ES8600752A1 - Un procedimiento para la preparacion de nuevos derivados de tiosulfonamida. - Google Patents
Un procedimiento para la preparacion de nuevos derivados de tiosulfonamida.Info
- Publication number
- ES8600752A1 ES8600752A1 ES533389A ES533389A ES8600752A1 ES 8600752 A1 ES8600752 A1 ES 8600752A1 ES 533389 A ES533389 A ES 533389A ES 533389 A ES533389 A ES 533389A ES 8600752 A1 ES8600752 A1 ES 8600752A1
- Authority
- ES
- Spain
- Prior art keywords
- intraocular pressure
- derivatives
- thiophenesulfonamide
- topical treatment
- preparation
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D333/28—Halogen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/38—Heterocyclic compounds having sulfur as a ring hetero atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D333/30—Hetero atoms other than halogen
- C07D333/34—Sulfur atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
PROCEDIMIENTO PARA LA PREPARACION DE NUEVOS DERIVADOS DE TIOFENSULFONAMIDA.CONSISTE EN HACER REACCIONAR UN COMPUESTO DE FORMULA (II) CON UN COMPUESTO DE FORMULA (III) PARA OBTENER DERIVADOS DE TIOFENSULFONAMIDA O SALES OFTALMOLOGICAMENTE ACEPTABLES DE LOS MISMOS, DONDE X ES; N ES 0 O 1; Y R ES ALQUILO C 1 A 8 DE CADENA LINEAL O RAMIFICADA, HALOALQUILO C 1 A 18 DONDE HALO ES CLORO, BROMO O FLUOR, ALCOXI C 1 A 13 CARBONIL ALQUILO C 1 A 15, CICLOALQUILO C 3 A 6 Y OTROS. LA REACCION SE LLEVA A CABO EN UN DISOLVENTE TAL COMO DIMETILFORMAMIDA, PIRIDINA, ACETONA, ACETATO DE ETILO Y OTROS, CON O SIN UN CATALIZADOR Y A TEMPERATURA ENTRE 0JC Y LA DEL PUNTO DE EBULLICION DEL DISOLVENTE.SON UTILES EN EL TRATAMIENTO DE LA PRESION INTRAOCULAR ELEVADA Y PARA EL TRATAMIENTO DE LA ENFERMEDAD CONOCIDA COMO GLAUCOMA.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US06/505,604 US4486444A (en) | 1983-06-20 | 1983-06-20 | (Hydroxybenzoyl)thiophenesulfonamide and acyl derivatives thereof for the topical treatment of elevated intraocular pressure |
US06/505,673 US4542152A (en) | 1983-05-23 | 1983-06-20 | 5-[Phenylsulfonyl(or sulfinyl)]thiophene-2-sulfonamides for the topical treatment of elevated intraocular pressure |
US06/505,618 US4477466A (en) | 1983-05-23 | 1983-06-20 | Acyloxy derivatives of [phenylsulfonyl(or sulfinyl)]thiophenesulfonamide for the topical treatment of elevated intraocular pressure |
Publications (2)
Publication Number | Publication Date |
---|---|
ES8600752A1 true ES8600752A1 (es) | 1985-10-16 |
ES533389A0 ES533389A0 (es) | 1985-10-16 |
Family
ID=27414296
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES533389A Granted ES533389A0 (es) | 1983-06-20 | 1984-06-13 | Un procedimiento para la preparacion de nuevos derivados de tiosulfonamida. |
Country Status (4)
Country | Link |
---|---|
EP (1) | EP0130109B1 (es) |
CA (1) | CA1219867A (es) |
DE (1) | DE3479728D1 (es) |
ES (1) | ES533389A0 (es) |
Families Citing this family (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0182691B1 (en) * | 1984-11-02 | 1990-07-04 | Merck & Co. Inc. | Substituted thiophene-2-sulfonamides and their preparation |
US4665090A (en) * | 1985-10-09 | 1987-05-12 | Merck & Co., Inc. | Substituted thiophene-2-sulfonamide antiglaucoma agents |
DE3667056D1 (en) * | 1985-12-24 | 1989-12-28 | Merck & Co Inc | Substituted thiophene-2-sulfonamide antiglaucoma agents |
US4677113A (en) * | 1986-04-22 | 1987-06-30 | Riker Laboratories, Inc. | Di-t-butylphenols substituted by a thenoyl group |
US4847289A (en) * | 1987-06-08 | 1989-07-11 | Merck & Co., Inc. | Thiophene sulfonamide antiglaucoma agents |
DK641189A (da) * | 1988-12-19 | 1990-06-20 | Merck & Co Inc | Praeparat til behandling af glaucom og fremgangsmaade til fremstilling af et saadant praeparat |
EP0375299A1 (en) * | 1988-12-19 | 1990-06-27 | Merck & Co. Inc. | Combinations of angiotensin converting enzyme, and carbonic anhydrase, inhibitors for treating glaucoma |
US5300499A (en) * | 1992-09-02 | 1994-04-05 | Allergan, Inc. | 5-substituted 3-thiophene sulfonamides as antiglaucoma agents |
US5629345A (en) * | 1993-07-23 | 1997-05-13 | Vide Pharmaceuticals | Methods and compositions for ATP-sensitive K+ channel inhibition for lowering intraocular pressure |
US5965620A (en) * | 1993-07-23 | 1999-10-12 | Vide Pharmaceuticals | Methods and compositions for ATP-sensitive K+ channel inhibition for lowering intraocular pressure |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB1459571A (en) * | 1974-09-12 | 1976-12-22 | Pfizer Ltd | Thiophene-2-sulphonamide derivatives and their use as therapeutic agents sheet orienting apparatus |
GB1468111A (en) * | 1976-01-08 | 1977-03-23 | Pfizer Ltd | Thiophene-sulphonamides |
ZA813332B (en) * | 1980-06-21 | 1982-05-26 | Pfizer | Larvicides and isecticides |
AR241136A1 (es) * | 1981-07-13 | 1991-11-29 | Merck E Co Inc | Procedimiento para preparar esteres de 6-hidroxi-2-benzotiazolsulfonamida para tratamiento topicode presion intraocular elevada" |
US4386098A (en) * | 1981-11-03 | 1983-05-31 | Merck & Co., Inc. | 6-Hydroxy-2-benzothiazolesulfonamide for the topical treatment of elevated intraocular pressure |
-
1984
- 1984-06-13 ES ES533389A patent/ES533389A0/es active Granted
- 1984-06-15 EP EP19840401235 patent/EP0130109B1/en not_active Expired
- 1984-06-15 DE DE8484401235T patent/DE3479728D1/de not_active Expired
- 1984-06-18 CA CA000456792A patent/CA1219867A/en not_active Expired
Also Published As
Publication number | Publication date |
---|---|
EP0130109B1 (en) | 1989-09-13 |
DE3479728D1 (en) | 1989-10-19 |
CA1219867A (en) | 1987-03-31 |
EP0130109A3 (en) | 1986-11-26 |
EP0130109A2 (en) | 1985-01-02 |
ES533389A0 (es) | 1985-10-16 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FD1A | Patent lapsed |
Effective date: 19970303 |