ES8604556A1 - Procedimiento para preparar derivados de flaveno y tioflave-no - Google Patents

Procedimiento para preparar derivados de flaveno y tioflave-no

Info

Publication number
ES8604556A1
ES8604556A1 ES545717A ES545717A ES8604556A1 ES 8604556 A1 ES8604556 A1 ES 8604556A1 ES 545717 A ES545717 A ES 545717A ES 545717 A ES545717 A ES 545717A ES 8604556 A1 ES8604556 A1 ES 8604556A1
Authority
ES
Spain
Prior art keywords
flavene
thioflavene
derivatives
compounds
manufacture
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES545717A
Other languages
English (en)
Other versions
ES545717A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
GSK Consumer Healthcare SARL
Original Assignee
Zyma SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Zyma SA filed Critical Zyma SA
Publication of ES8604556A1 publication Critical patent/ES8604556A1/es
Publication of ES545717A0 publication Critical patent/ES545717A0/es
Expired legal-status Critical Current

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D335/00Heterocyclic compounds containing six-membered rings having one sulfur atom as the only ring hetero atom
    • C07D335/04Heterocyclic compounds containing six-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D335/06Benzothiopyrans; Hydrogenated benzothiopyrans
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D311/00Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/58Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4
    • C07D311/60Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4 with aryl radicals attached in position 2

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Immunology (AREA)
  • Pulmonology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Saccharide Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)
  • Pyrane Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

PROCEDIMIENTO PARA PREPARAR DERIVADOS DE FLAVENO Y TIOFLAVENO. COMPRENDE: A) HACER REACCIONAR UN COMPUESTO DE FORMULA (II) CON OXIHALURO DE FOSFORO, PO(HAL)3, Y UNA FORMAMIDA DE FORMULA (III) PARA OBTENER COMPUESTOS DE FORMULA (I), EN DONDE Z ES HALOGENO Y Z2 ES FORMILO, Y LAS SALES DE TALES COMPUESTOS QUE TIENEN UN GRUPO FORMADOR DE SAL; O B) HACER REACCIONAR UN COMPUESTO DE FORMULA (IIA) CON UN COMPUESTO DE FORMULA (III), PARA OBTENER COMPUESTOS DE FORMULA (I), EN DONDE Z1 ES FORMILO Y Z2 ES HALOGENO. SIENDO: A Y B, ANILLOS INSUSTITUIDOS O SUSTITUIDOS; R Y R, H, ALQUILO INFERIOR O FENILO; Y, O, S, SULFINILO O SULFONILO; Y Z Y Z2, UNO HALOGENO Y OTRO FORMILO. SE UTILIZA EN EL TRATAMIENTO DE ENFERMEDADES DEL TRACTO RESPIRATORIO.
ES545717A 1983-08-31 1985-07-30 Procedimiento para preparar derivados de flaveno y tioflave-no Expired ES8604556A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB838323292A GB8323292D0 (en) 1983-08-31 1983-08-31 Flavene and thioflavene derivatives

Publications (2)

Publication Number Publication Date
ES8604556A1 true ES8604556A1 (es) 1986-02-01
ES545717A0 ES545717A0 (es) 1986-02-01

Family

ID=10548080

Family Applications (2)

Application Number Title Priority Date Filing Date
ES535589A Expired ES8706140A1 (es) 1983-08-31 1984-08-31 Procedimiento para preparar derivados de flaveno y tioflaveno
ES545717A Expired ES8604556A1 (es) 1983-08-31 1985-07-30 Procedimiento para preparar derivados de flaveno y tioflave-no

Family Applications Before (1)

Application Number Title Priority Date Filing Date
ES535589A Expired ES8706140A1 (es) 1983-08-31 1984-08-31 Procedimiento para preparar derivados de flaveno y tioflaveno

Country Status (20)

Country Link
US (1) US4935441A (es)
EP (1) EP0139615B1 (es)
JP (1) JPS60149580A (es)
AT (1) ATE42285T1 (es)
AU (1) AU578252B2 (es)
CA (1) CA1237438A (es)
DD (1) DD234008A5 (es)
DE (1) DE3477778D1 (es)
DK (1) DK416084A (es)
ES (2) ES8706140A1 (es)
FI (1) FI82459C (es)
GB (2) GB8323292D0 (es)
GR (1) GR80257B (es)
HU (1) HU201919B (es)
IL (1) IL72777A (es)
NO (1) NO843454L (es)
NZ (1) NZ209394A (es)
PH (1) PH20920A (es)
PT (1) PT79145B (es)
ZA (1) ZA846788B (es)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE161254T1 (de) * 1990-07-27 1998-01-15 Chugai Pharmaceutical Co Ltd Benzopyranderivat
AU3867997A (en) 1996-08-27 1998-03-19 Shionogi & Co., Ltd. Chromene-3-carboxylate derivatives
KR100985103B1 (ko) * 2008-08-07 2010-10-05 덕성여자대학교 산학협력단 티오플라바논 유도체의 제조 방법
CN110615784B (zh) * 2019-10-25 2022-10-25 南开大学 具有黄酮骨架的内酯类似物的合成及应用

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8323293D0 (en) * 1983-08-31 1983-10-05 Zyma Sa Substituted flavene and thioflavene derivatives

Also Published As

Publication number Publication date
IL72777A0 (en) 1984-11-30
FI82459B (fi) 1990-11-30
NO843454L (no) 1985-03-01
DE3477778D1 (en) 1989-05-24
PT79145A (en) 1984-09-01
NZ209394A (en) 1987-11-27
GB2145719A (en) 1985-04-03
PH20920A (en) 1987-05-28
EP0139615A2 (en) 1985-05-02
EP0139615A3 (en) 1986-01-02
ES535589A0 (es) 1987-06-01
HU201919B (en) 1991-01-28
ZA846788B (en) 1985-04-24
ES545717A0 (es) 1986-02-01
US4935441A (en) 1990-06-19
FI843363A0 (fi) 1984-08-27
DK416084A (da) 1985-03-01
GB8421777D0 (en) 1984-10-03
HUT36818A (en) 1985-10-28
EP0139615B1 (en) 1989-04-19
AU578252B2 (en) 1988-10-20
JPS60149580A (ja) 1985-08-07
FI843363A (fi) 1985-03-01
AU3257184A (en) 1985-03-07
GB2145719B (en) 1987-02-04
IL72777A (en) 1988-03-31
CA1237438A (en) 1988-05-31
ES8706140A1 (es) 1987-06-01
DD234008A5 (de) 1986-03-19
GB8323292D0 (en) 1983-10-05
ATE42285T1 (de) 1989-05-15
PT79145B (en) 1986-11-14
GR80257B (en) 1985-01-02
DK416084D0 (da) 1984-08-30
FI82459C (fi) 1991-03-11

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Legal Events

Date Code Title Description
MM4A Patent lapsed

Effective date: 19960401