ES8603835A1 - Procedimiento de preparacion de nuevos derivados a-etilben- zol con un grupo piridinometoxi sustituido y de sus sales deadicion acidas y cuaternarias - Google Patents
Procedimiento de preparacion de nuevos derivados a-etilben- zol con un grupo piridinometoxi sustituido y de sus sales deadicion acidas y cuaternariasInfo
- Publication number
- ES8603835A1 ES8603835A1 ES543788A ES543788A ES8603835A1 ES 8603835 A1 ES8603835 A1 ES 8603835A1 ES 543788 A ES543788 A ES 543788A ES 543788 A ES543788 A ES 543788A ES 8603835 A1 ES8603835 A1 ES 8603835A1
- Authority
- ES
- Spain
- Prior art keywords
- preparation
- pharmaceutical compositions
- compositions containing
- pyridine derivatives
- pyridine
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D213/28—Radicals substituted by singly-bound oxygen or sulphur atoms
- C07D213/30—Oxygen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P39/00—General protective or antinoxious agents
- A61P39/02—Antidotes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Toxicology (AREA)
- Gastroenterology & Hepatology (AREA)
- Pyridine Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Decoration By Transfer Pictures (AREA)
- Control Of Electric Motors In General (AREA)
- Emergency Protection Circuit Devices (AREA)
Abstract
PROCEDIMIENTO DE PREPARACION DE NUEVOS DERIVADOS AP07-ETILBENZOL CON UN GRUPO PIRIDINOMETOXI SUSTITUIDO Y DE SUS SALES DE ADICION ACIDAS Y CUATERNARIAS. CONSISTE EN HACER REACCIONAR UNA PROPIOFENONA DE FORMULA (II) CON UN REACTIVO DE GRINARD DE FORMULA (III) PARA OBTENER NUEVOS DERIVADOS A-ETILBENZOL CON UN GRUPO SUSTITUIDO Y SUS SALES DE ADICION ACIDAS Y CUATERNARIAS DE FORMULA (I) DONDE R1 Y R2 REPRESENTAN INDEPENDIENTEMENTE ENTRE SI H, HALOGENO, TRIHALOMETILO, ALQUILO DE C 1 A 4 O ALCOXILO DE C 1 A 4. LA REACCION SE EFECTUA EN UN DISOLVENTE ORGANICO COMO ACETONA, ETANOL, ACETONITRILO O MEZCLAS DE ELLOS Y A TEMPERATURA ENTRE LA AMBIENTE Y LA DEL PUNTO DE EBULLICION DEL DISOLVENTE EMPLEADO. TIENEN APLICACIONES FARMACEUTICAS POR INHIBIR EL SISTEMA ENZIMATICO DE LA MONOOXIGENASA MICROSOMATICA DEL HIGADO.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
HU824183A HU186654B (en) | 1982-12-28 | 1982-12-28 | Process for producing new pyridine derivatives, acid additional salts and quaternary salts and pharmaceutical compositions containing them |
Publications (2)
Publication Number | Publication Date |
---|---|
ES8603835A1 true ES8603835A1 (es) | 1986-01-01 |
ES543788A0 ES543788A0 (es) | 1986-01-01 |
Family
ID=10967238
Family Applications (3)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES528453A Expired ES8600244A1 (es) | 1982-12-28 | 1983-12-27 | Procedimiento de preparacion de nuevos derivados piridinicos y de sus sales de adicion acidas y cuaternarias |
ES543788A Granted ES543788A0 (es) | 1982-12-28 | 1985-06-01 | Procedimiento de preparacion de nuevos derivados a-etilben- zol con un grupo piridinometoxi sustituido y de sus sales deadicion acidas y cuaternarias |
ES543787A Granted ES543787A0 (es) | 1982-12-28 | 1985-06-01 | Procedimiento de preparacion de nuevos derivados a-etilben- zol con un grupo piridinometoxi sustituido y de sus sales deadicion acidas y cuaternarias |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES528453A Expired ES8600244A1 (es) | 1982-12-28 | 1983-12-27 | Procedimiento de preparacion de nuevos derivados piridinicos y de sus sales de adicion acidas y cuaternarias |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES543787A Granted ES543787A0 (es) | 1982-12-28 | 1985-06-01 | Procedimiento de preparacion de nuevos derivados a-etilben- zol con un grupo piridinometoxi sustituido y de sus sales deadicion acidas y cuaternarias |
Country Status (14)
Country | Link |
---|---|
US (1) | US4598080A (es) |
EP (1) | EP0113587B1 (es) |
JP (1) | JPS59130868A (es) |
AT (1) | ATE23995T1 (es) |
AU (1) | AU560420B2 (es) |
CA (1) | CA1210010A (es) |
DE (1) | DE3368050D1 (es) |
DK (1) | DK158663C (es) |
ES (3) | ES8600244A1 (es) |
FI (1) | FI78907C (es) |
GR (1) | GR79148B (es) |
HU (1) | HU186654B (es) |
IL (1) | IL70551A (es) |
ZA (1) | ZA839612B (es) |
Families Citing this family (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4778931A (en) * | 1982-12-01 | 1988-10-18 | Usv Pharmaceutical Corporation | Certain [3-(1-hydroxy hexyl-tetrahydro)naphthalenes], the corresponding naphthalenes having anti-inflammatory and anti-allergic activity |
US4794188A (en) * | 1982-12-01 | 1988-12-27 | Usv Pharmaceutical Corporation | Certain unsymmetrical quinolinyl ethers having anti-inflammatory and anti-allergic activity |
IE56702B1 (en) * | 1982-12-01 | 1991-11-06 | Usv Pharma Corp | Antiinflammatory antiallergic compounds |
JPS61110675U (es) * | 1984-12-25 | 1986-07-12 | ||
DE3617183A1 (de) * | 1985-11-16 | 1987-05-27 | Bayer Ag | Substituierte benzylether |
GB8603475D0 (en) * | 1986-02-12 | 1986-03-19 | Glaxo Group Ltd | Chemical compounds |
GB8711802D0 (en) * | 1987-05-19 | 1987-06-24 | Fujisawa Pharmaceutical Co | Dithioacetal compounds |
ATE123278T1 (de) * | 1991-03-25 | 1995-06-15 | Takeda Chemical Industries Ltd | Verfahren zur herstellung von ethern. |
AU2007293373A1 (en) * | 2006-09-01 | 2008-03-13 | Merck Sharp & Dohme Corp. | Inhibitors of 5 -lipoxygenase activating protein (FLAP) |
JP2010530419A (ja) * | 2007-06-20 | 2010-09-09 | メルク・シャープ・エンド・ドーム・コーポレイション | ジフェニル置換アルカン |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3381013A (en) * | 1964-01-15 | 1968-04-30 | Bristol Myers Co | Heterocyclicamino ethers of benzylphenols |
US4094908A (en) * | 1973-08-15 | 1978-06-13 | Richter Gedeon Vegyeszeti Gyar Rt. | Alpha-substituted benzhydrol derivatives |
DE2516331A1 (de) * | 1974-04-18 | 1975-11-06 | Ciba Geigy Ag | Phenylaralkyl-aether und -thioaether |
-
1982
- 1982-12-28 HU HU824183A patent/HU186654B/hu not_active IP Right Cessation
-
1983
- 1983-12-23 AT AT83307963T patent/ATE23995T1/de active
- 1983-12-23 AU AU22906/83A patent/AU560420B2/en not_active Ceased
- 1983-12-23 DE DE8383307963T patent/DE3368050D1/de not_active Expired
- 1983-12-23 CA CA000444204A patent/CA1210010A/en not_active Expired
- 1983-12-23 EP EP83307963A patent/EP0113587B1/en not_active Expired
- 1983-12-27 DK DK601283A patent/DK158663C/da not_active IP Right Cessation
- 1983-12-27 ES ES528453A patent/ES8600244A1/es not_active Expired
- 1983-12-27 FI FI834791A patent/FI78907C/fi not_active IP Right Cessation
- 1983-12-27 ZA ZA839612A patent/ZA839612B/xx unknown
- 1983-12-27 JP JP58244943A patent/JPS59130868A/ja active Granted
- 1983-12-27 US US06/565,831 patent/US4598080A/en not_active Expired - Fee Related
- 1983-12-27 IL IL70551A patent/IL70551A/xx unknown
- 1983-12-28 GR GR73362A patent/GR79148B/el unknown
-
1985
- 1985-06-01 ES ES543788A patent/ES543788A0/es active Granted
- 1985-06-01 ES ES543787A patent/ES543787A0/es active Granted
Also Published As
Publication number | Publication date |
---|---|
IL70551A (en) | 1987-02-27 |
JPH0130821B2 (es) | 1989-06-22 |
ZA839612B (en) | 1984-08-29 |
HU186654B (en) | 1985-09-30 |
EP0113587B1 (en) | 1986-12-03 |
CA1210010A (en) | 1986-08-19 |
US4598080A (en) | 1986-07-01 |
ES528453A0 (es) | 1985-10-01 |
GR79148B (es) | 1984-10-02 |
DK158663B (da) | 1990-07-02 |
ES8603834A1 (es) | 1986-01-01 |
FI78907B (fi) | 1989-06-30 |
ATE23995T1 (de) | 1986-12-15 |
AU560420B2 (en) | 1987-04-09 |
DK601283A (da) | 1984-06-29 |
DK601283D0 (da) | 1983-12-27 |
FI834791A0 (fi) | 1983-12-27 |
FI834791A (fi) | 1984-06-29 |
IL70551A0 (en) | 1984-03-30 |
JPS59130868A (ja) | 1984-07-27 |
ES543788A0 (es) | 1986-01-01 |
DE3368050D1 (en) | 1987-01-15 |
FI78907C (fi) | 1989-10-10 |
EP0113587A1 (en) | 1984-07-18 |
DK158663C (da) | 1990-11-19 |
AU2290683A (en) | 1984-07-05 |
ES8600244A1 (es) | 1985-10-01 |
ES543787A0 (es) | 1986-01-01 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FD1A | Patent lapsed |
Effective date: 19970401 |