ES8507513A1 - Un procedimiento para preparar derivados bis-dioxopiperazinicos - Google Patents
Un procedimiento para preparar derivados bis-dioxopiperazinicosInfo
- Publication number
- ES8507513A1 ES8507513A1 ES537206A ES537206A ES8507513A1 ES 8507513 A1 ES8507513 A1 ES 8507513A1 ES 537206 A ES537206 A ES 537206A ES 537206 A ES537206 A ES 537206A ES 8507513 A1 ES8507513 A1 ES 8507513A1
- Authority
- ES
- Spain
- Prior art keywords
- radical
- carbon atoms
- substituted
- alkoxy
- unsubstituted
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
- C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
- C07D241/06—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having one or two double bonds between ring members or between ring members and non-ring members
- C07D241/08—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having one or two double bonds between ring members or between ring members and non-ring members with oxygen atoms directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
PROCEDIMIENTO PARA PREPARAR DERIVADOS BIS-DIOXOPIPERAZINICOS.CONSISTE EN TRATAR UN COMPUESTO DE FORMULA (II) CON UN DERIVADO REACTIVO DE UN COMPUESTO DE FORMULA (III), COMO UN CLORURO O ANHIDRIDO ORGANICO, EN UN DISOLVENTE POLAR ATROPICO, COMO ACETONITRILO, O CLOROFORMO, A UNA TEMPERATURA ENTRE C10JC A 120JC, EN PRESENCIA DE AGENTES DE CONDENSACION COMO YODURO DE 1-METIL-2-CLOROPIRIDINILO, DURANTE 1 A 24 HORAS, PARA OBTENER UN COMPUESTO DERIVADO DE BIS-DIOXOPIPERAZINICOS DE FORMULA (I) Y SUS SALES NO TOXICAS. SIENDO: R UN ALQUILO DE C 1 A 27, UN RADICAL CICLOALQUILO DE C 3 A 7 Y OTROS.SE UTILIZAN EN FARMACOLOGIA COMO ANTITUMORAL Y ANTIMETASTATICO POR SU BAJA TOXICIDAD.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP58204448A JPS6097963A (ja) | 1983-10-31 | 1983-10-31 | ビス−ジオキソピペラジン誘導体,その製造方法及びそれからなる抗腫瘍剤 |
Publications (2)
Publication Number | Publication Date |
---|---|
ES8507513A1 true ES8507513A1 (es) | 1985-09-01 |
ES537206A0 ES537206A0 (es) | 1985-09-01 |
Family
ID=16490690
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES537206A Granted ES537206A0 (es) | 1983-10-31 | 1984-10-30 | Un procedimiento para preparar derivados bis-dioxopiperazinicos |
Country Status (9)
Country | Link |
---|---|
US (1) | US4650799A (es) |
EP (1) | EP0140327B1 (es) |
JP (1) | JPS6097963A (es) |
AU (1) | AU571273B2 (es) |
CA (1) | CA1244430A (es) |
DE (1) | DE3482322D1 (es) |
DK (1) | DK162639C (es) |
ES (1) | ES537206A0 (es) |
NO (1) | NO170682C (es) |
Families Citing this family (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH0674251B2 (ja) * | 1986-02-07 | 1994-09-21 | 全薬工業株式▲会▼社 | ビス−ジオキソピペラジン誘導体 |
JP3050598B2 (ja) * | 1990-07-04 | 2000-06-12 | 全薬工業株式会社 | 水溶性ビスージオキソピペラジン誘導体 |
CA2766033C (en) * | 2009-06-25 | 2016-09-20 | Alkermes, Inc. | Prodrugs of nh-acidic compounds |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
NL273690A (es) * | 1961-01-19 | 1900-01-01 | ||
GB1234935A (en) * | 1967-07-03 | 1971-06-09 | Nat Res Dev | Piperazine derivatives |
GB1236947A (en) * | 1968-08-15 | 1971-06-23 | Ici Ltd | Process for the preparation of piperazine derivatives |
DE2511891A1 (de) * | 1975-03-19 | 1976-10-07 | Gruenenthal Chemie | Neue derivate des 2,6-dioxopiperazins, verfahren zu ihrer herstellung, diese verbindungen enthaltende arzneimittel sowie verfahren zu deren herstellung |
CH635828A5 (de) * | 1978-08-30 | 1983-04-29 | Ciba Geigy Ag | N-substituierte imide und bisimide. |
US4404381A (en) * | 1981-06-19 | 1983-09-13 | The Dow Chemical Company | Novel 3,5-diketo-piperazinyl compounds containing epoxide substituted imides |
US4536564A (en) * | 1983-12-09 | 1985-08-20 | The Dow Chemical Company | Polyamide from bis-carboxy containing 3,5,3',5'-tetraoxo-1,2-dipiperazine compound and diamine |
-
1983
- 1983-10-31 JP JP58204448A patent/JPS6097963A/ja active Granted
-
1984
- 1984-10-16 DK DK493384A patent/DK162639C/da not_active IP Right Cessation
- 1984-10-17 AU AU34416/84A patent/AU571273B2/en not_active Ceased
- 1984-10-19 NO NO844183A patent/NO170682C/no not_active IP Right Cessation
- 1984-10-23 EP EP84112763A patent/EP0140327B1/en not_active Expired - Lifetime
- 1984-10-23 DE DE8484112763T patent/DE3482322D1/de not_active Expired - Fee Related
- 1984-10-25 US US06/664,700 patent/US4650799A/en not_active Expired - Lifetime
- 1984-10-30 CA CA000466567A patent/CA1244430A/en not_active Expired
- 1984-10-30 ES ES537206A patent/ES537206A0/es active Granted
Also Published As
Publication number | Publication date |
---|---|
EP0140327A3 (en) | 1986-07-23 |
EP0140327B1 (en) | 1990-05-23 |
DK162639C (da) | 1992-04-13 |
DK493384D0 (da) | 1984-10-16 |
CA1244430A (en) | 1988-11-08 |
AU3441684A (en) | 1985-05-09 |
EP0140327A2 (en) | 1985-05-08 |
AU571273B2 (en) | 1988-04-14 |
NO844183L (no) | 1985-05-02 |
NO170682B (no) | 1992-08-10 |
ES537206A0 (es) | 1985-09-01 |
US4650799A (en) | 1987-03-17 |
DE3482322D1 (de) | 1990-06-28 |
JPS6097963A (ja) | 1985-05-31 |
DK493384A (da) | 1985-05-01 |
NO170682C (no) | 1992-11-18 |
DK162639B (da) | 1991-11-25 |
JPS6334153B2 (es) | 1988-07-08 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FD1A | Patent lapsed |
Effective date: 20041102 |