ES8601914A1 - Procedimiento para preparar un compuesto de 2, (monoanelado(3 4-, 4, 5- y 5, 6-) piridilalquilensulfinil)-benzimidazoles substituidos. - Google Patents
Procedimiento para preparar un compuesto de 2, (monoanelado(3 4-, 4, 5- y 5, 6-) piridilalquilensulfinil)-benzimidazoles substituidos.Info
- Publication number
- ES8601914A1 ES8601914A1 ES533853A ES533853A ES8601914A1 ES 8601914 A1 ES8601914 A1 ES 8601914A1 ES 533853 A ES533853 A ES 533853A ES 533853 A ES533853 A ES 533853A ES 8601914 A1 ES8601914 A1 ES 8601914A1
- Authority
- ES
- Spain
- Prior art keywords
- alkylsulfinyl
- alkylthio
- benzimidazole derivatives
- benzimidazole
- pyridylmethylthio
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
- C07D491/044—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
- C07D491/052—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring the oxygen-containing ring being six-membered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
- C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
- C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
- C07D235/24—Benzimidazoles; Hydrogenated benzimidazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
- C07D235/28—Sulfur atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Quinoline Compounds (AREA)
- Other In-Based Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Abstract
PROCEDIMIENTO PARA PREPARAR UN COMPUESTO DE 2,MONOANELADO(3,4-, 4,5- Y 5,6)-PIRIDILALQUILENSUFINIL-BENZIMIDAZOLES SUSTITUIDOS. CONSISTE EN HACER REACCIONAR UN COMPUESTO DE FORMULA (II) CON UN COMPUESTO DE FORMULA (III), EN DISOLVENTES POLARES, COMO METANOL, DIMETILSULFOXIDO, ACETONAS DIMETILFORMAMIDA, EN PRESENCIA DE UN ACEPTOR DE PROTONES, COMO HIDROXIDOS DE METALES ALCALINOS, CARBONATOS DE METALES ALCALINOS Y AMINAS TERCIARIAS, LA TEMPERATURA DEBE SER LA DE EBULLICION DEL DISOLVENTE USADO, PARA OBTENER UN COMPUESTO DE FORMULA (I). SIENDO: A Y B, IGUALES O DIFERENTES, H, -OR, Y OTROS; R1, ALQUILO DE C 1 A 4; D, SUSTITUYENTE BICICLICO DE FORMULA (IV), (V) O (VI); V, O2, S Y OTROS; X, S O SO; X, -OSO2-CH3 O CL; Y N, 0 O 1. SE UTILIZAN COMO AGENTES ANTISECRETORIOS Y CITOPROTECTORES GASTRICOS.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US51046883A | 1983-07-01 | 1983-07-01 |
Publications (2)
Publication Number | Publication Date |
---|---|
ES533853A0 ES533853A0 (es) | 1985-12-01 |
ES8601914A1 true ES8601914A1 (es) | 1985-12-01 |
Family
ID=24030850
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES533853A Expired ES8601914A1 (es) | 1983-07-01 | 1984-06-29 | Procedimiento para preparar un compuesto de 2, (monoanelado(3 4-, 4, 5- y 5, 6-) piridilalquilensulfinil)-benzimidazoles substituidos. |
Country Status (15)
Country | Link |
---|---|
EP (1) | EP0130729A3 (es) |
JP (1) | JPS6036483A (es) |
KR (1) | KR890000881B1 (es) |
AU (1) | AU573744B2 (es) |
CA (1) | CA1259070A (es) |
DK (1) | DK321884A (es) |
ES (1) | ES8601914A1 (es) |
FI (1) | FI83514C (es) |
GR (1) | GR81445B (es) |
IL (1) | IL72159A (es) |
MX (1) | MX161283A (es) |
NO (1) | NO164472C (es) |
NZ (1) | NZ208553A (es) |
PH (1) | PH20625A (es) |
ZA (1) | ZA844953B (es) |
Families Citing this family (17)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE3585252D1 (de) | 1984-07-06 | 1992-03-05 | Fisons Plc | Benzimidazole, und verfahren zu deren herstellung, deren formulierung und verwendung als magensaeuresekretionshemmende verbindungen. |
AU568441B2 (en) * | 1984-09-24 | 1987-12-24 | Upjohn Company, The | 2-(pyridylalkenesulfinyl) benzimidazole derivatives |
EP0187977B1 (en) * | 1984-12-18 | 1990-08-29 | Otsuka Pharmaceutical Co., Ltd. | Tetrahydroquinoline derivatives, process for preparing the same and anti-peptic ulcer compositions containg the same |
AU5768886A (en) | 1985-05-24 | 1986-11-27 | G.D. Searle & Co. | 2-((1-h-benzimidazol-2-ylsulfinyl)methyl)benzenamines |
US5869513A (en) * | 1985-05-24 | 1999-02-09 | G. D. Searle & Co. | 2- (1H-benzimidazol-2-ylsulfinyl)methyl!benzenamines |
FI864138A (fi) * | 1985-10-16 | 1987-04-17 | Fisons Plc | Heterocykliska blandningar. |
ES2038612T3 (es) * | 1986-03-28 | 1993-08-01 | Otsuka Pharmaceutical Co., Ltd. | Compuestos de hidroquinolina, composiciones que los contienen y procedimientos para prepararlas. |
ES2031853T3 (es) * | 1986-07-01 | 1993-01-01 | Shionogi Seiyaku Kabushiki Kaisha | Un procedimiento para preparar derivados de isoquinolina sustituidos. |
US4687775A (en) * | 1986-07-17 | 1987-08-18 | G. D. Searle & Co. | 2-[(Imidazo[1,2-a]pyridinylmethyl)sulfinyl]-1H-benzimidazoles |
US4772619A (en) * | 1986-07-17 | 1988-09-20 | G. D. Searle & Co. | [(1H-benzimidazol-2-ylsulfinyl)methyl]-2-pyridinamines |
US4721718A (en) * | 1986-08-18 | 1988-01-26 | G. D. Searle & Co. | 2-[(imidazo[1,2-a]pyridin-3-ylmethyl)sulfinyl]-1H-benzimidazoles useful in the treatment and prevention of ulcers |
JPS6452782A (en) * | 1987-05-19 | 1989-02-28 | Shionogi & Co | Thienopyridine derivative and antiulcer agent |
US4839365A (en) * | 1987-05-19 | 1989-06-13 | Shinogi & Co., Ltd. | Thienopyridine derivatives useful in treating gastric ulcers |
WO1995029897A1 (en) * | 1994-04-29 | 1995-11-09 | G.D. Searle & Co. | METHOD OF USING (H+/K+) ATPase INHIBITORS AS ANTIVIRAL AGENTS |
WO1997000875A1 (en) * | 1995-06-21 | 1997-01-09 | Korea Research Institute Of Chemical Technology | Benzimidazole derivatives containing fused pyridine |
DK1308159T3 (da) * | 1995-09-21 | 2005-02-14 | Pharma Pass Ii Llc | Farmaceutisk sammensætning indeholdende en syre-labil omeprazol og fremgangsmåde til fremstilling deraf |
US20060024362A1 (en) | 2004-07-29 | 2006-02-02 | Pawan Seth | Composition comprising a benzimidazole and process for its manufacture |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
SE416649B (sv) * | 1974-05-16 | 1981-01-26 | Haessle Ab | Forfarande for framstellning av foreningar som paverkar magsyrasekretionen |
SE7804231L (sv) * | 1978-04-14 | 1979-10-15 | Haessle Ab | Magsyrasekretionsmedel |
US4359465A (en) * | 1980-07-28 | 1982-11-16 | The Upjohn Company | Methods for treating gastrointestinal inflammation |
ZA825106B (en) * | 1981-08-13 | 1983-04-27 | Haessle Ab | Novel pharmaceutical compositions |
US4472409A (en) * | 1981-11-05 | 1984-09-18 | Byk Gulden Lomberg Chemische Fabrik Gesellschaft Mit Beschrankter Haftung | 2-Pyridylmethyl thio(sulfinyl)benzimidazoles with gastric acid secretion inhibiting effects |
SE8300736D0 (sv) * | 1983-02-11 | 1983-02-11 | Haessle Ab | Novel pharmacologically active compounds |
-
1984
- 1984-06-14 CA CA000456621A patent/CA1259070A/en not_active Expired
- 1984-06-18 NZ NZ208553A patent/NZ208553A/en unknown
- 1984-06-18 EP EP84304112A patent/EP0130729A3/en not_active Withdrawn
- 1984-06-19 IL IL72159A patent/IL72159A/xx unknown
- 1984-06-25 MX MX201779A patent/MX161283A/es unknown
- 1984-06-27 GR GR75136A patent/GR81445B/el unknown
- 1984-06-28 AU AU29996/84A patent/AU573744B2/en not_active Ceased
- 1984-06-28 ZA ZA844953A patent/ZA844953B/xx unknown
- 1984-06-29 FI FI842631A patent/FI83514C/fi not_active IP Right Cessation
- 1984-06-29 ES ES533853A patent/ES8601914A1/es not_active Expired
- 1984-06-29 DK DK321884A patent/DK321884A/da not_active Application Discontinuation
- 1984-06-29 PH PH30907A patent/PH20625A/en unknown
- 1984-06-29 NO NO842645A patent/NO164472C/no unknown
- 1984-06-30 KR KR1019840003792A patent/KR890000881B1/ko not_active IP Right Cessation
- 1984-06-30 JP JP59136436A patent/JPS6036483A/ja active Pending
Also Published As
Publication number | Publication date |
---|---|
MX161283A (es) | 1990-08-28 |
AU573744B2 (en) | 1988-06-23 |
FI83514B (fi) | 1991-04-15 |
ES533853A0 (es) | 1985-12-01 |
IL72159A (en) | 1987-12-31 |
JPS6036483A (ja) | 1985-02-25 |
FI83514C (fi) | 1991-07-25 |
GR81445B (es) | 1984-12-11 |
NO164472C (no) | 1990-10-10 |
DK321884A (da) | 1985-01-02 |
FI842631A0 (fi) | 1984-06-29 |
ZA844953B (en) | 1985-02-27 |
FI842631A (fi) | 1985-01-02 |
KR850001201A (ko) | 1985-03-16 |
EP0130729A2 (en) | 1985-01-09 |
PH20625A (en) | 1987-03-06 |
NZ208553A (en) | 1987-07-31 |
NO842645L (no) | 1985-01-02 |
KR890000881B1 (ko) | 1989-04-12 |
AU2999684A (en) | 1985-01-03 |
NO164472B (no) | 1990-07-02 |
EP0130729A3 (en) | 1986-08-06 |
IL72159A0 (en) | 1984-10-31 |
DK321884D0 (da) | 1984-06-29 |
CA1259070A (en) | 1989-09-05 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
ES8601914A1 (es) | Procedimiento para preparar un compuesto de 2, (monoanelado(3 4-, 4, 5- y 5, 6-) piridilalquilensulfinil)-benzimidazoles substituidos. | |
HUT60719A (en) | Process for producing 3-aminopiperidine derivatives | |
AU4292589A (en) | Gas-permeable, liquid-impermeable nonwoven material | |
HUT39151A (en) | Process for production of diaril acetilens | |
OA09230A (en) | "Détection of chemicals by immunoassay". | |
HU913454D0 (en) | Process for the production of 3-amido-indolyle-derivatives | |
HUT50199A (en) | Inoculated sulphonated poliesther compositions applicable for treating of textiles and fibrous materials and process for production of these compositions | |
PT80361A (en) | 2-(n-substitutedguanidino)-4-heteroaeylthiazole antiulcer agents | |
IL68630A (en) | Preparation of 2-guanidino-4-(2-(substituted amino)-4-imidazolyl)-thiazoles and novel intermediates used therefor | |
FR2603276B1 (fr) | Procede de production de glycols et de glycerol par hydrogenolyse d'alditols | |
ZA858499B (en) | A novel class of hypoglycemic agents | |
FR2562081B1 (fr) | Procede de preparation d'oxydes de fer pigmentaires rouges a partir de sulfate ferreux residuaire | |
GB8618288D0 (en) | Intension joints | |
IT8722786A0 (it) | Processo per l'incenerimento di rdf (refuse derived fuel) in un bruciatore per la produzione di clinker per cementi. | |
FR2570321B1 (fr) | Nouvelles techniques et machine pour l'elaboration, la projection et le transfert de beton a base de fibres de verre et analogue | |
ES2044144T3 (es) | Nuevo procedimiento para la produccion de 4,6-dimetil-7-hidroxinonan-3-ona. | |
ZA865148B (en) | Preparation of 4,5-dihydrodithieno(3,4-b:3',4'-e)azepine-5,9-dione | |
EP0173753A4 (en) | 6-SUBSTITUTED PROSTAGLANDINE E 1 AND THEIR PRODUCTION. | |
FR2636398B1 (fr) | Machine de fabrication de bagues d'etancheite | |
SU1220344A1 (ru) | Установка для ферментативной обработки материалов | |
ES8602007A1 (es) | Procedimiento para preparar 2,6-dioxa-biciclo-(2,2,2)-octan-7-il-acetaldehidos | |
ES8603244A1 (es) | Procedimiento para la obtencion de derivados de 2-tiazolina y de 2-oxazolina | |
AU568110B2 (en) | Use of substituted 2-(2'-hydroxyaryl)-2h- benzotri azde sulfonates as photostabilising agents for natural and synthetic fibres. | |
CS665287A1 (en) | Agent for ash matters' anti-exhalation inoculation | |
CS875188A2 (en) | Connection of working machines' two-hand control |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
FD1A | Patent lapsed |
Effective date: 19970303 |