ES8506705A1 - Procedimiento para la preparacion de 3-(1-sustituido-4-piperidil)-1, 2-bencisoxazoles - Google Patents

Procedimiento para la preparacion de 3-(1-sustituido-4-piperidil)-1, 2-bencisoxazoles

Info

Publication number
ES8506705A1
ES8506705A1 ES529314A ES529314A ES8506705A1 ES 8506705 A1 ES8506705 A1 ES 8506705A1 ES 529314 A ES529314 A ES 529314A ES 529314 A ES529314 A ES 529314A ES 8506705 A1 ES8506705 A1 ES 8506705A1
Authority
ES
Spain
Prior art keywords
preparation
general formula
benzisoxazoles
piperidyl
medicaments
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES529314A
Other languages
English (en)
Other versions
ES529314A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Aventis Pharmaceuticals Inc
Original Assignee
Hoechst Roussel Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoechst Roussel Pharmaceuticals Inc filed Critical Hoechst Roussel Pharmaceuticals Inc
Publication of ES529314A0 publication Critical patent/ES529314A0/es
Publication of ES8506705A1 publication Critical patent/ES8506705A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C17/00—Preparation of halogenated hydrocarbons
    • C07C17/35—Preparation of halogenated hydrocarbons by reactions not affecting the number of carbon or of halogen atoms in the reaction
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C17/00—Preparation of halogenated hydrocarbons
    • C07C17/35—Preparation of halogenated hydrocarbons by reactions not affecting the number of carbon or of halogen atoms in the reaction
    • C07C17/354—Preparation of halogenated hydrocarbons by reactions not affecting the number of carbon or of halogen atoms in the reaction by hydrogenation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/12—Radicals substituted by oxygen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Neurosurgery (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Anesthesiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)

Abstract

PROCEDIMIENTO PARA LA PREPARACION DE 3-(1-SUSTITUIDO-4-PIPERIDIL)-1,2-BENCISOXAZOLES, DE FORMULA GENERAL (I), EN LA QUE X ES HALOGENO, ALCOHILO INFERIOR, ALCOXI INFERIOR O HIDROXI; Y R ES UN GRUPO DE FORMULA GENERAL (II), EN LA QUE N ES 2 O 3, SUS ANTIPODAS OPTICOS O SUS SALES DE ADICION DE ACIDO ACEPTABLES FARMACEUTICAMENTE.CONSISTE EN HACER REACCIONAR UN COMPUESTO DE FORMULA GENERAL (III), EN LA QUE X ES HIDROGENO, HALOGENO O ALCOHILO, EN PRESENCIA DE UN ACEPTOR DE ACIDO, UN ACTIVADOR DE DESPLAZAMIENTO Y UN DISOLVENTE ADECUADO, CON UN 3-(BVB-HALOALCOHIL)-6-FLUORO-1,2-BENDISOXAZOL, Y EN HIDROLIZAR, OPCIONALMENTE, EL COMPUESTO OBTENIDO.DE APLICACION EN EL TRATAMIENTO DE LA PSICOSIS.
ES529314A 1981-11-12 1984-01-31 Procedimiento para la preparacion de 3-(1-sustituido-4-piperidil)-1, 2-bencisoxazoles Expired ES8506705A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06/319,872 US4352811A (en) 1981-11-12 1981-11-12 3-(1-Substituted-4-piperidyl)-1,2-benzisoxazoles

Publications (2)

Publication Number Publication Date
ES529314A0 ES529314A0 (es) 1985-08-01
ES8506705A1 true ES8506705A1 (es) 1985-08-01

Family

ID=23243961

Family Applications (5)

Application Number Title Priority Date Filing Date
ES517249A Expired ES8405396A1 (es) 1981-11-12 1982-11-10 Procedimiento para la preparacion de 3-(1-sustituido-4-piperidil)-1,2-bencisoxazoles.
ES529313A Expired ES8506657A1 (es) 1981-11-12 1984-01-31 Procedimiento para la preparacion de 3-(1-sustituido-4-piperidil)-1, 2-bencisoxazoles
ES529312A Granted ES529312A0 (es) 1981-11-12 1984-01-31 Procedimiento para la preparacion de 3-(1-sustituido-4-piperidil)-1, 2-bencisoxazoles
ES529314A Expired ES8506705A1 (es) 1981-11-12 1984-01-31 Procedimiento para la preparacion de 3-(1-sustituido-4-piperidil)-1, 2-bencisoxazoles
ES529315A Granted ES529315A0 (es) 1981-11-12 1984-01-31 Procedimiento para la preparacion de 3-(1-sustituido-4-piperidil)-1, 2-bencisoxazoles

Family Applications Before (3)

Application Number Title Priority Date Filing Date
ES517249A Expired ES8405396A1 (es) 1981-11-12 1982-11-10 Procedimiento para la preparacion de 3-(1-sustituido-4-piperidil)-1,2-bencisoxazoles.
ES529313A Expired ES8506657A1 (es) 1981-11-12 1984-01-31 Procedimiento para la preparacion de 3-(1-sustituido-4-piperidil)-1, 2-bencisoxazoles
ES529312A Granted ES529312A0 (es) 1981-11-12 1984-01-31 Procedimiento para la preparacion de 3-(1-sustituido-4-piperidil)-1, 2-bencisoxazoles

Family Applications After (1)

Application Number Title Priority Date Filing Date
ES529315A Granted ES529315A0 (es) 1981-11-12 1984-01-31 Procedimiento para la preparacion de 3-(1-sustituido-4-piperidil)-1, 2-bencisoxazoles

Country Status (17)

Country Link
US (1) US4352811A (es)
EP (1) EP0079564B1 (es)
JP (1) JPS5890583A (es)
AT (1) ATE18669T1 (es)
AU (1) AU556307B2 (es)
CA (1) CA1196334A (es)
DE (1) DE3270015D1 (es)
DK (1) DK503082A (es)
ES (5) ES8405396A1 (es)
FI (1) FI823860L (es)
GR (1) GR78402B (es)
HU (1) HU191366B (es)
IL (1) IL67235A (es)
NO (1) NO823775L (es)
NZ (1) NZ202457A (es)
PT (1) PT75848A (es)
ZA (1) ZA828278B (es)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2074966A1 (es) * 1994-02-11 1995-09-16 Vita Invest Sa Procedimiento para la obtencion de 3-(2-(4-(6-fluo-ruro-benzo(d)isoxazol-3-il)-piperidin-1-il)-etil)-2-metil-6, 7,8,9-tetrahidro-4h-pirido-(1,2-a) pirimidin-4-ona.

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4355037A (en) * 1981-11-12 1982-10-19 Hoechst-Roussel Pharmaceuticals 3-(4-Piperidyl)-1,2-benzisoxales
US4352811A (en) * 1981-11-12 1982-10-05 Hoechst-Roussel Pharmaceuticals Inc. 3-(1-Substituted-4-piperidyl)-1,2-benzisoxazoles
US4469868A (en) * 1982-05-24 1984-09-04 Warner-Lambert Company Alkylimidazo[1,2-c]pyrazolo[3,4-e]pyrimidines
US4469869A (en) * 1982-08-11 1984-09-04 Hoechst-Roussel Pharmaceuticals, Inc. 3-(4-Piperidinium)-1,2-benzisoxazoles
US4458076A (en) * 1983-05-31 1984-07-03 Hoechst-Roussel Pharmaceuticals 3-(4-Piperidinyl)-1,2-benzisothiazoles
US4524074A (en) * 1983-05-31 1985-06-18 Hoechst-Roussel Pharmaceuticals Inc. 3-(4-Piperidinyl)-1,2-benzisothiazoles
US4528292A (en) * 1984-04-23 1985-07-09 Hoechst-Roussel Pharmaceuticals Inc. Antihypertensive 1,2-benzisothiazole piperidines
US4804663A (en) * 1985-03-27 1989-02-14 Janssen Pharmaceutica N.V. 3-piperidinyl-substituted 1,2-benzisoxazoles and 1,2-benzisothiazoles
IE58370B1 (en) * 1985-04-10 1993-09-08 Lundbeck & Co As H Indole derivatives
CA1335289C (en) * 1987-10-26 1995-04-18 Fujio Antoku Piperidinyl benzisoxazole derivatives, their production and pharmaceutical use
FR2654104B1 (fr) * 1989-11-07 1992-01-03 Adir Nouveaux derives du 1,2-benzisoxazole, leurs procedes de preparation et les compositions pharmaceutiques qui les contiennent.
FR2671350A1 (fr) * 1991-01-08 1992-07-10 Adir Nouveaux derives de benzisoxazole et de benzisothiazole, leur procede de preparation, et les compositions pharmaceutiques les renfermant.
US5147881A (en) * 1990-11-14 1992-09-15 Pfizer Inc 4-(1,2-benzisoxazolyl)piperidine antipsychotic agents
US5532240A (en) * 1991-12-26 1996-07-02 Yoshitomi Pharmaceutical Industries, Ltd. Condensed thiophene compound and pharmaceutical use thereof
KR100354270B1 (ko) 1993-11-19 2003-02-11 알커메스 컨트롤드 테라포이틱스 인코퍼레이티드 Ii 마이크로캡슐화된3-피페리디닐-치환된1,2-벤즈이속사졸및1,2-벤즈이소티아졸
FR2749304B1 (fr) * 1996-06-04 1998-06-26 Adir Nouveaux derives du 3-(piperid-4-yl)1,2-benzisoxazole et du 3-(piperazin-4-yl)1,2-benzisoxazole, leurs procedes de preparation et les compositions pharmaceutiques qui les contiennent
DK1054885T3 (da) * 1998-02-09 2007-10-15 Duphar Int Res Benzisoxasolderivater med D4-antagonistisk virkning
US20050232995A1 (en) 2002-07-29 2005-10-20 Yam Nyomi V Methods and dosage forms for controlled delivery of paliperidone and risperidone
ATE411797T2 (de) 2003-10-23 2008-11-15 Otsuka Pharma Co Ltd Sterile injizierbare aripiprazol-formulierung mit kontrollierter freisetzung und verfahren
JP4970290B2 (ja) * 2005-02-25 2012-07-04 ファイザー株式会社 ベンズイソキサゾール誘導体
MY152789A (en) * 2007-07-31 2014-11-28 Otsuka Pharma Co Ltd Methods for producing aripiprazole suspension and freeze-dried formulation
PT2079446E (pt) * 2007-08-21 2011-12-23 Teva Pharma Formulação de libertação sustida de paliperidona
CN101759693B (zh) * 2008-12-23 2011-09-14 江苏恩华药业股份有限公司 苯骈异恶唑哌啶衍生物及在制备镇痛、镇静药物中的应用
WO2016071723A1 (en) * 2014-11-03 2016-05-12 Sifavitor S.R.L. Process for the preparation of a fluspirilene intermediate
CN104829591B (zh) * 2015-04-27 2017-05-03 梯尔希（南京）药物研发有限公司 氘代匹莫齐特的制备方法

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE633495A (es) * 1962-06-13
US3678062A (en) * 1970-09-08 1972-07-18 American Cyanamid Co Certain 4-/(indazol-3-yl)-pyridinium/compounds
JPS5545545B2 (es) * 1972-03-17 1980-11-18
US4217349A (en) * 1974-07-01 1980-08-12 Sumitomo Chemical Company, Limited Benzisoxazole derivatives
JPS51136666A (en) * 1975-05-19 1976-11-26 Dainippon Pharmaceut Co Ltd Process for preparing 3-aminoalkyl-1,2-benzisoxazole derivatives.
FR2421899A1 (fr) * 1978-01-16 1979-11-02 Roussel Uclaf Nouveaux derives du tetrahydropyridinyl-indole et leurs sels, le procede de preparation et l'application a titre de medicaments de ces nouveaux produits
US4352811A (en) * 1981-11-12 1982-10-05 Hoechst-Roussel Pharmaceuticals Inc. 3-(1-Substituted-4-piperidyl)-1,2-benzisoxazoles

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2074966A1 (es) * 1994-02-11 1995-09-16 Vita Invest Sa Procedimiento para la obtencion de 3-(2-(4-(6-fluo-ruro-benzo(d)isoxazol-3-il)-piperidin-1-il)-etil)-2-metil-6, 7,8,9-tetrahidro-4h-pirido-(1,2-a) pirimidin-4-ona.

Also Published As

Publication number Publication date
EP0079564B1 (en) 1986-03-19
ES8506293A1 (es) 1985-07-01
ES529314A0 (es) 1985-08-01
ES529312A0 (es) 1985-07-01
ES8506658A1 (es) 1985-08-01
DE3270015D1 (en) 1986-04-24
AU556307B2 (en) 1986-10-30
ES529313A0 (es) 1985-07-16
IL67235A0 (en) 1983-03-31
AU9039182A (en) 1983-05-19
ES529315A0 (es) 1985-08-01
NO823775L (no) 1983-05-13
EP0079564A1 (en) 1983-05-25
IL67235A (en) 1987-03-31
HU191366B (en) 1987-02-27
ZA828278B (en) 1983-09-28
ATE18669T1 (de) 1986-04-15
JPS5890583A (ja) 1983-05-30
DK503082A (da) 1983-05-13
ES517249A0 (es) 1984-06-01
US4352811A (en) 1982-10-05
ES8506657A1 (es) 1985-07-16
NZ202457A (en) 1986-05-09
GR78402B (es) 1984-09-27
ES8405396A1 (es) 1984-06-01
FI823860A0 (fi) 1982-11-10
PT75848A (en) 1982-12-01
FI823860L (fi) 1983-05-13
CA1196334A (en) 1985-11-05

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