU AU26007/84A patent/AU571498B2/en not_active Expired
- 1984-03-22 ZA ZA842123A patent/ZA842123B/xx unknown
- 1984-03-22 GR GR74175A patent/GR81923B/el unknown
- 1984-03-23 JP JP59055933A patent/JPH0791188B2/ja not_active Expired - Lifetime
- 1984-03-23 ES ES530958A patent/ES8607964A1/es not_active Expired
-
1991
- 1991-12-19 CS CS913913A patent/CS391391A3/cs unknown
Also Published As
Publication number | Publication date |
---|---|
GR81923B (es) | 1984-12-12 |
CS391391A3 (en) | 1992-09-16 |
JPH0791188B2 (ja) | 1995-10-04 |
CA1284150C (en) | 1991-05-14 |
EP0120428B1 (en) | 1990-05-23 |
JPS59176282A (ja) | 1984-10-05 |
IE840707L (en) | 1984-09-24 |
GB8308062D0 (en) | 1983-05-05 |
NZ207594A (en) | 1987-07-31 |
EP0120428A1 (en) | 1984-10-03 |
IE57119B1 (en) | 1992-05-06 |
AU2600784A (en) | 1984-09-27 |
ZA842123B (en) | 1985-04-24 |
ES530958A0 (es) | 1986-06-01 |
DE3482323D1 (de) | 1990-06-28 |
AU571498B2 (en) | 1988-04-21 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
ES8607964A1 (es) | Un procedimiento para la preparacion del isomero (3s, 4r) de un compuesto | |
PH18691A (en) | Benzopyran compounds,pharmaceutical composition containing them and method of use | |
PT80689A (en) | Process for the preparation of novel chroman and chromene compounds having pharmacological activity pharmaceutical compositions containing same and theier use in the treatment of mammals | |
FI900499A0 (fi) | Kemiskt foerfarande. |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
FD1A | Patent lapsed |
Effective date: 20060315 |