ES8606390A1 - Un procedimiento para preparar nuevos peptidos atriales. - Google Patents
Un procedimiento para preparar nuevos peptidos atriales.Info
- Publication number
- ES8606390A1 ES8606390A1 ES537520A ES537520A ES8606390A1 ES 8606390 A1 ES8606390 A1 ES 8606390A1 ES 537520 A ES537520 A ES 537520A ES 537520 A ES537520 A ES 537520A ES 8606390 A1 ES8606390 A1 ES 8606390A1
- Authority
- ES
- Spain
- Prior art keywords
- ser
- gly
- arg
- phe
- atrial peptides
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/58—Atrial natriuretic factor complex; Atriopeptin; Atrial natriuretic peptide [ANP]; Cardionatrin; Cardiodilatin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/10—Antioedematous agents; Diuretics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Cardiology (AREA)
- General Chemical & Material Sciences (AREA)
- Biochemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Pharmacology & Pharmacy (AREA)
- Molecular Biology (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Endocrinology (AREA)
- Toxicology (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biophysics (AREA)
- Heart & Thoracic Surgery (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Abstract
PROCEDIMIENTO PARA LA PREPARACION DE PEPTIDOS ATRIALES QUE TIENEN UNA ACTIVIDAD NATRIURETICA POTENTE Y QUE COMPRENDEN LA SECUENCIA DE AMINOACIDOS DE FORMULA GENERAL (1), Y SUS SALES, ESTERES O AMIDAS FISIOLOGICAMENTE ACEPTABLES. COMPRENDE LAS SIGUIENTES OPERACIONES: PRIMERA, SE PREPARA UN HOMOGENEIZADO BRUTO DE TEJIDO ATRIAL DE MAMIFERO Y SE HIERVE EL MATERIAL QUE SOBRENADA; SEGUNDA, SE DESALIFICA EL MATERIAL QUE SOBRENADA POR CROMATOGRAFIA DE FILTRACION EN GEL SOBRE RESINA DE DEXTRANO RETICULADO; TERCERA, SE CROMATOGRAFIA POR FILTRACION EN GEL LA FRACCION DE PROTEINAS SOBRE RESINA DE DEXTRANO RETICULADO; CUARTA, SE CROMATOGRAFIA POR CAMBIO DE IONES LA FRACCION DE PROTEINAS DE BAJO PESO MOLECULAR; QUINTA, SE CROMATOGRAFIA POR CROMATOGRAFIA DE LIQUIDOS DE ALTO RENDIMIENTO LAS DOS FRACCIONES PRINCIPALES DE PROTEINA; Y POR ULTIMO, SE RECUPERAN LAS FRACCIONES DE PEPTIDO ATRIAL SEPARADAS.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US55137283A | 1983-11-10 | 1983-11-10 | |
US06/569,684 US4496544A (en) | 1983-11-10 | 1984-01-10 | Atrial Peptides |
Publications (2)
Publication Number | Publication Date |
---|---|
ES8606390A1 true ES8606390A1 (es) | 1986-04-01 |
ES537520A0 ES537520A0 (es) | 1986-04-01 |
Family
ID=27069747
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES537520A Expired ES8606390A1 (es) | 1983-11-10 | 1984-11-08 | Un procedimiento para preparar nuevos peptidos atriales. |
Country Status (12)
Country | Link |
---|---|
US (1) | US4496544A (es) |
EP (1) | EP0142487B1 (es) |
JP (1) | JPH0672156B2 (es) |
AU (1) | AU566235B2 (es) |
DE (1) | DE3480930D1 (es) |
DK (1) | DK533484A (es) |
ES (1) | ES8606390A1 (es) |
FI (1) | FI83661C (es) |
GR (1) | GR80905B (es) |
IE (1) | IE58819B1 (es) |
IL (1) | IL73466A (es) |
NO (1) | NO844489L (es) |
Families Citing this family (47)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0116784B1 (en) * | 1982-02-22 | 1992-06-10 | Queen's University At Kingston | Atrial natriuretic factor |
AU572173B2 (en) * | 1983-08-29 | 1988-05-05 | Institut De Recherches Cliniques De Montreal | Natriuretic factors |
JPS60136596A (ja) * | 1983-12-26 | 1985-07-20 | Suntory Ltd | ペプチド及びこれを有効成分とする利尿剤 |
US4952561A (en) * | 1984-02-07 | 1990-08-28 | Merck & Co., Inc. | Cardiac atrial peptides |
JPH0794473B2 (ja) * | 1984-03-02 | 1995-10-11 | サントリー株式会社 | 新規なペプチド及びこれを有効成分とする利尿剤 |
EP0180615B1 (en) * | 1984-04-19 | 1995-04-05 | Scios Nova Inc. | Novel atrial natriuretic/vasodilator polypeptides |
US5212286A (en) * | 1984-04-19 | 1993-05-18 | Scios Nova Inc. | Atrial natriuretic/vasodilator peptide compounds |
US4618600A (en) * | 1984-04-19 | 1986-10-21 | Biotechnology Research Associates, J.V. | Novel polypeptide diuretic/vasodilators |
WO1985004872A1 (en) * | 1984-04-24 | 1985-11-07 | The Salk Institute For Biological Studies | Atrial peptide analogs |
JPH0672157B2 (ja) * | 1984-08-29 | 1994-09-14 | 味の素株式会社 | 新規ペプチド |
US4652549A (en) * | 1985-01-22 | 1987-03-24 | Merck & Co., Inc. | Cardiac anti-hypertrophic agents |
US5087564A (en) * | 1985-06-20 | 1992-02-11 | Monsanto Company | Release of recombinant peptides from polypeptides using V8 endopeptidase |
US4757048A (en) * | 1985-11-05 | 1988-07-12 | Biotechnology Research Associates J.V. | Synthetic analogs of atrial natriuretic peptides |
JP3042782B2 (ja) * | 1985-11-05 | 2000-05-22 | サイオス インコーポレイテッド | 心房性ナトリウム尿***亢進ペプチド類似化合物 |
KR940001711B1 (ko) * | 1985-11-05 | 1994-03-05 | 캘리포니아 바이오테크널러지 인코포레이티드 | 심방성 나트륨이뇨성 펩티드의 동족체 |
DE3614833A1 (de) * | 1986-01-16 | 1987-07-23 | Hoechst Ag | Peptide mit vasorelaxierender, natriuretischer und diuretischer wirkung, verfahren zu ihrer herstellung, diese enthaltende mittel und ihre verwendung |
US4716147A (en) * | 1986-03-27 | 1987-12-29 | Monsanto Company | Synthetic airial peptides |
US4721704A (en) * | 1986-05-09 | 1988-01-26 | Peninsula Laboratories, Inc. | Potent synthetic atrial peptide analogs |
EP0246795A3 (en) * | 1986-05-20 | 1990-04-04 | Advanced Peptide Development Limited | Synthetic natriuretic peptides |
US4740499A (en) * | 1986-07-28 | 1988-04-26 | Monsanto Company | Method of enhancing the bioactivity of atrial peptides |
US5565606A (en) * | 1986-10-21 | 1996-10-15 | Hoechst Aktiengesellschaft | Synthesis of peptide aminoalkylamides and peptide hydrazides by the solid-phase method |
DE3723551A1 (de) * | 1987-07-16 | 1989-01-26 | Hoechst Ag | Peptide mit vasorelaxierender, natriuretischer und diuretischer wirkung, verfahren zu ihrer herstellung, diese enthaltende mittel und ihre verwendung |
US4804650A (en) * | 1986-10-28 | 1989-02-14 | Biotechnology Research Associates, J.V. | Analogs of atrial natriuretic peptides |
US5500230A (en) * | 1987-01-23 | 1996-03-19 | The General Hospital Corporation | Method for treatment of glaucoma with nitrogen containing guanylate cyclase activators |
WO1988005306A1 (en) * | 1987-01-23 | 1988-07-28 | The General Hospital Corporation | Atriopeptins, guanylate cyclase activators, and phosphodiesterase inhibitors as treatment for glaucoma, hydrocephalus and cerebral edema (cranial fluid volume dysfunction) |
IT1216865B (it) | 1987-02-03 | 1990-03-14 | Eniricerche Spa | Derivato argininico, procedimento per la sua preparazione e suo impiego nelle sintesi peptidiche. |
ATE90108T1 (de) * | 1987-10-09 | 1993-06-15 | Takeda Chemical Industries Ltd | Vasokonstriktor-peptid. |
US4935492A (en) * | 1987-12-24 | 1990-06-19 | California Biotechnology Inc. | Cyclic analogs of atrial natriuretic peptides |
US5047397A (en) * | 1988-08-26 | 1991-09-10 | California Biotechnology Inc. | Linear analogs of atrial natriuretic peptides |
CA1339210C (en) | 1988-05-31 | 1997-08-05 | John Lewicki | Recombinant techniques for production of novel natriuretic and vasodilator peptides |
US5114923A (en) * | 1988-05-31 | 1992-05-19 | California Biotechnology Inc. | Recombinant techniques for production of novel natriuretic and vasodilator peptides |
JP2801079B2 (ja) * | 1990-11-14 | 1998-09-21 | サントリー株式会社 | Anp関連新規ペプチド |
JP2809533B2 (ja) * | 1991-01-31 | 1998-10-08 | 壽之 松尾 | Cnp類似体ペプチド |
US5846932A (en) * | 1993-11-12 | 1998-12-08 | Genentech, Inc. | Receptor specific atrial natriuretic peptides |
US6525022B1 (en) | 1993-11-12 | 2003-02-25 | Genentech, Inc. | Receptor specific atrial natriuretic peptides |
US5665704A (en) * | 1993-11-12 | 1997-09-09 | Genentech, Inc. | Receptor specific atrial natriuretic peptides |
US5486519A (en) * | 1994-08-22 | 1996-01-23 | Greenwald; James E. | Method for treatment of acute renal failure |
US5521191A (en) * | 1994-10-17 | 1996-05-28 | Washington University | Method for treatment of arterial stenosis |
US20060177870A1 (en) * | 2003-04-28 | 2006-08-10 | Ciphergen Biosystems, Inc | Immunoassays |
CN101208353B (zh) * | 2003-06-20 | 2011-12-14 | 梅约医学教育与研究基金会 | 脑利尿钠肽的同种型 |
KR101434612B1 (ko) * | 2006-03-30 | 2014-08-26 | 팔라틴 테크놀로지스 인코포레이티드 | 사이클릭 나트륨 이뇨 펩타이드 구조물 |
AU2007233123A1 (en) * | 2006-03-30 | 2007-10-11 | Palatin Technologies, Inc. | Linear natriuretic peptide constructs |
US8580746B2 (en) | 2006-03-30 | 2013-11-12 | Palatin Technologies, Inc. | Amide linkage cyclic natriuretic peptide constructs |
CN101501067B (zh) | 2006-08-08 | 2013-01-16 | 梅约医学教育与研究基金会 | 利尿和利尿钠的多肽 |
WO2009036448A2 (en) * | 2007-09-15 | 2009-03-19 | Mayo Foundation For Medical Education And Research | Natriuretic peptide receptor-c agonists |
JP2014525439A (ja) | 2011-08-30 | 2014-09-29 | メイヨ・ファウンデーション・フォー・メディカル・エデュケーション・アンド・リサーチ | ナトリウム利尿ポリペプチド |
WO2013103896A1 (en) | 2012-01-06 | 2013-07-11 | Mayo Foundation For Medical Education And Research | Treating cardiovascular or renal diseases |
Family Cites Families (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ZA846084B (en) * | 1983-08-29 | 1985-05-29 | Montreal Inst Rech Cliniques | Natriuretic factors |
-
1984
- 1984-01-10 US US06/569,684 patent/US4496544A/en not_active Expired - Lifetime
- 1984-11-08 ES ES537520A patent/ES8606390A1/es not_active Expired
- 1984-11-09 IE IE288184A patent/IE58819B1/en not_active IP Right Cessation
- 1984-11-09 DK DK533484A patent/DK533484A/da not_active Application Discontinuation
- 1984-11-09 JP JP59236542A patent/JPH0672156B2/ja not_active Expired - Lifetime
- 1984-11-09 DE DE8484870149T patent/DE3480930D1/de not_active Expired - Lifetime
- 1984-11-09 EP EP84870149A patent/EP0142487B1/en not_active Expired - Lifetime
- 1984-11-09 FI FI844424A patent/FI83661C/fi not_active IP Right Cessation
- 1984-11-09 AU AU35252/84A patent/AU566235B2/en not_active Ceased
- 1984-11-09 GR GR80905A patent/GR80905B/el unknown
- 1984-11-09 IL IL73466A patent/IL73466A/xx not_active IP Right Cessation
- 1984-11-09 NO NO844489A patent/NO844489L/no unknown
Also Published As
Publication number | Publication date |
---|---|
FI844424A0 (fi) | 1984-11-09 |
AU566235B2 (en) | 1987-10-15 |
DK533484D0 (da) | 1984-11-09 |
NO844489L (no) | 1985-05-13 |
EP0142487B1 (en) | 1990-01-03 |
DE3480930D1 (de) | 1990-02-08 |
US4496544A (en) | 1985-01-29 |
IE842881L (en) | 1985-05-10 |
FI83661C (fi) | 1991-08-12 |
FI844424L (fi) | 1985-05-11 |
GR80905B (en) | 1985-04-02 |
ES537520A0 (es) | 1986-04-01 |
DK533484A (da) | 1985-05-11 |
IL73466A0 (en) | 1985-02-28 |
JPS60214797A (ja) | 1985-10-28 |
IE58819B1 (en) | 1993-11-17 |
JPH0672156B2 (ja) | 1994-09-14 |
FI83661B (fi) | 1991-04-30 |
IL73466A (en) | 1989-03-31 |
AU3525284A (en) | 1985-05-16 |
EP0142487A3 (en) | 1986-04-30 |
EP0142487A2 (en) | 1985-05-22 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FD1A | Patent lapsed |
Effective date: 20001102 |