ES8507491A1 - Un procedimiento para la preparacion de derivados de azetidina - Google Patents

Un procedimiento para la preparacion de derivados de azetidina

Info

Publication number
ES8507491A1
ES8507491A1 ES531562A ES531562A ES8507491A1 ES 8507491 A1 ES8507491 A1 ES 8507491A1 ES 531562 A ES531562 A ES 531562A ES 531562 A ES531562 A ES 531562A ES 8507491 A1 ES8507491 A1 ES 8507491A1
Authority
ES
Spain
Prior art keywords
preparation
optionally substituted
intermediates
aryl
compounds
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES531562A
Other languages
English (en)
Other versions
ES531562A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sankyo Co Ltd
Original Assignee
Sankyo Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from JP57145574A external-priority patent/JPS5946265A/ja
Priority claimed from JP57158604A external-priority patent/JPS5951286A/ja
Application filed by Sankyo Co Ltd filed Critical Sankyo Co Ltd
Publication of ES8507491A1 publication Critical patent/ES8507491A1/es
Publication of ES531562A0 publication Critical patent/ES531562A0/es
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
    • C07D205/02—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
    • C07D205/06—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D205/08—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with one oxygen atom directly attached in position 2, e.g. beta-lactams
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D477/00—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring
    • C07D477/02—Preparation
    • C07D477/04—Preparation by forming the ring or condensed ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
    • C07F7/1804—Compounds having Si-O-C linkages
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
    • C07F9/568—Four-membered rings
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

PROCEDIMIENTO PARA LA PREPARACION DE DERIVADOS DE AZETIDINA, DE FORMULA GENERAL (I), EN LA QUE R1 REPRESENTA HIDROGENO O UN GRUPO HIDROXI PROTEGIDO; R2 Y R3 SON IGUALES O DIFERENTES Y CADA UNO DE ELLOS REPRESENTA HIDROGENO O UN GRUPO ALQUILO O ARILO; R4 REPRESENTA UN GRUPO ALQUILO, ARILO O ALQUENILO; Y R5 REPRESENTA HIDROGENO O UN GRUPO CARBOXI PROTEGIDO.CONSISTE EN HACER REACCIONAR UN COMPUESTO DE FORMULA GENERAL (II) CON UN COMPUESTO DE FORMULA GENERAL (III), EN LA QUE R6 REPRESENTA UN GRUPO ALCOXI, ARILOXI, DIALQUILAMINO O DIARILAMINO, Y EN CICLAR EL PRODUCTO OBTENIDO EN DICHA REACCION.DE APLICACION COMO COMPUESTOS INTERMEDIARIOS EN LA PREPARACION DE CIERTOS DERIVADOS DE CARBAPENEM.
ES531562A 1982-08-24 1984-04-12 Un procedimiento para la preparacion de derivados de azetidina Granted ES531562A0 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP57145574A JPS5946265A (ja) 1982-08-24 1982-08-24 アゼチジノン誘導体の製造法
JP57158604A JPS5951286A (ja) 1982-09-10 1982-09-10 カルバペネム誘導体の製造法

Publications (2)

Publication Number Publication Date
ES8507491A1 true ES8507491A1 (es) 1985-09-01
ES531562A0 ES531562A0 (es) 1985-09-01

Family

ID=26476650

Family Applications (3)

Application Number Title Priority Date Filing Date
ES525138A Granted ES525138A0 (es) 1982-08-24 1983-08-24 Un procedimiento para la preparacion de derivados de azetidina.
ES531562A Granted ES531562A0 (es) 1982-08-24 1984-04-12 Un procedimiento para la preparacion de derivados de azetidina
ES531561A Expired ES8602796A1 (es) 1982-08-24 1984-04-12 Un procedimiento para la preparacion de derivados de azetidina

Family Applications Before (1)

Application Number Title Priority Date Filing Date
ES525138A Granted ES525138A0 (es) 1982-08-24 1983-08-24 Un procedimiento para la preparacion de derivados de azetidina.

Family Applications After (1)

Application Number Title Priority Date Filing Date
ES531561A Expired ES8602796A1 (es) 1982-08-24 1984-04-12 Un procedimiento para la preparacion de derivados de azetidina

Country Status (7)

Country Link
US (1) US5856556A (es)
EP (1) EP0102239B1 (es)
KR (1) KR900006449B1 (es)
CA (1) CA1232903A (es)
DE (1) DE3374063D1 (es)
ES (3) ES525138A0 (es)
FI (1) FI80887C (es)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4696923A (en) * 1984-04-23 1987-09-29 Merck & Co., Inc. 6-[1-hydroxyethyl]-2-SR8 -1-methyl-1-carbadethiapen-2-em-3-carboxylic acids
DK270685A (da) * 1984-06-29 1985-12-30 Hoffmann La Roche Carbapenemderivater
US4895939A (en) * 1986-02-24 1990-01-23 Bristol-Myers Company High percentage β-yield synthesis of carbapenem intermediates
ES2053508T3 (es) * 1986-11-24 1994-08-01 Fujisawa Pharmaceutical Co Compuestos de acidos 3-pirrolidinil-tio-1-azabiciclo(3.2.0)hept-2-eno-2-carboxilicos.
KR880006244A (ko) * 1986-11-24 1988-07-22 후지사와 도모 기찌 로 3-피롤리디닐티오-1-아자바이스클로[3.2.0]햅트2-엔-2-카르복실산 화합물 및 이의 제조방법
US4820815A (en) * 1987-09-01 1989-04-11 University Of Notre Dame Du Lac Azetidinone N-phosphonomethyl esters
US4925838A (en) * 1988-03-18 1990-05-15 Fujisawa Pharmaceutical Company, Ltd. 3-pyrrolidinylthio-1-azabicyclo[3.2.0]-hept-2-ene-2-carboxylic acid compounds
GB8811237D0 (en) * 1988-05-12 1988-06-15 Fujisawa Pharmaceutical Co 3-pyrrolidinylthio-1-azabicyclo(3.2.0)hept-2-ene-2-carboxylic acid derivatives
US4963544A (en) * 1988-05-23 1990-10-16 Fujisawa Pharmaceutical Company, Ltd. 3-pyrrolidinylthio-1-azabicyclo[3.2.0]-hept-2-ene-2-carboxylic acid compounds
GB8923844D0 (en) * 1989-10-23 1989-12-13 Fujisawa Pharmaceutical Co Carbapenem compounds
IL99513A0 (en) * 1990-09-20 1992-08-18 Hoechst Ag Process for the preparation of carbapenem compounds
GB9103034D0 (en) * 1991-02-13 1991-03-27 Fujisawa Pharmaceutical Co Processes for preparing carbapenem derivatives
GB9305813D0 (en) * 1993-03-20 1993-05-05 Glaxo Spa Chemical process
US6395894B2 (en) 1998-04-16 2002-05-28 Philip J. Pye Process for the synthesis of carbapenem intermidiates, and compounds produced
ATE263766T1 (de) 1998-06-17 2004-04-15 Merck & Co Inc Verfahren zur synthese von carbapenem- zwischenprodukten
US6194568B1 (en) 1998-07-13 2001-02-27 Merck & Co., Inc. Process for synthesizing carbapenem intermediates
US7241308B2 (en) * 2003-06-09 2007-07-10 Xtent, Inc. Stent deployment systems and methods
GB0400382D0 (en) * 2004-01-09 2004-02-11 Glaxo Group Ltd Novel processes

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1593524A (en) * 1976-11-19 1981-07-15 Merck & Co Inc 1-carba-2-penem-3-carboxylic acids
US4348320A (en) * 1976-11-19 1982-09-07 Merck & Co., Inc. Substituted azetidiones
US4446146A (en) * 1978-07-26 1984-05-01 Beecham Group Limited β-Lactam containing compounds, their preparation and use
JPS579784A (en) * 1980-06-23 1982-01-19 Sankyo Co Ltd Production of penem-3-carboxylic derivative
DK329381A (da) * 1980-07-24 1982-01-25 Takeda Chemical Industries Ltd Fremgangsmaade til frmstilling af 1,1-disubstitueret carba-z -penem samt salte og estere deraf
US4347183A (en) * 1981-02-02 1982-08-31 Schering Corporation Process for the synthesis of penems and carbapenems
EP0057565A1 (en) * 1981-02-04 1982-08-11 Beecham Group Plc Beta-lactam antibiotics, their preparation and use
EP0060077A1 (en) * 1981-03-04 1982-09-15 Beecham Group Plc Beta-lactam antibiotics, their preparation and use

Also Published As

Publication number Publication date
DE3374063D1 (en) 1987-11-19
US5856556A (en) 1999-01-05
ES8502708A1 (es) 1985-01-16
ES531561A0 (es) 1985-12-01
FI80887B (fi) 1990-04-30
KR840006008A (ko) 1984-11-21
ES531562A0 (es) 1985-09-01
FI833034A0 (fi) 1983-08-24
CA1232903A (en) 1988-02-16
ES525138A0 (es) 1985-01-16
FI833034A (fi) 1984-02-25
EP0102239A1 (en) 1984-03-07
FI80887C (fi) 1990-08-10
EP0102239B1 (en) 1987-10-14
ES8602796A1 (es) 1985-12-01
KR900006449B1 (ko) 1990-08-31

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Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 20040601